Gene Expression Literature Summary

• Symbol: Eya1
• Name: EYA transcriptional coactivator and phosphatase 1
• ID: MGI:109344

129 matching records from 129 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)		1	1	1	2		1		2		2		1		2			1			1			2
In situ RNA (section)		1	5	3	8	3	29	3	17	3	16	1	13	1	12		8	2		4	4	2	3	3
In situ RNA (whole mount)		1	7	3	11	3	18	2	10	1	5		5	1			1				1
In situ reporter (knock in)			3	3	3		3		1		1		3	1	5		3	3			2			5
Northern blot	1							1	1							1			1					1
Western blot					1					1		1	2		2
RT-PCR			1	1	3	1	1		8		8		6		9		2	1		4	7			8
cDNA clones									1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Eya1  EYA transcriptional coactivator and phosphatase 1   (Synonyms: bor)
Results	Reference
12*	J:38771 Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, Weil D, Cruaud C, Sahly I, Leibovici M, Bitner-Glindzicz M, Francis M, Lacombe D, Vigneron J, Charachon R, Boven K, Bedbeder P, Van Regemorter N, Weissenbach J, Petit C, A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat Genet. 1997 Feb;15(2):157-64
7*	J:181471 Ahmed M, Wong EY, Sun J, Xu J, Wang F, Xu PX, Eya1-six1 interaction is sufficient to induce hair cell fate in the cochlea by activating atoh1 expression in cooperation with sox2. Dev Cell. 2012 Feb 14;22(2):377-90
3*	J:184001 Ahmed M, Xu J, Xu PX, EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development. 2012 Jun;139(11):1965-77
2*	J:112841 Alkuraya FS, Saadi I, Lund JJ, Turbe-Doan A, Morton CC, Maas RL, SUMO1 haploinsufficiency leads to cleft lip and palate. Science. 2006 Sep 22;313(5794):1751
1	J:274580 Bademci G, Abad C, Incesulu A, Elian F, Reyahi A, Diaz-Horta O, Cengiz FB, Sineni CJ, Seyhan S, Atli EI, Basmak H, Demir S, Nik AM, Footz T, Guo S, Duman D, Fitoz S, Gurkan H, Blanton SH, Walter MA, Carlsson P, Walz K, Tekin M, FOXF2 is required for cochlear development in humans and mice. Hum Mol Genet. 2019 Apr 15;28(8):1286-1297
4	J:208419 Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M, Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4	J:228880 Birol O, Ohyama T, Edlund RK, Drakou K, Georgiades P, Groves AK, The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Dev Biol. 2016 Jan 1;409(1):139-51
1	J:232968 Boivin FJ, Sarin S, Lim J, Javidan A, Svajger B, Khalili H, Bridgewater D, Stromally expressed beta-catenin modulates Wnt9b signaling in the ureteric epithelium. PLoS One. 2015;10(3):e0120347
1	J:163537 Bouchard M, de Caprona D, Busslinger M, Xu P, Fritzsch B, Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol. 2010 Aug 20;10(1):89
3*	J:51411 Bulfone A, Gattuso C, Marchitiello A, Pardini C, Boncinelli E, Borsani G, Banfi S, Ballabio A, The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function. Hum Mol Genet. 1998 Dec;7(13):1997-2006
2	J:92326 Burton Q, Cole LK, Mulheisen M, Chang W, Wu DK, The role of Pax2 in mouse inner ear development. Dev Biol. 2004 Aug 1;272(1):161-75
1	J:276713 Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, Goetzman ES, Sims-Lucas S, Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation. J Am Soc Nephrol. 2019 Jul;30(7):1192-1205
2	J:100575 Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP, Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug;9(2):283-92
1*	J:51920 Caubit X, Thangarajah R, Theil T, Wirth J, Nothwang HG, Ruther U , Krauss S, Mouse Dac, a novel nuclear factor with homology to Drosophila dachshund shows a dynamic expression in the neural crest, the eye, the neocortex, and the limb bud. Dev Dyn. 1999 Jan;214(1):66-80
1*	J:316185 Cesario J, Ha S, Kim J, Kataria N, Jeong J, Candidate positive targets of LHX6 and LHX8 transcription factors in the developing upper jaw. Gene Expr Patterns. 2021 Nov 30;43:119227
