Gene Expression Literature Summary

• Symbol: Opn1mw
• Name: opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)
• ID: MGI:1097692

72 matching records from 72 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E17.5	E18.5	E	P
Immunohistochemistry (section)										1	56
In situ RNA (section)				1			1				8
Immunohistochemistry (whole mount)											5
Northern blot								1			3
Western blot											3
RT-PCR	1	1	1	1	2	1	1	1	1		20

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Opn1mw  opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)   (Synonyms: Gcp, green long wavelength sensitive cone opsin, green LWS cone opsin, Green opsin, G/R opsin, Midwavelength sensitive opsin, ML-opsin, M opsin, MWS opsin, Opn1lw, R/G opsin, Rsvp)
Results	Reference
4*	J:242163 Aavani T, Tachibana N, Wallace V, Biernaskie J, Schuurmans C, Temporal profiling of photoreceptor lineage gene expression during murine retinal development. Gene Expr Patterns. 2017 Jan;23-24:32-44
1*	J:197857 Ahmedli NB, Gribanova Y, Njoku CC, Naidu A, Young A, Mendoza E, Yamashita CK, Ozgul RK, Johnson JE, Fox DA, Farber DB, Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa. J Biol Chem. 2013 Apr 5;288(14):9742-54
1	J:305147 Aisa-Marin I, Lopez-Iniesta MJ, Milla S, Lillo J, Navarro G, de la Villa P, Marfany G, Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models. Neurobiol Dis. 2020 Dec;146:105122
1	J:273391 Aldunate EZ, Di Foggia V, Di Marco F, Hervas LA, Ribeiro JC, Holder DL, Patel A, Jannini TB, Thompson DA, Martinez-Barbera JP, Pearson RA, Ali RR, Sowden JC, Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision. Sci Rep. 2019 Feb 19;9(1):2314
1*	J:167740 Alfano G, Conte I, Caramico T, Avellino R, Arno B, Pizzo MT, Tanimoto N, Beck SC, Huber G, Dolle P, Seeliger MW, Banfi S, Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye. Development. 2011 Jan;138(2):261-71
1*	J:191149 Alves CH, Sanz Sanz A, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW, Wijnholds J, Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
1*	J:121116 Applebury ML, Farhangfar F, Glosmann M, Hashimoto K, Kage K, Robbins JT, Shibusawa N, Wondisford FE, Zhang H, Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis. Dev Dyn. 2007 May;236(5):1203-12
7*	J:70841 Bibb LC, Holt JK, Tarttelin EE, Hodges MD, Gregory-Evans K, Rutherford A, Lucas RJ, Sowden JC, Gregory-Evans CY, Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum Mol Genet. 2001 Jul 15;10(15):1571-9
1	J:278101 Brightman DS, Grant RL, Ruzycki PA, Suzuki R, Hennig AK, Chen S, MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep. 2018 Aug 9;8(1):11902
1	J:156665 Brzezinski JA 4th, Lamba DA, Reh TA, Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb;137(4):619-29
1	J:282598 Chaya T, Tsutsumi R, Varner LR, Maeda Y, Yoshida S, Furukawa T, Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation. EMBO J. 2019 Dec 2;38(23):e101409
2*	J:114905 Cheng H, Aleman TS, Cideciyan AV, Khanna R, Jacobson SG, Swaroop A, In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development. Hum Mol Genet. 2006 Sep 1;15(17):2588-602
1	J:266104 Choi JH, Jo HS, Lim S, Kim HT, Lee KW, Moon KH, Ha T, Kwak SS, Kim Y, Lee EJ, Joe CO, Kim JW, mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502
1	J:297748 Collin GB, Won J, Krebs MP, Hicks WJ, Charette JR, Naggert JK, Nishina PM, Disruption in murine Eml1 perturbs retinal lamination during early development. Sci Rep. 2020 Mar 27;10(1):5647
1*	J:107820 Corbo JC, Cepko CL, A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-Cone Syndrome. PLoS Genet. 2005 Aug 5;1(2):e11
1	J:287119 Cross SH, Mckie L, Hurd TW, Riley S, Wills J, Barnard AR, Young F, MacLaren RE, Jackson IJ, The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification. PLoS Genet. 2020 Apr;16(4):e1008583
1	J:173617 de Melo J, Peng GH, Chen S, Blackshaw S, The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneurons. Development. 2011 Jun;138(11):2325-36
1	J:284934 Findlay AS, McKie L, Keighren M, Clementson-Mobbs S, Sanchez-Pulido L, Wells S, Cross SH, Jackson IJ, Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function. Sci Rep. 2020 Jan 16;10(1):437
1	J:242481 Fu Y, Liu H, Ng L, Kim JW, Hao H, Swaroop A, Forrest D, Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor beta by the rod transcription factor NRL. J Biol Chem. 2014 Nov 21;289(47):32469-80
2*	J:143073 Fujieda H, Bremner R, Mears AJ, Sasaki H, Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development. J Neurochem. 2009 Jan;108(1):91-101
