Gene Expression Literature Summary

• Symbol: Slc8a1
• Name: solute carrier family 8 (sodium/calcium exchanger), member 1
• ID: MGI:107956

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)	1	1	2	1	1	3																1	1		3
In situ RNA (section)			2	1	1	1		2				2	1	6		1	1	2		2	1				7
Immunohistochemistry (whole mount)					1
In situ RNA (whole mount)								1
In situ reporter (knock in)		1	1	2	1	2	3		1				2												2
Northern blot	1							1	1			1			1				1				1		2
Western blot						3											1				1	1	1	1	12
RT-PCR		1	3	3	3	5		2	1	6	1	1		4		1		2		3			2	1	16
cDNA clones														1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Slc8a1  solute carrier family 8 (sodium/calcium exchanger), member 1   (Synonyms: D930008O12Rik, Ncx1)
Results	Reference
1	J:253754 Arora H, Boulberdaa M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, Dolle P, Nebigil CG, Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development. Sci Rep. 2016 May 6;6:25541
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3*	J:317274 Cerullo P, Brancaccio P, Anzilotti S, Vinciguerra A, Cuomo O, Fiorino F, Severino B, Di Vaio P, Di Renzo G, Annunziato L, Pignataro G, Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia. Neuropharmacology. 2018 Jun;135:180-191
1*	J:74096 Cho CH, Kim SS, Jeong MJ, Lee CO, Shin HS, The Na+ -Ca2+ exchanger is essential for embryonic heart development in mice. Mol Cells. 2000 Dec 31;10(6):712-22
3	J:106177 Cho CH, Lee SY, Shin HS, Philipson KD, Lee CO, Partial rescue of the Na+-Ca2+ exchanger (NCX1) knock-out mouse by transgenic expression of NCX1. Exp Mol Med. 2003 Apr 30;35(2):125-35
18	J:81603 Conway SJ, Kruzynska-Frejtag A, Wang J, Rogers R, Kneer PL, Chen H, Creazzo T, Menick DR, Koushik SV, Role of sodium-calcium exchanger (Ncx1) in embryonic heart development: a transgenic rescue?. Ann N Y Acad Sci. 2002 Nov;976:268-81
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:176723 Domes K, Ding J, Lemke T, Blaich A, Wegener JW, Brandmayr J, Moosmang S, Hofmann F, Truncation of murine cav1.2 at asp-1904 results in heart failure after birth. J Biol Chem. 2011 Sep 30;286(39):33863-71
2	J:294971 Fecher-Trost C, Lux F, Busch KM, Raza A, Winter M, Hielscher F, Belkacemi T, van der Eerden B, Boehm U, Freichel M, Weissgerber P, Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development. J Bone Miner Res. 2019 Apr;34(4):699-710
1*	J:174497 Funatsu N, Inoue T, Nakamura S, Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes. Cereb Cortex. 2004 Sep;14(9):1031-44
1	J:299975 Gharibeh L, Yamak A, Whitcomb J, Lu A, Joyal M, Komati H, Liang W, Fiset C, Nemer M, GATA6 is a regulator of sinus node development and heart rhythm. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2007322118
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:231595 Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL, Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
2*	J:119550 Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA, Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics. 2007 Feb 12;28(3):273-83
2	J:349860 Hashimoto K, Ohira M, Kodama A, Kimoto M, Inoue M, Tone S, Usui Y, Hanashima A, Goto T, Ogura Y, Ujihara Y, Mohri S, Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Sci Rep. 2024 Jun 14;14(1):13727
4*	J:46688 Kim I, Koh GY, Lee CO, Identification of alternatively spliced Na(+)-Ca2+ exchanger isoforms expressed in the heart. Comp Biochem Physiol B Biochem Mol Biol. 1998 Jan;119(1):157-61
1	J:307672 Knupp D, Cooper DA, Saito Y, Darnell RB, Miura P, NOVA2 regulates neural circRNA biogenesis. Nucleic Acids Res. 2021 Jul 9;49(12):6849-6862
6	J:184466 Koo TH, Yang H, An BS, Choi KC, Hyun SH, Jeung EB, Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k). Mol Reprod Dev. 2012 May;79(5):346-55
10*	J:58276 Koushik SV, Bundy J, Conway SJ, Sodium-calcium exchanger is initially expressed in a heart-restricted pattern within the early mouse embryo. Mech Dev. 1999 Oct;88(1):119-22
13*	J:69362 Koushik SV, Wang J, Rogers R, Moskophidis D, Lambert NA, Creazzo TL, Conway SJ, Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J. 2001 May;15(7):1209-11
1	J:347631 Li C, Zhang Y, Shen J, Bao H, Zhao Y, Li D, Li S, Liu Y, Yang J, Zhou Z, Gao K, Zhao L, Pei Y, Lu Y, Pan Z, Cai B, Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992
4	J:256343 Li M, Jiang C, Ye L, Wang S, Zhang H, Liu J, Hong H, The Role of Na+/Ca2+ Exchanger 1 in Maintaining Ductus Arteriosus Patency. Sci Rep. 2017 Aug 29;7(1):9826
4*	J:70280 Linask KK, Han MD, Artman M, Ludwig CA, Sodium-calcium exchanger (NCX-1) and calcium modulation: NCX protein expression patterns and regulation of early heart development. Dev Dyn. 2001 Jul;221(3):249-64
