Gene Expression Literature Summary

• Symbol: Neo1
• Name: neogenin
• ID: MGI:1097159

58 matching records from 58 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)		1		1	1	1		3				5		2	1	4		1		3		1	6
In situ RNA (section)	1	2		1	1	6	1	4	1	6	3	6	1	9	1	4	2	3	1	5		7	9
In situ RNA (whole mount)		1						2		1				2								1
In situ reporter (knock in)				2		3				1		2		2		1							3
Northern blot		1				1														1		1	1
Western blot						3				1		2		1					1		1	1	5
RT-PCR		1		1		3		1		2	1	3		3		2		1	1	1			5
cDNA clones		1	1										1										2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Neo1  neogenin   (Synonyms: 2610028H22Rik, D930014N22Rik, Igdcc2)
Results	Reference
2	J:60833 Alcantara S, Ruiz M, De Castro F, Soriano E, Sotelo C, Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system. Development. 2000 Apr;127(7):1359-72
1	J:170280 Andrusiak MG, McClellan KA, Dugal-Tessier D, Julian LM, Rodrigues SP, Park DS, Kennedy TE, Slack RS, Rb/E2F regulates expression of neogenin during neuronal migration. Mol Cell Biol. 2011 Jan;31(2):238-47
4	J:164943 Bae GU, Yang YJ, Jiang G, Hong M, Lee HJ, Tessier-Lavigne M, Kang JS, Krauss RS, Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro. Mol Biol Cell. 2009 Dec;20(23):4920-31
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:227232 Bin JM, Han D, Lai Wing Sun K, Croteau LP, Dumontier E, Cloutier JF, Kania A, Kennedy TE, Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death. Cell Rep. 2015 Aug 18;12(7):1099-106
6	J:79506 Bloch-Gallego E, Ezan F, Tessier-Lavigne M, Sotelo C, Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons. J Neurosci. 1999 Jun 1;19(11):4407-20
1	J:63609 Braisted JE, Catalano SM, Stimac R, Kennedy TE, Tessier-Lavigne M, Shatz CJ, O'Leary DD, Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. J Neurosci. 2000 Aug 1;20(15):5792-801
4	J:297714 Brignani S, Raj DDA, Schmidt ERE, Dudukcu O, Adolfs Y, De Ruiter AA, Rybiczka-Tesulov M, Verhagen MG, van der Meer C, Broekhoven MH, Moreno-Bravo JA, Grossouw LM, Dumontier E, Cloutier JF, Chedotal A, Pasterkamp RJ, Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron. 2020 Aug 19;107(4):684-702.e9
4	J:103829 Chen B, Schaevitz LR, McConnell SK, Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17184-9
3	J:158468 Conrad S, Stimpfle F, Montazeri S, Oldekamp J, Seid K, Alvarez-Bolado G, Skutella T, RGMb controls aggregation and migration of Neogenin-positive cells in vitro and in vivo. Mol Cell Neurosci. 2010 Feb;43(2):222-31
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
9*	J:79319 Engelkamp D, Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. Mech Dev. 2002 Oct;118(1-2):191
4*	J:123586 Fitzgerald DP, Bradford D, Cooper HM, Neogenin is expressed on neurogenic and gliogenic progenitors in the embryonic and adult central nervous system. Gene Expr Patterns. 2007 Aug;7(7):784-92
2	J:113144 Fitzgerald DP, Cole SJ, Hammond A, Seaman C, Cooper HM, Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain. Neuroscience. 2006 Oct 27;142(3):703-16
1*	J:108592 Fitzgerald DP, Seaman C, Cooper HM, Localization of Neogenin protein during morphogenesis in the mouse embryo. Dev Dyn. 2006 Jun;235(6):1720-5
7*	J:62806 Gad JM, Keeling SL, Shu T, Richards LJ, Cooper HM, The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. Exp Eye Res. 2000 Jun;70(6):711-22
13*	J:45336 Gad JM, Keeling SL, Wilks AF, Tan SS, Cooper HM, The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis. Dev Biol. 1997 Dec 15;192(2):258-73
