Gene Expression Literature Summary

• Symbol: Adm
• Name: adrenomedullin
• ID: MGI:108058

36 matching records from 36 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19	E20	E	P
Immunohistochemistry (section)	1		1	1	3	1	2	1	3	1	3	1	3	1	5	1	2	1	2	2	2					1		6
In situ RNA (section)	1		1		3	1	3	1	1	1	1	1	2	1		1	1	1	2		2	1		1			2	6
In situ RNA (whole mount)			1		1																							1
In situ reporter (knock in)							1						1		1						1							1
Northern blot	1	1	1		1		1		1	1			1				1	1			1	1		1				2
Western blot													1
RT-PCR			3		3		3		2	1	3		2		2		1	2	1			2	1		1	1	1	11
cDNA clones			1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Adm  adrenomedullin   (Synonyms: AM)
Results	Reference
6	J:99898 Bodegas E, Martinez A, Ozbun LL, Garayoa M, Letterio JJ, Montuenga LM, Jakowlew SB, Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally. Int J Dev Biol. 2004 Feb;48(1):67-70
5*	J:67044 Caron KM, Smithies O, Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):615-9
1	J:119006 de Guzman Strong C, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T, Millar SE, Ho IC, Pai SY, Segre JA, Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol. 2006 Nov 20;175(4):661-70
1*	J:225226 Dykes IM, van Bueren KL, Ashmore RJ, Floss T, Wurst W, Szumska D, Bhattacharya S, Scambler PJ, HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014 Jun 20;115(1):23-31
1	J:332240 Feng W, Bais A, He H, Rios C, Jiang S, Xu J, Chang C, Kostka D, Li G, Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages. Nat Commun. 2022 Dec 27;13(1):7960
2	J:130930 Fritz-Six KL, Dunworth WP, Li M, Caron KM, Adrenomedullin signaling is necessary for murine lymphatic vascular development. J Clin Invest. 2008 Jan;118(1):40-50
19	J:79633 Garayoa M, Bodegas E, Cuttitta F, Montuenga LM, Adrenomedullin in mammalian embryogenesis. Microsc Res Tech. 2002 Apr 1;57(1):40-54
1	J:62506 Hemberger M, Himmelbauer H, Ruschmann J, Zeitz C, Fundele R, cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion. Dev Biol. 2000 Jun 1;222(1):158-69
1	J:83701 Hemberger M, Nozaki T, Masutani M, Cross JC, Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion. Dev Dyn. 2003 Jun;227(2):185-91
1	J:259186 Heng X, Guo Q, Leung AW, Li JY, Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6:e23253
1	J:244834 Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B, ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713
1	J:170943 Holscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A, Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury. J Biol Chem. 2011 Apr 1;286(13):11185-94
1	J:162597 Hyvarinen J, Hassinen IE, Sormunen R, Maki JM, Kivirikko KI, Koivunen P, Myllyharju J, Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem. 2010 Apr 30;285(18):13646-57
5	J:130931 Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T, The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest. 2008 Jan;118(1):29-39
2	J:137276 Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R, Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008 Jun 19;453(7198):1117-21
1	J:214795 Klein KR, Karpinich NO, Espenschied ST, Willcockson HH, Dunworth WP, Hoopes SL, Kushner EJ, Bautch VL, Caron KM, Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev Cell. 2014 Sep 8;30(5):528-40
5	J:135979 Knox K, Baker JC, Genomic evolution of the placenta using co-option and duplication and divergence. Genome Res. 2008 May;18(5):695-705
1*	J:50869 Ko MSH, Threat TA, Wang X, Horton JH, Cui Y, Pryor E, Paris J , Wells-Smith J , Kitchen JR , Rowe LB , Eppig J , Satoh T , Brant L , Fujiwara H , Yotsumoto S , Nakashima H, Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
2	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
1	J:127228 Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML, Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006 Dec;11(6):845-57
1	J:323097 Li-Villarreal N, Wong RLY, Garcia MD, Udan RS, Poche RA, Rasmussen TL, Rhyner AM, Wythe JD, Dickinson ME, FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac. Development. 2022 Apr 1;149(7):dev200131
3*	J:147318 Lopez-Garcia C, Lopez-Contreras AJ, Cremades A, Castells MT, Marin F, Schreiber F, Penafiel R, Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. Endocrinology. 2008 Oct;149(10):5012-23
1	J:103815 Masino AM, Gallardo TD, Wilcox CA, Olson EN, Williams RS, Garry DJ, Transcriptional regulation of cardiac progenitor cell populations. Circ Res. 2004 Aug 20;95(4):389-97
1*	J:265444 Matsumoto L, Hirota Y, Saito-Fujita T, Takeda N, Tanaka T, Hiraoka T, Akaeda S, Fujita H, Shimizu-Hirota R, Igaue S, Matsuo M, Haraguchi H, Saito-Kanatani M, Fujii T, Osuga Y, HIF2alpha in the uterine stroma permits embryo invasion and luminal epithelium detachment. J Clin Invest. 2018 Jul 2;128(7):3186-3197
1	J:181273 Monks DC, Morrow BE, Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development. Dev Dyn. 2012 Mar;241(3):563-73
22*	J:49900 Montuenga LM, Mariano JM, Prentice MA, Cuttitta F, Jakowlew SB, Coordinate expression of transforming growth factor-beta1 and adrenomedullin in rodent embryogenesis. Endocrinology. 1998 Sep;139(9):3946-57
13	J:39741 Montuenga LM, Martinez A, Miller MJ, Unsworth EJ, Cuttitta F, Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action. Endocrinology. 1997 Jan;138(1):440-51
1*	J:170493 Pfister S, Jones VJ, Power M, Truisi GL, Khoo PL, Steiner KA, Kanai-Azuma M, Kanai Y, Tam PP, Loebel DA, Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55(1):45-58
1	J:333399 Rhee S, Paik DT, Yang JY, Nagelberg D, Williams I, Tian L, Roth R, Chandy M, Ban J, Belbachir N, Kim S, Zhang H, Phansalkar R, Wong KM, King DA, Valdez C, Winn VD, Morrison AJ, Wu JC, Red-Horse K, Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction. Eur Heart J. 2021 Nov 1;42(41):4264-4276
1	J:89608 Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju KH, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata Y, Kurihara H, Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation. 2001 Oct 16;104(16):1964-71
4	J:124878 Sierro F, Biben C, Martinez-Munoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Martinez-A C, Mackay CR, Mackay F, Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14759-64
2*	J:166934 Trollmann R, Rehrauer H, Schneider C, Krischke G, Huemmler N, Keller S, Rascher W, Gassmann M, Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1489-99
3*	J:206227 Wetzel-Strong SE, Li M, Klein KR, Nishikimi T, Caron KM, Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis. Dev Dyn. 2014 Feb;243(2):243-56
29*	J:51098 Yotsumoto S, Shimada T, Cui CY, Nakashima H, Fujiwara H, Ko MS, Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse. Dev Biol. 1998 Nov 15;203(2):264-75
1	J:304773 Yvernogeau L, Klaus A, Maas J, Morin-Poulard I, Weijts B, Schulte-Merker S, Berezikov E, Junker JP, Robin C, Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta. Blood. 2020 Aug 13;136(7):831-844
2	J:342367 Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN, Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777