Gene Expression Literature Summary

• Symbol: Alx4
• Name: aristaless-like homeobox 4
• ID: MGI:108359

111 matching records from 111 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17	E18.5	E	P
Immunohistochemistry (section)		1	1						1	1	1		2	1	1	1				1
In situ RNA (section)			4	1	8		5		3		6		5	5		2		2	3	5
In situ RNA (whole mount)	3	2	18	10	63	7	27		5		4			3					3
In situ reporter (knock in)			1		1		1
Northern blot			1				1		1		1					1		1		1
Western blot					1			1				1			1		1			2
RT-PCR			1		4		4		1	1			3	1		1		1
cDNA clones					2	1														1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Alx4  aristaless-like homeobox 4   (Synonyms: Aristaless-like 4)
Results	Reference
2	J:163487 Aggarwal VS, Carpenter C, Freyer L, Liao J, Petti M, Morrow BE, Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol. 2010 Aug 15;344(2):669-81
1	J:207610 Akiyama R, Kawakami H, Taketo MM, Evans SM, Wada N, Petryk A, Kawakami Y, Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol. 2014 Mar 1;387(1):37-48
5	J:91667 Antonopoulou I, Mavrogiannis LA, Wilkie AO, Morriss-Kay GM, Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation. J Anat. 2004 Jun;204(6):487-99
1	J:283343 Bastida MF, Perez-Gomez R, Trofka A, Zhu J, Rada-Iglesias A, Sheth R, Stadler HS, Mackem S, Ros MA, The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1090-1096
3*	J:71880 Beverdam A, Brouwer A, Reijnen M, Korving J, Meijlink F, Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development. 2001 Oct;128(20):3975-86
5*	J:71422 Beverdam A, Meijlink F, Expression patterns of group-I aristaless-related genes during craniofacial and limb development. Mech Dev. 2001 Sep;107(1-2):163-7
1	J:150764 Bildsoe H, Loebel DA, Jones VJ, Chen YT, Behringer RR, Tam PP, Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Dev Biol. 2009 Jul 15;331(2):176-88
1*	J:73689 Boras K, Hamel PA, Alx4 binding to LEF-1 regulates N-CAM promoter activity. J Biol Chem. 2002 Jan 11;277(2):1120-7
5*	J:111643 Boras-Granic K, Grosschedl R, Hamel PA, Genetic interaction between Lef1 and Alx4 is required for early embryonic development. Int J Dev Biol. 2006;50(7):601-10
1	J:188038 Bowers M, Eng L, Lao Z, Turnbull RK, Bao X, Riedel E, Mackem S, Joyner AL, Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3. Dev Biol. 2012 Oct 1;370(1):110-24
1*	J:116770 Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V, Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am J Hum Genet. 2006 Oct;79(4):668-78
3	J:109528 Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L, Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development. 2006 Jun;133(11):2263-73
2	J:171194 Capellini TD, Handschuh K, Quintana L, Ferretti E, Di Giacomo G, Fantini S, Vaccari G, Clarke SL, Wenger AM, Bejerano G, Sharpe J, Zappavigna V, Selleri L, Control of pelvic girdle development by genes of the Pbx family and Emx2. Dev Dyn. 2011 May;240(5):1173-89
2	J:169192 Capellini TD, Vaccari G, Ferretti E, Fantini S, He M, Pellegrini M, Quintana L, Di Giacomo G, Sharpe J, Selleri L, Zappavigna V, Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1. Development. 2010 Aug 1;137(15):2559-69
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1	J:196365 Compagnucci C, Debiais-Thibaud M, Coolen M, Fish J, Griffin JN, Bertocchini F, Minoux M, Rijli FM, Borday-Birraux V, Casane D, Mazan S, Depew MJ, Pattern and polarity in the development and evolution of the gnathostome jaw: Both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula. Dev Biol. 2013 May 15;377(2):428-48
1	J:171520 Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ, Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. Genesis. 2011 Apr;49(4):307-25
3	J:223288 Curtain M, Heffner CS, Maddox DM, Gudis P, Donahue LR, Murray SA, A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice. Mamm Genome. 2015 Apr;26(3-4):173-80
1*	J:264204 Deimling SJ, Lau K, Hui CC, Hopyan S, Genetic interaction between Gli3 and Ezh2 during limb pattern formation. Mech Dev. 2018 Jun;151:30-36
1	J:79553 Depew MJ, Lufkin T, Rubenstein JL, Specification of jaw subdivisions by Dlx genes. Science. 2002 Oct 11;298(5592):381-5