2	J:339855 Gannoun L, De Schrevel C, Belle M, Dauguet N, Achouri Y, Loriot A, Vanderaa C, Cordi S, Dili A, Heremans Y, Rooman I, Leclercq IA, Jacquemin P, Gatto L, Lemaigre FP, Axon guidance genes control hepatic artery development. Development. 2023 Aug 15;150(16):dev201642
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:229411 Hakanen J, Salminen M, Defects in neural guidepost structures and failure to remove leptomeningeal cells from the septal midline behind the interhemispheric fusion defects in Netrin1 deficient mice. Int J Dev Neurosci. 2015 Dec;47(Pt B):206-15
1	J:181586 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Ronne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD, Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
1	J:178482 Heckman-Stoddard BM, Vargo-Gogola T, Herrick MP, Visbal AP, Lewis MT, Settleman J, Rosen JM, P190A RhoGAP is required for mammary gland development. Dev Biol. 2011 Dec 1;360(1):1-10
3*	J:181269 Hong M, Schachter KA, Jiang G, Krauss RS, Neogenin regulates sonic hedgehog pathway activity during digit patterning. Dev Dyn. 2012 Mar;241(3):627-37
2*	J:232100 Huang Z, Sun D, Hu JX, Tang FL, Lee DH, Wang Y, Hu G, Zhu XJ, Zhou J, Mei L, Xiong WC, Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. J Neurosci. 2016 May 25;36(21):5833-49
5*	J:131673 Jiang Y, Liu MT, Gershon MD, Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. Dev Biol. 2003 Jun 15;258(2):364-84
6	J:235517 Kam JW, Dumontier E, Baim C, Brignall AC, Mendes da Silva D, Cowan M, Kennedy TE, Cloutier JF, RGMB and neogenin control cell differentiation in the developing olfactory epithelium. Development. 2016 May 1;143(9):1534-46
20*	J:42348 Keeling SL, Gad JM, Cooper HM, Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis. Oncogene. 1997 Aug 7;15(6):691-700
4	J:160796 Lee DH, Zhou LJ, Zhou Z, Xie JX, Jung JU, Liu Y, Xi CX, Mei L, Xiong WC, Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood. 2010 Apr 15;115(15):3136-45
1	J:234106 Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z, NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. Elife. 2016;5:e14264
1	J:67920 Leighton PA, Mitchell KJ, Goodrich LV, Lu X, Pinson K, Scherz P, Skarnes WC, Tessier-Lavigne M, Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 2001 Mar 8;410(6825):174-9
1	J:307518 Leo L, Gherardini L, Barone V, De Fusco M, Pietrobon D, Pizzorusso T, Casari G, Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet. 2011 Jun;7(6):e1002129
5	J:302366 Lin S, Liu W, Chen CL, Sun D, Hu JX, Li L, Ye J, Mei L, Xiong WC, Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation. J Mol Cell Biol. 2020 Jan 22;12(1):17-31
1*	J:90754 Liu Y, Stein E, Oliver T, Li Y, Brunken WJ, Koch M, Tessier-Lavigne M, Hogan BL, Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. Curr Biol. 2004 May 25;14(10):897-905
3*	J:84941 Loes S, Luukko K, Hals Kvinnsland I, Salminen M, Kettunen P, Developmentally regulated expression of Netrin-1 and -3 in the embryonic mouse molar tooth germ. Dev Dyn. 2003 Aug;227(4):573-7
1	J:343073 Luo PM, Gu X, Chaney C, Carroll T, Cleaver O, Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation. Development. 2023 Nov 15;150(22)
4	J:123412 Matilainen T, Haugas M, Kreidberg JA, Salminen M, Analysis of Netrin 1 receptors during inner ear development. Int J Dev Biol. 2007;51(5):409-14
2	J:122733 McClellan KA, Ruzhynsky VA, Douda DN, Vanderluit JL, Ferguson KL, Chen D, Bremner R, Park DS, Leone G, Slack RS, Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol Cell Biol. 2007 Jul;27(13):4825-43
