Gene Expression Literature Summary

• Symbol: Lpar1
• Name: lysophosphatidic acid receptor 1
• ID: MGI:108429

30 matching records from 30 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E18	E18.5	E19	P
Immunohistochemistry (section)								1				1			1						1
In situ RNA (section)			1		1	2	1			3	1	2		1	2	1		2	1		5
In situ RNA (whole mount)		1	2	1	1	1		1						2
In situ reporter (knock in)								1													1
Northern blot									1		3		1		3		1	2			6
Western blot																					2
RT-PCR	1		2	2	2			2		2		1	1		4	1		1	1	1	6
cDNA clones																					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lpar1  lysophosphatidic acid receptor 1   (Synonyms: Edg2, Gpcr26, Kdt2, LPA1, vzg-1)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4*	J:69160 Contos JJ, Chun J, The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene. 2001 Apr 18;267(2):243-53
2*	J:65882 Contos JJ, Fukushima N, Weiner JA, Kaushal D, Chun J, Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13384-9
1*	J:160820 Dubin AE, Herr DR, Chun J, Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010 May 26;30(21):7300-9
2	J:174115 Estivill-Torrus G, Llebrez-Zayas P, Matas-Rico E, Santin L, Pedraza C, De Diego I, Del Arco I, Fernandez-Llebrez P, Chun J, De Fonseca FR, Absence of LPA1 signaling results in defective cortical development. Cereb Cortex. 2008 Apr;18(4):938-50
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
3*	J:196844 Furuta D, Yamane M, Tsujiuchi T, Moriyama R, Fukushima N, Lysophosphatidic acid induces neurite branch formation through LPA3. Mol Cell Neurosci. 2012 May;50(1):21-34
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
12*	J:36844 Hecht JH, Weiner JA, Post SR, Chun J, Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol. 1996 Nov;135(4):1071-83
4	J:302131 Hu HB, Song ZQ, Song GP, Li S, Tu HQ, Wu M, Zhang YC, Yuan JF, Li TT, Li PY, Xu YL, Shen XL, Han QY, Li AL, Zhou T, Chun J, Zhang XM, Li HY, LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis. Nat Commun. 2021 Jan 28;12(1):662
1	J:338083 Hwang I, Kim BS, Ko HR, Cho S, Lee HY, Cho SW, Ryu D, Shim S, Ahn JY, Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice. Mol Psychiatry. 2022 Apr;27(4):2030-2041
1	J:71372 Ishii I, Friedman B, Ye X, Kawamura S, McGiffert C, Contos JJ, Kingsbury MA, Zhang G, Heller Brown J, Chun J, Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem. 2001 Sep 7;276(36):33697-704
3*	J:166492 Itoh R, Miura S, Takimoto A, Kondo S, Sano H, Hiraki Y, Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells. J Bone Miner Metab. 2010 Nov;28(6):659-71
1	J:213690 Jang Y, Lee MH, Lee J, Jung J, Lee SH, Yang DJ, Kim BW, Son H, Lee B, Chang S, Mori Y, Oh U, TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain. Pflugers Arch. 2014 Oct;466(10):1987-98
1	J:324531 Kim H, Gao EB, Draper A, Berens NC, Vihma H, Zhang X, Higashi-Howard A, Ritola KD, Simon JM, Kennedy AJ, Philpot BD, Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression. Elife. 2022 May 10;11:e72290
5*	J:321064 Kim NH, Sadra A, Park HY, Oh SM, Chun J, Yoon JK, Huh SO, HeLa E-Box Binding Protein, HEB, Inhibits Promoter Activity of the Lysophosphatidic Acid Receptor Gene Lpar1 in Neocortical Neuroblast Cells. Mol Cells. 2019 Feb 28;42(2):123-134
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:169062 Lopez-Juarez A, Morales-Lazaro S, Sanchez-Sanchez R, Sunkara M, Lomeli H, Velasco I, Morris AJ, Escalante-Alcalde D, Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. Glia. 2011 Apr;59(4):577-89
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2*	J:313631 McDonald WS, Miyamoto K, Rivera R, Kennedy G, Almeida BSV, Kingsbury MA, Chun J, Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells. Mol Brain. 2020 Dec 14;13(1):169
1*	J:79922 McGiffert C, Contos JJ, Friedman B, Chun J, Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. FEBS Lett. 2002 Oct 30;531(1):103-8
1*	J:241850 Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A, Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3
5*	J:140656 Ohuchi H, Hamada A, Matsuda H, Takagi A, Tanaka M, Aoki J, Arai H, Noji S, Expression patterns of the lysophospholipid receptor genes during mouse early development. Dev Dyn. 2008 Nov;237(11):3280-94
6*	J:276705 Suckau O, Gross I, Schrotter S, Yang F, Luo J, Wree A, Chun J, Baska D, Baumgart J, Kano K, Aoki J, Brauer AU, LPA1 , LPA2 , LPA4 , and LPA6 receptor expression during mouse brain development. Dev Dyn. 2019 May;248(5):375-395
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
4*	J:116891 Tanaka M, Okudaira S, Kishi Y, Ohkawa R, Iseki S, Ota M, Noji S, Yatomi Y, Aoki J, Arai H, Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem. 2006 Sep 1;281(35):25822-30
2*	J:321809 Uenaka M, Uyeda A, Nakahara T, Muramatsu R, LPA2 promotes neuronal differentiation and neurite formation in neocortical development. Biochem Biophys Res Commun. 2022 Apr 2;598:89-94
4*	J:110324 van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradere JP, Pettit TR, Wakelam MJ, Saulnier-Blache JS, Mummery CL, Moolenaar WH, Jonkers J, Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol. 2006 Jul;26(13):5015-22
6*	J:49099 Weiner JA, Hecht JH, Chun J, Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J Comp Neurol. 1998 Sep 7;398(4):587-98
1*	J:178322 Yung YC, Mutoh T, Lin ME, Noguchi K, Rivera RR, Choi JW, Kingsbury MA, Chun J, Lysophosphatidic acid signaling may initiate fetal hydrocephalus. Sci Transl Med. 2011 Sep 7;3(99):99ra87