Gene Expression Literature Summary

• Symbol: Gjb6
• Name: gap junction protein, beta 6
• ID: MGI:107588

20 matching records from 20 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2	E4	E9.5	E10.5	E11.5	E12	E12.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)										1	1		1	1		1	1	8
In situ RNA (section)			1			1					2					1		2
In situ RNA (whole mount)			2	1		1
In situ reporter (knock in)																		2
Northern blot																	1	1
Western blot																		4
RT-PCR	1	1	1	1	1		2	1	2			1	1	1	1	1		3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gjb6  gap junction protein, beta 6   (Synonyms: connexin 30, Cx30, D14Bwg0506e)
Results	Reference
3	J:89303 Buniello A, Montanaro D, Volinia S, Gasparini P, Marigo V, An expression atlas of connexin genes in the mouse. Genomics. 2004 May;83(5):812-20
3	J:135624 Cina C, Bechberger JF, Ozog MA, Naus CC, Expression of connexins in embryonic mouse neocortical development. J Comp Neurol. 2007 Sep 20;504(3):298-313
2	J:34343 Dahl E, Manthey D, Chen Y, Schwarz HJ, Chang YS, Lalley PA, Nicholson BJ, Willecke K, Molecular cloning and functional expression of mouse connexin-30,a gap junction gene highly expressed in adult brain and skin. J Biol Chem. 1996 Jul 26;271(30):17903-10
1	J:193352 Degen J, Dublin P, Zhang J, Dobrowolski R, Jokwitz M, Karram K, Trotter J, Jabs R, Willecke K, Steinhauser C, Theis M, Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity. FASEB J. 2012 Nov;26(11):4576-83
10	J:180242 Dupressoir A, Vernochet C, Harper F, Guegan J, Dessen P, Pierron G, Heidmann T, A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73
1	J:315134 Ezan P, Andre P, Cisternino S, Saubamea B, Boulay AC, Doutremer S, Thomas MA, Quenech'du N, Giaume C, Cohen-Salmon M, Deletion of astroglial connexins weakens the blood-brain barrier. J Cereb Blood Flow Metab. 2012 Aug;32(8):1457-67
1	J:308983 Farmer DT, Mlcochova H, Zhou Y, Koelling N, Wang G, Ashley N, Bugacov H, Chen HJ, Parvez R, Tseng KC, Merrill AE, Maxson RE Jr, Wilkie AOM, Crump JG, Twigg SRF, The developing mouse coronal suture at single-cell resolution. Nat Commun. 2021 Aug 10;12(1):4797
2	J:193630 Fujimoto A, Kurban M, Nakamura M, Farooq M, Fujikawa H, Kibbi AG, Ito M, Dahdah M, Matta M, Diab H, Shimomura Y, GJB6, of which mutations underlie Clouston syndrome, is a potential direct target gene of p63. J Dermatol Sci. 2013 Feb;69(2):159-66
6	J:172556 Gros D, Theveniau-Ruissy M, Bernard M, Calmels T, Kober F, Sohl G, Willecke K, Nargeot J, Jongsma HJ, Mangoni ME, Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate. Cardiovasc Res. 2010 Jan 1;85(1):45-55
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:91500 Houghton FD, Barr KJ, Walter G, Gabriel HD, Grummer R, Traub O, Leese HJ, Winterhager E, Kidder GM, Functional significance of gap junctional coupling in preimplantation development. Biol Reprod. 2002 May;66(5):1403-12
2*	J:284778 Huebner AK, Maier H, Maul A, Nietzsche S, Herrmann T, Praetorius J, Hubner CA, Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice. J Assoc Res Otolaryngol. 2019 Jun;20(3):233-245
3	J:209627 Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K, Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest. 2014 Apr 1;124(4):1598-607
2	J:319352 Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans SM, Cheng H, Chen J, Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival. J Am Heart Assoc. 2015 May 5;4(5)
2	J:346440 Pelz L, Dossou L, Kompier N, Juttner R, Siemonsmeier G, Meyer N, Lowenstein ED, Lahmann I, Kettenmann H, Birchmeier C, Rathjen FG, The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte coupling in mice. eNeuro. 2024 Feb 22;11(3):ENEURO.0283-23.2024
1	J:326535 Petitpre C, Faure L, Uhl P, Fontanet P, Filova I, Pavlinkova G, Adameyko I, Hadjab S, Lallemend F, Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification. Nat Commun. 2022 Jul 5;13(1):3878
4	J:101228 Sun J, Ahmad S, Chen S, Tang W, Zhang Y, Chen P, Lin X, Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts. Am J Physiol Cell Physiol. 2005 Mar;288(3):C613-23
1*	J:93582 von Maltzahn J, Euwens C, Willecke K, Sohl G, The novel mouse connexin39 gene is expressed in developing striated muscle fibers. J Cell Sci. 2004 Oct 15;117(Pt 22):5381-92
1	J:343328 Xie Z, Ma XH, Bai QF, Tang J, Sun JH, Jiang F, Guo W, Wang CM, Yang R, Wen YC, Wang FY, Chen YX, Zhang H, He DZ, Kelley MW, Yang S, Zhang WJ, ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
2*	J:327901 Ye Q, Bhojwani A, Hu JK, Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539