1	J:251433 Ha T, Moon KH, Dai L, Hatakeyama J, Yoon K, Park HS, Kong YY, Shimamura K, Kim JW, The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. Cell Rep. 2017 Apr 11;19(2):351-363
1	J:336925 Huang H, Kuang X, Zou Y, Zeng J, Du H, Tang H, Long C, Mao Y, Yu X, Wen C, Yan J, Shen H, MAP4K4 is involved in the neuronal development of retinal photoreceptors. Exp Eye Res. 2023 Jun 7;233:109524
1	J:286621 Iwagawa T, Aihara Y, Umutoni D, Baba Y, Murakami A, Miyado K, Watanabe S, Cd9 Protects Photoreceptors from Injury and Potentiates Edn2 Expression. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):7
1	J:105970 Jadhav AP, Mason HA, Cepko CL, Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development. 2006 Mar;133(5):913-23
3*	J:153683 Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D, Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17534-9
1*	J:203004 Karunakaran DK, Congdon S, Guerrette T, Banday AR, Lemoine C, Chhaya N, Kanadia R, The expression analysis of Sfrs10 and Celf4 during mouse retinal development. Gene Expr Patterns. 2013 Dec;13(8):425-36
1	J:160529 Katoh K, Omori Y, Onishi A, Sato S, Kondo M, Furukawa T, Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development. J Neurosci. 2010 May 12;30(19):6515-26
1	J:193195 Katoh K, Yamazaki R, Onishi A, Sanuki R, Furukawa T, G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells. J Neurosci. 2012 Dec 5;32(49):17658-70
1	J:279264 Kaufman ML, Park KU, Goodson NB, Chew S, Bersie S, Jones KL, Lamba DA, Brzezinski JA 4th, Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation. Dev Biol. 2019 Sep 15;453(2):155-167
1	J:335074 Kuzelova A, Dupacova N, Antosova B, Sunny SS, Kozmik Z Jr, Paces J, Skoultchi AI, Stopka T, Kozmik Z, Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Cells. 2023 Mar 28;12(7)
1	J:306330 Le D, Lim S, Min KW, Park JW, Kim Y, Ha T, Moon KH, Wagner KU, Kim JW, Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity. Mol Cells. 2021 Mar 31;44(3):168-178
1	J:282250 Li Y, Hao H, Swerdel MR, Cho HY, Lee KB, Hart RP, Lyu YL, Cai L, Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network. J Neurosci Res. 2017 Oct;95(10):1951-1964
1	J:314167 Lim S, Kim YJ, Park S, Choi JH, Sung YH, Nishimori K, Kozmik Z, Lee HW, Kim JW, mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079
2*	J:131378 Liu H, Etter P, Hayes S, Jones I, Nelson B, Hartman B, Forrest D, Reh TA, NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina. J Neurosci. 2008 Jan 16;28(3):749-56
7	J:335506 Liu H, Lu A, Kelley KA, Forrest D, Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function. Endocrinology. 2023 Jan 9;164(3)
2	J:357738 Liu Y, Ng L, Liu H, Heuer H, Forrest D, Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2402560121
3	J:158094 Lu A, Ng L, Ma M, Kefas B, Davies TF, Hernandez A, Chan CC, Forrest D, Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice. Endocrinology. 2009 Mar;150(3):1536-44
3*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
1	J:167071 Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH, Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol. 2011 Jan 1;349(1):90-9
1	J:141248 Mao CA, Wang SW, Pan P, Klein WH, Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. Development. 2008 Oct;135(20):3379-88
1*	J:297493 Matos-Rodrigues GE, Tan PB, Rocha-Martins M, Charlier CF, Gomes AL, Cabral-Miranda F, Grigaravicius P, Hofmann TG, Frappart PO, Martins RAP, Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome. Dis Model Mech. 2020 Oct 30;13(10):dmm045807
1	J:333797 Min KW, Kim N, Lee JH, Sung Y, Kim M, Lee EJ, Kim JM, Kim JH, Lee J, Cho W, Yang JM, Kim N, Kim J, Lee CJ, Park YG, Lee SH, Lee HW, Kim JW, Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant. Exp Mol Med. 2023 Feb;55(2):385-400
1*	J:88451 Mori M, Metzger D, Picaud S, Hindelang C, Simonutti M, Sahel J, Chambon P, Mark M, Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium. Am J Pathol. 2004 Feb;164(2):701-10
3	J:66737 Ng L, Hurley JB, Dierks B, Srinivas M, Salto C, Vennstrom B, Reh TA, Forrest D, A thyroid hormone receptor that is required for the development of green cone photoreceptors. Nat Genet. 2001 Jan;27(1):94-8
2	J:334815 Ng L, Liu H, Liu Y, Forrest D, Biphasic expression of thyroid hormone receptor TRbeta1 in mammalian retina and anterior ocular tissues. Front Endocrinol (Lausanne). 2023;14:1174600
3	J:174592 Ng L, Lu A, Swaroop A, Sharlin DS, Swaroop A, Forrest D, Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development. J Neurosci. 2011 Aug 3;31(31):11118-25
1	J:159022 Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B, St Germain DL, Hernandez A, Pugh EN Jr, Forrest D, Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. J Neurosci. 2010 Mar 3;30(9):3347-57
