Gene Expression Literature Summary

• Symbol: Kdm1a
• Name: lysine (K)-specific demethylase 1A
• ID: MGI:1196256

29 matching records from 29 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E6.5	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	P
Immunohistochemistry (section)							2			1	1	3	2	3	2		2		1		2		1		3			5
In situ RNA (section)												1		1	2	1		1		1		1	2	1				2
Immunohistochemistry (whole mount)	1	2	1			1
In situ reporter (knock in)	1	1	1		1	2	1	1	1	1	1	1
Northern blot																												1
Western blot		1									1			2	1		2						1		2		1	6
RT-PCR	2	2	2	2	2	2					1	1		3	1		1				3		1		2	1	1	8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kdm1a  lysine (K)-specific demethylase 1A   (Synonyms: 1810043O07Rik, Aof2, Kdm1, LSD1, mKIAA0601)
Results	Reference
1*	J:176660 Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM, A high-resolution molecular atlas of the fetal mouse lower urogenital tract. Dev Dyn. 2011 Oct;240(10):2364-77
4	J:269736 Ancelin K, Syx L, Borensztein M, Ranisavljevic N, Vassilev I, Briseno-Roa L, Liu T, Metzger E, Servant N, Barillot E, Chen CJ, Schule R, Heard E, Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation. Elife. 2016 Feb 2;5:e08851
11*	J:326668 Astro V, Ramirez-Calderon G, Pennucci R, Caroli J, Saera-Vila A, Cardona-Londono K, Forastieri C, Fiacco E, Maksoud F, Alowaysi M, Sogne E, Falqui A, Gonzalez F, Montserrat N, Battaglioli E, Mattevi A, Adamo A, Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. iScience. 2022 Jul 15;25(7):104665
7	J:203762 Burton A, Muller J, Tu S, Padilla-Longoria P, Guccione E, Torres-Padilla ME, Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
1	J:205214 Dalton RP, Lyons DB, Lomvardas S, Co-opting the unfolded protein response to elicit olfactory receptor feedback. Cell. 2013 Oct 10;155(2):321-32
5*	J:226595 Foster CT, Dovey OM, Lezina L, Luo JL, Gant TW, Barlev N, Bradley A, Cowley SM, Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol Cell Biol. 2010 Oct;30(20):4851-63
6	J:198108 Fuentes P, Canovas J, Berndt FA, Noctor SC, Kukuljan M, CoREST/LSD1 control the development of pyramidal cortical neurons. Cereb Cortex. 2012 Jun;22(6):1431-41
1	J:227271 Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan ZJ, Gao X, Chen HQ, Zhu MS, Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13627-32
6*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:330708 Guo P, Hoang N, Sanchez J, Zhang EH, Rajawasam K, Trinidad K, Sun H, Zhang H, The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis. Nat Commun. 2022 Nov 5;13(1):6696
6	J:346895 Guo P, Lim RC, Rajawasam K, Trinh T, Sun H, Zhang H, A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13
2	J:201572 Kerenyi MA, Shao Z, Hsu YJ, Guo G, Luc S, O'Brien K, Fujiwara Y, Peng C, Nguyen M, Orkin SH, Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2013;2:e00633
1*	J:240583 Latos PA, Goncalves A, Oxley D, Mohammed H, Turro E, Hemberger M, Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Nat Commun. 2015 Jul 24;6:7776
8	J:344312 Liu H, Zhou R, Li S, Dong J, Fang Y, Luo Y, Su H, Lai B, Liang L, Zhang D, Zhang Y, Shyy JY, Zhou B, Yuan Z, Wang Y, Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722
2	J:200085 Lyons DB, Allen WE, Goh T, Tsai L, Barnea G, Lomvardas S, An epigenetic trap stabilizes singular olfactory receptor expression. Cell. 2013 Jul 18;154(2):325-36
1	J:321687 Lyons DB, Magklara A, Goh T, Sampath SC, Schaefer A, Schotta G, Lomvardas S, Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons. Cell Rep. 2014 Nov 6;9(3):884-92
1*	J:268318 Miesfeld JB, Moon MS, Riesenberg AN, Contreras AN, Kovall RA, Brown NL, Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina. Sci Rep. 2018 Jul 5;8(1):10195
1*	J:271628 Nagamori I, Kobayashi H, Nishimura T, Yamagishi R, Katahira J, Kuramochi-Miyagawa S, Kono T, Nakano T, Relationship between PIWIL4-Mediated H3K4me2 Demethylation and piRNA-Dependent DNA Methylation. Cell Rep. 2018 Oct 9;25(2):350-356
1*	J:281311 Nakano Y, Wiechert S, Banfi B, Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8
9	J:270116 Nicholson TB, Singh AK, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Goetschkes M, Capodieci P, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T, A hypomorphic lsd1 allele results in heart development defects in mice. PLoS One. 2013;8(4):e60913
1	J:257955 Patel D, Shimomura A, Majumdar S, Holley MC, Hashino E, The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLoS One. 2018;13(1):e0191689
1	J:250940 Scionti I, Hayashi S, Mouradian S, Girard E, Esteves de Lima J, Morel V, Simonet T, Wurmser M, Maire P, Ancelin K, Metzger E, Schule R, Goillot E, Relaix F, Schaeffer L, LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription. Cell Rep. 2017 Feb 21;18(8):1996-2006
10	J:215367 Shao GB, Chen JC, Zhang LP, Huang P, Lu HY, Jin J, Gong AH, Sang JR, Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):603-13
1*	J:176253 Vacik T, Stubbs JL, Lemke G, A novel mechanism for the transcriptional regulation of Wnt signaling in development. Genes Dev. 2011 Sep 1;25(17):1783-95
5	J:292264 Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M, LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 Apr 29;11(1):2082
7	J:144527 Wang J, Hevi S, Kurash JK, Lei H, Gay F, Bajko J, Su H, Sun W, Chang H, Xu G, Gaudet F, Li E, Chen T, The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet. 2009 Jan;41(1):125-9
7*	J:121427 Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass CK, Fu XD, Rosenfeld MG, Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 2007 Apr 19;446(7138):882-7
2*	J:317374 Zhang M, Lu Q, Miller AH, Barnthouse NC, Wang J, Dynamic epigenetic mechanisms regulate age-dependent SOX9 expression in mouse articular cartilage. Int J Biochem Cell Biol. 2016 Mar;72:125-134
1	J:206436 Zhu D, Holz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Gunther T, Arnold SJ, Schule R, Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells. Nat Commun. 2014;5:3174