Symbol Name ID |
Wnt8a
wingless-type MMTV integration site family, member 8A MGI:107924 |
Age | E3.5 | E5.5 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E | P |
Immunohistochemistry (section) | 1 | 1 | 1 | ||||||||||||||||||||||||
In situ RNA (section) | 1 | 1 | 2 | 2 | 2 | 3 | 1 | 1 | 4 | 2 | 3 | 3 | 1 | 5 | 3 | 1 | 1 | 1 | 4 | 2 | 3 | 9 | |||||
Immunohistochemistry (whole mount) | 1 | ||||||||||||||||||||||||||
In situ RNA (whole mount) | 1 | 2 | 3 | 9 | 7 | 2 | 1 | 2 | 3 | 2 | 1 | 1 | 1 | ||||||||||||||
In situ reporter (knock in) | 1 | ||||||||||||||||||||||||||
RT-PCR | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 5 | 5 | 9 | 1 | 6 | 1 | 7 | 4 | 3 | 1 | 1 | 3 | 2 | 12 | ||||||
RNase protection | 1 |
Wnt8a wingless-type MMTV integration site family, member 8A (Synonyms: Stra11) | |
Results | Reference |
3 | J:169706 Abdul-Ghani M, Dufort D, Stiles R, De Repentigny Y, Kothary R, Megeney LA, Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals. Mol Cell Biol. 2011 Jan;31(1):163-78 |
3 | J:155074 Agalliu D, Takada S, Agalliu I, McMahon AP, Jessell TM, Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron. 2009 Mar 12;61(5):708-20 |
7* | J:89153 Ang SJ, Stump RJ, Lovicu FJ, McAvoy JW, Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development. Gene Expr Patterns. 2004 May;4(3):289-95 |
1* | J:135507 Bayle J, Fitch J, Jacobsen K, Kumar R, Lafyatis R, Lemaire R, Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol. 2008 Apr;128(4):871-81 |
5* | J:152099 Bi Y, Huang J, He Y, Zhu GH, Su Y, He BC, Luo J, Wang Y, Kang Q, Luo Q, Chen L, Zuo GW, Jiang W, Liu B, Shi Q, Tang M, Zhang BQ, Weng Y, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N, Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. J Cell Biochem. 2009 Jun 26;108(1):295-303 |
4* | J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247 |
13* | J:35540 Bouillet P, Oulad-Abdelghani M, Ward SJ, Bronner S, Chambon P, Dolle P, A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid. Mech Dev. 1996 Aug;58(1-2):141-52 |
1 | J:214093 Cambier L, Plate M, Sucov HM, Pashmforoush M, Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71 |
1 | J:239523 Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, Kuruvilla R, Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E619-E628 |
1 | J:307439 Chen SR, Tang JX, Cheng JM, Hao XX, Wang YQ, Wang XX, Liu YX, Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models. Cell Death Dis. 2016 Jun 30;7(6):e2281 |
2 | J:98338 Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE, Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development. 2004 Oct;131(19):4819-29 |
5 | J:148823 Corrigan PM, Dobbin E, Freeburn RW, Wheadon H, Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells Dev. 2009 Jun;18(5):759-72 |
2* | J:222431 Cunningham TJ, Kumar S, Yamaguchi TP, Duester G, Wnt8a and Wnt3a cooperate in the axial stem cell niche to promote mammalian body axis extension. Dev Dyn. 2015 Jun;244(6):797-807 |
1 | J:254209 Da Silva F, Rocha AS, Motamedi FJ, Massa F, Basboga C, Morrison H, Wagner KD, Schedl A, Coronary Artery Formation Is Driven by Localized Expression of R-spondin3. Cell Rep. 2017 Aug 22;20(8):1745-1754 |
1* | J:82803 Dabdoub A, Donohue MJ, Brennan A, Wolf V, Montcouquiol M, Sassoon DA, Hseih JC, Rubin JS, Salinas PC, Kelley MW, Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development. 2003 Jun;130(11):2375-84 |
1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
1 | J:196515 Fu J, Hsu W, Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. J Invest Dermatol. 2013 Apr;133(4):890-8 |
5* | J:330442 Garcia-Padilla C, Dominguez JN, Lodde V, Munk R, Abdelmohsen K, Gorospe M, Jimenez-Sabado V, Ginel A, Hove-Madsen L, Aranega AE, Franco D, Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation. FASEB J. 2022 Jan;36(1):e22051 |
1 | J:226667 Goodnough LH, Dinuoscio GJ, Ferguson JW, Williams T, Lang RA, Atit RP, Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors. PLoS Genet. 2014 Feb;10(2):e1004152 |
3* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
13* | J:60429 Jaspard B, Couffinhal T, Dufourcq P, Moreau C, Duplaa C, Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis. Mech Dev. 2000 Feb;90(2):263-7 |