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*	J:328711 Fernandez-Guerrero M, Zdral S, Castilla-Ibeas A, Lopez-Delisle L, Duboule D, Ros MA, Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis. Dev Dyn. 2022 Sep;251(9):1550-1575
1	J:159210 Galli A, Robay D, Osterwalder M, Bao X, Benazet JD, Tariq M, Paro R, Mackem S, Zeller R, Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 2010;6(4):e1000901
2*	J:316178 Gamart J, Barozzi I, Laurent F, Reinhardt R, Martins LR, Oberholzer T, Visel A, Zeller R, Zuniga A, SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning. Development. 2021 Dec 1;148(23):dev200182
11	J:246663 Garg A, Bansal M, Gotoh N, Feng GS, Zhong J, Wang F, Kariminejad A, Brooks S, Zhang X, Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis. PLoS Genet. 2017 Oct;13(10):e1007047
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1	J:193110 Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ, Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1;374(1):185-97
2*	J:79899 Grotewold L, Ruther U, The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly. Dev Biol. 2002 Nov 1;251(1):129-41
2	J:327183 Gu R, Zhang S, Saha SK, Ji Y, Reynolds K, McMahon M, Sun B, Islam M, Trainor PA, Chen Y, Xu Y, Chai Y, Burkart-Waco D, Zhou CJ, Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts. Development. 2022 Jul 15;149(14):dev200533
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:166749 Hammock EA, Eagleson KL, Barlow S, Earls LR, Miller DM 3rd, Levitt P, Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Neural Dev. 2010;5(1):32
1	J:233374 Hayashi S, Akiyama R, Wong J, Tahara N, Kawakami H, Kawakami Y, Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development. PLoS Genet. 2016 Jun;12(6):e1006138
1	J:202450 He F, Soriano P, A Critical Role for PDGFRalpha Signaling in Medial Nasal Process Development. PLoS Genet. 2013 Sep;9(9):e1003851
1*	J:149502 Hill P, Gotz K, Ruther U, A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud. Dev Biol. 2009 Apr 15;328(2):506-16
1	J:125087 Hill P, Wang B, Ruther U, The molecular basis of Pallister Hall associated polydactyly. Hum Mol Genet. 2007 Sep 1;16(17):2089-96
1*	J:181269 Hong M, Schachter KA, Jiang G, Krauss RS, Neogenin regulates sonic hedgehog pathway activity during digit patterning. Dev Dyn. 2012 Mar;241(3):627-37
9	J:50255 Hudson R, Taniguchi-Sidle A, Boras K, Wiggan O, Hamel PA, Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions. Dev Dyn. 1998 Oct;213(2):159-69
1	J:184018 Itou J, Kawakami H, Quach T, Osterwalder M, Evans SM, Zeller R, Kawakami Y, Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development. 2012 May;139(9):1620-9
1	J:320497 Iyyanar PPR, Wu Z, Lan Y, Hu YC, Jiang R, Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Front Cell Dev Biol. 2022;10:777887
3	J:232412 Jeon S, Seong RH, Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet. 2016 Mar;12(3):e1005915
2	J:168865 Jory A, Le Roux I, Gayraud-Morel B, Rocheteau P, Cohen-Tannoudji M, Cumano A, Tajbakhsh S, Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite. Stem Cells. 2009 Nov;27(11):2769-80
1	J:128941 Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y, Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 1;312(1):435-47
1	J:205405 Kozhemyakina E, Ionescu A, Lassar AB, GATA6 is a crucial regulator of Shh in the limb bud. PLoS Genet. 2014 Jan;10(1):e1004072
2	J:165721 Krawchuk D, Weiner SJ, Chen YT, Lu BC, Costantini F, Behringer RR, Laufer E, Twist1 activity thresholds define multiple functions in limb development. Dev Biol. 2010 Nov 1;347(1):133-46
1	J:101708 Kuijper S, Beverdam A, Kroon C, Brouwer A, Candille S, Barsh G, Meijlink F, Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development. 2005 Apr;132(7):1601-10
3*	J:101265 Kuijper S, Feitsma H, Sheth R, Korving J, Reijnen M, Meijlink F, Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh. Dev Biol. 2005 Sep 15;285(2):533-44
1	J:214694 Kur E, Mecklenburg N, Cabrera RM, Willnow TE, Hammes A, LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15;127(Pt 10):2261-8
2	J:163651 Lakhwani S, Garcia-Sanz P, Vallejo M, Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects. Dev Biol. 2010 Aug 15;344(2):869-80
