Gene Expression Literature Summary

• Symbol: Jag2
• Name: jagged 2
• ID: MGI:1098270

146 matching records from 146 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1.5	E2	E2.5	E3.5	E4	E4.5	E5.5	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E20	E	P
Immunohistochemistry (section)														1		1		1		1	2		2	1	1		1		1			2	1		1
In situ RNA (section)							1	1	2	1	1	3	1	8	1	4	2	21	3	14	3	21	2	16		10	1	8	1	11	1			5	12
In situ RNA (whole mount)										2	3	4	3	4	2	4	1	2	1	2		1		1					1					2
In situ reporter (knock in)																																			1
Northern blot																																			3
Western blot																		1										1				1
RT-PCR	1	2	1	2	2	1	1	1		1	3	6	1	6	3	3	3	6	4	11	1	12	3	5	2	11	3	8	1	6		1		3	27
cDNA clones																2		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Jag2  jagged 2   (Synonyms: D12Ggc2e, Serh)
Results	Reference
1*	J:82633 Adamska M, MacDonald BT, Meisler MH, Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb. Dev Biol. 2003 Mar 15;255(2):350-62
1	J:95764 Alappat SR, Zhang Z, Suzuki K, Zhang X, Liu H, Jiang R, Yamada G, Chen Y, The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol. 2005 Jan 1;277(1):102-13
4	J:251150 Aoki H, Ogino H, Tomita H, Hara A, Kunisada T, Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:49606 Bell SM, Lan Y, Jiang R, Gridley T, Exclusion of Jagged2 as a candidate for the legless gene. Mamm Genome. 1998 Sep;9(9):778-9
1	J:249355 Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bauerle T, Hartwig J, Baumgart J, Kruger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH, Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun. 2017 Jun 28;8:15922
1	J:282886 Blackwood CA, Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone. Neuroscience. 2019 Aug 10;413:230-238
3	J:291930 Blackwood CA, Bailetti A, Nandi S, Gridley T, Hebert JM, Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice. Front Cell Dev Biol. 2020;8:113
3	J:147887 Borkosky SS, Nagatsuka H, Orita Y, Tsujigiwa H, Yoshinobu J, Gunduz M, Rodriguez AP, Missana LR, Nishizaki K, Nagai N, Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse. Biocell. 2008 Dec;32(3):251-8
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
1	J:185338 Boucherat O, Chakir J, Jeannotte L, The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways. Biol Open. 2012;q:677-691
1	J:239317 Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK, Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. Differentiation. 2017 Mar - Apr;94:8-20
2	J:164021 Bremer J, O'Connor T, Tiberi C, Rehrauer H, Weis J, Aguzzi A, Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS One. 2010;5(8):e12450
2	J:76133 Brennan J, Karl J, Capel B, Divergent Vascular Mechanisms Downstream of Sry Establish the Arterial System in the XY Gonad. Dev Biol. 2002 Apr 15;244(2):418-28
5	J:310741 Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML, Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 2014 Dec 22;31(6):707-21
3*	J:51411 Bulfone A, Gattuso C, Marchitiello A, Pardini C, Boncinelli E, Borsani G, Banfi S, Ballabio A, The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function. Hum Mol Genet. 1998 Dec;7(13):1997-2006
1	J:92326 Burton Q, Cole LK, Mulheisen M, Chang W, Wu DK, The role of Pax2 in mouse inner ear development. Dev Biol. 2004 Aug 1;272(1):161-75
1	J:186083 Calderon L, Boehm T, Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments. Cell. 2012 Mar 30;149(1):159-72
1	J:289039 Candi E, Rufini A, Terrinoni A, Giamboi-Miraglia A, Lena AM, Mantovani R, Knight R, Melino G, DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11999-2004
