Gene Expression Literature Summary

• Symbol: Gab1
• Name: growth factor receptor bound protein 2-associated protein 1
• ID: MGI:108088

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2.5	E3.5	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E16	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)						1		1	1		1			1		1	3
In situ RNA (section)										1	3
Immunohistochemistry (whole mount)			1
In situ reporter (knock in)						1			1	1		1				1	2
Northern blot							1										2
Western blot					1		1	2			1		1	1	1		3
RT-PCR	1	1	2	1		1									1		4
cDNA clones																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gab1  growth factor receptor bound protein 2-associated protein 1
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:296619 Fan Y, Richelme S, Avazeri E, Audebert S, Helmbacher F, Dono R, Maina F, Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis. PLoS Genet. 2015;11(9):e1005533
6	J:61790 Itoh M, Yoshida Y, Nishida K, Narimatsu M, Hibi M, Hirano T, Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol Cell Biol. 2000 May;20(10):3695-704
2	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
3	J:310318 Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X, Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 1;127(Pt 3):571-82
1*	J:198109 Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones ML, Rakic S, Molnar Z, Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59
2	J:233610 Peng Y, Lu Z, Li G, Piechowicz M, Anderson M, Uddin Y, Wu J, Qiu S, The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain. Mol Psychiatry. 2016 Jul;21(7):925-35
2	J:68751 Sachs M, Brohmann H, Zechner D, Muller T, Hulsken J, Walther I, Schaeper U, Birchmeier C, Birchmeier W, Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol. 2000 Sep 18;150(6):1375-84
1*	J:149737 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ, The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
5	J:125303 Schaeper U, Vogel R, Chmielowiec J, Huelsken J, Rosario M, Birchmeier W, Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15376-81
1	J:270726 Shimada IS, Hwang SH, Somatilaka BN, Wang X, Skowron P, Kim J, Kim M, Shelton JM, Rajaram V, Xuan Z, Taylor MD, Mukhopadhyay S, Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis. Cell Rep. 2018 Jan 30;22(5):1169-1184
4*	J:267060 Sutherland L, Ruhe M, Gattegno-Ho D, Mann K, Greaves J, Koscielniak M, Meek S, Lu Z, Waterfall M, Taylor R, Tsakiridis A, Brown H, Maciver SK, Joshi A, Clinton M, Chamberlain LH, Smith A, Burdon T, LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. J Cell Sci. 2018 Sep 20;131(18):jcs222257
2*	J:36572 Weidner KM, Di Cesare S, Sachs M, Brinkmann V, Behrens J, Birchmeier W, Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature. 1996 Nov 14;384(6605):173-6
5	J:98531 Xie Y, Wang Y, Sun T, Wang F, Trostinskaia A, Puscheck E, Rappolee DA, Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells. Mol Reprod Dev. 2005 May;71(1):1-11
8	J:251516 Yasui T, Masaki T, Arita Y, Ishibashi T, Inagaki T, Okazawa M, Oka T, Shioyama W, Yamauchi-Takihara K, Komuro I, Sakata Y, Nakaoka Y, Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes. PLoS One. 2016;11(11):e0166710
2*	J:261178 Yousaf R, Ahmed ZM, Giese AP, Morell RJ, Lagziel A, Dabdoub A, Wilcox ER, Riazuddin S, Friedman TB, Riazuddin S, Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. J Clin Invest. 2018 Apr 2;128(4):1509-1522
1*	J:85269 Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS, GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem. 2003 Sep 5;278(36):34641-53