Gene Expression Literature Summary

• Symbol: Prom1
• Name: prominin 1
• ID: MGI:1100886

72 matching records from 72 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	1	2	4	3	3	2	5	1	7	3	8		4	5	1	6		7	3		4	3	24
In situ RNA (section)									1		1		1	2		1	1		1		1		6
Immunohistochemistry (whole mount)																				1			1
In situ RNA (whole mount)		1	1
In situ reporter (knock in)					1		1				2			3				1					4
Northern blot																							2
Western blot						1	1	1	1	1	1	1	1				1						4
RT-PCR											1		1								2		6
cDNA clones																							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prom1  prominin 1   (Synonyms: 4932416E19Rik, AC133, CD133, Prom, Prom-1)
Results	Reference
1	J:312332 Arai Y, Sampaio JL, Wilsch-Brauninger M, Ettinger AW, Haffner C, Huttner WB, Lipidome of midbody released from neural stem and progenitor cells during mammalian cortical neurogenesis. Front Cell Neurosci. 2015;9:325
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:113146 Cappello S, Attardo A, Wu X, Iwasato T, Itohara S, Wilsch-Brauninger M, Eilken HM, Rieger MA, Schroeder TT, Huttner WB, Brakebusch C, Gotz M, The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci. 2006 Sep;9(9):1099-107
6	J:148440 Corbeil D, Joester A, Fargeas CA, Jaszai J, Garwood J, Hellwig A, Werner HB, Huttner WB, Expression of distinct splice variants of the stem cell marker prominin-1 (CD133) in glial cells. Glia. 2009 Jun;57(8):860-74
1*	J:152211 Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P, Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Glia. 2009 Oct;57(13):1450-7
1	J:226960 Cuevas E, Rybak-Wolf A, Rohde AM, Nguyen DT, Wulczyn FG, Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain. Front Cell Dev Biol. 2015;3:20
1	J:171226 Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B, GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
3*	J:194466 Denny KJ, Coulthard LG, Jeanes A, Lisgo S, Simmons DG, Callaway LK, Wlodarczyk B, Finnell RH, Woodruff TM, Taylor SM, C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. J Immunol. 2013 Apr 1;190(7):3493-9
1	J:166772 DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE, Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 2010;10:112
5	J:168197 Dubreuil V, Marzesco AM, Corbeil D, Huttner WB, Wilsch-Brauninger M, Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J Cell Biol. 2007 Feb 12;176(4):483-95
1	J:236353 Dudok JJ, Murtaza M, Henrique Alves C, Rashbass P, Wijnholds J, Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon. Neurosci Res. 2016 Jul;108:12-23
1*	J:262004 Espana-Serrano L, Guerra Martin-Palanco N, Montero-Pedrazuela A, Perez-Santamarina E, Vidal R, Garcia-Consuegra I, Valdizan EM, Pazos A, Palomo T, Jimenez-Arriero MA, Guadano-Ferraz A, Hoenicka J, The Addiction-Related Protein ANKK1 is Differentially Expressed During the Cell Cycle in Neural Precursors. Cereb Cortex. 2017 May 1;27(5):2809-2819
2	J:211183 Flaht-Zabost A, Gula G, Ciszek B, Czarnowska E, Jankowska-Steifer E, Madej M, Niderla-Bielinska J, Radomska-Lesniewska D, Ratajska A, Cardiac mouse lymphatics: developmental and anatomical update. Anat Rec (Hoboken). 2014 Jun;297(6):1115-30
2	J:196515 Fu J, Hsu W, Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. J Invest Dermatol. 2013 Apr;133(4):890-8
1	J:170886 Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM, The basement membrane of hair follicle stem cells is a muscle cell niche. Cell. 2011 Feb 18;144(4):577-89
1	J:355097 Gao C, Chen L, Chen E, Tsilosani A, Xia Y, Zhang W, Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells. J Am Soc Nephrol. 2021 Dec 1;32(12):3035-3049
1	J:139508 Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP, Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008 Aug 1;22(15):2111-24
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:181586 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Ronne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD, Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
2	J:253782 Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, Deng Q, Kadkhodaei B, Ericson J, Arenas E, Perlmann T, Simon A, Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Sci Rep. 2016 Jun 1;6:26448
1	J:296116 Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Feraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blaser S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M, ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 Apr 15;129(5):2145-2162
