Gene Expression Literature Summary

• Symbol: Mesp1
• Name: mesoderm posterior 1
• ID: MGI:107785

47 matching records from 47 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E15.5	E17.5	E	P
In situ RNA (section)		1	2	5	1			1		1			1		1		3
Immunohistochemistry (whole mount)		1	1	1	1	1
In situ RNA (whole mount)	1	10	10	15	5	4	2	7	1	2	2			1		6
In situ reporter (knock in)		2	2	2	2	1		2
Northern blot								1				1					1
RT-PCR		2	1	6	1	5		2	1		1						2
cDNA clones				1
RNase protection																	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mesp1  mesoderm posterior 1   (Synonyms: bHLHc5)
Results	Reference
5	J:311976 Ajima R, Sakakibara Y, Sakurai-Yamatani N, Muraoka M, Saga Y, Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice. Development. 2021 Oct 15;148(20):dev194613
2*	J:184591 Aoyama M, Sun-Wada GH, Yamamoto A, Yamamoto M, Hamada H, Wada Y, Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75
1	J:54606 Barrantes IB, Elia AJ, Wunsch K, De Angelis MH, Mak TW, Rossant J, Conlon RA, Gossler A, de la Pompa JL, Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol. 1999 May 6;9(9):470-80
1	J:221142 Beketaev I, Zhang Y, Kim EY, Yu W, Qian L, Wang J, Critical role of YY1 in cardiac morphogenesis. Dev Dyn. 2015 May;244(5):669-80
2*	J:229171 Beketaev I, Zhang Y, Weng KC, Rhee S, Yu W, Liu Y, Mager J, Wang J, cis-regulatory control of Mesp1 expression by YY1 and SP1 during mouse embryogenesis. Dev Dyn. 2016 Mar;245(3):379-87
3*	J:202883 Cai W, Albini S, Wei K, Willems E, Guzzo RM, Tsuda M, Giordani L, Spiering S, Kurian L, Yeo GW, Puri PL, Mercola M, Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment. Genes Dev. 2013 Nov 1;27(21):2332-44
2	J:315974 Chen X, Wang L, Huang R, Qiu H, Wang P, Wu D, Zhu Y, Ming J, Wang Y, Wang J, Na J, Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program. Protein Cell. 2019 May;10(5):327-346
1	J:213158 Cho A, Tang Y, Davila J, Deng S, Chen L, Miller E, Wernig M, Graef IA, Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron. 2014 Apr 2;82(1):109-24
4	J:176969 Costello I, Pimeisl IM, Drager S, Bikoff EK, Robertson EJ, Arnold SJ, The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol. 2011 Sep;13(9):1084-91
3	J:243956 Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR, Id genes are essential for early heart formation. Genes Dev. 2017 Aug 9;
1*	J:180827 David R, Jarsch VB, Schwarz F, Nathan P, Gegg M, Lickert H, Franz WM, Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell. Cardiovasc Res. 2011 Oct 1;92(1):115-22
3*	J:232545 Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau BG, Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife. 2014;3
5	J:333140 Dominguez MH, Krup AL, Muncie JM, Bruneau BG, Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart. Cell. 2023 Feb 2;186(3):479-496.e23
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:79491 Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA, Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 2002 Oct 15;16(20):2650-61
1	J:71983 Haraguchi S, Kitajima S, Takagi A, Takeda H, Inoue T, Saga Y, Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development. Mech Dev. 2001 Oct;108(1-2):59-69
3*	J:200708 Jin JZ, Ding J, Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation. Dev Biol. 2013 Sep 1;381(1):170-8
4	J:62984 Kitajima S, Takagi A, Inoue T, Saga Y, MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development. 2000 Aug;127(15):3215-26
1	J:186421 Klaus A, Muller M, Schulz H, Saga Y, Martin JF, Birchmeier W, Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10921-6
2	J:336868 Kokkinopoulos I, Ishida H, Saba R, Ruchaya P, Cabrera C, Struebig M, Barnes M, Terry A, Kaneko M, Shintani Y, Coppen S, Shiratori H, Ameen T, Mein C, Hamada H, Suzuki K, Yashiro K, Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo. PLoS One. 2015;10(10):e0140831
1	J:71693 Kume T, Jiang H, Topczewska JM, Hogan BL, The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 2001 Sep 15;15(18):2470-82
2	J:219384 Lescroart F, Chabab S, Lin X, Rulands S, Paulissen C, Rodolosse A, Auer H, Achouri Y, Dubois C, Bondue A, Simons BD, Blanpain C, Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development. Nat Cell Biol. 2014 Sep;16(9):829-40