1*	J:150759 Lallemand Y, Bensoussan V, Cloment CS, Robert B, Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol. 2009 Jul 15;331(2):189-98
2	J:98917 Lallemand Y, Nicola MA, Ramos C, Bach A, Cloment CS, Robert B, Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development. Development. 2005 Jul;132(13):3003-14
1*	J:58081 Lettice L, Hecksher-Sorensen J, Hill RE, The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs. Development. 1999 Nov;126(21):4729-36
2*	J:226028 Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA, Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103
1	J:102949 Li C, Xu X, Nelson DK, Williams T, Kuehn MR, Deng CX, FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis. Development. 2005 Nov;132(21):4755-64
3*	J:213418 Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC, Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40
2	J:296151 Liu J, Chanumolu SK, White KM, Albahrani M, Otu HH, Nawshad A, Transcriptional analysis of cleft palate in TGFbeta3 mutant mice. Sci Rep. 2020 Sep 10;10(1):14940
2	J:146638 Liu N, Barbosa AC, Chapman SL, Bezprozvannaya S, Qi X, Richardson JA, Yanagisawa H, Olson EN, DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development. 2009 Mar;136(6):933-42
1*	J:99697 Liu W, Selever J, Murali D, Sun X, Brugger SM, Ma L, Schwartz RJ, Maxson R, Furuta Y, Martin JF, Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol. 2005 Jul 15;283(2):282-93
3	J:79482 Liu Y, Liu C, Yamada Y, Fan CM, growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development. 2002 Nov;129(22):5289-300
2	J:276721 Liu Z, Li C, Xu J, Lan Y, Liu H, Li X, Maire P, Wang X, Jiang R, Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development. J Dent Res. 2019 May;98(5):572-579
1*	J:180785 Loebel DA, Hor AC, Bildsoe H, Jones V, Chen YT, Behringer RR, Tam PP, Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton. Dev Biol. 2012 Feb 15;362(2):132-40
2*	J:78343 Loebel DA, O'Rourke MP, Steiner KA, Banyer J, Tam PP, Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002 Jul;33(3):103-13
1	J:136057 Lu P, Yu Y, Perdue Y, Werb Z, The apical ectodermal ridge is a timer for generating distal limb progenitors. Development. 2008 Apr;135(8):1395-405
3*	J:272508 Ma J, Lwigale P, Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):661-676
1	J:228335 Makino S, Zhulyn O, Mo R, Puviindran V, Zhang X, Murata T, Fukumura R, Ishitsuka Y, Kotaki H, Matsumaru D, Ishii S, Hui CC, Gondo Y, T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One. 2015;10(3):e0119455
2*	J:71389 Manley NR, Barrow JR, Zhang T, Capecchi MR, Hoxb2 and hoxb4 act together to specify ventral body wall formation. Dev Biol. 2001 Sep 1;237(1):130-44
1*	J:149478 Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP, Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr;16(4):600-6
8	J:234759 Matsumaru D, Haraguchi R, Moon AM, Satoh Y, Nakagata N, Yamamura K, Takahashi N, Kitazawa S, Yamada G, Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation. Eur J Hum Genet. 2014 Mar;22(3):350-7
1	J:139169 Menke DB, Guenther C, Kingsley DM, Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs. Development. 2008 Aug;135(15):2543-53
1	J:144017 Minoux M, Antonarakis GS, Kmita M, Duboule D, Rijli FM, Rostral and caudal pharyngeal arches share a common neural crest ground pattern. Development. 2009 Feb;136(4):637-45
1	J:103158 Moribe H, Takagi T, Kondoh H, Higashi Y, Suppression of polydactyly of the Gli3 mutant (extra toes) by deltaEF1 homozygous mutation. Dev Growth Differ. 2000 Aug;42(4):367-76
2*	J:344235 Nguyen TT, Mitchell JM, Kiel MD, Kenny CP, Li H, Jones KL, Cornell RA, Williams TJ, Nichols JT, Van Otterloo E, TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway. Development. 2024 Jan 1;151(1):dev202095
2	J:78407 O'Rourke MP, Soo K, Behringer RR, Hui CC, Tam PP, Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev Biol. 2002 Aug 1;248(1):143-56
2	J:256374 Ogoh H, Yamagata K, Nakao T, Sandell LL, Yamamoto A, Yamashita A, Tanga N, Suzuki M, Abe T, Kitabayashi I, Watanabe T, Sakai D, Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development. Sci Rep. 2017 Sep 20;7(1):11922
