Gene Expression Literature Summary

• Symbol: Rgs4
• Name: regulator of G-protein signaling 4
• ID: MGI:108409

30 matching records from 30 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)					1		1	1
In situ RNA (section)		1	1	2	5	1	5	4	6	2	1		1	3	5
Immunohistochemistry (whole mount)							1	1
In situ RNA (whole mount)	1	1	2							1
In situ reporter (knock in)					1		1	1	1						2
Northern blot							1
Western blot								1	2						1
RT-PCR					2			1	3	2		1			5
cDNA clones			1				1							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Rgs4  regulator of G-protein signaling 4   (Synonyms: ESTM48, ESTM50)
Results	Reference
1	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
1	J:353339 Butts JC, Wu SR, Durham MA, Dhindsa RS, Revelli JP, Ljungberg MC, Saulnier O, McLaren ME, Taylor MD, Zoghbi HY, A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7
6*	J:119269 Caqueret A, Boucher F, Michaud JL, Laminar organization of the early developing anterior hypothalamus. Dev Biol. 2006 Oct 1;298(1):95-106
1*	J:147160 Chambers D, Wilson LJ, Alfonsi F, Hunter E, Saxena U, Blanc E, Lumsden A, Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. Neural Dev. 2009;4:6
1	J:147117 Cheng TW, Gong Q, Secreted TARSH regulates olfactory mitral cell dendritic complexity. Eur J Neurosci. 2009 Mar;29(6):1083-95
2*	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
1	J:283226 Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ, Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:160656 Eng SR, Dykes IM, Lanier J, Fedtsova N, Turner EE, POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia. Neural Dev. 2007;2:3
1	J:243840 Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B, Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511
12*	J:86070 Grillet N, Dubreuil V, Dufour HD, Brunet JF, Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b. J Neurosci. 2003 Nov 19;23(33):10613-21
5	J:98888 Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF, Generation and characterization of Rgs4 mutant mice. Mol Cell Biol. 2005 May;25(10):4221-8
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:177585 Hesse K, Vaupel K, Kurt S, Buettner R, Kirfel J, Moser M, AP-2delta is a crucial transcriptional regulator of the posterior midbrain. PLoS One. 2011;6(8):e23483
2*	J:209053 Hoekstra EJ, von Oerthel L, van der Linden AJ, Schellevis RD, Scheppink G, Holstege FC, Groot-Koerkamp MJ, van der Heide LP, Smidt MP, Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons. Eur J Neurosci. 2013 Jan;37(1):23-32
2	J:254511 Inoue K, Hirose M, Inoue H, Hatanaka Y, Honda A, Hasegawa A, Mochida K, Ogura A, The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Cell Rep. 2017 May 2;19(5):949-956
2	J:218509 Kim HJ, Ryu J, Woo HM, Cho SS, Sung MK, Kim SC, Park MH, Park T, Koo SK, Patterns of gene expression associated with Pten deficiency in the developing inner ear. PLoS One. 2014;9(6):e97544
8	J:316188 Lee MJ, Kim DE, Zakrzewska A, Yoo YD, Kim SH, Kim ST, Seo JW, Lee YS, Dorn GW 2nd, Oh U, Kim BY, Kwon YT, Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes. J Biol Chem. 2012 Jul 6;287(28):24043-52
1*	J:102474 Lee MJ, Tasaki T, Moroi K, An JY, Kimura S, Davydov IV, Kwon YT, RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15030-5
3	J:157314 Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS, Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol. 2009;10(10):R104
1	J:351810 Morales L, Castro-Robles B, Abellan A, Desfilis E, Medina L, A novel telencephalon-opto-hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala. J Comp Neurol. 2021 Jul 1;529(10):2418-2449
5*	J:172381 Osterberg N, Wiehle M, Oehlke O, Heidrich S, Xu C, Fan CM, Krieglstein K, Roussa E, Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons. PLoS One. 2011;6(4):e19239
1*	J:336866 Puelles L, Hidalgo-Sanchez M, The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11)
2	J:317827 Sawai A, Pfennig S, Bulajic M, Miller A, Khodadadi-Jamayran A, Mazzoni EO, Dasen JS, PRC1 sustains the integrity of neural fate in the absence of PRC2 function. Elife. 2022 Jan 7;11:e72769
4	J:178647 Serafimidis I, Heximer S, Beis D, Gavalas A, G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. Mol Cell Biol. 2011 Nov;31(22):4442-53
1	J:332291 Song H, Morrow BE, Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development. Dev Biol. 2022 Dec 12;494:71-84
1	J:286533 Tenney AP, Livet J, Belton T, Prochazkova M, Pearson EM, Whitman MC, Kulkarni AB, Engle EC, Henderson CE, Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Cell Rep. 2019 Oct 8;29(2):437-452.e4
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:259070 Tischfield DJ, Saraswat DK, Furash A, Fowler SC, Fuccillo MV, Anderson SA, Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. Neurobiol Dis. 2017 Jul;103:174-183
1	J:326542 van de Haar LL, Riga D, Boer JE, Garritsen O, Adolfs Y, Sieburgh TE, van Dijk RE, Watanabe K, van Kronenburg NCH, Broekhoven MH, Posthuma D, Meye FJ, Basak O, Pasterkamp RJ, Molecular signatures and cellular diversity during mouse habenula development. Cell Rep. 2022 Jul 5;40(1):111029