4	J:145187 Chen B, Kim EH, Xu PX, Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4. Dev Biol. 2009 Feb 1;326(1):75-85
1*	J:74329 Clark SW, Fee BE, Cleveland JL, Misexpression of the eyes absent family triggers the apoptotic program. J Biol Chem. 2002 Feb 1;277(5):3560-7
1	J:206594 Daou N, Lecolle S, Lefebvre S, della Gaspera B, Charbonnier F, Chanoine C, Armand AS, A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
1	J:201586 Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ, Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol. 2013 Sep;15(9):1035-44
3	J:282348 Dasgupta K, Chung JU, Asam K, Jeong J, Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dev Biol. 2019 Nov 15;455(2):434-448
3	J:181488 Delgado-Olguin P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG, Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012;44(3):343-7
1	J:131873 Depreux FF, Darrow K, Conner DA, Eavey RD, Liberman MC, Seidman CE, Seidman JG, Eya4-deficient mice are a model for heritable otitis media. J Clin Invest. 2008 Feb;118(2):651-8
2	J:221164 Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM, Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
1	J:200106 Duncan JS, Fritzsch B, Continued expression of GATA3 is necessary for cochlear neurosensory development. PLoS One. 2013;8(4):e62046
13	J:170236 El-Hashash AH, Al Alam D, Turcatel G, Bellusci S, Warburton D, Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 1;350(1):112-26
2	J:198889 El-Hashash AH, Turcatel G, Varma S, Berika M, Al Alam D, Warburton D, Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012 Sep 1;125(Pt 17):4036-48
2*	J:83365 Esquela AF, Lee SJ, Regulation of metanephric kidney development by growth/differentiation factor 11. Dev Biol. 2003 May 15;257(2):356-70
2*	J:163648 Fairbridge NA, Dawe CE, Niri FH, Kooistra MK, King-Jones K, McDermid HE, Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors. Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):619-25
4*	J:304751 Fedou C, Lescat O, Feuillet G, Buleon M, Neau E, Breuil B, Alves M, Batut J, Blader P, Decramer S, Saulnier-Blache JS, Klein J, Buffin-Meyer B, Schanstra JP, The low affinity p75 neurotrophin receptor is down-regulated in congenital anomalies of the kidney and the urinary tract: Possible involvement in early nephrogenesis. Biochem Biophys Res Commun. 2020 Dec 17;533(4):786-791
3	J:160589 Freyer L, Morrow BE, Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle. Dev Dyn. 2010 Jun;239(6):1708-22
2	J:153202 Gerber SD, Steinberg F, Beyeler M, Villiger PM, Trueb B, The murine Fgfrl1 receptor is essential for the development of the metanephric kidney. Dev Biol. 2009 Nov 1;335(1):106-19
1	J:77351 Goudreau G, Petrou P, Reneker LW, Graw J, Loster J, Gruss P, Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8719-24
1	J:90324 Grieshammer U, Le Ma, Plump AS, Wang F, Tessier-Lavigne M, Martin GR, SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004 May;6(5):709-17
2	J:119948 Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, Laclef C, Xu PX, Maire P, Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 2007 Feb 15;302(2):602-16
1	J:180774 Grimsley-Myers CM, Sipe CW, Wu DK, Lu X, Redundant functions of Rac GTPases in inner ear morphogenesis. Dev Biol. 2012 Feb 15;362(2):172-86
1	J:104408 Grote D, Souabni A, Busslinger M, Bouchard M, Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development. 2006 Jan;133(1):53-61
1*	J:161785 Gu WX, Kania A, Identification of genes controlled by LMX1B in E13.5 mouse limbs. Dev Dyn. 2010 Aug;239(8):2246-55
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3	J:172023 Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X, A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr 1;121(4):1585-95
