Gene Expression Literature Summary

• Symbol: Hdac2
• Name: histone deacetylase 2
• ID: MGI:1097691

60 matching records from 60 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E6.5	E7.5	E8	E9.5	E10	E10.5	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)								1			2	1	3	3		3	2	3	7		3	1	5	2	1		4		11
In situ RNA (section)													1	4		1	2	4	1	1	2	1		1		1	1		5
Immunohistochemistry (whole mount)	1	1		1	1	1	1																						1
In situ RNA (whole mount)												1	1	1			1				1
Western blot	1	1		1	1	1	1			1	1	1	3	3	1	4	2	2	2	1	3	1	3	1	2		4	2	11
RT-PCR	1	1	1	2	1	1	2		1							2		1	4		2	2	2	2			3	1	12
cDNA clones									1								1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hdac2  histone deacetylase 2   (Synonyms: D10Wsu179e, Yy1bp)
Results	Reference
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
2	J:239777 Boucherat O, Landry-Truchon K, Berube-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L, Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015 Sep 01;142(17):2981-95
1	J:95385 Cao D, Wang Z, Zhang CL, Oh J, Xing W, Li S, Richardson JA, Wang DZ, Olson EN, Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan;25(1):364-76
1	J:93021 Chang S, McKinsey TA, Zhang CL, Richardson JA, Hill JA, Olson EN, Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol. 2004 Oct;24(19):8467-76
1	J:116008 Chang S, Young BD, Li S, Qi X, Richardson JA, Olson EN, Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell. 2006 Jul 28;126(2):321-34
2	J:238877 Chen S, Yao X, Li Y, Saifudeen Z, Bachvarov D, El-Dahr SS, Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 2015 Mar 15;142(6):1180-92
1	J:251599 Chen W, Chen L, Zhang Z, Meng F, Huang G, Sheng P, Zhang Z, Liao W, MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. Biochim Biophys Acta. 2016 Dec;1863(12):2881-2891
3*	J:217429 Cho OH, Mallappa C, Hernandez-Hernandez JM, Rivera-Perez JA, Imbalzano AN, Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development. Dev Dyn. 2015 Jan;244(1):43-55
1	J:260456 Duteil D, Tourrette Y, Eberlin A, Willmann D, Patel D, Friedrichs N, Muller JM, Schule R, The histone acetyltransferase inhibitor Nir regulates epidermis development. Development. 2018 Mar 21;145(6):dev158543
1*	J:266522 Elsen GE, Bedogni F, Hodge RD, Bammler TK, MacDonald JW, Lindtner S, Rubenstein JLR, Hevner RF, The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571
1	J:306853 Feng Q, Luo Y, Zhang XN, Yang XF, Hong XY, Sun DS, Li XC, Hu Y, Li XG, Zhang JF, Li X, Yang Y, Wang Q, Liu GP, Wang JZ, MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. Autophagy. 2020 Apr;16(4):641-658
3*	J:240709 Ferreira RC, Popova EY, James J, Briones MR, Zhang SS, Barnstable CJ, Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina. J Biol Chem. 2017 Feb 10;292(6):2422-2440
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:93248 Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA, Dudekula DB, VanBuren V, Ko MS, Age-associated alteration of gene expression patterns in mouse oocytes. Hum Mol Genet. 2004 Nov 1;13(19):2263-78
2	J:162637 Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP, Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature. 2010 Jul 1;466(7302):62-7
6	J:210607 Jacob C, Lotscher P, Engler S, Baggiolini A, Varum Tavares S, Brugger V, John N, Buchmann-Moller S, Snider PL, Conway SJ, Yamaguchi T, Matthias P, Sommer L, Mantei N, Suter U, HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia. J Neurosci. 2014 Apr 23;34(17):6112-22
1	J:256001 Jung EM, Moffat JJ, Liu J, Dravid SM, Gurumurthy CB, Kim WY, Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707
4*	J:226173 Keil KP, Altmann HM, Abler LL, Hernandez LL, Vezina CM, Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. Dev Dyn. 2015 Nov;244(11):1404-14
2*	J:50869 Ko MSH, Threat TA, Wang X, Horton JH, Cui Y, Pryor E, Paris J , Wells-Smith J , Kitchen JR , Rowe LB , Eppig J , Satoh T , Brant L , Fujiwara H , Yotsumoto S , Nakashima H, Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
7*	J:76941 Lagger G, O'Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, Schuettengruber B, Hauser C, Brunmeir R, Jenuwein T, Seiser C, Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 2002 Jun 3;21(11):2672-81
4	J:168590 LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE, Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell. 2010 Dec 14;19(6):807-18
2	J:189468 Lenoir O, Flosseau K, Ma FX, Blondeau B, Mai A, Bassel-Duby R, Ravassard P, Olson EN, Haumaitre C, Scharfmann R, Specific control of pancreatic endocrine beta- and delta-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes. 2011 Nov;60(11):2861-71
2	J:264403 Li Q, Jiao J, Li H, Wan H, Zheng C, Cai J, Bao S, Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling. J Cell Sci. 2018 Jul 25;131(14):jcs217406
1*	J:135330 Li X, Kato Y, Tsuji Y, Tsunoda Y, The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. Cloning Stem Cells. 2008 Mar;10(1):133-42
3	J:264112 Liu H, Chen S, Yao X, Li Y, Chen CH, Liu J, Saifudeen Z, El-Dahr SS, Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles. Development. 2018 May 18;145(10):dev153619
2*	J:114661 Lyu YL, Lin CP, Azarova AM, Cai L, Wang JC, Liu LF, Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol. 2006 Nov;26(21):7929-41