3*	J:127437 Metzger M, Conrad S, Alvarez-Bolado G, Skutella T, Just L, Gene expression of the repulsive guidance molecules during development of the mouse intestine. Dev Dyn. 2005 Sep;234(1):169-75
3	J:203346 Milla LA, Arros A, Espinoza N, Remke M, Kool M, Taylor MD, Pfister SM, Wainwright BJ, Palma V, Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. Int J Cancer. 2014 Jan 1;134(1):21-31
2	J:188355 Miyoshi G, Fishell G, Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. Neuron. 2012 Jun 21;74(6):1045-58
1	J:86051 Muller M, Jabs N, Lork DE, Fritzsch B, Sander M, Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons. Development. 2003 Dec;130(23):5815-26
2	J:179910 Palmesino E, Haddick PC, Tessier-Lavigne M, Kania A, Genetic Analysis of DSCAM's Role as a Netrin-1 Receptor in Vertebrates. J Neurosci. 2012 Jan 11;32(2):411-6
1	J:250766 Poliak S, Morales D, Croteau LP, Krawchuk D, Palmesino E, Morton S, Cloutier JF, Charron F, Dalva MB, Ackerman SL, Kao TJ, Kania A, Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons. Elife. 2015 Dec 3;4:e10841
1	J:221584 Quesnel-Vallieres M, Irimia M, Cordes SP, Blencowe BJ, Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Genes Dev. 2015 Apr 1;29(7):746-59
2	J:345597 Quilez S, Dumontier E, Baim C, Kam J, Cloutier JF, Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465
1	J:306140 Ren X, Yao LL, Pan JX, Zhang JS, Mei L, Wang YG, Xiong WC, Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy. Neurobiol Dis. 2021 Jul;154:105339
1	J:94375 Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC, Focal adhesion kinase in netrin-1 signaling. Nat Neurosci. 2004 Nov;7(11):1204-12
5	J:305520 Robinson RA, Griffiths SC, van de Haar LL, Malinauskas T, van Battum EY, Zelina P, Schwab RA, Karia D, Malinauskaite L, Brignani S, van den Munkhof MH, Dudukcu O, De Ruiter AA, Van den Heuvel DMA, Bishop B, Elegheert J, Aricescu AR, Pasterkamp RJ, Siebold C, Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell. 2021 Apr 15;184(8):2103-2120.e31
3*	J:127109 Schnichels S, Conrad S, Warstat K, Henke-Fahle S, Skutella T, Schraermeyer U, Julien S, Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J. Gene Expr Patterns. 2007 Dec;8(1):1-11
1	J:228291 Shinmyo Y, Asrafuzzaman Riyadh M, Ahmed G, Bin Naser I, Hossain M, Takebayashi H, Kawasaki H, Ohta K, Tanaka H, Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex. Nat Commun. 2015;6:10232
1	J:96006 Steele-Perkins G, Plachez C, Butz KG, Yang G, Bachurski CJ, Kinsman SL, Litwack ED, Richards LJ, Gronostajski RM, The transcription factor gene Nfib is essential for both lung maturation and brain development. Mol Cell Biol. 2005 Jan;25(2):685-98
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
4*	J:199400 van den Heuvel DM, Hellemons AJ, Pasterkamp RJ, Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain. PLoS One. 2013;8(2):e55828
2	J:227692 van Erp S, van den Heuvel DM, Fujita Y, Robinson RA, Hellemons AJ, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ, Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. Dev Cell. 2015 Dec 7;35(5):537-52
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:211644 Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB, Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science. 2014 Jun 13;344(6189):1275-9
2	J:271541 Yung AR, Druckenbrod NR, Cloutier JF, Wu Z, Tessier-Lavigne M, Goodrich LV, Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS. Cell Rep. 2018 Feb 13;22(7):1666-1680
1	J:226697 Yung AR, Nishitani AM, Goodrich LV, Phenotypic analysis of mice completely lacking netrin 1. Development. 2015 Nov 1;142(21):3686-91