1	J:261899 Hasten E, McDonald-McGinn DM, Crowley TB, Zackai E, Emanuel BS, Morrow BE, Racedo SE, Dysregulation of TBX1 dosage in the anterior heart field results in congenital heart disease resembling the 22q11.2 duplication syndrome. Hum Mol Genet. 2018 Jun 1;27(11):1847-1857
2*	J:74492 Heanue TA, Davis RJ, Rowitch DH, Kispert A, McMahon AP, Mardon G, Tabin CJ, Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev. 2002 Feb;111(1-2):75-87
2*	J:207609 Hilliard SA, Yao X, El-Dahr SS, Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014 Mar 1;387(1):1-14
2*	J:348632 Huang B, Zeng Z, Kim S, Fausto CC, Koppitch K, Li H, Li Z, Chen X, Guo J, Zhang CC, Ma T, Medina P, Schreiber ME, Xia MW, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, Lindstrom NO, McMahon AP, Li Z, Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease. Cell Stem Cell. 2024 Apr 22;
1*	J:206879 Huang T, Krimm RF, BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014 Feb 15;386(2):308-20
1	J:82307 Hulander M, Kiernan AE, Blomqvist SR, Carlsson P, Samuelsson EJ, Johansson BR, Steel KP, Enerback S, Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development. 2003 May;130(9):2013-25
1	J:164582 Hurd EA, Poucher HK, Cheng K, Raphael Y, Martin DM, The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development. 2010 Sep;137(18):3139-50
2	J:315409 Huyghe A, Van den Ackerveken P, Sacheli R, Prevot PP, Thelen N, Renauld J, Thiry M, Delacroix L, Nguyen L, Malgrange B, MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5. Cell Rep. 2015 Oct 6;13(1):31-42
1	J:291050 Ide S, Finer G, Maezawa Y, Onay T, Souma T, Scott R, Ide K, Akimoto Y, Li C, Ye M, Zhao X, Baba Y, Minamizuka T, Jin J, Takemoto M, Yokote K, Quaggin SE, Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development. J Am Soc Nephrol. 2018 Dec;29(12):2795-2808
1	J:101263 Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ, Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol. 2005 Sep 15;285(2):554-69
2	J:117734 James RG, Kamei CN, Wang Q, Jiang R, Schultheiss TM, Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development. 2006 Aug;133(15):2995-3004
1	J:305429 Kaiser M, Wojahn I, Rudat C, Ludtke TH, Christoffels VM, Moon A, Kispert A, Trowe MO, Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
13	J:51285 Kalatzis V, Sahly I, El-Amraoui A, Petit C, Eya1 expression in the developing ear and kidney: towards the understanding of the pathogenesis of Branchio-Oto-Renal (BOR) syndrome. Dev Dyn. 1998 Dec;213(4):486-99
4	J:166952 Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS, Dachshund homologues play a conserved role in islet cell development. Dev Biol. 2010 Dec 15;348(2):143-52
2	J:238554 Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Muller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS, Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Nat Cell Biol. 2016 Dec;18(12):1269-1280
1	J:171512 Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ, Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development. 2011 Apr;138(7):1247-57
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:99437 Kuure S, Sainio K, Vuolteenaho R, Ilves M, Wartiovaara K, Immonen T, Kvist J, Vainio S, Sariola H, Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching. Mech Dev. 2005 Jun;122(6):765-80
3*	J:187563 Landgraf K, Bollig F, Trowe MO, Besenbeck B, Ebert C, Kruspe D, Kispert A, Hanel F, Englert C, Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development. Mol Cell Biol. 2010 Dec;30(24):5764-75
2*	J:154369 Lanier J, Dykes IM, Nissen S, Eng SR, Turner EE, Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. Dev Dyn. 2009 Oct 29;238(12):3065-3079
