Gene Expression Literature Summary

• Symbol: Myh9
• Name: myosin, heavy polypeptide 9, non-muscle
• ID: MGI:107717

51 matching records from 51 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2.5	E3	E3.5	E5.5	E6.5	E7.5	E8	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)							1	2	1	1	2	1	3	2	4	5	5	1	9	2	3	1	7	1	1	1	4	11
In situ RNA (section)															1		1		3		1					1	1	2
Immunohistochemistry (whole mount)	1	1	1	1	1	1							1				2					1						1
In situ RNA (whole mount)													1	1
In situ reporter (knock in)																			1
Western blot													1		1				1				4		1	3		14
RT-PCR	1		1	1		1										1	1		1		1		1	1		1		6
cDNA clones																												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Myh9  myosin, heavy polypeptide 9, non-muscle   (Synonyms: D0Jmb2, E030044M24Rik, Fltn, Myhn-1, Myhn1, myosin IIA, NMHC II-A)
Results	Reference
1	J:278104 Acebedo AR, Suzuki K, Hino S, Alcantara MC, Sato Y, Haga H, Matsumoto KI, Nakao M, Shimamura K, Takeo T, Nakagata N, Miyagawa S, Nishinakamura R, Adelstein RS, Yamada G, Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice. Commun Biol. 2019;2:95
2	J:307822 Beal R, Alonso-Carriazo Fernandez A, Grammatopoulos DK, Matter K, Balda MS, ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis. Front Cell Dev Biol. 2021;9:658006
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:351096 Chen X, Li Y, Xu J, Cui Y, Wu Q, Yin H, Li Y, Gao C, Jiang L, Wang H, Wen Z, Yao Z, Wu Z, Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation. Elife. 2024 Jun 3;12
1	J:325357 Chomiak AA, Guo Y, Kopsidas CA, McDaniel DP, Lowe CC, Pan H, Zhou X, Zhou Q, Doughty ML, Feng Y, Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022 Jun 17;25(6):104354
2	J:94940 Conti MA, Even-Ram S, Liu C, Yamada KM, Adelstein RS, Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J Biol Chem. 2004 Oct 1;279(40):41263-6
2*	J:202224 Crish J, Conti MA, Sakai T, Adelstein RS, Egelhoff TT, Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality. Dev Biol. 2013 Oct 1;382(1):136-48
4	J:267925 Diaz-Horta O, Abad C, Cengiz FB, Bademci G, Blackwelder P, Walz K, Tekin M, Ripor2 is involved in auditory hair cell stereociliary bundle structure and orientation. J Mol Med (Berl). 2018 Nov;96(11):1227-1238
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:240644 Fan X, Yang H, Kumar S, Tumelty KE, Pisarek-Horowitz A, Rasouly HM, Sharma R, Chan S, Tyminski E, Shamashkin M, Belghasem M, Henderson JM, Coyle AJ, Salant DJ, Berasi SP, Lu W, SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI Insight. 2016 Nov 17;1(19):e86934
1	J:324294 Goering JP, Wenger LW, Stetsiv M, Moedritzer M, Hall EG, Isai DG, Jack BM, Umar Z, Rickabaugh MK, Czirok A, Saadi I, In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events. Hum Mol Genet. 2021 Dec 17;31(1):18-31
3	J:90427 Golomb E, Ma X, Jana SS, Preston YA, Kawamoto S, Shoham NG, Goldin E, Conti MA, Sellers JR, Adelstein RS, Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family. J Biol Chem. 2004 Jan 23;279(4):2800-8
2	J:243207 Haque F, Kaku Y, Fujimura S, Ohmori T, Adelstein RS, Nishinakamura R, Non-muscle myosin II deletion in the developing kidney causes ureter-bladder misconnection and apical extrusion of the nephric duct lineage epithelia. Dev Biol. 2017 Jul 01;427(1):121-130
1*	J:68051 Herring BP, Lyons GE, Hoggatt AM, Gallagher PJ, Telokin expression is restricted to smooth muscle tissues during mouse development. Am J Physiol Cell Physiol. 2001 Jan;280(1):C12-21
1	J:349163 Huycke TR, Hakkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ, Patterning and folding of intestinal villi by active mesenchymal dewetting. Cell. 2024 Jun 6;187(12):3072-3089.e20
3	J:222409 Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO, Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol. 2015 Apr;13(4):e1002122
2	J:199510 Lee J, Andreeva A, Sipe CW, Liu L, Cheng A, Lu X, PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium. Curr Biol. 2012 Jun 5;22(11):956-66
1	J:310879 Lesko AC, Keller R, Chen P, Sutherland A, Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure. Dev Biol. 2021 Oct;478:59-75
1	J:264609 Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y, Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 Sep 1;441(1):191-203
2	J:309353 Li M, Li S, Rao Y, Cui S, Gou K, Loss of smooth muscle myosin heavy chain results in the bladder and stomach developing lesion during foetal development in mice. J Genet. 2018 Jun;97(2):469-475
1	J:355649 Li Q, Jiang S, Lei K, Han H, Chen Y, Lin W, Xiong Q, Qi X, Gan X, Sheng R, Wang Y, Zhang Y, Ma J, Li T, Lin S, Zhou C, Chen D, Yuan Q, Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism. J Clin Invest. 2024 Sep 10;134(20)
2	J:246153 Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS, N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017 Aug 01;428(1):118-134
4	J:142122 Lu W, Seeholzer SH, Han M, Arnold AS, Serrano M, Garita B, Philp NJ, Farthing C, Steele P, Chen J, Linask KK, Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping. Dev Dyn. 2008 Dec;237(12):3577-90
