Gene Expression Literature Summary

• Symbol: Limk2
• Name: LIM domain kinase 2
• ID: MGI:1197517

19 matching records from 19 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E7.5	E8.5	E9.5	E10	E11.5	E12	E13.5	E14	E14.5	E15.5	E16	E17.5	E18	E18.5	P
Immunohistochemistry (section)														1	1	1					3
In situ RNA (section)													1		2	2	1		1		1
Immunohistochemistry (whole mount)																					1
In situ RNA (whole mount)																1
Northern blot										1		1		1			1		1		1
Western blot									1						1			1		1	5
RT-PCR	1	1	1	1	1	1	1	1	1		1			1			1				5
cDNA clones									1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Limk2  LIM domain kinase 2   (Synonyms: A930024P04Rik, Limk2a, Limk2b, LIM kinase 2, whe)
Results	Reference
3*	J:108459 Acevedo K, Moussi N, Li R, Soo P, Bernard O, LIM kinase 2 is widely expressed in all tissues. J Histochem Cytochem. 2006 May;54(5):487-501
2*	J:195280 Andrews WD, Zito A, Memi F, Jones G, Tamamaki N, Parnavelas JG, Limk2 mediates semaphorin signalling in cortical interneurons migrating through the subpallium. Biol Open. 2013 Mar 15;2(3):277-82
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:308882 Dennison BJC, Larson ED, Fu R, Mo J, Fantauzzo KA, Srsf3 mediates alternative RNA splicing downstream of PDGFRalpha signaling in the facial mesenchyme. Development. 2021 Jul 15;148(14):dev199448
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4*	J:276652 Fang Q, Zhang Y, Da P, Shao B, Pan H, He Z, Cheng C, Li D, Guo J, Wu X, Guan M, Liao M, Zhang Y, Sha S, Zhou Z, Wang J, Wang T, Su K, Chai R, Chen F, Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Sci Rep. 2019 Mar 4;9(1):3357
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1*	J:157948 Jiang XS, Wassif CA, Backlund PS, Song L, Holtzclaw LA, Li Z, Yergey AL, Porter FD, Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications. Hum Mol Genet. 2010 Apr 1;19(7):1347-57
9*	J:44929 Koshimizu U, Takahashi H, Yoshida MC, Nakamura T, cDNA cloning, genomic organization, and chromosomal localization of the mouse LIM motif-containing kinase gene, Limk2. Biochem Biophys Res Commun. 1997 Dec 18;241(2):243-50
4	J:290602 Mao R, Deng R, Wei Y, Han L, Meng Y, Xie W, Jia Z, LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration. Mol Brain. 2019 Jul 18;12(1):67
2	J:161853 Mokalled MH, Johnson A, Kim Y, Oh J, Olson EN, Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development. 2010 Jul;137(14):2365-74
1*	J:347204 Morita R, Kihira M, Nakatsu Y, Nomoto Y, Ogawa M, Ohashi K, Mizuno K, Tachikawa T, Ishimoto Y, Morishita Y, Tsuji T, Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations. PLoS One. 2016;11(9):e0161336
1	J:186592 Nekrasova T, Minden A, Role for p21-activated kinase PAK4 in development of the mammalian heart. Transgenic Res. 2012 Aug;21(4):797-811
4	J:192231 Rice DS, Hansen GM, Liu F, Crist MJ, Newhouse MM, Potter D, Xu N, Abuin A, Vogel PJ, Zambrowicz BP, Keratinocyte migration in the developing eyelid requires LIMK2. PLoS One. 2012;7(10):e47168
1	J:185948 Rosario M, Schuster S, Juttner R, Parthasarathy S, Tarabykin V, Birchmeier W, Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. Genes Dev. 2012 Aug 1;26(15):1743-57
1	J:129038 Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C, Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46
3	J:119920 Ybot-Gonzalez P, Savery D, Gerrelli D, Signore M, Mitchell CE, Faux CH, Greene ND, Copp AJ, Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development. 2007 Feb;134(4):789-99
1	J:280168 Zhu C, Cheng C, Wang Y, Muhammad W, Liu S, Zhu W, Shao B, Zhang Z, Yan X, He Q, Xu Z, Yu C, Qian X, Lu L, Zhang S, Zhang Y, Xiong W, Gao X, Xu Z, Chai R, Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice. Front Mol Neurosci. 2018;11:362