5	J:133298 Lux CT, Yoshimoto M, McGrath K, Conway SJ, Palis J, Yoder MC, All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac. Blood. 2008 Apr 1;111(7):3435-8
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
1	J:186596 Nakamura TY, Jeromin A, Mikoshiba K, Wakabayashi S, Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals. Circ Res. 2011 Aug 19;109(5):512-23
2	J:120229 Narlis M, Grote D, Gaitan Y, Boualia SK, Bouchard M, Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol. 2007 Apr;18(4):1121-9
5*	J:198109 Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones ML, Rakic S, Molnar Z, Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59
2	J:104891 Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R, Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development. 2006 Jan;133(1):151-61
4	J:134787 Pyrski M, Koo JH, Polumuri SK, Ruknudin AM, Margolis JW, Schulze DH, Margolis FL, Sodium/calcium exchanger expression in the mouse and rat olfactory systems. J Comp Neurol. 2007 Apr 20;501(6):944-58
2*	J:98210 Radzyukevich TL, Moseley AE, Shelly DA, Redden GA, Behbehani MM, Lingrel JB, Paul RJ, Heiny JA, The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm. Am J Physiol Cell Physiol. 2004 Nov;287(5):C1300-10
2*	J:102710 Reuter H, Henderson SA, Han T, Mottino GA, Frank JS, Ross RS, Goldhaber JI, Philipson KD, Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Cell Calcium. 2003 Jul;34(1):19-26
1*	J:103484 Reuter H, Henderson SA, Han T, Ross RS, Goldhaber JI, Philipson KD, The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002 Feb 22;90(3):305-8
1*	J:219479 Reynolds JO, Chiang DY, Wang W, Beavers DL, Dixit SS, Skapura DG, Landstrom AP, Song LS, Ackerman MJ, Wehrens XH, Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013 Oct 1;100(1):44-53
2	J:199136 Rog-Zielinska EA, Thomson A, Kenyon CJ, Brownstein DG, Moran CM, Szumska D, Michailidou Z, Richardson J, Owen E, Watt A, Morrison H, Forrester LM, Bhattacharya S, Holmes MC, Chapman KE, Glucocorticoid receptor is required for foetal heart maturation. Hum Mol Genet. 2013 Aug 15;22(16):3269-82
1	J:227218 Sharma P, Abbasi C, Lazic S, Teng AC, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO, Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391
1	J:316473 Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G, Minichiello L, Kwon C, Heart neurons use clock genes to control myocyte proliferation. Sci Adv. 2021 Dec 3;7(49):eabh4181
1	J:162596 Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, Fine DM, Hanft LM, McDonald KS, Molkentin JD, Krenz M, Yang S, Ji J, TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem. 2010 Apr 30;285(18):13721-35
9	J:238633 Tyser RC, Miranda AM, Chen CM, Davidson SM, Srinivas S, Riley PR, Calcium handling precedes cardiac differentiation to initiate the first heartbeat. Elife. 2016 Oct 11;5:e17113
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:102564 Wakimoto K, Fujimura H, Iwamoto T, Oka T, Kobayashi K, Kita S, Kudoh S, Kuro-o M, Nabeshima Y, Shigekawa M, Imai Y, Komuro I, Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes. Comp Biochem Physiol B Biochem Mol Biol. 2003 May;135(1):9-15
11*	J:74176 Wakimoto K, Kuro-o M, Yanaka N, Komuro I, Nabeshima YI, Imai Y, Expression of Na+/Ca(2+) exchanger (NCX1) gene in the developmental mouse embryo and adult mouse brain. Comp Biochem Physiol B Biochem Mol Biol. 2001 Sep;130(2):191-8
1*	J:244948 Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO, Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. J Am Heart Assoc. 2014 Oct 20;3(5):e001018
4*	J:167034 Wansleeben C, Feitsma H, Tertoolen L, Kroon C, Guryev V, Cuppen E, Meijlink F, A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction. Int J Dev Biol. 2010;54(10):1465-71
1*	J:117394 Xu L, Renaud L, Muller JG, Baicu CF, Bonnema DD, Zhou H, Kappler CS, Kubalak SW, Zile MR, Conway SJ, Menick DR, Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation. J Biol Chem. 2006 Nov 10;281(45):34430-40
2	J:119674 Yamaguchi Y, Yonemura S, Takada S, Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development. 2006 Dec;133(23):4737-48
1	J:344873 Yang Y, Wang X, Tan Y, Xu Y, Guo X, Wu Y, Wang W, Jing R, Zhu F, Ye D, Zhang Q, Lu C, Kang J, Wang G, LncCMRR Plays an Important Role in Cardiac Differentiation by Regulating the Purb/Flk1 Axis. Stem Cells. 2023 Jan 30;41(1):11-25
1	J:142482 Yin Z, Jones GN, Towns WH 2nd, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS, Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation. 2008 Mar 18;117(11):1414-22
1	J:97579 Zhao R, Watt AJ, Li J, Luebke-Wheeler J, Morrisey EE, Duncan SA, GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2005 Apr;25(7):2622-31