1*	J:90276 Ota MS, Loebel DA, O'Rourke MP, Wong N, Tsoi B, Tam PP, Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells. Dev Dyn. 2004 Jun;230(2):216-28
14*	J:44699 Qu S, Li L, Wisdom R, Alx-4: cDNA cloning and characterization of a novel paired-type homeodomain protein. Gene. 1997 Dec 12;203(2):217-23
9	J:43769 Qu S, Niswender KD, Ji Q, van der Meer R, Keeney D, Magnuson MA , Wisdom R, Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development. 1997 Oct;124(20):3999-4008
2	J:345597 Quilez S, Dumontier E, Baim C, Kam J, Cloutier JF, Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465
2*	J:85739 Rice R, Rice DP, Olsen BR, Thesleff I, Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol. 2003 Oct 1;262(1):75-87
7	J:328710 Rockwell DM, O'Connor AK, Bentley-Ford MR, Haycraft CJ, Croyle MJ, Brewer KM, Berbari NF, Kesterson RA, Yoder BK, A transgenic Alx4-CreER mouse to analyze anterior limb and nephric duct development. Dev Dyn. 2022 Sep;251(9):1524-1534
1	J:87798 Sagai T, Masuya H, Tamura M, Shimizu K, Yada Y, Wakana S, Gondo Y, Noda T, Shiroishi T, Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh). Mamm Genome. 2004 Jan;15(1):23-34
1	J:102845 Santagati F, Minoux M, Ren SY, Rijli FM, Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis. Development. 2005 Nov;132(22):4927-36
1	J:128571 Selever J, Liu W, Lu MF, Behringer RR, Martin JF, Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. Dev Biol. 2004 Dec 15;276(2):268-79
2	J:317430 Sharma D, Mirando AJ, Leinroth A, Long JT, Karner CM, Hilton MJ, HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. PLoS Genet. 2021 Dec;17(12):e1009982
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1*	J:77801 Soo K, O'Rourke MP, Khoo PL, Steiner KA, Wong N, Behringer RR, Tam PP, Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo. Dev Biol. 2002 Jul 15;247(2):251-70
1	J:350460 Soussi G, Girdziusaite A, Jhanwar S, Palacio V, Notaro M, Sheth R, Zeller R, Zuniga A, TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development. Development. 2024 Jun 1;151(11)
1	J:78402 Sun X, Mariani FV, Martin GR, Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature. 2002 Aug 1;418(6897):501-8
3*	J:50307 Takahashi M, Tamura K, Buscher D, Masuya H, Yonei-Tamura S, Matsumoto K, Naitoh-Matsuo M, Takeuchi J, Ogura K, Shiroishi T, Ogura T, Belmonte JC, The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development [published erratum appears in Development 1998 Dec;125(23):preceding 4595]. Development. 1998 Nov;125(22):4417-25
2	J:77675 te Welscher P, Fernandez-Teran M, Ros MA, Zeller R, Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. Genes Dev. 2002 Feb 15;16(4):421-6
1	J:139045 Thomason HA, Dixon MJ, Dixon J, Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling. Dev Biol. 2008 Sep 1;321(1):273-82
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:101736 Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X, Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development. 2005 Oct;132(19):4235-45
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:137357 Vivatbutsiri P, Ichinose S, Hytonen M, Sainio K, Eto K, Iseki S, Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant. J Anat. 2008 May;212(5):603-11
1	J:286823 Wang L, Tang Q, Xu J, Li H, Yang T, Li L, Machon O, Hu T, Chen Y, The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice. J Biol Chem. 2020 Apr 17;295(16):5449-5460
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1	J:175770 Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S, Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development. 2011 Sep;138(17):3759-67
1	J:203059 Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM, Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19438-43
2	J:309090 Xu J, Liu H, Lan Y, Adam M, Clouthier DE, Potter S, Jiang R, Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. Elife. 2019 Jan 14;8:e40315
1	J:81331 Yada Y, Makino S, Chigusa-Ishiwa S, Shiroishi T, The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Int J Dev Biol. 2002;46(7):975-82
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