3	J:332317 Lin X, Swedlund B, Ton MN, Ghazanfar S, Guibentif C, Paulissen C, Baudelet E, Plaindoux E, Achouri Y, Calonne E, Dubois C, Mansfield W, Zaffran S, Marioni JC, Fuks F, Gottgens B, Lescroart F, Blanpain C, Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors. Nat Cell Biol. 2022 Jul;24(7):1114-1128
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
2*	J:321209 Magli A, Schnettler E, Swanson SA, Borges L, Hoffman K, Stewart R, Thomson JA, Keirstead SA, Perlingeiro RC, Pax3 and Tbx5 specify whether PDGFRalpha+ cells assume skeletal or cardiac muscle fate in differentiating embryonic stem cells. Stem Cells. 2014 Aug;32(8):2072-83
7	J:119678 Morimoto M, Kiso M, Sasaki N, Saga Y, Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. Dev Biol. 2006 Dec 15;300(2):687-98
1	J:81152 Mukhopadhyay M, Teufel A, Yamashita T, Agulnick AD, Chen L, Downs KM, Schindler A, Grinberg A, Huang SP, Dorward D, Westphal H, Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development. 2003 Feb;130(3):495-505
1	J:237500 Osipovich AB, Gangula R, Vianna PG, Magnuson MA, Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Development. 2016 Dec 15;143(24):4595-4607
1*	J:67152 Perea-Gomez A, Lawson KA, Rhinn M, Zakin L, Brulet P, Mazan S, Ang SL, Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo. Development. 2001 Mar;128(5):753-65
1*	J:53656 Perea-Gomez A, Shawlot W, Sasaki H, Behringer RR, Ang S, HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development. 1999 Oct;126(20):4499-511
1	J:157256 Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D, Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development. 2010 Jan;137(2):249-59
3*	J:301247 Probst S, Sagar, Tosic J, Schwan C, Grun D, Arnold SJ, Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation. Development. 2021 Jan 7;148(1):dev193789
4*	J:49903 Saga Y, Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement. Mech Dev. 1998 Jul;75(1-2):53-66
15	J:35774 Saga Y, Hata N, Kobayashi S, Magnuson T, Seldin MF, Taketo MM, MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. Development. 1996 Sep;122(9):2769-78
5	J:42014 Saga Y, Hata N, Koseki H, Taketo MM, Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 1997 Jul 15;11(14):1827-39
12*	J:55840 Saga Y, Miyagawa-Tomita S, Takagi A, Kitajima S, Miyazaki Ji, Inoue T, MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999 Aug;126(15):3437-47
1	J:236978 Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL, Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep;14(9):e2000197
1	J:167045 Sasaki N, Kiso M, Kitagawa M, Saga Y, The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis. Development. 2011 Jan;138(1):55-64
2	J:341093 Schule KM, Weckerle J, Probst S, Wehmeyer AE, Zissel L, Schroder CM, Tekman M, Kim GJ, Schlagl IM, Sagar, Arnold SJ, Eomes restricts Brachyury functions at the onset of mouse gastrulation. Dev Cell. 2023 Sep 25;58(18):1627-1642.e7
1	J:120635 Takahashi Y, Kitajima S, Inoue T, Kanno J, Saga Y, Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites. Development. 2005 Feb;132(4):787-96
1	J:122532 Takahashi Y, Yasuhiko Y, Kitajima S, Kanno J, Saga Y, Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation. Dev Biol. 2007 Apr 15;304(2):593-603
3	J:238633 Tyser RC, Miranda AM, Chen CM, Davidson SM, Srinivas S, Riley PR, Calcium handling precedes cardiac differentiation to initiate the first heartbeat. Elife. 2016 Oct 11;5:e17113
1	J:340402 Wang R, Yang X, Chen J, Zhang L, Griffiths JA, Cui G, Chen Y, Qian Y, Peng G, Li J, Wang L, Marioni JC, Tam PPL, Jing N, Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nat Commun. 2023 Sep 14;14(1):5675
1	J:238549 Warrier S, Nuwayhid S, Sabatino JA, Sugrue KF, Zohn IE, Supt20 is required for development of the axial skeleton. Dev Biol. 2017 Jan 15;421(2):245-257
1	J:141112 Yasuhiko Y, Kitajima S, Takahashi Y, Oginuma M, Kagiwada H, Kanno J, Saga Y, Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2. Development. 2008 Nov;135(21):3511-9
1*	J:62914 Yoon JK, Moon RT, Wold B, The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. Dev Biol. 2000 Jun 15;222(2):376-91