Gene Expression Literature Summary

• Symbol: Efnb3
• Name: ephrin B3
• ID: MGI:109196

77 matching records from 77 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)					1		2				2	1	3	1	1			3		1		7
In situ RNA (section)			1	1	2	1	4	1	6	1	7	2	12	3	7	2	1	1	1	9	3	8
In situ RNA (whole mount)	2		2						1						1						2
In situ reporter (knock in)		1	1		2		1				1				1		2	1				1
Northern blot														1					1			3
Western blot													1
RT-PCR							2		2		2		1		2		1	1		1		3
cDNA clones	1																					1
RNase protection			1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Efnb3  ephrin B3   (Synonyms: EFL-6, ELF-3, Elk-L3, Epl8, LERK-8, NLERK-2)
Results	Reference
1	J:67296 Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R, The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell. 2001 Jan 12;104(1):57-69
1*	J:98302 Altick AL, Dravis C, Bowdler T, Henkemeyer M, Mastick GS, EphB receptor tyrosine kinases control morphological development of the ventral midbrain. Mech Dev. 2005 Apr;122(4):501-12
1	J:196665 Arvanitis DN, Behar A, Tryoen-Toth P, Bush JO, Jungas T, Vitale N, Davy A, Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013 May;140(10):2082-92
1	J:128980 Awatramani R, Soriano P, Rodriguez C, Mai JJ, Dymecki SM, Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet. 2003 Sep;35(1):70-5
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
8*	J:45668 Bergemann AD, Zhang L, Chiang MK, Brambilla R, Klein R, Flanagan JG, Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene. 1998 Jan 29;16(4):471-80
2*	J:321845 Bernhardt N, Memic F, Velica A, Tran MA, Vieillard J, Sayyab S, Chersa T, Andersson L, Whelan PJ, Boije H, Kullander K, Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26. eNeuro. 2022 Mar-Apr;9(2):ENEURO.0518-21.2022
1	J:353444 Bessa P, Newman AG, Yan K, Schaub T, Dannenberg R, Lajko D, Eilenberger J, Brunet T, Textoris-Taube K, Kemmler E, Deng P, Banerjee P, Ravindran E, Preissner R, Rosario M, Tarabykin V, Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059
1*	J:245526 Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ, A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977
1*	J:60855 Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M, Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 2000 Mar;127(6):1231-41
1	J:315303 Bouche E, Romero-Ortega MI, Henkemeyer M, Catchpole T, Leemhuis J, Frotscher M, May P, Herz J, Bock HH, Reelin induces EphB activation. Cell Res. 2013 Apr;23(4):473-90
1	J:73073 Chapouton P, Schuurmans C, Guillemot F, Gotz M, The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum. Development. 2001 Dec;128(24):5149-59
1	J:97008 Chen ZY, Sun C, Reuhl K, Bergemann A, Henkemeyer M, Zhou R, Abnormal hippocampal axon bundling in EphB receptor mutant mice. J Neurosci. 2004 Mar 10;24(10):2366-74
1	J:182705 Choe Y, Siegenthaler JA, Pleasure SJ, A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron. 2012 Feb 23;73(4):698-712
1	J:179898 Coate TM, Raft S, Zhao X, Ryan AK, Crenshaw EB 3rd, Kelley MW, Otic Mesenchyme Cells Regulate Spiral Ganglion Axon Fasciculation through a Pou3f4/EphA4 Signaling Pathway. Neuron. 2012 Jan 12;73(1):49-63
1*	J:70369 Coonan JR, Greferath U, Messenger J, Hartley L, Murphy M, Boyd AW, Dottori M, Galea MP, Bartlett PF, Development and reorganization of corticospinal projections in EphA4 deficient mice. J Comp Neurol. 2001 Jul 23;436(2):248-62
1*	J:73773 de Diego I, Kyriakopoulou K, Karagogeos D, Wassef M, Multiple influences on the migration of precerebellar neurons in the caudal medulla. Development. 2002 Jan;129(2):297-306
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:111207 Dionne MS, Brunet LJ, Eimon PM, Harland RM, Noggin is required for correct guidance of dorsal root ganglion axons. Dev Biol. 2002 Nov 15;251(2):283-93
1*	J:50573 Dottori M, Hartley L, Galea M, Paxinos G, Polizzotto M, Kilpatrick T, Bartlett PF, Murphy M, Kontgen F, Boyd AW, EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13248-53
3*	J:173636 Dravis C, Henkemeyer M, Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues. Dev Biol. 2011 Jul 1;355(1):138-51
1	J:116671 Dravis C, Wu T, Chumley MJ, Yokoyama N, Wei S, Wu DK, Marcus DC, Henkemeyer M, EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph. Hear Res. 2007 Jan;223(1-2):93-104
1	J:207512 Escalante A, Murillo B, Morenilla-Palao C, Klar A, Herrera E, Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS. Neuron. 2013 Dec 18;80(6):1392-406