1	J:264379 Cardenas A, Villalba A, de Juan Romero C, Pico E, Kyrousi C, Tzika AC, Tessier-Lavigne M, Ma L, Drukker M, Cappello S, Borrell V, Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell. 2018 Jul 26;174(3):590-606.e21
2	J:108618 Carson C, Murdoch B, Roskams AJ, Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium. Dev Dyn. 2006 Jun;235(6):1678-88
1	J:170491 Casanova JC, Uribe V, Badia-Careaga C, Giovinazzo G, Torres M, Sanz-Ezquerro JJ, Apical ectodermal ridge morphogenesis in limb development is controlled by Arid3b-mediated regulation of cell movements. Development. 2011 Mar;138(6):1195-205
3	J:108824 Casey LM, Lan Y, Cho ES, Maltby KM, Gridley T, Jiang R, Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn. 2006 Apr 10;235(7):1830-1844
1*	J:75936 Cau E, Casarosa S, Guillemot F, Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development. 2002 Apr;129(8):1871-80
3	J:97734 Chen L, Al-Awqati Q, Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol. 2005 May;288(5):F939-52
1	J:205488 Chin SS, Romano RA, Nagarajan P, Sinha S, Garrett-Sinha LA, Aberrant epidermal differentiation and disrupted DeltaNp63/Notch regulatory axis in Ets1 transgenic mice. Biol Open. 2013;2(12):1336-45
1	J:229484 Conte D, Garaffo G, Lo Iacono N, Mantero S, Piccolo S, Cordenonsi M, Perez-Morga D, Orecchia V, Poli V, Merlo GR, The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand. Hum Mol Genet. 2016 Feb 15;25(4):740-54
4*	J:93160 Cormier S, Vandormael-Pournin S, Babinet C, Cohen-Tannoudji M, Developmental expression of the Notch signaling pathway genes during mouse preimplantation development. Gene Expr Patterns. 2004 Oct;4(6):713-7
1	J:171226 Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B, GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
9	J:271384 D'Amato G, Luxan G, del Monte-Nieto G, Martinez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jimenez-Borreguero LJ, de la Pompa JL, Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol. 2016 Jan;18(1):7-20
1	J:178290 del Monte G, Casanova JC, Guadix JA, MacGrogan D, Burch JB, Perez-Pomares JM, de la Pompa JL, Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis. Circ Res. 2011 Apr 1;108(7):824-36
1	J:215675 Deng M, Luo XJ, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan AE, Gan L, LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea. J Neurosci. 2014 Jul 23;34(30):10072-7
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4*	J:206224 Dixit R, Tachibana N, Touahri Y, Zinyk D, Logan C, Schuurmans C, Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expr Patterns. 2014 Jan;14(1):42-54
2	J:257440 Dvoriantchikova G, Tao W, Pappas S, Gaidosh G, Tse DT, Ivanov D, Pelaez D, Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1098-1109
3	J:264144 Eley L, Alqahtani AM, MacGrogan D, Richardson RV, Murphy L, Salguero-Jimenez A, Sintes Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson DJ, A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7:e34110
3	J:272386 Fan X, Wang D, Burgmaier JE, Teng Y, Romano RA, Sinha S, Yi R, Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin. Dev Cell. 2018 Oct 8;47(1):21-37.e5
3	J:63320 Favier B, Fliniaux I, Thelu J, Viallet JP, Demarchez M, Jahoda CA, Dhouailly D, Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators. Dev Dyn. 2000 Jul;218(3):426-37
3	J:56675 Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A, Screpanti I, Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int Immunol. 1999 Jul;11(7):1017-25
