Gene Expression Literature Summary

• Symbol: Ifng
• Name: interferon gamma
• ID: MGI:107656

33 matching records from 33 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E19.5	E20	E	P
Immunohistochemistry (section)				1						1	2		1	1	1	1		1	1	1		1
In situ RNA (section)							1			1	1	1	1	1	1	1		1	1
In situ RNA (whole mount)			1										1
In situ reporter (knock in)																						1
Northern blot											1
RT-PCR	1	1	2		1	1	2	1	2		6	2	2	2	1	2	1	3	2	2	1	13
RNase protection																						2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ifng  interferon gamma   (Synonyms: Ifg, IFN-gamma)
Results	Reference
1*	J:93240 Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y, Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A. 2004 Dec 9;101(45):16016-21
1	J:263707 Brown HM, Green ES, Tan TCY, Gonzalez MB, Rumbold AR, Hull ML, Norman RJ, Packer NH, Robertson SA, Thompson JG, Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy. Sci Rep. 2018 Feb 1;8(1):2114
1	J:67398 Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ, The characterization of mice with a targeted combined deficiency of protein c and factor XI. Am J Pathol. 2001 Feb;158(2):469-79
1	J:324684 Dang Y, Souchet C, Moresi F, Jeljeli M, Raquillet B, Nicco C, Chouzenoux S, Lagoutte I, Marcellin L, Batteux F, Doridot L, BCG-trained innate immunity leads to fetal growth restriction by altering immune cell profile in the mouse developing placenta. J Leukoc Biol. 2022 May;111(5):1009-1020
7	J:21326 Deman J, Humblet C, Martin MT, Boniver J, Defresne MP, Analysis by in situ hybridization of cytokine mRNA expression in the murine developing thymus. Int Immunol. 1994 Oct;6(10):1613-9
8*	J:35158 Deman J, Van Meurs M, Claassen E, Humblet C, Boniver J, Defresne MP, In vivo expression of interleukin-1 beta (IL-1 beta), IL-2, IL-4, IL-6, tumour necrosis factor-alpha and interferon-gamma in the fetal murine thymus. Immunology. 1996 Sep;89(1):152-7
1	J:82631 Fukuda K, Yoshida H, Sato T, Furumoto TA, Mizutani-Koseki Y, Suzuki Y, Saito Y, Takemori T, Kimura M, Sato H, Taniguchi M, Nishikawa S, Nakayama T, Koseki H, Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Dev Biol. 2003 Mar 15;255(2):278-89
1	J:226998 Gao D, Li T, Li XD, Chen X, Li QZ, Wight-Carter M, Chen ZJ, Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705
1	J:339248 Geng X, Zhang C, Li M, Wang J, Ji F, Feng H, Xing M, Li F, Zhang L, Li W, Chen Z, Hickson ID, Shen H, Ying S, PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response. Adv Sci (Weinh). 2022 Mar;9(7):e2103837
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:283846 Hirsch S, El-Achkar T, Robbins L, Basta J, Heitmeier M, Nishinakamura R, Rauchman M, A mouse model of Townes-Brocks syndrome expressing a truncated mutant Sall1 protein is protected from acute kidney injury. Am J Physiol Renal Physiol. 2015 Nov 15;309(10):F852-63
1	J:176596 Hu D, Cross JC, Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta. Dev Biol. 2011 Oct 1;358(1):231-9
1	J:349097 Imai T, Lin J, Kaya GG, Ju E, Kondylis V, Kelepouras K, Liccardi G, Kim C, Pasparakis M, The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity. 2024 May 7;
2	J:137276 Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R, Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008 Jun 19;453(7198):1117-21
7*	J:17723 Kohchi C, Noguchi K, Tanabe Y, Mizuno D, Soma G, Constitutive expression of TNF-alpha and -beta genes in mouse embryo: roles of cytokines as regulator and effector on development. Int J Biochem. 1994 Jan;26(1):111-9
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:306875 Lakhia R, Yheskel M, Flaten A, Ramalingam H, Aboudehen K, Ferre S, Biggers L, Mishra A, Chaney C, Wallace DP, Carroll T, Igarashi P, Patel V, Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression. JCI Insight. 2020 Apr 9;5(7)
2*	J:324243 Lei Z, Liu W, Nie Y, Yang Y, Chen G, Huang L, Wu H, Lei Y, Chen L, Hu Q, Rong H, Yu S, Song Q, Tong F, Guo J, EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice. Front Immunol. 2022;13:843378
2	J:161777 Li L, Walker TL, Zhang Y, Mackay EW, Bartlett PF, Endogenous interferon gamma directly regulates neural precursors in the non-inflammatory brain. J Neurosci. 2010 Jul 7;30(27):9038-50
7*	J:44503 Montgomery RA, Dallman MJ, Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny. Cytokine. 1997 Oct;9(10):717-26
7*	J:55762 Montgomery RA, Dallman MJ, Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J Immunol. 1991 Jul 15;147(2):554-60
1	J:141401 Okabe Y, Kawane K, Nagata S, IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation. Eur J Immunol. 2008 Nov;38(11):3150-8
1	J:265031 Sequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G, Watt FM, Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nat Commun. 2018 Aug 24;9(1):3437
1	J:148113 Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y, Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia. 2009 May;52(5):962-71
1	J:279494 Tang Y, Tu H, Zhang J, Zhao X, Wang Y, Qin J, Lin X, K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019 Sep 13;10(1):4157
1	J:224212 Vendrell V, Lopez-Hernandez I, Duran Alonso MB, Feijoo-Redondo A, Abello G, Galvez H, Giraldez F, Lamonerie T, Schimmang T, Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea. Development. 2015 Aug 15;142(16):2792-800
1*	J:317911 Wang L, Yu H, Cheng H, He K, Fang Z, Ge L, Cheng T, Jin Y, Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver. Cell Death Dis. 2017 Mar 30;8(3):e2722
1	J:168909 Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY, Dragon (repulsive guidance molecule B) inhibits IL-6 expression in macrophages. J Immunol. 2011 Feb 1;186(3):1369-76
1	J:344311 Yan W, Chen S, Wang Y, You Y, Lu Y, Wang W, Wu B, Du J, Peng S, Cai W, Xiao Y, Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94
2*	J:94874 Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S, Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol. 2005 Jan;6(1):49-56
3	J:263559 Yun K, Hurwitz AA, Perantoni AO, Constitutive metanephric mesenchyme-specific expression of interferon-gamma causes renal dysplasia by regulating Sall1 expression. PLoS One. 2018;13(5):e0197356
7	J:309397 Yuzwa SA, Yang G, Borrett MJ, Clarke G, Cancino GI, Zahr SK, Zandstra PW, Kaplan DR, Miller FD, Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks. Neuron. 2016 Sep 7;91(5):988-1004
1*	J:281166 Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H, Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun. 2019 Sep 13;10(1):4158