1 | J:199291 Jiang M, Ku WY, Fu J, Offermanns S, Hsu W, Que J, Gpr177 regulates pulmonary vasculature development. Development. 2013 Sep;140(17):3589-94 |
1 | J:273296 Kaiser K, Gyllborg D, Prochazka J, Salasova A, Kompanikova P, Molina FL, Laguna-Goya R, Radaszkiewicz T, Harnos J, Prochazkova M, Potesil D, Barker RA, Casado AG, Zdrahal Z, Sedlacek R, Arenas E, Villaescusa JC, Bryja V, WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. Nat Commun. 2019 Apr 2;10(1):1498 |
5* | J:98792 Kemp C, Willems E, Abdo S, Lambiv L, Leyns L, Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Dev Dyn. 2005 May 5;233(3):1064-1075 |
4* | J:117138 Kimura T, Nakamura T, Murayama K, Umehara H, Yamano N, Watanabe S, Taketo MM, Nakano T, The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression. Dev Biol. 2006 Dec 15;300(2):545-53 |
1 | J:103272 Kimura-Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo JA, Aizawa S, Matsui Y, Matsuo I, Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell. 2005 Nov;9(5):639-50 |
4 | J:164056 Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D, Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10894-9 |
1* | J:119933 Lewis SL, Khoo PL, Andrea De Young R, Bildsoe H, Wakamiya M, Behringer RR, Mukhopadhyay M, Westphal H, Tam PP, Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mech Dev. 2007 Feb;124(2):157-165 |
1 | J:134688 Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP, Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development. 2008 May;135(10):1791-801 |
1* | J:98484 Lickert H, Cox B, Wehrle C, Taketo MM, Kemler R, Rossant J, Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005 Jun;132(11):2599-609 |
2* | J:70601 Lickert H, Kispert A, Kutsch S, Kemler R, Expression patterns of Wnt genes in mouse gut development. Mech Dev. 2001 Jul;105(1-2):181-4 |
3* | J:139251 Lin C, Yin Y, Long F, Ma L, Tissue-specific requirements of beta-catenin in external genitalia development. Development. 2008 Aug;135(16):2815-25 |
1 | J:168206 Liu Y, Shi J, Lu CC, Wang ZB, Lyuksyutova AI, Song XJ, Zou Y, Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat Neurosci. 2005 Sep;8(9):1151-9 |
1* | J:173123 Mahoney Rogers AA, Zhang J, Shim K, Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling. Dev Biol. 2011 May 1;353(1):94-104 |
1* | J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806 |
2* | J:177133 Mehta V, Abler LL, Keil KP, Schmitz CT, Joshi PS, Vezina CM, Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract. Dev Dyn. 2011 Nov;240(11):2548-60 |
2 | J:104700 Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Belmonte JC, Chien KR, Ruiz-Lozano P, Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18455-60 |
1 | J:148515 Miyagawa S, Satoh Y, Haraguchi R, Suzuki K, Iguchi T, Taketo MM, Nakagata N, Matsumoto T, Takeyama KI, Kato S, Yamada G, Genetic interactions of the Androgen and Wnt/{beta}-catenin Pathways for the Masculinization of External Genitalia. Mol Endocrinol. 2009 June;23(6):871-880 |
2 | J:187747 Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS, Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science. 2012 Oct 5;338(6103):108-13 |
1 | J:81152 Mukhopadhyay M, Teufel A, Yamashita T, Agulnick AD, Chen L, Downs KM, Schindler A, Grinberg A, Huang SP, Dorward D, Westphal H, Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development. 2003 Feb;130(3):495-505 |
3 | J:327818 Murphy P, Armit C, Hill B, Venkataraman S, Frankel P, Baldock RA, Davidson DR, Integrated analysis of Wnt signalling system component gene expression. Development. 2022 Aug 15;149(16):dev200312 |
1* | J:53473 Niederreither K, Vermot J, Schuhbaur B, Chambon P, Dolle P, Retinoic acid synthesis and hindbrain patterning in the mouse embryo. Development. 2000 Jan;127(1):75-85 |
1 | J:314598 Nik AM, Reyahi A, Ponten F, Carlsson P, Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling. Gastroenterology. 2013 May;144(5):1001-11 |
1 | J:180300 Noda T, Oki S, Kitajima K, Harada T, Komune S, Meno C, Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo. Dev Biol. 2012 Feb 1;362(1):83-93 |
4* | J:105983 Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK, Wnt signals mediate a fate decision between otic placode and epidermis. Development. 2006 Mar;133(5):865-75 |