1	J:355222 Nord C, Jones I, Garcia-Maestre M, Hagglund AC, Carlsson L, Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits. Dev Dyn. 2024 Oct;253(10):922-939
2	J:248772 Olivares AM, Han Y, Soto D, Flattery K, Marini J, Mollema N, Haider A, Escher P, DeAngelis MM, Haider NB, The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017 Sep 1;429(1):343-355
1	J:178434 Omori Y, Chaya T, Katoh K, Kajimura N, Sato S, Muraoka K, Ueno S, Koyasu T, Kondo M, Furukawa T, Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22671-6
1	J:230346 Omori Y, Kitamura T, Yoshida S, Kuwahara R, Chaya T, Irie S, Furukawa T, Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Genes Cells. 2015 May;20(5):408-26
1	J:303303 Pan M, Yin Y, Wang X, Wang Q, Zhang L, Hu H, Wang C, Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. Autophagy. 2020 Aug 2;:1-16
1	J:186563 Prasov L, Glaser T, Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7). Dev Biol. 2012 Aug 15;368(2):214-30
1	J:309713 Rhee KD, Yu J, Zhao CY, Fan G, Yang XJ, Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival. Cell Death Dis. 2012 Nov 22;3:e427
1	J:154061 Riesenberg AN, Liu Z, Kopan R, Brown NL, Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci. 2009 Oct 14;29(41):12865-77
2	J:103712 Roberts MR, Hendrickson A, McGuire CR, Reh TA, Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina. Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2897-904
1*	J:264207 Rodgers HM, Huffman VJ, Voronina VA, Lewandoski M, Mathers PH, The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Mech Dev. 2018 Jun;151:18-29
1	J:239714 Ronquillo CC, Hanke-Gogokhia C, Revelo MP, Frederick JM, Jiang L, Baehr W, Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation. FASEB J. 2016 Oct;30(10):3400-3412
1	J:179521 Saghizadeh M, Gribanova Y, Akhmedov NB, Farber DB, ZBED4, a cone and Muller cell protein in human retina, has a different cellular expression in mouse. Mol Vis. 2011;17:2011-8
3	J:179784 Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Uneo S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T, miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci. 2011 Sep;14(9):1125-34
1	J:216471 Sapkota D, Chintala H, Wu F, Fliesler SJ, Hu Z, Mu X, Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4086-95
1	J:153655 Satoh S, Tang K, Iida A, Inoue M, Kodama T, Tsai SY, Tsai MJ, Furuta Y, Watanabe S, The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors. J Neurosci. 2009 Oct 7;29(40):12401-11
1	J:293722 Sawant OB, Jidigam VK, Fuller RD, Zucaro OF, Kpegba C, Yu M, Peachey NS, Rao S, The circadian clock gene Bmal1 is required to control the timing of retinal neurogenesis and lamination of Muller glia in the mouse retina. FASEB J. 2019 Aug;33(8):8745-8758
1	J:320423 Sharma V, Nayak J, DeRossi C, Charbono A, Ichikawa M, Ng BG, Grajales-Esquivel E, Srivastava A, Wang L, He P, Scott DA, Russell J, Contreras E, Guess CM, Krajewski S, Del Rio-Tsonis K, Freeze HH, Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice. FASEB J. 2014 Apr;28(4):1854-69
2*	J:249375 Smiley S, Nickerson PE, Comanita L, Daftarian N, El-Sehemy A, Tsai EL, Matan-Lithwick S, Yan K, Thurig S, Touahri Y, Dixit R, Aavani T, De Repentingy Y, Baker A, Tsilfidis C, Biernaskie J, Sauve Y, Schuurmans C, Kothary R, Mears AJ, Wallace VA, Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line. Sci Rep. 2016 Mar 11;6:22867
1	J:111028 Srinivas M, Ng L, Liu H, Jia L, Forrest D, Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta. Mol Endocrinol. 2006 Aug;20(8):1728-41
1	J:91136 Tasheva ES, Ke A, Deng Y, Jun C, Takemoto LJ, Koester A, Conrad GW, Differentially expressed genes in the lens of mimecan-null mice. Mol Vis. 2004 Jun 17;10:403-16
2*	J:279788 Wen B, Li S, Li H, Chen Y, Ma X, Wang J, Lu F, Qu J, Hou L, Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium. Sci Rep. 2016 Feb 15;6:21208
1*	J:274764 Wu KC, Chen XJ, Jin GH, Wang XY, Yang DD, Li YP, Xiang L, Zhang BW, Zhou GH, Zhang CJ, Jin ZB, Deletion of miR-182 Leads to Retinal Dysfunction in Mice. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1265-1274
2*	J:108438 Yanagi Y, Takezawa S, Kato S, Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3489-94
1	J:326028 Yang Y, Jiang X, Li X, Sun K, Zhu X, Zhou B, Specific ablation of Hippo signalling component Yap1 in retinal progenitors and Muller cells results in late onset retinal degeneration. J Cell Physiol. 2022 Jun;237(6):2673-2689
1	J:108702 Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM, Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 2006 May 15;20(10):1308-20