4	J:218584 Feng YM, Liang GJ, Pan B, Qin XS, Zhang XF, Chen CL, Li L, Cheng SF, De Felici M, Shen W, Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse. Cell Cycle. 2014;13(5):782-91
1	J:214092 Firulli BA, Fuchs RK, Vincentz JW, Clouthier DE, Firulli AB, Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development. 2014 Aug;141(15):3050-61
1	J:102852 Francis JC, Radtke F, Logan MP, Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud. Dev Dyn. 2005 Dec;234(4):1006-15
1	J:183770 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H, Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012 Jun 1;21(11):2524-37
6*	J:199123 Gasperowicz M, Rai A, Cross JC, Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta. Gene Expr Patterns. 2013 Oct;13(7):249-54
1*	J:87736 Gazit R, Krizhanovsky V, Ben-Arie N, Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Development. 2004 Feb;131(4):903-13
5*	J:152922 Golson ML, Le Lay J, Gao N, Bramswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH, Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech Dev. 2009 Aug-Sep;126(8-9):687-99
6	J:183603 Grieskamp T, Rudat C, Ludtke TH, Norden J, Kispert A, Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res. 2011 Apr 1;108(7):813-23
1	J:104840 Grishina IB, Kim SY, Ferrara C, Makarenkova HP, Walden PD, BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev Biol. 2005 Dec 15;288(2):334-47
6*	J:187652 Guo M, Zhang H, Bian F, Li G, Mu X, Wen J, Mao G, Teng Z, Xia G, Zhang M, P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis. Front Biosci (Elite Ed). 2012 Jun 1;4:2631-44
1	J:251433 Ha T, Moon KH, Dai L, Hatakeyama J, Yoon K, Park HS, Kong YY, Shimamura K, Kim JW, The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. Cell Rep. 2017 Apr 11;19(2):351-363
1	J:96967 Hahn KL, Johnson J, Beres BJ, Howard S, Wilson-Rawls J, Lunatic fringe null female mice are infertile due to defects in meiotic maturation. Development. 2005 Feb;132(4):817-28
1	J:306386 Han X, Wei Y, Wu X, Gao J, Yang Z, Zhao C, PDK1 Regulates Transition Period of Apical Progenitors to Basal Progenitors by Controlling Asymmetric Cell Division. Cereb Cortex. 2020 Jan 10;30(1):406-420
2*	J:125514 Hartman BH, Hayashi T, Nelson BR, Bermingham-McDonogh O, Reh TA, Dll3 is expressed in developing hair cells in the mammalian cochlea. Dev Dyn. 2007 Oct;236(10):2875-83
5	J:84012 Hayes AJ, Dowthwaite GP, Webster SV, Archer CW, The distribution of Notch receptors and their ligands during articular cartilage development. J Anat. 2003 Jun;202(6):495-502
1*	J:339600 Hermosilla Aguayo V, Martin P, Tian N, Zheng J, Aho R, Losa M, Selleri L, ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling. Dev Biol. 2023 Aug 10;503:25-42
1	J:118039 High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA, An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest. 2007 Feb 1;117(2):353-363
1	J:232434 Huang H, Yang X, Bao M, Cao H, Miao X, Zhang X, Gan L, Qiu M, Zhang Z, Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem. 2016 Mar 25;291(13):7107-18
1	J:317063 Huang X, Zhao K, Jiang M, Qiu D, Zhou J, Yang Z, The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms. J Biol Chem. 2021 Nov 25;298(1):101449
2	J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120
1*	J:170495 Ikeda K, Kageyama R, Suzuki Y, Kawakami K, Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. Int J Dev Biol. 2010;54(10):1453-64
1	J:124645 Itoi M, Tsukamoto N, Yoshida H, Amagai T, Mesenchymal cells are required for functional development of thymic epithelial cells. Int Immunol. 2007 Aug;19(8):953-64
5	J:46930 Jiang R, Lan Y, Chapman HD, Shawber C, Norton CR, Serreze DV, Weinmaster G, Gridley T, Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 1998 Apr 1;12(7):1046-57
