Symbol Name ID |
Lhx8
LIM homeobox protein 8 MGI:1096343 |
Age | E1.5 | E2 | E2.5 | E3 | E3.5 | E4.5 | E9 | E9.5 | E10.5 | E11.5 | E12 | E12.5 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16.5 | E17 | E17.5 | E18.5 | E | P |
Immunohistochemistry (section) | 2 | 3 | 1 | 1 | 1 | 1 | 6 | ||||||||||||||||
In situ RNA (section) | 6 | 12 | 3 | 16 | 21 | 2 | 13 | 1 | 13 | 6 | 1 | 10 | 3 | 23 | |||||||||
Immunohistochemistry (whole mount) | 1 | 1 | 2 | ||||||||||||||||||||
In situ RNA (whole mount) | 1 | 7 | 11 | 5 | 3 | 1 | 1 | 2 | 2 | ||||||||||||||
In situ reporter (knock in) | 2 | 2 | 2 | 1 | 2 | 2 | 3 | ||||||||||||||||
Northern blot | 1 | 1 | 1 | ||||||||||||||||||||
Western blot | 1 | 1 | 1 | ||||||||||||||||||||
RT-PCR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 4 | 1 | 5 | 1 | 3 | 3 | 1 | 3 | 1 | 1 | 11 | ||||
cDNA clones | 1 | 3 | 1 | 3 | |||||||||||||||||||
RNase protection | 1 | 1 | 1 | 1 | 1 | 1 |
Lhx8 LIM homeobox protein 8 (Synonyms: L3, Lhx7) | |
Results | Reference |
1 | J:310312 Abe M, Cox TC, Firulli AB, Kanai SM, Dahlka J, Lim KC, Engel JD, Clouthier DE, GATA3 is essential for separating patterning domains during facial morphogenesis. Development. 2021 Sep 1;148(17):dev199534 |
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1 | J:333560 Ahmed NY, Knowles R, Liu L, Yan Y, Li X, Schumann U, Wang Y, Sontani Y, Reynolds N, Natoli R, Wen J, Del Pino I, Mi D, Dehorter N, Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder. Front Cell Dev Biol. 2023;11:1112062 |
1* | J:238553 Allaway KC, Machold R, Developmental specification of forebrain cholinergic neurons. Dev Biol. 2017 Jan 01;421(1):1-7 |
1 | J:328140 Asgarian Z, Oliveira MG, Stryjewska A, Maragkos I, Rubin AN, Magno L, Pachnis V, Ghorbani M, Hiebert SW, Denaxa M, Kessaris N, MTG8 interacts with LHX6 to specify cortical interneuron subtype identity. Nat Commun. 2022 Sep 5;13(1):5217 |
1* | J:109310 Ballow D, Meistrich ML, Matzuk M, Rajkovic A, Sohlh1 is essential for spermatogonial differentiation. Dev Biol. 2006 Jun 1;294(1):161-7 |
2 | J:150764 Bildsoe H, Loebel DA, Jones VJ, Chen YT, Behringer RR, Tam PP, Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Dev Biol. 2009 Jul 15;331(2):176-88 |
1 | J:339096 Biswas S, Chan CS, Rubenstein JLR, Gan L, The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus. Dev Biol. 2023 Aug 1;503:10-24 |
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1* | J:207523 Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK, Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014 Jun 1;390(1):1-13 |
4* | J:269929 Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME, Rubenstein J, Berube NG, CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. J Neurosci. 2019 Jan 2;39(1):177-192 |
1 | J:133494 Elshatory Y, Gan L, The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci. 2008 Mar 26;28(13):3291-7 |
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1* | J:152838 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD, A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408 |
1 | J:259576 Funato N, Kokubo H, Nakamura M, Yanagisawa H, Saga Y, Specification of jaw identity by the Hand2 transcription factor. Sci Rep. 2016 Jun 22;6:28405 |
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1 | J:220860 Magnani D, Morle L, Hasenpusch-Theil K, Paschaki M, Jacoby M, Schurmans S, Durand B, Theil T, The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93 |
1 | J:306613 Magno L, Asgarian Z, Pendolino V, Velona T, Mackintosh A, Lee F, Stryjewska A, Zimmer C, Guillemot F, Farrant M, Clark B, Kessaris N, Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior. Cell Rep. 2021 Jun 15;35(11):109249 |
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1 | J:184343 Magno L, Kretz O, Bert B, Ersozlu S, Vogt J, Fink H, Kimura S, Vogt A, Monyer H, Nitsch R, Naumann T, The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1. Eur J Neurosci. 2011 Dec;34(11):1767-82 |
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1* | J:86704 Maynard TM, Haskell GT, Peters AZ, Sikich L, Lieberman JA, LaMantia AS, A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14433-8 |
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2 | J:100340 Mori T, Yuxing Z, Takaki H, Takeuchi M, Iseki K, Hagino S, Kitanaka J, Takemura M, Misawa H, Ikawa M, Okabe M, Wanaka A, The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur J Neurosci. 2004 Jun;19(12):3129-41 |
1 | J:78037 Muzio L, DiBenedetto B, Stoykova A, Boncinelli E, Gruss P, Mallamaci A, Conversion of cerebral cortex into basal ganglia in Emx2(-/-) Pax6(Sey/Sey) double-mutant mice. Nat Neurosci. 2002 Aug;5(8):737-45 |
1 | J:242687 Nandi S, Gutin G, Blackwood CA, Kamatkar NG, Lee KW, Fishell G, Wang F, Goldfarb M, Hebert JM, FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon. J Neurosci. 2017 Jun 07;37(23):5690-5698 |
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1 | J:326570 Niu W, Spradling AC, Mouse oocytes develop in cysts with the help of nurse cells. Cell. 2022 Jul 7;185(14):2576-2590.e12 |
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1* | J:172381 Osterberg N, Wiehle M, Oehlke O, Heidrich S, Xu C, Fan CM, Krieglstein K, Roussa E, Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons. PLoS One. 2011;6(4):e19239 |
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1 | J:225813 Puelles L, Morales-Delgado N, Merchan P, Castro-Robles B, Martinez-de-la-Torre M, Diaz C, Ferran JL, Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area. Brain Struct Funct. 2016 Jul;221(6):3027-65 |
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1 | J:266826 Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR, Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron. 2016 Sep 21;91(6):1260-1275 |
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1 | J:259182 Silva CG, Peyre E, Adhikari MH, Tielens S, Tanco S, Van Damme P, Magno L, Krusy N, Agirman G, Magiera MM, Kessaris N, Malgrange B, Andrieux A, Janke C, Nguyen L, Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell. 2018 Feb 22;172(5):1063-1078.e19 |
1 | J:247178 Singh R, Braga M, Reddy ST, Lee SJ, Parveen M, Grijalva V, Vergnes L, Pervin S, Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017 May 01;158(5):1217-1230 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/27/2024 MGI 6.24 |
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