1	J:86619 Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG, Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54
1*	J:93820 Lillevali K, Matilainen T, Karis A, Salminen M, Partially overlapping expression of Gata2 and Gata3 during inner ear development. Dev Dyn. 2004 Dec;231(4):775-81
3	J:122519 Linton JM, Martin GR, Reichardt LF, The ECM protein nephronectin promotes kidney development via integrin {alpha}8{beta}1-mediated stimulation of Gdnf expression. Development. 2007 Jul;134(13):2501-9
1*	J:121311 Liu Z, Yu S, Manley NR, Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol. 2007 May 1;305(1):333-46
1	J:157251 Lokmane L, Heliot C, Garcia-Villalba P, Fabre M, Cereghini S, vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. Development. 2010 Jan;137(2):347-57
1	J:301249 Lopez-Delgado AC, Delgado I, Cadenas V, Sanchez-Cabo F, Torres M, Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid. Development. 2021 Jan 4;148(1):dev193813
1	J:202226 Lu K, Reddy R, Berika M, Warburton D, El-Hashash AH, Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol. 2013 Oct 1;382(1):110-23
1*	J:146220 Maclean G, Dolle P, Petkovich M, Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning. Dev Dyn. 2009 Mar;238(3):732-45
3	J:204605 Minoux M, Kratochwil CF, Ducret S, Amin S, Kitazawa T, Kurihara H, Bobola N, Vilain N, Rijli FM, Mouse Hoxa2 mutations provide a model for microtia and auricle duplication. Development. 2013 Nov;140(21):4386-97
2*	J:112887 Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG, Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol. 2006 Sep 15;297(2):566-86
3	J:137524 Mugford JW, Sipila P, Kobayashi A, Behringer RR, McMahon AP, Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol. 2008 Jul 15;319(2):396-405
4	J:152419 Mugford JW, Yu J, Kobayashi A, McMahon AP, High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol. 2009 Sep 15;333(2):312-23
2	J:331901 Muthu V, Rohacek AM, Yao Y, Rakowiecki SM, Brown AS, Zhao YT, Meyers J, Won KJ, Ramdas S, Brown CD, Peterson KA, Epstein DJ, Genomic architecture of Shh-dependent cochlear morphogenesis. Development. 2019 Sep 19;146(18)
2	J:157941 Nie X, Sun J, Gordon RE, Cai CL, Xu PX, SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. Development. 2010 Mar;137(5):755-65
1*	J:171473 Nie X, Xu J, El-Hashash A, Xu PX, Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol. 2011 Apr 1;352(1):141-51
2	J:71242 Nishinakamura R, Matsumoto Y, Nakao K, Nakamura K, Sato A, Copeland NG, Gilbert DJ, Jenkins NA, Scully S, Lacey DL, Katsuki M, Asashima M, Yokota T, Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development. 2001 Aug;128(16):3105-15
2	J:104891 Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R, Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development. 2006 Jan;133(1):151-61
1*	J:104488 Ozaki H, Nakamura K, Funahashi J, Ikeda K, Yamada G, Tokano H, Okamura HO, Kitamura K, Muto S, Kotaki H, Sudo K, Horai R, Iwakura Y, Kawakami K, Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
1	J:185279 Paces-Fessy M, Fabre M, Lesaulnier C, Cereghini S, Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis. Hum Mol Genet. 2012 Jul 15;21(14):3143-55
1	J:142530 Pitera JE, Scambler PJ, Woolf AS, Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Hum Mol Genet. 2008 Dec 15;17(24):3953-64
3	J:107078 Poladia DP, Kish K, Kutay B, Hains D, Kegg H, Zhao H, Bates CM, Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev Biol. 2006 Mar 15;291(2):325-39
2*	J:103131 Purcell P, Oliver G, Mardon G, Donner AL, Maas RL, Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns. 2005 Dec;6(1):110-8