4	J:137800 Jin JZ, Li Q, Higashi Y, Darling DS, Ding J, Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion. Cell Tissue Res. 2008 Jul;333(1):29-38
2*	J:161213 Jin JZ, Tan M, Warner DR, Darling DS, Higashi Y, Gridley T, Ding J, Mesenchymal cell remodeling during mouse secondary palate reorientation. Dev Dyn. 2010 Jul;239(7):2110-7
3*	J:216310 Jin JZ, Warner DR, Lu Q, Pisano MM, Greene RM, Ding J, Deciphering TGF-beta3 function in medial edge epithelium specification and fusion during mouse secondary palate development. Dev Dyn. 2014 Dec;243(12):1536-43
1*	J:49462 Jones P, May G, Healy L, Brown J, Hoyne G, Delassus S, Enver T, Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells. Blood. 1998 Sep 1;92(5):1505-11
1	J:234343 Kawasaki M, Kawasaki K, Oommen S, Blackburn J, Watanabe M, Nagai T, Kitamura A, Maeda T, Liu B, Schmidt-Ullrich R, Akiyama T, Inoue J, Hammond NL, Sharpe PT, Ohazama A, Regional regulation of Filiform tongue papillae development by Ikkalpha/Irf6. Dev Dyn. 2016 Sep;245(9):937-46
6	J:245137 Kawata M, Taniguchi Y, Mori D, Yano F, Ohba S, Chung UI, Shimogori T, Mills AA, Tanaka S, Saito T, Different regulation of limb development by p63 transcript variants. PLoS One. 2017;12(3):e0174122
1	J:180905 Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA, Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug;138(15):3225-33
4	J:176833 Kim TH, Shivdasani RA, Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med. 2011 Apr 11;208(4):677-88
1	J:199204 Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M, Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice. Hepatology. 2013 Jun;57(6):2502-13
11	J:96080 Kong Y, Glickman J, Subramaniam M, Shahsafaei A, Allamneni KP, Aster JC, Sklar J, Sunday ME, Functional diversity of notch family genes in fetal lung development. Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L1075-83
1	J:130369 Koo BK, Yoon MJ, Yoon KJ, Im SK, Kim YY, Kim CH, Suh PG, Jan YN, Kong YY, An obligatory role of mind bomb-1 in notch signaling of Mammalian development. PLoS One. 2007;2(11):e1221
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:244349 Kousa YA, Moussa D, Schutte BC, IRF6 expression in basal epithelium partially rescues Irf6 knockout mice. Dev Dyn. 2017 Sep;246(9):670-681
2	J:225061 Kouskoura T, Kozlova A, Alexiou M, Blumer S, Zouvelou V, Katsaros C, Chiquet M, Mitsiadis TA, Graf D, The etiology of cleft palate formation in BMP7-deficient mice. PLoS One. 2013;8(3):e59463
2	J:62571 Krebs LT, Xue Y, Norton CR, Shutter JR, Maguire M, Sundberg JP, Gallahan D, Closson V, Kitajewski J, Callahan R, Smith GH, Stark KL, Gridley T, Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 2000 Jun 1;14(11):1343-52
4*	J:321979 Kurz J, Weiss AC, Thiesler H, Qasrawi F, Deuper L, Kaur J, Rudat C, Ludtke TH, Wojahn I, Hildebrandt H, Trowe MO, Kispert A, Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735
1*	J:88448 Kusumi K, Dunwoodie SL, Krumlauf R, Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system. Mech Dev. 2001 Jan;100(1):141-4
1*	J:63189 Lammert E, Brown J, Melton DA, Notch gene expression during pancreatic organogenesis. Mech Dev. 2000 Jun;94(1-2):199-203
2*	J:53432 Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T , Kelley MW, Notch signalling pathway mediates hair cell development in mammalian cochlea [see comments]. Nat Genet. 1999 Mar;21(3):289-92
2	J:107400 Laurikkala J, Mikkola ML, James M, Tummers M, Mills AA, Thesleff I, p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development. 2006 Apr;133(8):1553-63