2	J:60774 Feng G, Laskowski MB, Feldheim DA, Wang H, Lewis R, Frisen J, Flanagan JG, Sanes JR, Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers. Neuron. 2000 Feb;25(2):295-306
8*	J:35772 Gale NW, Flenniken A, Compton DC, Jenkins N, Copeland NG, Gilbert DJ, Davis S, Wilkinson DG, Yancopoulos GD, Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene. 1996 Sep 19;13(6):1343-52
1	J:106994 Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK, Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 2006 Mar 22;25(6):1242-52
2	J:70266 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR, Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:181586 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Ronne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD, Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
1	J:186283 Hashimoto M, Ito R, Kitamura N, Namba K, Hisano Y, Epha4 controls the midline crossing and contralateral axonal projections of inferior olive neurons. J Comp Neurol. 2012 Jun 1;520(8):1702-20
4	J:60835 Imondi R, Wideman C, Kaprielian Z, Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons. Development. 2000 Apr;127(7):1397-410
3	J:162837 Islam S, Loizides AM, Fialkovich JJ, Grand RJ, Montgomery RK, Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010 Sep;55(9):2478-88
1*	J:119301 Kadison SR, Murakami F, Matise MP, Kaprielian Z, The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord. Dev Biol. 2006 Aug 15;296(2):499-513
3	J:186538 Katayama K, Leslie JR, Lang RA, Zheng Y, Yoshida Y, Left-Right Locomotor Circuitry Depends on RhoA-Driven Organization of the Neuroepithelium in the Developing Spinal Cord. J Neurosci. 2012 Jul 25;32(30):10396-407
6	J:278254 Katori S, Noguchi-Katori Y, Itohara S, Iwasato T, Spinal RacGAP alpha-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance. J Neurosci. 2017 Aug 9;37(32):7682-7699
2	J:68814 Kullander K, Croll SD, Zimmer M, Pan L, McClain J, Hughes V, Zabski S, DeChiara TM, Klein R, Yancopoulos GD, Gale NW, Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev. 2001 Apr 1;15(7):877-88
2	J:67274 Kullander K, Mather NK, Diella F, Dottori M, Boyd AW, Klein R, Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Neuron. 2001 Jan;29(1):73-84
1	J:82686 Liu J, Wilson S, Reh T, BMP receptor 1b is required for axon guidance and cell survival in the developing retina. Dev Biol. 2003 Apr 1;256(1):34-48
1	J:168206 Liu Y, Shi J, Lu CC, Wang ZB, Lyuksyutova AI, Song XJ, Zou Y, Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat Neurosci. 2005 Sep;8(9):1151-9
1	J:214959 Lodato S, Molyneaux BJ, Zuccaro E, Goff LA, Chen HH, Yuan W, Meleski A, Takahashi E, Mahony S, Rinn JL, Gifford DK, Arlotta P, Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
1	J:176643 Luria V, Krawchuk D, Jessell TM, Laufer E, Kania A, Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb. Neuron. 2008 Dec 26;60(6):1039-53
1*	J:203998 Luxey M, Jungas T, Laussu J, Audouard C, Garces A, Davy A, Eph:ephrin-B1 forward signaling controls fasciculation of sensory and motor axons. Dev Biol. 2013 Nov 15;383(2):264-74
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
3	J:104532 Mendes SW, Henkemeyer M, Liebl DJ, Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain. J Neurosci. 2006 Jan 18;26(3):882-92
1	J:226023 Murillo B, Ruiz-Reig N, Herrera M, Fairen A, Herrera E, Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain. J Neurosci. 2015 Aug 12;35(32):11266-80
3	J:241748 Nakamura PA, Hsieh CY, Cramer KS, EphB signaling regulates target innervation in the developing and deafferented auditory brainstem. Dev Neurobiol. 2012 Sep;72(9):1243-55
1	J:240082 Noh H, Lee H, Park E, Park S, Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling. Development. 2016 Feb 01;143(3):461-72
1*	J:156952 North HA, Karim A, Jacquin MF, Donoghue MJ, EphA4 is necessary for spatially selective peripheral somatosensory topography. Dev Dyn. 2010 Feb;239(2):630-8
1	J:150346 North HA, Zhao X, Kolk SM, Clifford MA, Ziskind DM, Donoghue MJ, Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development. 2009 Jul;136(14):2467-76
1	J:308605 Ohayon D, Aguirrebengoa M, Escalas N, Jungas T, Soula C, Transcriptome profiling of the Olig2-expressing astrocyte subtype reveals their unique molecular signature. iScience. 2021 Jul 23;24(7):102806
3	J:207511 Paixao S, Balijepalli A, Serradj N, Niu J, Luo W, Martin JH, Klein R, EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron. 2013 Dec 18;80(6):1407-20
4*	J:83513 Pickles JO, Expression of Ephs and ephrins in developing mouse inner ear. Hear Res. 2003 Apr;178(1-2):44-51
