Gene Expression Literature Summary

• Symbol: Tnfrsf11b
• Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
• ID: MGI:109587

41 matching records from 41 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E5.5	E6.5	E7	E7.5	E8.5	E9.5	E10.5	E11	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)														1			1			2
In situ RNA (section)									1	2	2	1	1	1				1		1
Northern blot			1					1				1			1			1		2
RT-PCR	1	1		1	1	1	1		1		2		2	2		1	1	5	1	25
cDNA clones																				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tnfrsf11b  tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)   (Synonyms: OCIF, Opg, OPG, osteoclastogenesis inhibitory factor, TR1)
Results	Reference
1	J:309392 Amano K, Densmore MJ, Lanske B, Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72
1*	J:310847 Chen H, Ghori-Javed FY, Rashid H, Adhami MD, Serra R, Gutierrez SE, Javed A, Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation. J Bone Miner Res. 2014 Dec;29(12):2653-65
1	J:224562 Chen Q, Sinha K, Deng JM, Yasuda H, Krahe R, Behringer RR, de Crombrugghe B, Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation. J Bone Miner Res. 2015 Sep;30(9):1608-17
1	J:232617 Chen Z, Yue SX, Zhou G, Greenfield EM, Murakami S, ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. J Bone Miner Res. 2015 May;30(5):765-74
1	J:146483 de Frutos CA, Dacquin R, Vega S, Jurdic P, Machuca-Gayet I, Nieto MA, Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J. 2009 Mar 18;28(6):686-96
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*	J:51348 Gao YH, Shinki T, Yuasa T, Kataoka-Enomoto H, Komori T, Suda T, Yamaguchi A, Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF). Biochem Biophys Res Commun. 1998 Nov 27;252(3):697-702
5	J:98430 Glass DA 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G, Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005 May;8(5):751-64
1	J:199943 Golovchenko S, Hattori T, Hartmann C, Gebhardt M, Gebhard S, Hess A, Pausch F, Schlund B, von der Mark K, Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation. Bone. 2013 Jul;55(1):102-12
1	J:158620 Guo J, Liu M, Yang D, Bouxsein ML, Saito H, Galvin RJ, Kuhstoss SA, Thomas CC, Schipani E, Baron R, Bringhurst FR, Kronenberg HM, Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab. 2010 Feb 3;11(2):161-71
1	J:167738 Hardouin SN, Guo R, Romeo PH, Nagy A, Aubin JE, Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. Development. 2011 Jan;138(2):203-13
1	J:338183 Hariri H, Kose O, Bezdjian A, Daniel SJ, St-Arnaud R, USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in Osteoblasts and Bone Marrow Adipocytes. J Bone Miner Res. 2023 Apr;38(4):578-596
1*	J:233142 Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F, Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar;14(3):306-14
1	J:317377 Hinoi E, Nakatani E, Yamamoto T, Iezaki T, Takahata Y, Fujita H, Ishiura R, Takamori M, Yoneda Y, The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osterix and Osteocalcin. J Bone Miner Res. 2012 Dec;27(12):2526-34
1	J:217455 Holm E, Aubin JE, Hunter GK, Beier F, Goldberg HA, Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone. 2015 Feb;71:145-54
2	J:237341 Houben A, Kostanova-Poliakova D, Weissenbock M, Graf J, Teufel S, von der Mark K, Hartmann C, beta-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis. Development. 2016 Oct 15;143(20):3826-3838
1*	J:230169 Isaac J, Erthal J, Gordon J, Duverger O, Sun HW, Lichtler AC, Stein GS, Lian JB, Morasso MI, DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo. Cell Death Differ. 2014 Sep;21(9):1365-76
1*	J:235526 Jauregui EJ, Akil O, Acevedo C, Hall-Glenn F, Tsai BS, Bale HA, Liebenberg E, Humphrey MB, Ritchie RO, Lustig LR, Alliston T, Parallel mechanisms suppress cochlear bone remodeling to protect hearing. Bone. 2016 Aug;89:7-15
2	J:143588 Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y, BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11
