Gene Expression Literature Summary

• Symbol: Sema3b
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
• ID: MGI:107561

42 matching records from 42 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
In situ RNA (section)	1	1	4	1	9	8	1	11	1	8	1	13	2	3	1		3	1	8
In situ RNA (whole mount)	1											1
In situ reporter (knock in)			1			1		1
Northern blot			1		1	1		1				1		1		1			1
RT-PCR			1		2	1	1	1		2		1			1	1	1		4
cDNA clones								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sema3b  sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B   (Synonyms: LUCA-1, SemA, SemA, sema5, Semaa, semaV)
Results	Reference
7	J:221787 Arbeille E, Reynaud F, Sanyas I, Bozon M, Kindbeiter K, Causeret F, Pierani A, Falk J, Moret F, Castellani V, Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366
1	J:160872 Bron R, Vermeren M, Kokot N, Andrews W, Little GE, Mitchell KJ, Cohen J, Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism. Neural Dev. 2007;2:21
3	J:49908 Chedotal A, Del Rio JA, Ruiz M, He Z, Borrell V, de Castro F, Ezan F, Goodman CS, Tessier-Lavigne M, Sotelo C, Soriano E, Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development. 1998 Nov;125(21):4313-23
4	J:103829 Chen B, Schaevitz LR, McConnell SK, Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17184-9
4	J:124081 Chung L, Yang TL, Huang HR, Hsu SM, Cheng HJ, Huang PH, Semaphorin signaling facilitates cleft formation in the developing salivary gland. Development. 2007 Aug;134(16):2935-45
2	J:75436 Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD, Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. Neuron. 2002 Mar 14;33(6):877-92
1	J:226819 Coate TM, Spita NA, Zhang KD, Isgrig KT, Kelley MW, Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons. Elife. 2015;4
1*	J:100439 Cohen S, Funkelstein L, Livet J, Rougon G, Henderson CE, Castellani V, Mann F, A semaphorin code defines subpopulations of spinal motor neurons during mouse development. Eur J Neurosci. 2005 Apr;21(7):1767-76
2	J:111207 Dionne MS, Brunet LJ, Eimon PM, Harland RM, Noggin is required for correct guidance of dorsal root ganglion axons. Dev Biol. 2002 Nov 15;251(2):283-93
2	J:174966 Erskine L, Reijntjes S, Pratt T, Denti L, Schwarz Q, Vieira JM, Alakakone B, Shewan D, Ruhrberg C, VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron. 2011 Jun 9;70(5):951-65
2	J:105299 Falk J, Bechara A, Fiore R, Nawabi H, Zhou H, Hoyo-Becerra C, Bozon M, Rougon G, Grumet M, Puschel AW, Sanes JR, Castellani V, Dual functional activity of semaphorin 3B is required for positioning the anterior commissure. Neuron. 2005 Oct 6;48(1):63-75
6	J:331696 Gerstmann K, Kindbeiter K, Telley L, Bozon M, Reynaud F, Theoulle E, Charoy C, Jabaudon D, Moret F, Castellani V, A balance of noncanonical Semaphorin signaling from the cerebrospinal fluid regulates apical cell dynamics during corticogenesis. Sci Adv. 2022 Nov 16;8(46):eabo4552
1*	J:229257 Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y, Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:175792 Jelcick AS, Yuan Y, Leehy BD, Cox LC, Silveira AC, Qiu F, Schenk S, Sachs AJ, Morrison MA, Nystuen AM, DeAngelis MM, Haider NB, Genetic variations strongly influence phenotypic outcome in the mouse retina. PLoS One. 2011;6(7):e21858
1	J:65749 Jimenez D, Garcia C, de Castro F, Chedotal A, Sotelo C, de Carlos JA, Valverde F, Lopez-Mascaraque L, Evidence for intrinsic development of olfactory structures in Pax-6 mutant mice. J Comp Neurol. 2000 Dec 18;428(3):511-26
1	J:205955 Katayama K, Imai F, Suto F, Yoshida Y, Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons. PLoS One. 2013;8(8):e72512
