Gene Expression Literature Summary
|
Symbol Name ID |
Sftpc
surfactant associated protein C MGI:109517 |
| Age | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E20 | E | P |
| Immunohistochemistry (section) | 1 | 1 | 1 | 4 | 1 | 1 | 15 | 1 | 16 | 1 | 20 | 3 | 34 | 7 | 159 | 2 | 3 | 4 | 6 | 112 | |||
| In situ RNA (section) | 1 | 1 | 2 | 3 | 1 | 3 | 1 | 5 | 5 | 4 | 4 | 13 | 1 | 2 | 10 | ||||||||
| Immunohistochemistry (whole mount) | 1 | 1 | 2 | ||||||||||||||||||||
| In situ RNA (whole mount) | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | ||||||||||||||
| In situ reporter (knock in) | 1 | ||||||||||||||||||||||
| Northern blot | 1 | 1 | 3 | 4 | 7 | 1 | 1 | 6 | |||||||||||||||
| Western blot | 1 | 2 | 3 | 3 | 6 | 25 | 2 | 1 | 1 | 1 | 20 | ||||||||||||
| RT-PCR | 1 | 1 | 1 | 2 | 9 | 1 | 7 | 4 | 12 | 2 | 9 | 1 | 13 | 2 | 21 | 6 | 74 | 2 | 3 | 2 | 2 | 43 | |
| cDNA clones | 1 | ||||||||||||||||||||||
| RNase protection | 1 | 2 | |||||||||||||||||||||
| Nuclease S1 | 1 | 1 | 1 | 2 | 1 |
| Sftpc surfactant associated protein C (Synonyms: Bricd6, pro-SpC, Sftp-2, Sftp2, SP-C, SPC) | |
| Results | Reference |
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| 2* | J:28289 Clark JC, Wert SE, Bachurski CJ, Stahlman MT, Stripp BR, Weaver TE, Whitsett JA, Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7794-8 |
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| 1 | J:172214 Davis H, Lewis A, Spencer-Dene B, Tateossian H, Stamp G, Behrens A, Tomlinson I, FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol. 2011 Jun;224(2):180-9 |
| 3* | J:85424 DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert SE, Weaver TE, Bachurski CJ, Clark JC, Whitsett JA, TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem. 2003 Sep 12;278(37):35574-83 |
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| 1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
| 1 | J:236306 Ding Z, Liu Y, Rubio V, He J, Minze LJ, Shi ZZ, OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression. Mol Cell Biol. 2016 Oct 15;36(20):2568-82 |
| 1 | J:169134 Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X, Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development. 2011 Mar;138(5):971-81 |
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| 1* | J:117591 Grad I, McKee TA, Ludwig SM, Hoyle GW, Ruiz P, Wurst W, Floss T, Miller CA 3rd, Picard D, The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol. 2006 Dec;26(23):8976-83 |
| 1 | J:90281 Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL, Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60 |
| 1 | J:76918 Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL, Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53 |
| 2* | J:75698 Grunder A, Ebel TT, Mallo M, Schwarzkopf G, Shimizu T, Sippel AE, Schrewe H, Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002 Mar;112(1-2):69-77 |
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| 2* | J:248980 Guo H, Kazadaeva Y, Ortega FE, Manjunath N, Desai TJ, Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung. Dev Biol. 2017 Oct 1;430(1):214-223 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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