1*	J:145552 Risley M, Garrod D, Henkemeyer M, McLean W, EphB2 and EphB3 forward signalling are required for palate development. Mech Dev. 2009 Mar-Apr;126(3-4):230-9
2*	J:57797 Rogers JH, Ciossek T, Menzel P, Pasquale EB, Eph receptors and ephrins demarcate cerebellar lobules before and during their formation. Mech Dev. 1999 Sep;87(1-2):119-28
1	J:314317 Rudolph J, Gerstmann K, Zimmer G, Steinecke A, Doding A, Bolz J, A dual role of EphB1/ephrin-B3 reverse signaling on migrating striatal and cortical neurons originating in the preoptic area: should I stay or go away?. Front Cell Neurosci. 2014;8:185
1	J:171618 Saeger BM, Suhm M, Neubuser A, Ephrin/ephrin receptor expression during early stages of mouse inner ear development. Dev Dyn. 2011 Jun;240(6):1578-85
2	J:171375 Senturk A, Pfennig S, Weiss A, Burk K, Acker-Palmer A, Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration. Nature. 2011 Apr 21;472(7343):356-60
1	J:325971 Shibata M, Pattabiraman K, Lorente-Galdos B, Andrijevic D, Kim SK, Kaur N, Muchnik SK, Xing X, Santpere G, Sousa AMM, Sestan N, Regulation of prefrontal patterning and connectivity by retinoic acid. Nature. 2021 Oct;598(7881):483-488
1	J:304680 Skarlatou S, Herent C, Toscano E, Mendes CS, Bouvier J, Zampieri N, Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection. Cell Rep. 2020 Jun 9;31(10):107741
1*	J:68841 Stuckmann I, Weigmann A, Shevchenko A, Mann M, Huttner WB, Ephrin B1 is expressed on neuroepithelial cells in correlation with neocortical neurogenesis. J Neurosci. 2001 Apr 15;21(8):2726-37
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:214020 Toyoda Y, Shinohara R, Thumkeo D, Kamijo H, Nishimaru H, Hioki H, Kaneko T, Ishizaki T, Furuyashiki T, Narumiya S, EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination. Genes Cells. 2013 Oct;18(10):873-85
3*	J:105961 van Eyll JM, Passante L, Pierreux CE, Lemaigre FP, Vanderhaeghen P, Rousseau GG, Eph receptors and their ephrin ligands are expressed in developing mouse pancreas. Gene Expr Patterns. 2006 Apr;6(4):353-9
3	J:183871 Villasenor A, Marty-Santos L, Dravis C, Fletcher P, Henkemeyer M, Cleaver O, EphB3 marks delaminating endocrine progenitor cells in the developing pancreas. Dev Dyn. 2012 May;241(5):1008-19
1*	J:127119 Visel A, Carson J, Oldekamp J, Warnecke M, Jakubcakova V, Zhou X, Shaw CA, Alvarez-Bolado G, Eichele G, Regulatory pathway analysis by high-throughput in situ hybridization. PLoS Genet. 2007 Oct 19;3(10):1867-83
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:75288 Wang HU, Chen ZF, Anderson DJ, Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998 May 29;93(5):741-53
1	J:214811 Weiss AC, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe MO, Rudat C, Costantini F, Adams RH, Kispert A, Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. 2014 Sep;141(17):3420-30
1	J:139011 Wilkinson GA, Schittny JC, Reinhardt DP, Klein R, Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn. 2008 Aug;237(8):2220-34
1*	J:85573 Williams SE, Mann F, Erskine L, Sakurai T, Wei S, Rossi DJ, Gale NW, Holt CE, Mason CA, Henkemeyer M, Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron. 2003 Sep 11;39(6):919-35
2	J:297072 Wurmser M, Chaverot N, Madani R, Sakai H, Negroni E, Demignon J, Saint-Pierre B, Mouly V, Amthor H, Tapscott S, Birchmeier C, Tajbakhsh S, Le Grand F, Sotiropoulos A, Maire P, SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis. Development. 2020 Oct 9;147(19):dev185975
1	J:334513 Yan K, Bormuth I, Bormuth O, Tutukova S, Renner A, Bessa P, Schaub T, Rosario M, Tarabykin V, TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6. Cereb Cortex. 2023 Feb 20;33(5):1752-1767
1	J:327333 Yang KY, Zhao S, Feng H, Shen J, Chen Y, Wang ST, Wang SJ, Zhang YX, Wang Y, Guo C, Liu H, Tang TS, Ca(2+) homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling. Cell Death Dis. 2022 Aug 4;13(8):674
4	J:87497 Yokoyama N, Romero MI, Cowan CA, Galvan P, Helmbacher F, Charnay P, Parada LF, Henkemeyer M, Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron. 2001 Jan;29(1):85-97
1	J:178901 Zimmer G, Rudolph J, Landmann J, Gerstmann K, Steinecke A, Gampe C, Bolz J, Bidirectional EphrinB3/EphA4 Signaling Mediates the Segregation of Medial Ganglionic Eminence- and Preoptic Area-Derived Interneurons in the Deep and Superficial Migratory Stream. J Neurosci. 2011 Dec 14;31(50):18364-80
2	J:154920 Zirzow S, Ludtke TH, Brons JF, Petry M, Christoffels VM, Kispert A, Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol. 2009 Dec 15;336(2):145-55