1	J:153883 Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ, Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J Neurosci. 2009 Oct 7;29(40):12542-57
1	J:188362 Kuwajima T, Yoshida Y, Takegahara N, Petros TJ, Kumanogoh A, Jessell TM, Sakurai T, Mason C, Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing. Neuron. 2012 May 24;74(4):676-90
1	J:241102 Leone DP, Panagiotakos G, Heavner WE, Joshi P, Zhao Y, Westphal H, McConnell SK, Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation. Cereb Cortex. 2017 Feb 01;27(2):1686-1699
5	J:91290 Lillesaar C, Fried K, Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage. Neuroscience. 2004;125(1):149-61
7*	J:68163 Loes S, Kettunen P, Kvinnsland IH, Taniguchi M, Fujisawa H, Luukko K, Expression of class 3 semaphorins and neuropilin receptors in the developing mouse tooth. Mech Dev. 2001 Mar;101(1-2):191-4
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:330969 Martins LF, Brambilla I, Motta A, de Pretis S, Bhat GP, Badaloni A, Malpighi C, Amin ND, Imai F, Almeida RD, Yoshida Y, Pfaff SL, Bonanomi D, Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity. Neuron. 2022 Oct 7;
1*	J:159029 Matsuda I, Fukaya M, Nakao H, Nakao K, Matsumoto H, Mori K, Watanabe M, Aiba A, Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice. Neurosci Res. 2010 Mar;66(3):321-9
2	J:192712 Meadows SM, Fletcher PJ, Moran C, Xu K, Neufeld G, Chauvet S, Mann F, Krieg PA, Cleaver O, Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
2*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2	J:156992 Nawabi H, Briancon-Marjollet A, Clark C, Sanyas I, Takamatsu H, Okuno T, Kumanogoh A, Bozon M, Takeshima K, Yoshida Y, Moret F, Abouzid K, Castellani V, A midline switch of receptor processing regulates commissural axon guidance in vertebrates. Genes Dev. 2010 Feb 15;24(4):396-410
5*	J:332131 Perera SN, Williams RM, Lyne R, Stubbs O, Buehler DP, Sauka-Spengler T, Noda M, Micklem G, Southard-Smith EM, Baker CVH, Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach. Glia. 2020 Dec;68(12):2550-2584
9*	J:25500 Puschel AW, Adams RH, Betz H, Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
6*	J:37600 Puschel AW, Adams RH, Betz H, The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins. Mol Cell Neurosci. 1996 May;7(5):419-31
1*	J:277791 Sar Shalom H, Goldner R, Golan-Vaishenker Y, Yaron A, Balance between BDNF and Semaphorins gates the innervation of the mammary gland. Elife. 2019 Jan 10;8:e41162
1*	J:136315 Takahashi K, Ishida M, Hirokawa K, Takahashi H, Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus. Dev Dyn. 2008 Jun;237(6):1699-708
1	J:171050 Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH, Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:214891 Torigoe M, Yamauchi K, Tamada A, Matsuda I, Aiba A, Castellani V, Murakami F, Role of neuropilin-2 in the ipsilateral growth of midbrain dopaminergic axons. Eur J Neurosci. 2013 May;37(10):1573-83
1*	J:226501 Uchida Y, James JM, Suto F, Mukouyama YS, Class 3 semaphorins negatively regulate dermal lymphatic network formation. Biol Open. 2015;4(9):1194-205
2	J:97316 van der Weyden L, Adams DJ, Harris LW, Tannahill D, Arends MJ, Bradley A, Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT vector. Genesis. 2005 Apr;41(4):171-8
1*	J:217271 Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI, The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem. 2012 Oct 26;287(44):37282-95
4*	J:138310 Xu C, Fan CM, Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. Gene Expr Patterns. 2008 Sep;8(7-8):502-7
1	J:144660 Yoshida Y, Han B, Mendelsohn M, Jessell TM, PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron. 2006 Dec 7;52(5):775-88