1	J:104946 Kieslinger M, Folberth S, Dobreva G, Dorn T, Croci L, Erben R, Consalez GG, Grosschedl R, EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Dev Cell. 2005 Dec;9(6):757-67
3	J:340406 Lai Y, Guo Y, Liao C, Mao C, Liu J, Ren C, Yang W, Luo L, Chen W, Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development. Sci Rep. 2023 Sep 13;13(1):15170
1	J:109487 Lange AW, Yutzey KE, NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K. Dev Biol. 2006 Apr 15;292(2):407-17
1*	J:203695 Lieben L, Stockmans I, Moermans K, Carmeliet G, Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. Bone. 2013 Nov;57(1):123-31
2	J:296151 Liu J, Chanumolu SK, White KM, Albahrani M, Otu HH, Nawshad A, Transcriptional analysis of cleft palate in TGFbeta3 mutant mice. Sci Rep. 2020 Sep 10;10(1):14940
6*	J:49549 Mizuno A, Murakami A, Nakagawa N, Yasuda H, Tsuda E, Morinaga T, Higashio K, Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis. Gene. 1998 Jul 30;215(2):339-43
1*	J:274110 Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M, Fgf21 regulates T-cell development in the neonatal and juvenile thymus. Sci Rep. 2017 Mar 23;7(1):330
5	J:88395 Ohazama A, Courtney JM, Sharpe PT, Opg, Rank, and Rankl in Tooth Development: Co-ordination of Odontogenesis and Osteogenesis. J Dent Res. 2004 Mar;83(3):241-4
1	J:263575 Ruiz P, Martin-Millan M, Gonzalez-Martin MC, Almeida M, Gonzalez-Macias J, Ros MA, CathepsinKCre mediated deletion of betacatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells. Sci Rep. 2016 Nov 2;6:36201
2*	J:152946 Sferruzzi-Perri AN, Macpherson AM, Roberts CT, Robertson SA, Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
1	J:235082 Shimazu J, Wei J, Karsenty G, Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148. Cell Rep. 2016 Apr 5;15(1):27-35
2	J:330577 Shin M, Mori S, Mizoguchi T, Arai A, Kajiya H, Okamoto F, Bartlett JD, Matsushita M, Udagawa N, Okabe K, Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis. Bone. 2022 Oct 7;166:116579
7*	J:39641 Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R , Nguyen HQ , Wooden S , Bennett L , Boone T , Shimamoto G , DeRose M , Elliott R , Colombero A , Tan HL , Trail G , Sullivan J , Davy E , Bucay N , Renshaw-Gegg L , Hughes TM , Hill D , Pattison W , Campbell P , Boyle WJ , et al, Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997 Apr 18;89(2):309-19
1	J:159823 Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM, Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol. 2010 May 3;189(3):511-25
1	J:326699 Tosun B, Wolff LI, Houben A, Nutt S, Hartmann C, Osteoclasts and Macrophages-Their Role in Bone Marrow Cavity Formation During Mouse Embryonic Development. J Bone Miner Res. 2022 Jun 11;
1	J:183534 Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F, Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet. 2012 Mar;8(3):e1002577
2*	J:320741 Vesela B, Svandova E, Hovorakova M, Peterkova R, Kratochvilova A, Pasovska M, Ramesova A, Lesot H, Matalova E, Specification of Sprouty2 functions in osteogenesis in in vivo context. Organogenesis. 2019;15(4):111-119
1	J:185130 Wei J, Shi Y, Zheng L, Zhou B, Inose H, Wang J, Guo XE, Grosschedl R, Karsenty G, miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 2012 May 14;197(4):509-21
1*	J:307192 Yadav PS, Feng S, Cong Q, Kim H, Liu Y, Yang Y, Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2020100118
1	J:134882 Zhang C, Cho K, Huang Y, Lyons JP, Zhou X, Sinha K, McCrea PD, de Crombrugghe B, Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6936-41
1	J:168525 Zhang S, Xiao Z, Luo J, He N, Mahlios J, Quarles LD, Dose-dependent effects of Runx2 on bone development. J Bone Miner Res. 2009 Nov;24(11):1889-904
1	J:292430 Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y, Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Elife. 2020 Mar 18;9:e52779