2	J:245570 Ma X, Adelstein RS, A point mutation in Myh10 causes major defects in heart development and body wall closure. Circ Cardiovasc Genet. 2014 Jun;7(3):257-65
1	J:127463 Ma X, Bao J, Adelstein RS, Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice. Mol Biol Cell. 2007 Jun;18(6):2305-12
2	J:92081 Ma X, Kawamoto S, Hara Y, Adelstein RS, A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons. Mol Biol Cell. 2004 Jun;15(6):2568-79
1	J:247626 Ma X, Sung DC, Yang Y, Wakabayashi Y, Adelstein RS, Nonmuscle myosin IIB regulates epicardial integrity and epicardium-derived mesenchymal cell maturation. J Cell Sci. 2017 Aug 15;130(16):2696-2706
1	J:308031 Ma X, Uchida Y, Wei T, Liu C, Adams RH, Kubota Y, Gutkind JS, Mukouyama YS, Adelstein RS, Nonmuscle myosin 2 regulates cortical stability during sprouting angiogenesis. Mol Biol Cell. 2020 Aug 15;31(18):1974-1987
5	J:125412 Maddala R, Skiba N, Vasantha Rao P, Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse. Differentiation. 2007 Oct;75(8):713-25
6	J:90712 Marigo V, Nigro A, Pecci A, Montanaro D, Di Stazio M, Balduini CL, Savoia A, Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains. Genomics. 2004 Jun;83(6):1125-33
1	J:203133 Metzis V, Courtney AD, Kerr MC, Ferguson C, Rondon Galeano MC, Parton RG, Wainwright BJ, Wicking C, Patched1 is required in neural crest cells for the prevention of orofacial clefts. Hum Mol Genet. 2013 Dec 15;22(24):5026-35
9	J:91334 Mhatre AN, Li J, Kim Y, Coling DE, Lalwani AK, Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear. J Neurosci Res. 2004 May 1;76(3):296-305
4*	J:18718 Mieziewska K, Szel A, Van Veen T, Aguirre GD, Philp N, Redistribution of insoluble interphotoreceptor matrix components during photoreceptor differentiation in the mouse retina. J Comp Neurol. 1994 Jul 1;345(1):115-24
3	J:187967 Plosa EJ, Gooding KA, Zent R, Prince LS, Nonmuscle myosin II regulation of lung epithelial morphology. Dev Dyn. 2012 Nov;241(11):1770-81
2	J:244798 Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R, Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons. J Am Soc Nephrol. 2015 May;26(5):1081-91
2	J:248868 Ridge LA, Mitchell K, Al-Anbaki A, Shaikh Qureshi WM, Stephen LA, Tenin G, Lu Y, Lupu IE, Clowes C, Robertson A, Barnes E, Wright JA, Keavney B, Ehler E, Lovell SC, Kadler KE, Hentges KE, Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development. PLoS Genet. 2017 Oct;13(10):e1007068
3	J:163649 Sani FV, Kaartinen V, El Shahawy M, Linde A, Gritli-Linde A, Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse. Eur J Oral Sci. 2010 Jun;118(3):221-36
10*	J:308323 Schliffka MF, Tortorelli AF, Ozguc O, de Plater L, Polzer O, Pelzer D, Maitre JL, Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development. Elife. 2021 Apr 19;10:e68536
1*	J:256230 Shin SW, John Vogt E, Jimenez-Movilla M, Baibakov B, Dean J, Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017 Nov 21;8(1):1643
3	J:218919 Sumigray K, Zhou K, Lechler T, Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. PLoS One. 2014;9(7):e101824
3*	J:308237 Sun J, Qiao YN, Tao T, Zhao W, Wei LS, Li YQ, Wang W, Wang Y, Zhou YW, Zheng YY, Chen X, Pan HC, Zhang XN, Zhu MS, Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction. Front Physiol. 2020;11:593966
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:339444 Trela E, Lan Q, Myllymaki SM, Villeneuve C, Lindstrom R, Kumar V, Wickstrom SA, Mikkola ML, Cell influx and contractile actomyosin force drive mammary bud growth and invagination. J Cell Biol. 2021 Aug 2;220(8)
6*	J:51992 Tsuda T, Majumder K, Linask KK, Differential expression of flectin in the extracellular matrix and left-right asymmetry in mouse embryonic heart during looping stages. Dev Genet. 1998;23(3):203-14
2*	J:44181 Tullio AN, Accili D, Ferrans VJ, Yu ZX, Takeda K, Grinberg A , Westphal H , Preston YA , Adelstein RS, Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12407-12
1	J:68664 Tullio AN, Bridgman PC, Tresser NJ, Chan CC, Conti MA, Adelstein RS, Hara Y, Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. J Comp Neurol. 2001 Apr 23;433(1):62-74
3	J:163702 Wang A, Ma X, Conti MA, Liu C, Kawamoto S, Adelstein RS, Nonmuscle myosin II isoform and domain specificity during early mouse development. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14645-50
13	J:149532 Yamamoto N, Okano T, Ma X, Adelstein RS, Kelley MW, Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development. 2009 Jun;136(12):1977-86
1	J:192804 Yates LL, Schnatwinkel C, Hazelwood L, Chessum L, Paudyal A, Hilton H, Romero MR, Wilde J, Bogani D, Sanderson J, Formstone C, Murdoch JN, Niswander LA, Greenfield A, Dean CH, Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol. 2013 Jan 15;373(2):267-80
1	J:159690 Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CH, The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet. 2010 Jun 1;19(11):2251-67
2	J:317371 Zhang Y, Liu C, Adelstein RS, Ma X, Replacing nonmuscle myosin 2A with myosin 2C1 permits gastrulation but not placenta vascular development in mice. Mol Biol Cell. 2018 Sep 15;29(19):2326-2335