Gene Expression Literature Summary

• Symbol: Lama4
• Name: laminin, alpha 4
• ID: MGI:109321

55 matching records from 55 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E20	E	P
Immunohistochemistry (section)		2	2	1	1		2	1	2		1		3	2	4		6		2		3	1		3	17
In situ RNA (section)			2				1	1		2	1	1	6		3	1	1	1		2	1				7
In situ RNA (whole mount)			1		2				2		2
In situ reporter (knock in)																									1
Northern blot	1					2						1		1			1	1		1				1	4
Western blot																					1
RT-PCR				1			1	1	2	1		2	4	1	1	1	1	2		3	2		1	1	8
cDNA clones													1						1					1	2
RNase protection																			1						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lama4  laminin, alpha 4   (Synonyms: laminin [a]4)
Results	Reference
2	J:176572 Ackroyd MR, Whitmore C, Prior S, Kaluarachchi M, Nikolic M, Mayer U, Muntoni F, Brown SC, Fukutin-related protein alters the deposition of laminin in the eye and brain. J Neurosci. 2011 Sep 7;31(36):12927-35
2	J:208419 Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M, Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:96910 Blaess S, Graus-Porta D, Belvindrah R, Radakovits R, Pons S, Littlewood-Evans A, Senften M, Guo H, Li Y, Miner JH, Reichardt LF, Muller U, Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci. 2004 Mar 31;24(13):3402-12
2*	J:84903 Bolcato-Bellemin AL, Lefebvre O, Arnold C, Sorokin L, Miner JH, Kedinger M, Simon-Assmann P, Laminin alpha5 chain is required for intestinal smooth muscle development. Dev Biol. 2003 Aug 15;260(2):376-90
1	J:194489 Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX, The wilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2. Biol Reprod. 2013;88(3):56
3	J:173927 Copp AJ, Carvalho R, Wallace A, Sorokin L, Sasaki T, Greene ND, Ybot-Gonzalez P, Regional differences in the expression of laminin isoforms during mouse neural tube development. Matrix Biol. 2011 May;30(4):301-9
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:332217 Feng J, Han X, Yuan Y, Cho CK, Janeckova E, Guo T, Pareek S, Rahman MS, Zheng B, Bi J, Jing J, Zhang M, Xu J, Ho TV, Chai Y, TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. Elife. 2022 Dec 21;11
3	J:41572 Frieser M, Nockel H, Pausch F, Roder C, Hahn A, Deutzmann R , Sorokin LM, Cloning of the mouse laminin alpha 4 cDNA. Expression in a subset of endothelium. Eur J Biochem. 1997 Jun 15;246(3):727-35
1	J:244596 Furlan A, Dyachuk V, Kastriti ME, Calvo-Enrique L, Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko PV, Ernfors P, Adameyko I, Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. Science. 2017 Jul 07;357(6346)
4	J:152865 Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH, Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15;332(2):273-86
1	J:243226 Geraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG, Schledzewski K, Goerdt S, GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017 Mar 01;127(3):1099-1114
1*	J:98797 Gersdorff N, Muller M, Otto S, Poschadel R, Hubner S, Miosge N, Basement membrane composition in the early mouse embryo day 7. Dev Dyn. 2005 May 13;233(3):1140-1148
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:282887 Harvey T, Flamenco S, Fan CM, A Tppp3(+)Pdgfra(+) tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis. Nat Cell Biol. 2019 Dec;21(12):1490-1503
1*	J:331476 Hazra R, Brine L, Garcia L, Benz B, Chirathivat N, Shen MM, Wilkinson JE, Lyons SK, Spector DL, Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev Cell. 2022 Nov 7;57(21):2450-2468.e7