1 | J:114817 Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, Ohgi KA, Wu W, Taketo MM, Kemler R, Grosschedl R, Rose D, Li X, Rosenfeld MG, Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell. 2006 May 5;125(3):593-605 |
6* | J:71419 Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE, Millar SE, Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev. 2001 Sep;107(1-2):69-82 |
1 | J:144016 Ribes V, Le Roux I, Rhinn M, Schuhbaur B, Dolle P, Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development. 2009 Feb;136(4):665-76 |
1 | J:298302 Ru J, Guo D, Fan J, Zhang J, Ju R, Ouyang H, Wei L, Liu Y, Liu C, Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis. Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):6 |
5* | J:61450 Sapin V, Bouillet P, Oulad-Abdelghani M, Dastugue B, Chambon P, Dolle P, Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation. Mech Dev. 2000 Apr;92(2):295-9 |
1 | J:253067 Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF, Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455 |
1 | J:331973 Simonson L, Oldham E, Chang H, Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development. Development. 2022 Nov 15;149(22):dev200816 |
1* | J:37450 Studer M, Lumsden A, Ariza-McNaughton L, Bradley A, Krumlauf R, Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1. Nature. 1996 Dec 19-26;384(6610):630-4 |
1 | J:84052 Stump RJ, Ang S, Chen Y, von Bahr T, Lovicu FJ, Pinson K, de Iongh RU, Yamaguchi TP, Sassoon DA, McAvoy JW, A role for Wnt/beta-catenin signaling in lens epithelial differentiation. Dev Biol. 2003 Jul 1;259(1):48-61 |
2* | J:133947 Summerhurst K, Stark M, Sharpe J, Davidson D, Murphy P, 3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19). Gene Expr Patterns. 2008 May;8(5):331-48 |
1 | J:217059 Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE, Kondoh H, Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature. 2011 Feb 17;470(7334):394-8 |
2* | J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511 |
1* | J:160254 Urness LD, Paxton CN, Wang X, Schoenwolf GC, Mansour SL, FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol. 2010 Apr 15;340(2):595-604 |
3 | J:194132 Vendrell V, Vazquez-Echeverria C, Lopez-Hernandez I, Alonso BD, Martinez S, Pujades C, Schimmang T, Roles of Wnt8a during formation and patterning of the mouse inner ear. Mech Dev. 2013 Feb;130(2-3):160-8 |
1* | J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6 |
1 | J:270088 Wang Y, Lu P, Wu B, Morrow BE, Zhou B, NOTCH maintains developmental cardiac gene network through WNT5A. J Mol Cell Cardiol. 2018 Dec;125:98-105 |
1* | J:77089 Weidenfeld J, Shu W, Zhang L, Millar SE, Morrisey EE, The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem. 2002 Jun 7;277(23):21061-70 |
7* | J:146657 Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S, Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr Patterns. 2009 Apr;9(4):215-23 |
1 | J:171463 Wong EY, Wang XA, Mak SS, Sae-Pang JJ, Ling KW, Fritzsch B, Sham MH, Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning. Dev Biol. 2011 Apr 15;352(2):382-92 |
2 | J:226692 Wright KD, Mahoney Rogers AA, Zhang J, Shim K, Cooperative and independent functions of FGF and Wnt signaling during early inner ear development. BMC Dev Biol. 2015;15:33 |
1 | J:165556 Yu H, Smallwood PM, Wang Y, Vidaltamayo R, Reed R, Nathans J, Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development. 2010 Nov;137(21):3707-17 |
2 | J:124891 Zaghetto AA, Paina S, Mantero S, Platonova N, Peretto P, Bovetti S, Puche A, Piccolo S, Merlo GR, Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J Neurosci. 2007 Sep 5;27(36):9757-68 |
1 | J:207612 Zhang L, Li H, Yu J, Cao J, Chen H, Zhao H, Zhao J, Yao Y, Cheng H, Wang L, Zhou R, Yao Z, Guo X, Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72 |
2* | J:105879 Zhang TJ, Hoffman BG, Ruiz de Algara T, Helgason CD, SAGE reveals expression of Wnt signalling pathway members during mouse prostate development. Gene Expr Patterns. 2006 Mar;6(3):310-24 |
1* | J:150714 Zhao X, Duester G, Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension. Gene Expr Patterns. 2009 Sept;9(6):430-5 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/27/2024 MGI 6.24 |
![]() |
|