Gene Expression Literature Summary

• Symbol: Dab2
• Name: disabled 2, mitogen-responsive phosphoprotein
• ID: MGI:109175

42 matching records from 42 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2.5	E3	E3.5	E4	E4.5	E5	E5.5	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)					5	1	8	6	1	3			1	2	1	1	1	1		1	1		1		1		11
In situ RNA (section)								1		1				1			1			1		1		1			2
Immunohistochemistry (whole mount)		1	3	1	4	1						1	1	1
In situ RNA (whole mount)						1		1		2		1		2
In situ reporter (knock in)													1	1		1	1		1								1
Northern blot																											1
Western blot								1						1													2
RT-PCR	1		1		1			1		3	1		1	3		1	1			1							1
cDNA clones									1	1																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dab2  disabled 2, mitogen-responsive phosphoprotein   (Synonyms: 5730435J12Rik, D15Wsu122e, D630005B22Rik, p96)
Results	Reference
2	J:100380 Airik R, Karner M, Karis A, Karner J, Gene expression analysis of Gata3-/- mice by using cDNA microarray technology. Life Sci. 2005 Apr 15;76(22):2559-68
1	J:170416 Artus J, Piliszek A, Hadjantonakis AK, The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol. 2011 Feb 15;350(2):393-404
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3*	J:139638 Cai KQ, Capo-Chichi CD, Rula ME, Yang DH, Xu XX, Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis. Dev Dyn. 2008 Sep 24;237(10):2820-2829
1	J:112232 Chazaud C, Rossant J, Disruption of early proximodistal patterning and AVE formation in Apc mutants. Development. 2006 Sep;133(17):3379-87
1	J:108748 Chazaud C, Yamanaka Y, Pawson T, Rossant J, Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell. 2006 May;10(5):615-24
11*	J:140134 Cheung KK, Mok SC, Rezaie P, Chan WY, Dynamic expression of Dab2 in the mouse embryonic central nervous system. BMC Dev Biol. 2008;8:76
9*	J:55266 Cho SY, Cho SY, Lee SH, Park SS, Differential expression of mouse Disabled 2 gene in retinoic acid-treated F9 embryonal carcinoma cells and early mouse embryos. Mol Cells. 1999 Apr 30;9(2):179-84
1	J:242105 Fiorenzano A, Pascale E, D'Aniello C, Acampora D, Bassalert C, Russo F, Andolfi G, Biffoni M, Francescangeli F, Zeuner A, Angelini C, Chazaud C, Patriarca EJ, Fico A, Minchiotti G, Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency. Nat Commun. 2016 Sep 02;7:12589
6*	J:130836 Gerbe F, Cox B, Rossant J, Chazaud C, Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst. Dev Biol. 2008 Jan 15;313(2):594-602
1	J:87048 Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA, Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development. 2004 Jan;131(1):165-79
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:154667 Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM, Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7
1	J:266273 Honda A, Kita T, Seshadri SV, Misaki K, Ahmed Z, Ladbury JE, Richardson GP, Yonemura S, Ladher RK, FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8388-8393
1	J:101263 Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ, Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol. 2005 Sep 15;285(2):554-69
2	J:299860 Jin L, Chen Y, Crossman DK, Datta A, Vu T, Mobley JA, Basu MK, Scarduzio M, Wang H, Chang C, Datta PK, STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Nat Commun. 2020 Nov 23;11(1):5941
2*	J:50869 Ko MSH, Threat TA, Wang X, Horton JH, Cui Y, Pryor E, Paris J , Wells-Smith J , Kitchen JR , Rowe LB , Eppig J , Satoh T , Brant L , Fujiwara H , Yotsumoto S , Nakashima H, Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
1	J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
1	J:270950 Lin K, Zhang S, Shi Q, Zhu M, Gao L, Xia W, Geng B, Zheng Z, Xu EY, Essential requirement of mammalian Pumilio family in embryonic development. Mol Biol Cell. 2018 Nov 26;29(24):2922-2932