1*	J:280803 Ma J, Zhang LQ, He ZX, He XX, Wang YJ, Jian YL, Wang X, Zhang BB, Su C, Lu J, Huang BQ, Zhang Y, Wang GY, Guo WX, Qiu DL, Mei L, Xiong WC, Zheng YW, Zhu XJ, Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin. PLoS Biol. 2019 Oct;17(10):e3000461
21*	J:137260 Ma P, Schultz RM, Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. Dev Biol. 2008 Jul 1;319(1):110-20
2*	J:104974 MacDonald JL, Gin CS, Roskams AJ, Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development. Dev Biol. 2005 Dec 15;288(2):461-73
4*	J:139010 MacDonald JL, Roskams AJ, Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development. Dev Dyn. 2008 Aug;237(8):2256-67
2	J:164144 Macdonald JL, Verster A, Berndt A, Roskams AJ, MBD2 and MeCP2 regulate distinct transitions in the stage-specific differentiation of olfactory receptor neurons. Mol Cell Neurosci. 2010 May;44(1):55-67
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2	J:249971 Milstone ZJ, Lawson G, Trivedi CM, Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development, and craniofacial morphogenesis. Dev Dyn. 2017 Dec;246(12):1015-1026
1	J:148408 Montgomery RL, Hsieh J, Barbosa AC, Richardson JA, Olson EN, Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7876-81
8*	J:170372 Murko C, Lagger S, Steiner M, Seiser C, Schoefer C, Pusch O, Expression of class I histone deacetylases during chick and mouse development. Int J Dev Biol. 2010;54(10):1527-37
1*	J:313620 Nabeshima R, Nishimura O, Maeda T, Shimizu N, Ide T, Yashiro K, Sakai Y, Meno C, Kadota M, Shiratori H, Kuraku S, Hamada H, Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Elife. 2018 Aug 2;7:e36435
1*	J:321553 Neupane S, Berardinelli SJ, Cameron DC, Grady RC, Komatsu DE, Percival CJ, Takeuchi M, Ito A, Liu TW, Nairn AV, Moremen KW, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. Matrix Biol. 2022 Feb 12;
3	J:240892 Nitarska J, Smith JG, Sherlock WT, Hillege MM, Nott A, Barshop WD, Vashisht AA, Wohlschlegel JA, Mitter R, Riccio A, A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Cell Rep. 2016 Nov 01;17(6):1683-1698
9*	J:194321 Nott A, Nitarska J, Veenvliet JV, Schacke S, Derijck AA, Sirko P, Muchardt C, Pasterkamp RJ, Smidt MP, Riccio A, S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3113-8
1	J:178379 Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P, Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
6*	J:268084 Saha A, Tiwari S, Dharmarajan S, Otteson DC, Belecky-Adams TL, Class I histone deacetylases in retinal progenitors and differentiating ganglion cells. Gene Expr Patterns. 2018 Dec;30:37-48
1	J:196596 Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA, Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Dev Biol. 2013 May 15;377(2):333-44
1	J:277890 Stefanovic S, Barnett P, van Duijvenboden K, Weber D, Gessler M, Christoffels VM, GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development. Nat Commun. 2014 Apr 28;5:3680
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
7	J:278287 Tang T, Zhang Y, Wang Y, Cai Z, Lu Z, Li L, Huang R, Hagelkruys A, Matthias P, Zhang H, Seiser C, Xie Y, HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development. Neuron. 2019 Mar 20;101(6):1117-1133.e5
1	J:337714 Taura Y, Tozawa T, Fujimoto T, Ichise E, Chiyonobu T, Itoh K, Iehara T, Myosin Va, a Novel Interaction Partner of STXBP1, Is Required to Transport Syntaxin1A to the Plasma Membrane. Neuroscience. 2023 Jun 12;524:256-268
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
6	J:213843 Tiwari S, Dharmarajan S, Shivanna M, Otteson DC, Belecky-Adams TL, Histone deacetylase expression patterns in developing murine optic nerve. BMC Dev Biol. 2014;14:30
11*	J:89931 Tou L, Liu Q, Shivdasani RA, Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol. 2004 Apr;24(8):3132-9
7	J:121697 Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA, Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31
2*	J:164279 Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, Hannenhalli S, Epstein JA, Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell. 2010 Sep 14;19(3):450-9
1*	J:176253 Vacik T, Stubbs JL, Lemke G, A novel mechanism for the transcriptional regulation of Wnt signaling in development. Genes Dev. 2011 Sep 1;25(17):1783-95
1	J:91601 Van Eynde A, Nuytten M, Dewerchin M, Schoonjans L, Keppens S, Beullens M, Moons L, Carmeliet P, Stalmans W, Bollen M, The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol. 2004 Jul;24(13):5863-74
1	J:94631 Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton JM, Richardson JA, Karsenty G, Olson EN, Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 2004 Nov 12;119(4):555-66
5	J:195044 Wang Y, Tian Y, Morley MP, Lu MM, Demayo FJ, Olson EN, Morrisey EE, Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell. 2013 Feb 25;24(4):345-58
1*	J:310487 Xiang C, Frietze KK, Bi Y, Li Y, Dal Pozzo V, Pal S, Alexander N, Baubet V, D'Acunto V, Mason CE, Davuluri RV, Dahmane N, RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons. Mol Cell Biol. 2021 Jun 23;41(7):e0052620
5	J:317798 Yoo JY, Larouche M, Goldowitz D, The expression of HDAC1 and HDAC2 during cerebellar cortical development. Cerebellum. 2013 Aug;12(4):534-46
3*	J:150849 Yu Z, Mannik J, Soto A, Lin KK, Andersen B, The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. EMBO J. 2009 Jul 8;28(13):1890-903
1	J:353625 Zhu Y, Huang Y, Tang T, Xie Y, HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural progenitor transition during brain development. iScience. 2024 Sep 20;27(9):110600