Gene Expression Literature Summary

• Symbol: Bad
• Name: BCL2-associated agonist of cell death
• ID: MGI:1096330

29 matching records from 29 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4	E8.5	E9	E9.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E18	E18.5	E	P
Immunohistochemistry (section)																								1	1	2
Northern blot	1	1	1	1	1	1		1																	1	2
Western blot									1	2	1		2													5
RT-PCR	1	1		2			1			1	2	1		1	1	1		1	1	2	1		1	2		4
cDNA clones																	1			1						1
RNase protection												1			1			1				1				2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Bad  BCL2-associated agonist of cell death   (Synonyms: Bbc2)
Results	Reference
2*	J:68216 Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, Vidal M, Alkema M, Berns A, Koseki H, Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development. 2001 May;128(9):1587-97
1	J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
1	J:321352 Chen X, Zhong J, Dong D, Liu G, Yang P, Endoplasmic Reticulum Stress-Induced CHOP Inhibits PGC-1alpha and Causes Mitochondrial Dysfunction in Diabetic Embryopathy. Toxicol Sci. 2017 Aug 1;158(2):275-285
1	J:96826 Di-Poi N, Ng CY, Tan NS, Yang Z, Hemmings BA, Desvergne B, Michalik L, Wahli W, Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol. 2005 Mar;25(5):1696-712
1*	J:147670 Done SC, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, Tryggvason K, Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int. 2008 Mar;73(6):697-704
1	J:154416 Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL, Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 2009 Sep;58(9):2059-69
2	J:337771 El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T, Voss AK, Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
4*	J:56116 Exley GE, Tang C, McElhinny AS, Warner CM, Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos. Biol Reprod. 1999 Jul;61(1):231-9
1*	J:85726 Fernandez EL, Gustafson AL, Andersson M, Hellman B, Dencker L, Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc. Toxicol Sci. 2003 Nov;76(1):162-70
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:302364 Gausseres B, Liu J, Foppen E, Tourrel-Cuzin C, Rodriguez Sanchez-Archidona A, Delangre E, Cruciani-Guglielmacci C, Pons S, Maskos U, Thorens B, Magnan C, Movassat J, Maouche K, The Constitutive Lack of alpha7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse. Biomolecules. 2020 Jul 16;10(7):1057
2	J:101397 Gotz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, Troppmair J, Jablonka S, Holtmann B, Reed JC, Rapp UR, Sendtner M, Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci. 2005 Sep;8(9):1169-78
8*	J:50202 Jurisicova A, Latham KE, Casper RF, Casper RF, Varmuza SL, Expression and regulation of genes associated with cell death during murine preimplantation embryo development. Mol Reprod Dev. 1998 Nov;51(3):243-53
2*	J:170203 Lague MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D, Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E936-46
5	J:149321 Montalvo V, Gery I, Constitutive pro-apoptotic molecules are differentially expressed in the fetal and adult mouse eye. Curr Eye Res. 2009 Apr;34(4):328-32
1	J:42260 Moser M, Pscherer A, Roth C, Becker J, Mucher G, Zerres K, Dixkens C , Weis J , Guay-Woodford L , Buettner R , Fassler R, Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev. 1997 Aug 1;11(15):1938-48
1	J:299239 Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Mark KV, Sakane C, Kaneko H, Komori T, Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genet. 2020 Nov;16(11):e1009169
3	J:84987 Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP, Kutok JL, Le Beau MM, Greenberg ME, Korsmeyer SJ, Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9324-9
5*	J:59317 Roth KA, Kuan C, Haydar TF, D'Sa-Eipper C, Shindler KS, Zheng TS, Kuida K, Flavell RA, Rakic P, Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):466-71
1	J:63161 Rucker EB 3rd, Dierisseau P, Wagner KU, Garrett L, Wynshaw-Boris A, Flaws JA, Hennighausen L, Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol Endocrinol. 2000 Jul;14(7):1038-52
2*	J:261957 Svandova EB, Vesela B, Lesot H, Poliard A, Matalova E, Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination. Histochem Cell Biol. 2017 Apr;147(4):497-510
1	J:242317 Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y, Fei J, Wang ZG, Lacking of palladin leads to multiple cellular events changes which contribute to NTD. Neural Dev. 2017 Mar 24;12(1):4
1	J:250342 Wang F, Xu C, Reece EA, Li X, Wu Y, Harman C, Yu J, Dong D, Wang C, Yang P, Zhong J, Yang P, Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. Nat Commun. 2017 May 05;8:15182
1	J:57319 Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF, Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet. 1999 Sep;23(1):32-40
1*	J:341382 Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y, Zhou B, Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
1	J:151770 Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M, Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia. 2009 Oct;52(10):2130-41
3	J:42326 Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ, Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995 Jan 27;80(2):285-91
1	J:256712 Yu C, Ji SY, Dang YJ, Sha QQ, Yuan YF, Zhou JJ, Yan LY, Qiao J, Tang F, Fan HY, Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Cell Res. 2016 Mar;26(3):275-87
1	J:315123 Zhong J, Xu C, Gabbay-Benziv R, Lin X, Yang P, Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy. Free Radic Biol Med. 2016 Jul;96:234-44