2	J:193958 Huh SH, Narhi K, Lindfors PH, Haara O, Yang L, Ornitz DM, Mikkola ML, Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013 Feb 15;27(4):450-8
4	J:121090 Ito Y, Hamazaki TS, Ohnuma K, Tamaki K, Asashima M, Okochi H, Isolation of murine hair-inducing cells using the cell surface marker prominin-1/CD133. J Invest Dermatol. 2007 May;127(5):1052-60
1	J:194049 Johansson PA, Irmler M, Acampora D, Beckers J, Simeone A, Gotz M, The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
1	J:277950 Kang HM, Huang S, Reidy K, Han SH, Chinga F, Susztak K, Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice. Cell Rep. 2016 Feb 2;14(4):861-871
1	J:147274 Karpowicz P, Willaime-Morawek S, Balenci L, DeVeale B, Inoue T, van der Kooy D, E-Cadherin regulates neural stem cell self-renewal. J Neurosci. 2009 Mar 25;29(12):3885-96
1	J:172044 Katayama K, Melendez J, Baumann JM, Leslie JR, Chauhan BK, Nemkul N, Lang RA, Kuan CY, Zheng Y, Yoshida Y, Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7607-12
6	J:227725 Kaushal GS, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM, Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation. J Invest Dermatol. 2015 Dec;135(12):2926-34
1	J:170126 Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M, Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011 Feb;138(4):653-65
4	J:92286 Kosodo Y, Roper K, Haubensak W, Marzesco AM, Corbeil D, Huttner WB, Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J. 2004 Jun 2;23(11):2314-24
1	J:143251 Kosodo Y, Toida K, Dubreuil V, Alexandre P, Schenk J, Kiyokage E, Attardo A, Mora-Bermudez F, Arii T, Clarke JD, Huttner WB, Cytokinesis of neuroepithelial cells can divide their basal process before anaphase. EMBO J. 2008 Dec 3;27(23):3151-63
1	J:168023 Lahti L, Saarimaki-Vire J, Rita H, Partanen J, FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors. Dev Biol. 2011 Jan 15;349(2):270-82
3	J:291514 Lee J, Shin JE, Lee B, Kim H, Jeon Y, Ahn SH, Chi SW, Cho Y, The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15955-15966
1*	J:202344 Lesko MH, Driskell RR, Kretzschmar K, Goldie SJ, Watt FM, Sox2 modulates the function of two distinct cell lineages in mouse skin. Dev Biol. 2013 Oct 1;382(1):15-26
1	J:101702 Li B, Nair M, Mackay DR, Bilanchone V, Hu M, Fallahi M, Song H, Dai Q, Cohen PE, Dai X, Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005 Mar;132(6):1463-73
3	J:202127 Main H, Radenkovic J, Jin SB, Lendahl U, Andersson ER, Notch signaling maintains neural rosette polarity. PLoS One. 2013;8(5):e62959
11	J:99843 Marzesco AM, Janich P, Wilsch-Brauninger M, Dubreuil V, Langenfeld K, Corbeil D, Huttner WB, Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J Cell Sci. 2005 Jul 1;118(Pt 13):2849-58
1	J:194986 Mavila N, James D, Utley S, Cu N, Coblens O, Mak K, Rountree CB, Kahn M, Wang KS, Fibroblast growth factor receptor-mediated activation of AKT-beta-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells. PLoS One. 2012;7(11):e50401
4*	J:59407 Maw MA, Corbeil D, Koch J, Hellwig A, Wilson-Wheeler JC, Bridges RJ, Kumaramanickavel G, John S, Nancarrow D, Roper K, Weigmann A, Huttner WB, Denton MJ, A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. Hum Mol Genet. 2000 Jan 1;9(1):27-34
2	J:310308 Monaco S, Baur K, Hellwig A, Holzl-Wenig G, Mandl C, Ciccolini F, A Flow Cytometry-Based Approach for the Isolation and Characterization of Neural Stem Cell Primary Cilia. Front Cell Neurosci. 2018;12:519
1	J:230332 Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K, Disappearance of centroacinar cells in the Notch ligand-deficient pancreas. Genes Cells. 2015 Jun;20(6):500-11
6	J:333189 Nambiar SM, Lee J, Yanum JA, Garcia V, Jiang H, Dai G, Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy. Am J Physiol Gastrointest Liver Physiol. 2023 Jan 1;324(1):G38-G50
1	J:229930 Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G, The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5:e09584
1	J:165035 Niklasson M, Bergstrom T, Zhang XQ, Gustafsdottir SM, Sjogren M, Edqvist PH, Vennstrom B, Forsberg M, Forsberg-Nilsson K, Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells. Exp Cell Res. 2010 Oct 15;316(17):2779-89
1	J:219210 Nikolaou KC, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, Talianidis I, Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 2015 Feb 12;34(4):430-47
