Gene Expression Literature Summary

• Symbol: Kdm6a
• Name: lysine (K)-specific demethylase 6A
• ID: MGI:1095419

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E6.5	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)											1						1	1	1			2	1		1	1				2
In situ RNA (section)														2				1	1										1
Immunohistochemistry (whole mount)	1							1																						1
In situ reporter (knock in)											1			1	1
Northern blot																														2
Western blot	1													2		2	1	1		1	1		1				1	1		1
RT-PCR	2	1	1	2	2	3	2	1	1	1	3	1	2	1	1	2	1	2	1					1	1		1			7
cDNA clones										1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kdm6a  lysine (K)-specific demethylase 6A   (Synonyms: Utx)
Results	Reference
6	J:291558 Bai L, Yang L, Zhao C, Song L, Liu X, Bai C, Su G, Wei Z, Li G, Histone Demethylase UTX is an Essential Factor for Zygotic Genome Activation and Regulates Zscan4 Expression in Mouse Embryos. Int J Biol Sci. 2019;15(11):2363-2372
1	J:257205 Borensztein M, Okamoto I, Syx L, Guilbaud G, Picard C, Ancelin K, Galupa R, Diabangouaya P, Servant N, Barillot E, Surani A, Saitou M, Chen CJ, Anastassiadis K, Heard E, Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass. Nat Commun. 2017 Nov 3;8(1):1297
7	J:203762 Burton A, Muller J, Tu S, Padilla-Longoria P, Guccione E, Torres-Padilla ME, Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
4*	J:46792 Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P, The UTX gene escapes X inactivation in mice and humans. Hum Mol Genet. 1998 Apr;7(4):737-42
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2*	J:323190 Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho TV, Xu J, Chai Y, KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Elife. 2022 Feb 25;11:e74595
1	J:207400 Iida A, Iwagawa T, Kuribayashi H, Satoh S, Mochizuki Y, Baba Y, Nakauchi H, Furukawa T, Koseki H, Murakami A, Watanabe S, Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3751-6
2	J:150959 Kalantry S, Purushothaman S, Bowen RB, Starmer J, Magnuson T, Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature. 2009 Jul 30;460(7255):647-51
2*	J:333188 Koizumi M, Eto H, Saeki M, Seki M, Fukushima T, Mukai S, Ide H, Sera Y, Iwasaki M, Suzuki Y, Tohei A, Kishi Y, Honda H, UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death. FASEB J. 2022 Dec;36(12):e22662
6	J:180125 Lee S, Lee JW, Lee SK, UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program. Dev Cell. 2012 Jan 17;22(1):25-37
6	J:312817 Lei X, Jiao J, UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling. Stem Cell Reports. 2018 Apr 10;10(4):1193-1207
2	J:228600 Li Q, Wang HY, Chepelev I, Zhu Q, Wei G, Zhao K, Wang RF, Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. PLoS Genet. 2014 Jul;10(7):e1004524
1	J:185555 Mugford JW, Yee D, Magnuson T, Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation. Development. 2012 Jun;139(12):2130-8
3	J:314576 Narayanan R, Pirouz M, Kerimoglu C, Pham L, Wagener RJ, Kiszka KA, Rosenbusch J, Seong RH, Kessel M, Fischer A, Stoykova A, Staiger JF, Tuoc T, Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development. Cell Rep. 2015 Dec 1;13(9):1842-54
3	J:247259 Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M, New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266
1	J:242516 Sessa A, Ciabatti E, Drechsel D, Massimino L, Colasante G, Giannelli S, Satoh T, Akira S, Guillemot F, Broccoli V, The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways. Cereb Cortex. 2017 Jun 01;27(6):3378-3396
2	J:294895 Shpargel KB, Mangini CL, Xie G, Ge K, Magnuson T, The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology. Development. 2020 Jul 17;147(21):dev187997
5	J:201868 Shpargel KB, Sengoku T, Yokoyama S, Magnuson T, UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet. 2012 Sep;8(9):e1002964
7	J:294365 Umutoni D, Iwagawa T, Baba Y, Tsuhako A, Honda H, Aihara M, Watanabe S, H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar cells in the mouse retina. Genes Cells. 2020 Jun;25(6):402-412
1*	J:190157 Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K, UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15324-9
2	J:206774 Wolstenholme JT, Rissman EF, Bekiranov S, Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 2013 Mar;12(2):166-80
3*	J:76911 Xu J, Burgoyne PS, Arnold AP, Sex differences in sex chromosome gene expression in mouse brain. Hum Mol Genet. 2002 Jun 1;11(12):1409-19
3	J:313616 Zhang F, Zhao X, Jiang R, Wang Y, Wang X, Gu Y, Xu L, Ye J, Chen CD, Guo S, Zhang D, Zhao D, Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice. Front Cell Dev Biol. 2021;9:642931
2	J:282261 Zhao J, Tian Y, Zhang H, Qu L, Chen Y, Liu Q, Luo Y, Wu X, p53 Mutant p53(N236S) Induces Neural Tube Defects in Female Embryos. Int J Biol Sci. 2019;15(9):2006-2015