Gene Expression Literature Summary

• Symbol: Kif2a
• Name: kinesin family member 2A
• ID: MGI:108390

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E11.5	E12	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)				1	2	1	1	1	1	1	1	1	2	1	4
In situ RNA (section)							3								1
Western blot			1		1		1		1			1			3
RT-PCR	1	1	1			1	1		1	1			1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kif2a  kinesin family member 2A   (Synonyms: Kif2, Kns2, M-kinesin)
Results	Reference
4*	J:302541 Akkaya C, Atak D, Kamacioglu A, Akarlar BA, Guner G, Bayam E, Taskin AC, Ozlu N, Ince-Dunn G, Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation. Development. 2021 Feb 22;148(4):dev192674
1*	J:317479 Bizzotto S, Uzquiano A, Dingli F, Ershov D, Houllier A, Arras G, Richards M, Loew D, Minc N, Croquelois A, Houdusse A, Francis F, Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex. Sci Rep. 2017 Dec 11;7(1):17308
4*	J:255527 Broix L, Asselin L, Silva CG, Ivanova EL, Tilly P, Gilet JG, Lebrun N, Jagline H, Muraca G, Saillour Y, Drouot N, Reilly ML, Francis F, Benmerah A, Bahi-Buisson N, Belvindrah R, Nguyen L, Godin JD, Chelly J, Hinckelmann MV, Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development. Hum Mol Genet. 2018 Jan 15;27(2):224-238
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:273130 Ding W, Wu Q, Sun L, Pan NC, Wang X, Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex. J Neurosci. 2019 Mar 13;39(11):1994-2010
6	J:286645 Gilet JG, Ivanova EL, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok BH, Allingham JS, Chelly J, Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny. Hum Mol Genet. 2020 Mar 27;29(5):766-784
3	J:333076 Hakanen J, Parmentier N, Sommacal L, Garcia-Sanchez D, Aittaleb M, Vertommen D, Zhou L, Ruiz-Reig N, Tissir F, The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain. Prog Neurobiol. 2022 Jan;208:102177
3	J:355868 Revil T, Gaffney D, Dias C, Majewski J, Jerome-Majewska LA, Alternative splicing is frequent during early embryonic development in mouse. BMC Genomics. 2010 Jun 23;11:399
4	J:333796 Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, Nguyen L, Gailly P, Tissir F, KIF2A deficiency causes early-onset neurodegeneration. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2209714119
2	J:333000 Ruiz-Reig N, Garcia-Sanchez D, Schakman O, Gailly P, Tissir F, Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons. Front Mol Neurosci. 2022;15:1110986
8	J:245691 Sun D, Zhou X, Yu HL, He XX, Guo WX, Xiong WC, Zhu XJ, Regulation of neural stem cell proliferation and differentiation by Kinesin family member 2a. PLoS One. 2017;12(6):e0179047
1	J:236302 Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA, Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25;166(5):1147-1162.e15