1*	J:85874 Leimeister C, Schumacher N, Gessler M, Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development. Gene Expr Patterns. 2003 Oct;3(5):595-8
1	J:300878 Lena AM, Rossi V, Osterburg S, Smirnov A, Osterburg C, Tuppi M, Cappello A, Amelio I, Dotsch V, De Felici M, Klinger FG, Annicchiarico-Petruzzelli M, Valensise H, Melino G, Candi E, The p63 C-terminus is essential for murine oocyte integrity. Nat Commun. 2021 Jan 15;12(1):383
2	J:264609 Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y, Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 Sep 1;441(1):191-203
1	J:185603 Li S, Wang Y, Zhang Y, Lu MM, Demayo FJ, Dekker JD, Tucker PW, Morrisey EE, Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 2012 Jul;139(14):2500-9
7*	J:42994 Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J, Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol. 1997 Oct;17(10):6057-67
1	J:73776 Lutolf S, Radtke F, Aguet M, Suter U, Taylor V, Notch1 is required for neuronal and glial differentiation in the cerebellum. Development. 2002 Jan;129(2):373-85
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
4	J:320754 Martin-Lanneree S, Halliez S, Hirsch TZ, Hernandez-Rapp J, Passet B, Tomkiewicz C, Villa-Diaz A, Torres JM, Launay JM, Beringue V, Vilotte JL, Mouillet-Richard S, The Cellular Prion Protein Controls Notch Signaling in Neural Stem/Progenitor Cells. Stem Cells. 2017 Mar;35(3):754-765
2	J:194050 Massa F, Garbay S, Bouvier R, Sugitani Y, Noda T, Gubler MC, Heidet L, Pontoglio M, Fischer E, Hepatocyte nuclear factor 1beta controls nephron tubular development. Development. 2013 Feb;140(4):886-96
1*	J:67157 McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weinmaster G, Jiang R, Gridley T, Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development. 2001 Feb;128(4):491-502
3	J:332403 Miller SR, Perera SN, Benito C, Stott SR, Baker CV, Evidence for a Notch1-mediated transition during olfactory ensheathing cell development. J Anat. 2016 Sep;229(3):369-83
6	J:164590 Mitsiadis TA, Graf D, Luder H, Gridley T, Bluteau G, BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Development. 2010 Sep;137(18):3025-35
6	J:339608 Mitsiadis TA, Pagella P, Capellini TD, Smith MM, The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model. Cell Mol Life Sci. 2023 Jun 18;80(7):182
1	J:334075 Mitsiadis TA, Pagella P, Gomes Rodrigues H, Tsouknidas A, Ramenzoni LL, Radtke F, Mehl A, Viriot L, Notch Signaling Pathway in Tooth Shape Variations throughout Evolution. Cells. 2023 Feb 27;12(5)
2	J:98508 Mitsiadis TA, Regaudiat L, Gridley T, Role of the Notch signalling pathway in tooth morphogenesis. Arch Oral Biol. 2005 Feb;50(2):137-40
2	J:238903 Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV, Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15;142(2):258-67
1*	J:192269 Mukhopadhyay A, Krishnaswami SR, Cowing-Zitron C, Hung NJ, Reilly-Rhoten H, Burns J, Yu BD, Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development. Dev Biol. 2013 Jan 15;373(2):373-82
4*	J:78344 Mustonen T, Tummers M, Mikami T, Itoh N, Zhang N, Gridley T, Thesleff I, Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Dev Biol. 2002 Aug 15;248(2):281-93
2	J:42726 Nakayama H, Liu Y, Stifani S, Cross JC, Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev Genet. 1997;21(1):21-30
1	J:214133 Nantie LB, Himes AD, Getz DR, Raetzman LT, Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification. Mol Endocrinol. 2014 May;28(5):731-44
4*	J:151457 Nelson BR, Hartman BH, Ray CA, Hayashi T, Bermingham-McDonogh O, Reh TA, Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn. 2009 Feb 2;238(9):2163-2178