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3	J:269227 Mathieu M, Drelon C, Rodriguez S, Tabbal H, Septier A, Damon-Soubeyrand C, Dumontet T, Berthon A, Sahut-Barnola I, Djari C, Batisse-Lignier M, Pointud JC, Richard D, Kerdivel G, Calmejane MA, Boeva V, Tauveron I, Lefrancois-Martinez AM, Martinez A, Val P, Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12265-E12274
5*	J:103780 Maurer ME, Cooper JA, Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J Cell Sci. 2005 Nov 15;118(Pt 22):5345-55
3*	J:242917 Meng Y, Cai KQ, Moore R, Tao W, Tse JD, Smith ER, Xu XX, Pten facilitates epiblast epithelial polarization and proamniotic lumen formation in early mouse embryos. Dev Dyn. 2017 Jul;246(7):517-530
1	J:260470 Meng Y, Moore R, Tao W, Smith ER, Tse JD, Caslini C, Xu XX, GATA6 phosphorylation by Erk1/2 propels exit from pluripotency and commitment to primitive endoderm. Dev Biol. 2018 Apr 1;436(1):55-65
4*	J:205046 Moore R, Cai KQ, Tao W, Smith ER, Xu XX, Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues. BMC Dev Biol. 2013;13:39
2*	J:315320 Moore R, Tao W, Smith ER, Xu XX, The primitive endoderm segregates from the epiblast in beta1 integrin-deficient early mouse embryos. Mol Cell Biol. 2014 Feb;34(3):560-72
4	J:75911 Morris SM, Tallquist MD, Rock CO, Cooper JA, Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 2002 Apr 2;21(7):1555-64
4*	J:63029 Morrisey EE, Musco S, Chen MY, Lu MM, Leiden JM, Parmacek MS, The gene encoding the mitogen-responsive phosphoprotein Dab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm. J Biol Chem. 2000 Jun 30;275(26):19949-54
1	J:278935 Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF, MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. FASEB J. 2018 Jun 7;:fj201701274RR
1	J:116773 Oda M, Yamagiwa A, Yamamoto S, Nakayama T, Tsumura A, Sasaki H, Nakao K, Li E, Okano M, DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev. 2006 Dec 15;20(24):3382-94
1*	J:138816 Plusa B, Piliszek A, Frankenberg S, Artus J, Hadjantonakis AK, Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development. 2008 Sep;135(18):3081-91
1	J:242325 Posfai E, Petropoulos S, de Barros FR, Schell JP, Jurisica I, Sandberg R, Lanner F, Rossant J, Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo. Elife. 2017 Feb 22;6:e22906
1	J:315733 Saiz N, Grabarek JB, Sabherwal N, Papalopulu N, Plusa B, Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst. Development. 2013 Nov;140(21):4311-22
1	J:213580 Schrode N, Saiz N, Di Talia S, Hadjantonakis AK, GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014 May 27;29(4):454-67
2	J:287213 Scortegagna M, Berthon A, Settas N, Giannakou A, Garcia G, Li JL, James B, Liddington RC, Vilches-Moure JG, Stratakis CA, Ronai ZA, The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion. JCI Insight. 2017 Dec 7;2(23)
1	J:320521 Sharma R, Mei A, Mathew V, Kashpur O, Wallingford MC, Interaction of extraembryonic microglia and neonatal brain development. Exp Neurol. 2022 Jan 19;351:113986
1	J:233303 Vidal V, Sacco S, Rocha AS, da Silva F, Panzolini C, Dumontet T, Doan TM, Shan J, Rak-Raszewska A, Bird T, Vainio S, Martinez A, Schedl A, The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3. Genes Dev. 2016 Jun 15;30(12):1389-94
2	J:168655 Wang Y, Smedberg JL, Cai KQ, Capo-Chichi DC, Xu XX, Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation. Dev Dyn. 2011 Mar;240(3):566-76
1	J:228855 Wicklow E, Blij S, Frum T, Hirate Y, Lang RA, Sasaki H, Ralston A, HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genet. 2014 Oct;10(10):e1004618
1*	J:121266 Yang DH, Cai KQ, Roland IH, Smith ER, Xu XX, Disabled-2 is an epithelial surface positioning gene. J Biol Chem. 2007 Apr 27;282(17):13114-22
9	J:146504 Yang DH, Smith ER, Cai KQ, Xu XX, c-fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development. Dev Dyn. 2009 Mar;238(3):514-23
4*	J:79862 Yang DH, Smith ER, Roland IH, Sheng Z, He J, Martin WD, Hamilton TC, Lambeth JD, Xu XX, Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol. 2002 Nov 1;251(1):27-44