Gene Expression Literature Summary

• Symbol: Brca2
• Name: breast cancer 2, early onset
• ID: MGI:109337

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E1.5	E2	E6.5	E7.5	E8.5	E9.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)												1	1	1					1				2
In situ RNA (section)				2	2	1	1		2	2			2	1	3	1	1	1			1		3
Immunohistochemistry (whole mount)																							1
In situ RNA (whole mount)									1
Northern blot					1		1		1	2	1		1		1		1		1				3
Western blot	1														1								1
RT-PCR		1	1		1	2	1	1					1			1	1	1	1	1		3	6
cDNA clones						1			1		1				1								2
RNase protection				1									1								1		2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Brca2  breast cancer 2, early onset   (Synonyms: Fancd1, RAB163)
Results	Reference
3*	J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3*	J:74077 Bennett LM, McAllister KA, Blackshear PE, Malphurs J, Goulding G, Collins NK, Ward T, Bunch DO, Eddy EM, Davis BJ, Wiseman RW, BRCA2-null embryonic survival is prolonged on the BALB/c genetic background. Mol Carcinog. 2000 Jul;28(3):174-83
4	J:74101 Bernard-Gallon DJ, De Latour MP, Sylvain V, Vissac C, Aunoble B, Chassagne J, Bignon YJ, Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Int J Oncol. 2001 Feb;18(2):271-80
5	J:45456 Blackshear PE, Goldsworthy SM, Foley JF, McAllister KA, Bennett LM, Collins NK, Bunch DO, Brown P, Wiseman RW, Davis BJ, Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene. 1998 Jan 8;16(1):61-8
1	J:316183 Cai Y, Yoneda M, Tomita T, Kurotani R, Okamoto M, Kido T, Abe H, Mitzner W, Guha A, Kimura S, Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. BMC Pulm Med. 2015 Jul 16;15:72
6	J:38616 Connor F, Smith A, Wooster R, Stratton M, Dixon A, Campbell E , Tait TM , Freeman T , Ashworth A, Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene. Hum Mol Genet. 1997 Feb;6(2):291-300
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:325537 Dong MZ, Ouyang YC, Gao SC, Ma XS, Hou Y, Schatten H, Wang ZB, Sun QY, PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development. Development. 2022 May 15;149(10):dev200351
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
3	J:46812 Friedman LS, Thistlethwaite FC, Patel KJ, Yu VP, Lee H, Venkitaraman AR , Abel KJ , Carlton MB , Hunter SM , Colledge WH , Evans MJ , Ponder BA, Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res. 1998 Apr 1;58(7):1338-43
2*	J:265719 Goffena J, Lefcort F, Zhang Y, Lehrmann E, Chaverra M, Felig J, Walters J, Buksch R, Becker KG, George L, Elongator and codon bias regulate protein levels in mammalian peripheral neurons. Nat Commun. 2018 Mar 1;9(1):889
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
2*	J:215685 Lamparter C, Winn LM, Tissue-specific effects of valproic acid on DNA repair genes and apoptosis in postimplantation mouse embryos. Toxicol Sci. 2014 Sep;141(1):59-67
2	J:337931 Li L, Sun Y, Davis AE, Shah SH, Hamed LK, Wu MR, Lin CH, Ding JB, Wang S, Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells. Cell Rep. 2023 Jun 1;42(6):112596
1*	J:67272 Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R, A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. Cell. 2001 Jan 26;104(2):247-57
1	J:309380 Mei L, Qv M, Bao H, He Q, Xu Y, Zhang Q, Shi W, Ren Q, Yan Z, Xu C, Tang C, Hussain M, Zeng LH, Wu X, SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling. Oncogene. 2021 Sep;40(35):5357-5366
1	J:301847 Ni L, Xie H, Tan L, Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models. Mol Reprod Dev. 2016 Dec;83(12):1060-1069
9	J:40064 Rajan JV, Marquis ST, Gardner HP, Chodosh LA, Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol. 1997 Apr 15;184(2):385-401
1*	J:161528 Rantakari P, Nikkila J, Jokela H, Ola R, Pylkas K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R, Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet. 2010 Aug 1;19(15):3021-9
10*	J:39116 Sharan SK, Bradley A, Murine Brca2: sequence, map position, and expression pattern. Genomics. 1997 Mar 1;40(2):234-41
7	J:39764 Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C , Sands A , Eichele G , Hasty P , Bradley A, Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments]. Nature. 1997 Apr 24;386(6627):804-10
6	J:40595 Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW, Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 1997 May 15;11(10):1242-52
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:306240 Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y, Alteration of DNA Damage Response Causes Cleft Palate. Front Physiol. 2021;12:649492
2	J:273173 Zhang J, Fujiwara Y, Yamamoto S, Shibuya H, A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. Nat Commun. 2019 Feb 13;10(1):722