2*	J:86842 Norgaard GA, Jensen JN, Jensen J, FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol. 2003 Dec 15;264(2):323-38
1	J:167091 Nyeng P, Bjerke MA, Norgaard GA, Qu X, Kobberup S, Jensen J, Fibroblast growth factor 10 represses premature cell differentiation during establishment of the intestinal progenitor niche. Dev Biol. 2011 Jan 1;349(1):20-34
6	J:134393 Nyeng P, Norgaard GA, Kobberup S, Jensen J, FGF10 signaling controls stomach morphogenesis. Dev Biol. 2007 Mar 1;303(1):295-310
1	J:274877 Padget RL, Mohite SS, Hoog TG, Justis BS, Green BE, Udan RS, Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development. Mech Dev. 2019 Apr;156:8-19
1*	J:65652 Post LC, Ternet M, Hogan BL, Notch/Delta expression in the developing mouse lung. Mech Dev. 2000 Nov;98(1-2):95-8
2	J:51644 Powell BC, Passmore EA, Nesci A, Dunn SM, The Notch signalling pathway in hair growth. Mech Dev. 1998 Nov;78(1-2):189-92
1*	J:244304 Richardson R, Mitchell K, Hammond NL, Mollo MR, Kouwenhoven EN, Wyatt ND, Donaldson IJ, Zeef L, Burgis T, Blance R, van Heeringen SJ, Stunnenberg HG, Zhou H, Missero C, Romano RA, Sinha S, Dixon MJ, Dixon J, p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017 Jun;13(6):e1006828
2	J:150009 Richardson RJ, Dixon J, Jiang R, Dixon MJ, Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence. Hum Mol Genet. 2009 Jul 15;18(14):2632-42
3	J:97176 Robert-Moreno A, Espinosa L, de la Pompa JL, Bigas A, RBPj{kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development. 2005 Mar;132(5):1117-26
1	J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503
2	J:137647 Robert-Moreno A, Guiu J, Ruiz-Herguido C, Lopez ME, Ingles-Esteve J, Riera L, Tipping A, Enver T, Dzierzak E, Gridley T, Espinosa L, Bigas A, Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J. 2008 Jul 9;27(13):1886-95
2	J:323229 Rosendahl AH, Monnius M, Laitala A, Railo A, Miinalainen I, Heljasvaara R, Maki JM, Myllyharju J, Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia. J Biol Chem. 2022 Mar 2;298(4):101787
3*	J:82198 Schroder N, Gossler A, Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr Patterns. 2002 Dec;2(3-4):247-50
1	J:119082 Schuster-Gossler K, Cordes R, Gossler A, Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):537-42
4	J:84674 Seta Y, Seta C, Barlow LA, Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions. J Comp Neurol. 2003 Sep 8;464(1):49-61
4*	J:43502 Sidow A, Bulotsky MS, Kerrebrock AW, Bronson RT, Daly MJ, Reeve MP , Hawkins TL , Birren BW , Jaenisch R , Lander ES, Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature. 1997 Oct 16;389(6652):722-5
8*	J:294646 Stupnikov MR, Yang Y, Mori M, Lu J, Cardoso WV, Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation. Elife. 2019 Oct 21;8:e50487
4*	J:87397 Sumazaki R, Shiojiri N, Isoyama S, Masu M, Keino-Masu K, Osawa M, Nakauchi H, Kageyama R, Matsui A, Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet. 2004 Jan;36(1):83-7
1	J:78402 Sun X, Mariani FV, Martin GR, Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature. 2002 Aug 1;418(6897):501-8
2	J:236406 Takada Y, Fukuda A, Chiba T, Seno H, Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling. Development. 2016 Oct 1;143(19):3532-3539
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1	J:112461 Tang LS, Alger HM, Pereira FA, COUP-TFI controls Notch regulation of hair cell and support cell differentiation. Development. 2006 Sep;133(18):3683-93
1	J:230519 Tashakori M, Zhang Y, Xiong S, You MJ, Lozano G, p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis. Mol Cancer Res. 2016 Jan;14(1):56-65
