Gene Expression Literature Summary

• Symbol: Ccn3
• Name: cellular communication network factor 3
• ID: MGI:109185

25 matching records from 25 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18.5	E19	P
Immunohistochemistry (section)								1		1			1		1
In situ RNA (section)		1	1	3	1	1	3	5	1	4	4	1	1		3
In situ RNA (whole mount)										1
Northern blot													1		1
Western blot													1
RT-PCR	1						1	1		2	1	1	3	1	4
cDNA clones											1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ccn3  cellular communication network factor 3   (Synonyms: C130088N23Rik, CCN3, Nov)
Results	Reference
3	J:326693 Angelozzi M, Pellegrino da Silva R, Gonzalez MV, Lefebvre V, Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors. Cell Rep. 2022 Jul 12;40(2):111045
1*	J:272619 Aydogdu N, Rudat C, Trowe MO, Kaiser M, Ludtke TH, Taketo MM, Christoffels VM, Moon A, Kispert A, TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. Development. 2018 Nov 26;145(23):dev171827
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:202628 Bedore J, Sha W, McCann MR, Liu S, Leask A, Seguin CA, Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. Arthritis Rheum. 2013 Oct;65(10):2634-44
1*	J:127524 Davie JK, Cho JH, Meadows E, Flynn JM, Knapp JR, Klein WH, Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Dev Biol. 2007 Nov 15;311(2):650-64
1	J:297060 DeSisto J, O'Rourke R, Jones HE, Pawlikowski B, Malek AD, Bonney S, Guimiot F, Jones KL, Siegenthaler JA, Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function. Dev Cell. 2020 Jul 6;54(1):43-59.e4
1*	J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
1	J:307828 Farrell E, Armstrong AE, Grimes AC, Naya FJ, de Lange WJ, Ralphe JC, Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling. Front Physiol. 2018;9:1442
1*	J:150374 Garcia MI, Ghiani M, Lefort A, Libert F, Strollo S, Vassart G, LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol. 2009 Jul 1;331(1):58-67
1	J:307272 Godin P, Tsoi M, Paquet M, Boerboom D, YAP and TAZ are required for the postnatal development and the maintenance of the structural integrity of the oviduct. Reproduction. 2020 Aug;160(2):307-318
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:135676 Heath E, Tahri D, Andermarcher E, Schofield P, Fleming S, Boulter CA, Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene. BMC Dev Biol. 2008;8:18
3*	J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
4	J:155442 Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M, Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res. 2008 Nov;23(11):1751-64
4	J:160094 Lemaire R, Farina G, Bayle J, Dimarzio M, Pendergrass SA, Milano A, Whitfield ML, Lafyatis R, Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J Invest Dermatol. 2010 Jun;130(6):1514-23
2	J:290696 Lopez-Tello J, Perez-Garcia V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernandez de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN, Fetal and trophoblast PI3K p110alpha have distinct roles in regulating resource supply to the growing fetus in mice. Elife. 2019 Jun 26;8:e45282
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:289490 Menard A, Abou Nader N, Levasseur A, St-Jean G, Le Roy MLG, Boerboom D, Benoit-Biancamano MO, Boyer A, Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate. Endocrinology. 2020 May 1;161(5)
7	J:65675 Natarajan D, Andermarcher E, Schofield PN, Boulter CA, Mouse nov gene is expressed in hypaxial musculature and cranial structures derived from neural crest cells and placodes. Dev Dyn. 2000 Nov;219(3):417-25
4*	J:228383 Park M, Baek IJ, Kim H, Woo DK, Park YJ, Shim S, CCN3 overexpression inhibits growth of callosal projections via upregulation of RAB25. Biochem Biophys Res Commun. 2015 Jun 5;461(3):456-62
2	J:340735 Rose KP, Manilla G, Milon B, Zalzman O, Song Y, Coate TM, Hertzano R, Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset. iScience. 2023 Oct 20;26(10):107769
1	J:189624 Son EJ, Wu L, Yoon H, Kim S, Choi JY, Bok J, Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
1	J:286533 Tenney AP, Livet J, Belton T, Prochazkova M, Pearson EM, Whitman MC, Kulkarni AB, Engle EC, Henderson CE, Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Cell Rep. 2019 Oct 8;29(2):437-452.e4
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6