1	J:242314 Racedo SE, Hasten E, Lin M, Devakanmalai GS, Guo T, Ozbudak EM, Cai CL, Zheng D, Morrow BE, Reduced dosage of beta-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome. PLoS Genet. 2017 Mar;13(3):e1006687
1	J:219797 Ranghini EJ, Dressler GR, Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol. 2015 Mar 15;399(2):296-305
1*	J:56583 Ring BZ, Cordes SP, Overbeek PA, Barsh GS, Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development. 2000 Jan;127(2):307-17
2*	J:178471 Rumballe BA, Georgas KM, Combes AN, Ju AL, Gilbert T, Little MH, Nephron formation adopts a novel spatial topology at cessation of nephrogenesis. Dev Biol. 2011 Dec 1;360(1):110-22
6*	J:100569 Sajithlal G, Zou D, Silvius D, Xu PX, Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol. 2005 Aug 15;284(2):323-36
4	J:115344 Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G, Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28
1	J:331052 Sharma A, Meer M, Dapkunas A, Ihermann-Hella A, Kuure S, Vainio SJ, Iber D, Naillat F, FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells. Development. 2022 Nov 1;149(21):dev201012
3*	J:167305 Sims-Lucas S, Cusack B, Baust J, Eswarakumar VP, Masatoshi H, Takeuchi A, Bates CM, Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Dev Dyn. 2011 Jan;240(1):240-9
1	J:332291 Song H, Morrow BE, Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development. Dev Biol. 2022 Dec 12;494:71-84
1	J:241567 Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE, Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 Jun 01;144(11):2021-2031
1	J:171050 Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH, Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
1	J:88584 Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE, Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution. Development. 2004 Mar;131(6):1235-45
1	J:160285 Uchiyama Y, Sakaguchi M, Terabayashi T, Inenaga T, Inoue S, Kobayashi C, Oshima N, Kiyonari H, Nakagata N, Sato Y, Sekiguchi K, Miki H, Araki E, Fujimura S, Tanaka SS, Nishinakamura R, Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9240-5
1*	J:85072 Vitelli F, Viola A, Morishima M, Pramparo T, Baldini A, Lindsay E, TBX1 is required for inner ear morphogenesis. Hum Mol Genet. 2003 Aug 15;12(16):2041-8
1	J:224386 Wainwright EN, Wilhelm D, Combes AN, Little MH, Koopman P, ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015 Aug 15;404(2):88-102
5	J:172391 Walker KA, Sims-Lucas S, Caruana G, Cullen-McEwen L, Li J, Sarraj MA, Bertram JF, Stenvers KL, Betaglycan is required for the establishment of nephron endowment in the mouse. PLoS One. 2011;6(4):e18723
3*	J:178455 Wang C, Gargollo P, Guo C, Tang T, Mingin G, Sun Y, Li X, Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development. Dev Biol. 2011 Dec 1;360(1):186-94
3	J:291481 Wang L, Xie J, Zhang H, Tsang LH, Tsang SL, Braune EB, Lendahl U, Sham MH, Notch signalling regulates epibranchial placode patterning and segregation. Development. 2020 Feb 17;147(4):dev183665
3	J:334527 Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo MM, Trowe MO, Kispert A, Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. Development. 2023 Mar 15;150(6):dev201048
3	J:300975 Weiss AC, Rivera-Reyes R, Englert C, Kispert A, Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney. J Pathol. 2020 Nov;252(3):290-303
2*	J:88686 Wellik DM, Hawkes PJ, Capecchi MR, Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev. 2002 Jun 1;16(11):1423-32
1	J:134299 Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M, Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6
1	J:317791 Wilkinson LJ, Neal CS, Singh RR, Sparrow DB, Kurniawan ND, Ju A, Grieve SM, Dunwoodie SL, Moritz KM, Little MH, Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric beta-catenin signaling. Kidney Int. 2015 May;87(5):975-83
