Gene Expression Literature Summary

• Symbol: Hsd3b6
• Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
• ID: MGI:109598

20 matching records from 20 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E4.5	E6.5	E7	E7.5	E8.5	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)								1	1		1		1			1				2
In situ RNA (section)													4							1
Western blot						1														1
RT-PCR	1	1	1	1	1	2	2		2	2	2	2		3	2		1	2	2	10

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hsd3b6  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6   (Synonyms: 3beta-HSD VI)
Results	Reference
12*	J:39896 Abbaszade IG, Arensburg J, Park CH, Kasa-Vubu JZ, Orly J, Payne AH, Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy. Endocrinology. 1997 Apr;138(4):1392-9
6*	J:324263 Aksel S, Cao M, Derpinghaus A, Baskin LS, Cunha GR, Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from embryonic day 10 to adulthood. Differentiation. 2022 Mar 7;
3	J:54396 Baker PJ, Sha JA, McBride MW, Peng L, Payne AH, O'Shaughnessy PJ, Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development. Eur J Biochem. 1999 Mar;260(3):911-7
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:308912 Bergeron F, Boulende Sab A, Bouchard MF, Taniguchi H, Souchkova O, Brousseau C, Tremblay JJ, Pilon N, Viger RS, Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse. Andrology. 2019 May;7(3):357-372
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4*	J:125377 Hu L, Monteiro A, Johnston H, King P, O'shaughnessy PJ, Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. Reproduction. 2007 Oct;134(4):585-91
1	J:223361 Kaftanovskaya EM, Lopez C, Ferguson L, Myhr C, Agoulnik AI, Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB J. 2015 Jun;29(6):2327-37
1	J:227422 Karpova T, Ravichandiran K, Insisienmay L, Rice D, Agbor V, Heckert LL, Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice. Biol Reprod. 2015 Oct;93(4):83
1*	J:206507 Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL, ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013;9(7):e1003612
2*	J:147318 Lopez-Garcia C, Lopez-Contreras AJ, Cremades A, Castells MT, Marin F, Schreiber F, Penafiel R, Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. Endocrinology. 2008 Oct;149(10):5012-23
5*	J:46691 O'Shaughnessy PJ, Baker P, Sohnius U, Haavisto AM, Charlton HM, Huhtaniemi I, Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function. Endocrinology. 1998 Mar;139(3):1141-6
4	J:222045 Padua MB, Jiang T, Morse DA, Fox SC, Hatch HM, Tevosian SG, Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
1*	J:245773 Paikari A, D Belair C, Saw D, Blelloch R, The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Development. 2017 Oct 15;144(20):3731-3743
1	J:305434 Scovell JM, Bournat JC, Szafran AT, Solis M, Moore J, Rivera A, Chen CH, Zhang J, Wilken N, Seth A, Jorgez CJ, PRSS50 is a testis protease responsible for proper sperm tail formation and function. Development. 2021 Apr 15;148(8):dev197558
1	J:272573 Shima Y, Miyabayashi K, Sato T, Suyama M, Ohkawa Y, Doi M, Okamura H, Suzuki K, Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells. Development. 2018 Dec 5;145(23):dev169136
1	J:224387 Sisecioglu M, Budak H, Geffers L, Cankaya M, Ciftci M, Thaller C, Eichele G, Kufrevioglu OI, Ozdemir H, A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. J Lipid Res. 2015 Aug;56(8):1551-9
2	J:224628 Tevosian SG, Jimenez E, Hatch HM, Jiang T, Morse DA, Fox SC, Padua MB, Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors. Endocrinology. 2015 Jul;156(7):2503-17
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:346630 Zhang X, He H, Yu H, Teng X, Wang Z, Li C, Li J, Yang H, Shen J, Wu T, Zhang F, Zhang Y, Wu Q, Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature. Commun Biol. 2024 Mar 23;7(1):363