Gene Expression Literature Summary

• Symbol: Nek2
• Name: NIMA (never in mitosis gene a)-related expressed kinase 2
• ID: MGI:109359

13 matching records from 13 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E7.5	E8.5	E9.5	E10.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)												1		1		1
In situ RNA (section)		1		1					1							3
In situ RNA (whole mount)					1
In situ reporter (knock in)							1									1
Northern blot			1					1								3
Western blot	1				1											2
RT-PCR	1				1	1		2		1	1		1		1	5
cDNA clones																3
RNase protection																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nek2  NIMA (never in mitosis gene a)-related expressed kinase 2
Results	Reference
8	J:47160 Arama E, Yanai A, Kilfin G, Bernstein A, Motro B, Murine NIMA-related kinases are expressed in patterns suggesting distinct functions in gametogenesis and a role in the nervous system. Oncogene. 1998 Apr 9;16(14):1813-23
1*	J:273130 Ding W, Wu Q, Sun L, Pan NC, Wang X, Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex. J Neurosci. 2019 Mar 13;39(11):1994-2010
1	J:332091 Ding W, Zhang C, Wang B, Zhou X, Sun L, Zhong S, Liu J, Zhang J, Wang X, Wu Q, Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice. Sci China Life Sci. 2021 Mar;64(3):419-433
1	J:106827 Duvillie B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ, Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin. Endocrinology. 2002 Apr;143(4):1530-7
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
4*	J:99333 Matsuki T, Hori G, Furuichi T, Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system. Brain Res Mol Brain Res. 2005 May 20;136(1-2):231-54
4	J:41081 Rhee K, Wolgemuth DJ, The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes. Development. 1997 Jun;124(11):2167-77
1*	J:208452 Sasaki Y, Taya Y, Saito K, Fujita K, Aoba T, Fujiwara T, Molecular contribution to cleft palate production in cleft lip mice. Congenit Anom (Kyoto). 2014 May;54(2):94-9
4*	J:93521 Sonn S, Khang I, Kim K, Rhee K, Suppression of Nek2A in mouse early embryos confirms its requirement for chromosome segregation. J Cell Sci. 2004 Nov 1;117(Pt 23):5557-66
8	J:45011 Tanaka K, Parvinen M, Nigg EA, The in vivo expression pattern of mouse Nek2, a NIMA-related kinase, indicates a role in both mitosis and meiosis. Exp Cell Res. 1997 Dec 15;237(2):264-74
2	J:91673 Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX, Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem. 2004 Jul 9;279(28):29606-14
2*	J:268403 Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B, Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147