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:87765 Timmerman LA, Grego-Bessa J, Raya A, Bertran E, Perez-Pomares JM, Diez J, Aranda S, Palomo S, McCormick F, Izpisua-Belmonte JC, de la Pompa JL, Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 2004 Jan 1;18(1):99-115
2	J:142471 Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV, Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24;283(43):29532-44
2*	J:310882 Urbanek ME, Zuo J, Genetic predisposition to tinnitus in the UK Biobank population. Sci Rep. 2021 Sep 13;11(1):18150
5*	J:46031 Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI, JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions. Mech Dev. 1997 Dec;69(1-2):203-7
1	J:161912 van den Akker NM, Caolo V, Wisse LJ, Peters PP, Poelmann RE, Carmeliet P, Molin DG, Gittenberger-de Groot AC, Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Cardiovasc Res. 2008 May 1;78(2):366-75
1	J:133799 van den Akker NM, Molin DG, Peters PP, Maas S, Wisse LJ, van Brempt R, van Munsteren CJ, Bartelings MM, Poelmann RE, Carmeliet P, Gittenberger-de Groot AC, Tetralogy of fallot and alterations in vascular endothelial growth factor-A signaling and notch signaling in mouse embryos solely expressing the VEGF120 isoform. Circ Res. 2007 Mar 30;100(6):842-9
7	J:213069 Vanorny DA, Prasasya RD, Chalpe AJ, Kilen SM, Mayo KE, Notch signaling regulates ovarian follicle formation and coordinates follicular growth. Mol Endocrinol. 2014 Apr;28(4):499-511
1*	J:71910 Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G, Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev. 2001 Oct;108(1-2):161-4
5	J:291481 Wang L, Xie J, Zhang H, Tsang LH, Tsang SL, Braune EB, Lendahl U, Sham MH, Notch signalling regulates epibranchial placode patterning and segregation. Development. 2020 Feb 17;147(4):dev183665
1	J:295894 Wei G, Gao N, Chen J, Fan L, Zeng Z, Gao G, Li L, Fang G, Hu K, Pang X, Fan HY, Clevers H, Liu M, Zhang X, Li D, Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation. Development. 2020 Sep 2;147(17):dev185678
4	J:154916 Welsh IC, O'Brien TP, Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. Dev Biol. 2009 Dec 1;336(1):53-67
2	J:163652 Xu J, Krebs LT, Gridley T, Generation of mice with a conditional null allele of the Jagged2 gene. Genesis. 2010 Jun;48(6):390-3
1	J:173796 Yamamoto N, Chang W, Kelley MW, Rbpj regulates development of prosensory cells in the mammalian inner ear. Dev Biol. 2011 May 15;353(2):367-79
1	J:119916 Yang HS, Hinds PW, pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development. BMC Dev Biol. 2007;7:6
1	J:137915 Yoon MJ, Koo BK, Song R, Jeong HW, Shin J, Kim YW, Kong YY, Suh PG, Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol. 2008 Aug;28(15):4794-804
4	J:310317 Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H, Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res. 2014 Aug;24(8):925-42
1*	J:285853 Zhang S, Song Z, An L, Liu X, Hu XW, Naz A, Zhou R, Guo X, He L, Zhu H, WD40 repeat and FYVE domain containing 3 is essential for cardiac development. Cardiovasc Res. 2019 Jul 1;115(8):1320-1331
2	J:152966 Zhao X, D' Arca D, Lim WK, Brahmachary M, Carro MS, Ludwig T, Cardo CC, Guillemot F, Aldape K, Califano A, Iavarone A, Lasorella A, The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain. Dev Cell. 2009 Aug;17(2):210-21
4	J:148015 Zong Y, Panikkar A, Xu J, Antoniou A, Raynaud P, Lemaigre F, Stanger BZ, Notch signaling controls liver development by regulating biliary differentiation. Development. 2009 May;136(10):1727-39