Symbol Name ID |
Rock1
Rho-associated coiled-coil containing protein kinase 1 MGI:107927 |
Age | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18.5 | E | P |
Immunohistochemistry (section) | 3 | 3 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | |||||||||||||
In situ RNA (section) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||
Immunohistochemistry (whole mount) | 1 | ||||||||||||||||||||||
In situ RNA (whole mount) | 1 | 1 | 1 | 1 | |||||||||||||||||||
In situ reporter (knock in) | 1 | 1 | 1 | ||||||||||||||||||||
Northern blot | 1 | 1 | 1 | 2 | |||||||||||||||||||
Western blot | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 4 | |||||||||||||
RT-PCR | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | ||||||||||
cDNA clones | 1 | 1 |
Rock1 Rho-associated coiled-coil containing protein kinase 1 (Synonyms: 1110055K06Rik, Rock-I) | |
Results | Reference |
1* | J:323868 Bellchambers HM, Ware SM, Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects. Hum Mol Genet. 2021 Nov 30;30(24):2402-2415 |
1 | J:189363 Brown JA, Diggs-Andrews KA, Gianino SM, Gutmann DH, Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner. Mol Cell Neurosci. 2012 Jan;49(1):13-22 |
1 | J:266546 Brown JM, Garcia-Garcia MJ, Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics. Development. 2018 Oct 5;145(19):dev170019 |
2 | J:100324 Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andre A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M, Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. J Neurosci. 2005 Aug 17;25(33):7586-600 |
5* | J:91036 Causeret F, Hidalgo-Sanchez M, Fort P, Backer S, Popoff MR, Gauthier-Rouviere C, Bloch-Gallego E, Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1. Development. 2004 Jun;131(12):2841-52 |
3 | J:77297 Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F, Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron. 2000 Oct;28(1):115-27 |
1* | J:293794 Durbin MD, O'Kane J, Lorentz S, Firulli AB, Ware SM, SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects. Dev Biol. 2020 Aug 15;464(2):124-136 |
1 | J:171199 Herzog D, Loetscher P, van Hengel J, Knusel S, Brakebusch C, Taylor V, Suter U, Relvas JB, The Small GTPase RhoA Is Required to Maintain Spinal Cord Neuroepithelium Organization and the Neural Stem Cell Pool. J Neurosci. 2011 Mar 30;31(13):5120-5130 |
1* | J:206879 Huang T, Krimm RF, BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014 Feb 15;386(2):308-20 |
3 | J:155983 Ikeda T, Kanazawa T, Otsuka S, Ichii O, Hashimoto Y, Kon Y, Expression of caspase family and muscle- and apoptosis-specific genes during skeletal myogenesis in mouse embryo. J Vet Med Sci. 2009 Sep;71(9):1161-8 |
2 | J:189368 Kamijo H, Matsumura Y, Thumkeo D, Koike S, Masu M, Shimizu Y, Ishizaki T, Narumiya S, Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II. Genes Cells. 2011 Oct;16(10):1012-21 |
1* | J:85160 Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ, Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9843-8 |
2* | J:143534 Kim JY, Lee MJ, Cho KW, Lee JM, Kim YJ, Kim JY, Jung HI, Cho JY, Cho SW, Jung HS, Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development. Dev Biol. 2009 Jan 1;325(1):273-80 |
1 | J:167714 Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W, Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis. Development. 2011 Jan;138(2):303-15 |
1 | J:244106 Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT, YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. Elife. 2017 Mar 21;6:e21130 |
2 | J:245570 Ma X, Adelstein RS, A point mutation in Myh10 causes major defects in heart development and body wall closure. Circ Cardiovasc Genet. 2014 Jun;7(3):257-65 |
1 | J:219576 McGreevy EM, Vijayraghavan D, Davidson LA, Hildebrand JD, Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure. Biol Open. 2015;4(2):186-96 |
6* | J:35061 Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K, Narumiya S, ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93 |
5* | J:125029 Pelosi M, Marampon F, Zani BM, Prudente S, Perlas E, Caputo V, Cianetti L, Berno V, Narumiya S, Kang SW, Musaro A, Rosenthal N, ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program. Mol Cell Biol. 2007 Sep;27(17):6163-76 |
2 | J:258493 Phillips HM, Mahendran P, Singh E, Anderson RH, Chaudhry B, Henderson DJ, Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets. Cardiovasc Res. 2013 Aug 1;99(3):452-60 |
7 | J:106431 Phillips HM, Murdoch JN, Chaudhry B, Copp AJ, Henderson DJ, Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res. 2005 Feb 18;96(3):292-9 |
3 | J:220920 Phillips HM, Papoutsi T, Soenen H, Ybot-Gonzalez P, Henderson DJ, Chaudhry B, Neural crest cell survival is dependent on Rho kinase and is required for development of the mid face in mouse embryos. PLoS One. 2012;7(5):e37685 |
4 | J:98250 Shimizu Y, Thumkeo D, Keel J, Ishizaki T, Oshima H, Oshima M, Noda Y, Matsumura F, Taketo MM, Narumiya S, ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol. 2005 Mar 14;168(6):941-53 |
2 | J:84386 Thumkeo D, Keel J, Ishizaki T, Hirose M, Nonomura K, Oshima H, Oshima M, Taketo MM, Narumiya S, Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol. 2003 Jul;23(14):5043-55 |
1 | J:106856 Thumkeo D, Shimizu Y, Sakamoto S, Yamada S, Narumiya S, ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo. Genes Cells. 2005 Aug;10(8):825-34 |
1 | J:129038 Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C, Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46 |
3* | J:71032 Wei L, Roberts W, Wang L, Yamada M, Zhang S, Zhao Z, Rivkees SA, Schwartz RJ, Imanaka-Yoshida K, Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Development. 2001 Aug;128(15):2953-62 |
3 | J:119920 Ybot-Gonzalez P, Savery D, Gerrelli D, Signore M, Mitchell CE, Faux CH, Greene ND, Copp AJ, Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development. 2007 Feb;134(4):789-99 |
7* | J:81140 Zhao Z, Rivkees SA, Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation. Dev Dyn. 2003 Jan;226(1):24-32 |
3* | J:94515 Zhao Z, Rivkees SA, Rho-associated kinases play a role in endocardial cell differentiation and migration. Dev Biol. 2004 Nov 1;275(1):183-91 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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