4*	J:320689 Xu J, Li J, Ramakrishnan A, Yan H, Shen L, Xu PX, Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation. Front Cell Dev Biol. 2022;10:815249
1	J:208647 Xu J, Liu H, Park JS, Lan Y, Jiang R, Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014 Apr;141(7):1442-52
4	J:249581 Xu J, Ueno H, Xu CY, Chen B, Weissman IL, Xu PX, Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti. Nat Commun. 2017 May 11;8:15046
12	J:250210 Xu J, Wong EY, Cheng C, Li J, Sharkar MT, Xu CY, Chen B, Sun J, Jing D, Xu PX, Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis. Dev Cell. 2014 Nov 24;31(4):434-47
3*	J:223331 Xu J, Xu PX, Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation. Dev Dyn. 2015 Jul;244(7):866-73
2	J:354180 Xu M, Li S, Xie X, Guo L, Yu D, Zhuo J, Lin J, Kol L, Gan L, ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons. J Neurosci. 2024 Feb 21;44(8)
3*	J:57313 Xu PX, Adams J, Peters H, Brown MC, Heaney S, Maas R, Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
12	J:43703 Xu PX, Cheng J, Epstein JA, Maas RL, Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11974-9
11*	J:38379 Xu PX, Woo I, Her H, Beier DR, Maas RL, Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997 Jan;124(1):219-31
1*	J:83432 Xu PX, Zheng W, Huang L, Maire P, Laclef C, Silvius D, Six1 is required for the early organogenesis of mammalian kidney. Development. 2003 Jul;130(14):3085-94
5	J:79848 Xu PX, Zheng W, Laclef C, Maire P, Maas RL, Peters H, Xu X, Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development. 2002 Jul;129(13):3033-44
1	J:154470 Yallowitz AR, Gong KQ, Swinehart IT, Nelson LT, Wellik DM, Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo. Dev Biol. 2009 Nov 1;335(1):156-65
2	J:176365 Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM, Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. PLoS One. 2011;6(8):e23410
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1	J:270550 Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, Combes AN, Little MH, Daley GQ, Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis. Nat Commun. 2019 Jan 11;10(1):168
1	J:330827 Yoo D, Park J, Lee C, Song I, Lee YH, Yun T, Lee H, Heguy A, Han JY, Dasen JS, Kim H, Baek M, Little skate genome provides insights into genetic programs essential for limb-based locomotion. Elife. 2022 Oct 26;11:e78345
2	J:184004 Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden A, Rowitch DH, Stiles CD, Ma Q, Grimmond SM, Bailey TL, Little MH, McMahon AP, Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May;139(10):1863-73
9	J:254919 Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH, An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. Elife. 2017 Nov 15;6:e30126
3*	J:335760 Zhang T, Xu PX, The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood. Front Cell Dev Biol. 2023;11:1126968
2	J:84974 Zheng W, Huang L, Wei ZB, Silvius D, Tang B, Xu PX, The role of Six1 in mammalian auditory system development. Development. 2003 Sep;130(17):3989-4000
13*	J:140027 Zou D, Erickson C, Kim EH, Jin D, Fritzsch B, Xu PX, Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet. 2008 Nov 1;17(21):3340-56
3	J:108725 Zou D, Silvius D, Davenport J, Grifone R, Maire P, Xu PX, Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol. 2006 May 15;293(2):499-512
4	J:94396 Zou D, Silvius D, Fritzsch B, Xu PX, Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development. 2004 Nov;131(22):5561-72
5*	J:119574 Zou D, Silvius D, Rodrigo-Blomqvist S, Enerback S, Xu PX, Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev Biol. 2006 Oct 15;298(2):430-41