2	J:250521 Hecht JH, Siegenthaler JA, Patterson KP, Pleasure SJ, Primary cellular meningeal defects cause neocortical dysplasia and dyslamination. Ann Neurol. 2010 Oct;68(4):454-64
4	J:42319 Hirohata S, Kusachi S, Kondo J, Sano I, Murakami M, Doi M, Ninomiya Y, Tsuji T, Laminin alpha 1, alpha 2, alpha 4 and beta 1 chain mRNA expression in mouse embryonic, neonatal, and adult hearts. Jpn Heart J. 1997 Mar;38(2):281-9
1	J:184432 Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y, Arikawa-Hirasawa E, Laminin alpha1 is essential for mouse cerebellar development. Matrix Biol. 2012 Jan;31(1):17-28
11	J:43712 Iivanainen A, Kortesmaa J, Sahlberg C, Morita T, Bergmann U, Thesleff I, Tryggvason K, Primary structure, developmental expression, and immunolocalization of the murine laminin alpha4 chain. J Biol Chem. 1997 Oct 31;272(44):27862-8
3	J:329963 Janardhan HP, Dresser K, Hutchinson L, Trivedi CM, Pathological MAPK activation-mediated lymphatic basement membrane disruption causes lymphangiectasia that is treatable with ravoxertinib. JCI Insight. 2022 Sep 8;7(17):e153033
2	J:119297 Kikkawa Y, Miner JH, Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function. Dev Biol. 2006 Aug 1;296(1):265-77
3	J:100263 Kim IM, Ramakrishna S, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV, The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 2005 Jun 10;280(23):22278-86
2	J:72381 Klaffky E, Williams R, Yao CC, Ziober B, Kramer R, Sutherland A, Trophoblast-Specific Expression and Function of the Integrin alpha7 Subunit in the Peri-implantation Mouse Embryo. Dev Biol. 2001 Nov 1;239(1):161-75
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:250555 Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH, Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol. 2017 Mar;19(3):189-201
3	J:129899 Lathia JD, Patton B, Eckley DM, Magnus T, Mughal MR, Sasaki T, Caldwell MA, Rao MS, Mattson MP, ffrench-Constant C, Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol. 2007 Dec 20;505(6):630-43
10	J:55579 Lefebvre O, Sorokin L, Kedinger M, Simon-Assmann P, Developmental expression and cellular origin of the laminin alpha2, alpha4, and alpha5 chains in the intestine. Dev Biol. 1999 Jun 1;210(1):135-50
5	J:38223 Lentz SI, Miner JH, Sanes JR, Snider WD, Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons. J Comp Neurol. 1997 Feb 24;378(4):547-61
2	J:187983 Lopez-Escobar B, De Felipe B, Sanchez-Alcazar JA, Sasaki T, Copp AJ, Ybot-Gonzalez P, Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: Implications for regulation of BMP signalling. Dev Dyn. 2012 Nov;241(11):1808-15
1*	J:139122 Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K, Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12849-54
2	J:199683 McKee KK, Yang DH, Patel R, Chen ZL, Strickland S, Takagi J, Sekiguchi K, Yurchenco PD, Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012 Oct 1;125(Pt 19):4609-19
2	J:51557 Miner JH, Cunningham J, Sanes JR, Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain. J Cell Biol. 1998 Dec 14;143(6):1713-23
2*	J:59925 Miner JH, Li C, Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane. Dev Biol. 2000 Jan 15;217(2):278-89
8	J:40187 Miner JH, Patton BL, Lentz SI, Gilbert DJ, Snider WD, Jenkins NA, Copeland NG, Sanes JR, The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol. 1997 May 5;137(3):685-701
3	J:141609 Mokkapati S, Baranowsky A, Mirancea N, Smyth N, Breitkreutz D, Nischt R, Basement membranes in skin are differently affected by lack of nidogen 1 and 2. J Invest Dermatol. 2008 Sep;128(9):2259-67