5	J:152390 Nishide K, Nakatani Y, Kiyonari H, Kondo T, Glioblastoma formation from cell population depleted of Prominin1-expressing cells. PLoS One. 2009;4(8):e6869
1	J:176531 Nowakowski TJ, Mysiak KS, Pratt T, Price DJ, Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon. PLoS One. 2011;6(8):e23013
1	J:138579 Pawlisz AS, Mutch C, Wynshaw-Boris A, Chenn A, Walsh CA, Feng Y, Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination. Hum Mol Genet. 2008 Aug 15;17(16):2441-55
1	J:255488 Premarathne S, Murtaza M, Matigian N, Jolly LA, Wood SA, Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors. Sci Rep. 2017 Aug 14;7(1):8109
1	J:328936 Qin S, Yuan Y, Huang X, Tan Z, Hu X, Liu H, Pu Y, Ding YQ, Su Z, He C, Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37. Nucleic Acids Res. 2022 Aug 27;
2	J:243429 Rakotomamonjy J, Brunner M, Juschke C, Zang K, Huang EJ, Reichardt LF, Chenn A, Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia. Neural Dev. 2017 May 08;12(1):7
2	J:124218 Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N, Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007 Jul;10(7):819-27
1	J:266746 Rudkouskaya A, Welch I, Dagnino L, ILK modulates epithelial polarity and matrix formation in hair follicles. Mol Biol Cell. 2014 Mar;25(5):620-32
1	J:311928 Schmid MT, Weinandy F, Wilsch-Brauninger M, Huttner WB, Cappello S, Gotz M, The role of alpha-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration. Front Cell Neurosci. 2014;8:215
2	J:165253 Scott CE, Wynn SL, Sesay A, Cruz C, Cheung M, Gomez Gaviro MV, Booth S, Gao B, Cheah KS, Lovell-Badge R, Briscoe J, SOX9 induces and maintains neural stem cells. Nat Neurosci. 2010 Oct;13(10):1181-9
1	J:283792 Seishima R, Leung C, Yada S, Murad KBA, Tan LT, Hajamohideen A, Tan SH, Itoh H, Murakami K, Ishida Y, Nakamizo S, Yoshikawa Y, Wong E, Barker N, Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development. Nat Commun. 2019 Nov 26;10(1):5378
4	J:327293 Serra CFH, Liu H, Qian J, Mori M, Lu J, Cardoso WV, Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium. iScience. 2022 Aug 19;25(8):104751
1	J:302395 Shah K, King GD, Jiang H, A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells. J Mol Cell Biol. 2020 Jan 22;12(1):4-16
3*	J:343157 Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H, Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology. 2009 Jun;136(7):2187-2194.e1
1	J:215310 Sun W, Wilhelmina Aalders T, Oosterwijk E, Identification of potential bladder progenitor cells in the trigone. Dev Biol. 2014 Sep 1;393(1):84-92
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:197141 Tuoc TC, Boretius S, Sansom SN, Pitulescu ME, Frahm J, Livesey FJ, Stoykova A, Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness. Dev Cell. 2013 May 13;25(3):256-69
1	J:165742 VanDussen KL, Samuelson LC, Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev Biol. 2010 Oct 15;346(2):215-23
1	J:241851 Villani R, Hodgson S, Legrand J, Greaney J, Wong HY, Pichol-Thievend C, Adolphe C, Wainwight B, Francois M, Khosrotehrani K, Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development. 2017 May 15;144(10):1887-1895
2	J:196814 Wadhwa L, Bond WS, Perlaky L, Overbeek PA, Hurwitz MY, Chevez-Barrios P, Hurwitz RL, Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells. Invest Ophthalmol Vis Sci. 2012 Jun;53(7):3454-62
8*	J:44182 Weigmann A, Corbeil D, Hellwig A, Huttner WB, Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12425-30
1	J:152174 Weimer JM, Yokota Y, Stanco A, Stumpo DJ, Blackshear PJ, Anton ES, MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex. Development. 2009 Sep;136(17):2965-75
1	J:132649 Xu J, Kausalya PJ, Phua DC, Ali SM, Hossain Z, Hunziker W, Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Mol Cell Biol. 2008 Mar;28(5):1669-78
1	J:282241 Yang Y, Liu S, Lei Z, Chen G, Huang L, Yang F, Lei Y, Liu Y, Yang L, Liu W, Lai L, Guo J, Circular RNA profile in liver tissue of EpCAM knockout mice. Int J Mol Med. 2019 Sep;44(3):1063-1077
1*	J:57046 Zhadanov AB, Provance DW Jr, Speer CA, Coffin JD, Goss D, Blixt JA, Reichert CM, Mercer JA, Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development. Curr Biol. 1999 Aug 26;9(16):880-8
7	J:144215 Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ, Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 2009 Jan 29;457(7229):603-7