1	J:77264 Nguyen NM, Miner JH, Pierce RA, Senior RM, Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung. Dev Biol. 2002 Jun 15;246(2):231-44
4	J:242767 Nunes AM, Wuebbles RD, Sarathy A, Fontelonga TM, Deries M, Burkin DJ, Thorsteinsdottir S, Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy. Hum Mol Genet. 2017 Jun 01;26(11):2018-2033
1*	J:198109 Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones ML, Rakic S, Molnar Z, Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59
3	J:44761 Patton BL, Miner JH, Chiu AY, Sanes JR, Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice. J Cell Biol. 1997 Dec 15;139(6):1507-21
1*	J:84372 Previtali SC, Nodari A, Taveggia C, Pardini C, Dina G, Villa A, Wrabetz L, Quattrini A, Feltri ML, Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles. J Neurosci. 2003 Jul 2;23(13):5520-30
5*	J:203643 Radmanesh F, Caglayan AO, Silhavy JL, Yilmaz C, Cantagrel V, Omar T, Rosti B, Kaymakcalan H, Gabriel S, Li M, Sestan N, Bilguvar K, Dobyns WB, Zaki MS, Gunel M, Gleeson JG, Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities. Am J Hum Genet. 2013 Mar 7;92(3):468-74
2	J:331686 Ramadan R, Wouters VM, van Neerven SM, de Groot NE, Garcia TM, Muncan V, Franklin OD, Battle M, Carlson KS, Leach J, Sansom OJ, Boulard O, Chamaillard M, Vermeulen L, Medema JP, Huels DJ, The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut. Biol Open. 2022 Dec 15;11(12)
2	J:119481 Ramakrishna S, Kim IM, Petrovic V, Malin D, Wang IC, Kalin TV, Meliton L, Zhao YY, Ackerson T, Qin Y, Malik AB, Costa RH, Kalinichenko VV, Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box m1 transcription factor. Dev Dyn. 2007 Mar 15;236(4):1000-1013
6*	J:124120 Rebustini IT, Patel VN, Stewart JS, Layvey A, Georges-Labouesse E, Miner JH, Hoffman MP, Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling. Dev Biol. 2007 Aug 1;308(1):15-29
1	J:156199 Robel S, Mori T, Zoubaa S, Schlegel J, Sirko S, Faissner A, Goebbels S, Dimou L, Gotz M, Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia. 2009 Nov 15;57(15):1630-47
2	J:202984 Rockich BE, Hrycaj SM, Shih HP, Nagy MS, Ferguson MA, Kopp JL, Sander M, Wellik DM, Spence JR, Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4456-64
2	J:44059 Salmivirta K, Sorokin LM, Ekblom P, Differential expression of laminin alpha chains during murine tooth development. Dev Dyn. 1997 Nov;210(3):206-15
5	J:69804 Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM, Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol. 2001 May 28;153(5):933-46
1	J:322323 Song W, Li Q, Wang T, Li Y, Fan T, Zhang J, Wang Q, Pan J, Dong Q, Sun ZS, Wang Y, Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders. Brain Behav Immun. 2022 Mar 1;102:237-250
6	J:44408 Sorokin LM, Pausch F, Durbeej M, Ekblom P, Differential expression of five laminin alpha (1-5) chains in developing and adult mouse kidney. Dev Dyn. 1997 Dec;210(4):446-62
1	J:334330 Thomson E, Tran M, Robevska G, Ayers K, van der Bergen J, Gopalakrishnan Bhaskaran P, Haan E, Cereghini S, Vash-Margita A, Margetts M, Hensley A, Nguyen Q, Sinclair A, Koopman P, Pelosi E, Functional genomics analysis identifies loss of HNF1B function as a cause of Mayer-Rokitansky-Kuster-Hauser syndrome. Hum Mol Genet. 2023 Mar 6;32(6):1032-1047
1	J:47703 van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T, Wientjens E, Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol. 1998 Jun;18(6):3572-9
4	J:235682 Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsee J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE, Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016 Jun 1;143(11):1958-70