Gene Expression Literature Summary

• Symbol: Bcl2l11
• Name: BCL2 like 11
• ID: MGI:1197519

36 matching records from 36 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15.5	E17.5	E18.5	E	P
Immunohistochemistry (section)						1	1							1
In situ RNA (section)						1		1	1	1		2		1
In situ RNA (whole mount)	1	1
In situ reporter (knock in)							1	1	2	1		1		2
Western blot	3	1	1		1		1	1	2	2	1	1	1	3
RT-PCR		3		3		2		2	1	2	1	2		6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Bcl2l11  BCL2 like 11   (Synonyms: 1500006F24Rik, Bim, Bod)
Results	Reference
1	J:172398 Ackermann J, Ashton G, Lyons S, James D, Hornung JP, Jones N, Breitwieser W, Loss of ATF2 Function Leads to Cranial Motoneuron Degeneration during Embryonic Mouse Development. PLoS One. 2011;6(4):e19090
1	J:196570 Bae KB, Kim MO, Yu DH, Shin MJ, Kim HJ, Yuh HS, Ji YR, Kim JY, Kim JM, Hyun BH, Lee HC, Chang WK, Park SB, Kim do H, Lee HS, Choo YS, Lee S, Ryoo ZY, Overexpression of Jazf1 induces cardiac malformation through the upregulation of pro-apoptotic genes in mice. Transgenic Res. 2011 Oct;20(5):1019-31
3*	J:73316 Bouillet P, Cory S, Zhang LC, Strasser A, Adams JM, Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim. Dev Cell. 2001 Nov;1(5):645-53
1	J:333323 Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang ZY, Liu Y, PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Blood. 2023 Jan 19;141(3):244-259
3	J:236189 Chinnam M, Wang X, Zhang X, Goodrich DW, Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice. Mol Cell Biol. 2016 Jun 1;36(11):1621-7
3	J:208428 Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J, Dicer function is required in the metanephric mesenchyme for early kidney development. Am J Physiol Renal Physiol. 2014 Apr;306(7):F764-72
1*	J:116164 Dequeant ML, Glynn E, Gaudenz K, Wahl M, Chen J, Mushegian A, Pourquie O, A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science. 2006 Dec 8;314(5805):1595-8
1	J:297431 Dewhurst MR, Ow JR, Zafer G, van Hul NKM, Wollmann H, Bisteau X, Brough D, Choi H, Kaldis P, Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS Genet. 2020 Nov;16(11):e1009084
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:199353 Fleury M, Petit-Cocault L, Clay D, Souyri M, Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis. Int J Dev Biol. 2010;54(6-7):1067-74
1	J:270807 Grabow S, Kueh AJ, Ke F, Vanyai HK, Sheikh BN, Dengler MA, Chiang W, Eccles S, Smyth IM, Jones LK, de Sauvage FJ, Scott M, Whitehead L, Voss AK, Strasser A, Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities. Cell Rep. 2018 Sep 18;24(12):3285-3295.e4
2	J:239805 Grigaravicius P, Kaminska E, Hubner CA, McKinnon PJ, von Deimling A, Frappart PO, Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain. Cell Death Differ. 2016 Mar;23(3):454-68
1	J:162892 Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S Jr, Itoh H, Noda T, Kasuga M, Nakae J, PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E787-98
1	J:303990 Kon N, Churchill M, Li H, Mukherjee S, Manfredi JJ, Gu W, Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function. Cancer Res. 2021 Feb 15;81(4):935-944
1	J:276962 Kon N, Wang D, Gu W, Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo. Cell Death Dis. 2019 Mar 11;10(3):237
2	J:284194 Labi V, Peng S, Klironomos F, Munschauer M, Kastelic N, Chakraborty T, Schoeler K, Derudder E, Martella M, Mastrobuoni G, Hernandez-Miranda LR, Lahmann I, Kocks C, Birchmeier C, Kempa S, Quintanilla-Martinez de Fend L, Landthaler M, Rajewsky N, Rajewsky K, Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat. Genes Dev. 2019 Dec 1;33(23-24):1673-1687
1	J:199588 Luo XJ, Deng M, Xie X, Huang L, Wang H, Jiang L, Liang G, Hu F, Tieu R, Chen R, Gan L, GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Hum Mol Genet. 2013 Sep 15;22(18):3609-23
1*	J:240101 Lv J, Wang L, Gao Y, Ding YQ, Liu F, 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545
6	J:119922 Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS, BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007 Feb;12(2):221-34
2	J:178271 Migliorini D, Bogaerts S, Defever D, Vyas R, Denecker G, Radaelli E, Zwolinska A, Depaepe V, Hochepied T, Skarnes WC, Marine JC, Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. J Clin Invest. 2011 Apr 1;121(4):1329-43
1	J:296081 Nguyen PM, Dagley LF, Preaudet A, Lam N, Giam M, Fung KY, Aizel K, van Duijneveldt G, Tan CW, Hirokawa Y, Yip HYK, Love CG, Poh AR, Cruz A, Burstroem C, Feltham R, Abdirahman SM, Meiselbach K, Low RRJ, Palmieri M, Ernst M, Webb AI, Burgess T, Sieber OM, Bouillet P, Putoczki TL, Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. Cell Death Differ. 2020 Feb;27(2):742-757
4*	J:285867 Ni HM, Chen X, Chen L, DiFrancesca D, Harada H, Yin XM, The impact of genetic background and Bid on the phenotype of Bcl-2-deficiency in mice. Apoptosis. 2008 Jan;13(1):53-62
1	J:90966 Orelio C, Harvey KN, Miles C, Oostendorp RA, van der Horn K, Dzierzak E, The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression. Blood. 2004 Jun 1;103(11):4084-92
2	J:273075 Phua YL, Chu JY, Marrone AK, Bodnar AJ, Sims-Lucas S, Ho J, Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Rep. 2015 Oct;3(10)
1	J:299239 Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Mark KV, Sakane C, Kaneko H, Komori T, Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genet. 2020 Nov;16(11):e1009169
1	J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503
1	J:163670 Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA, An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Dev Cell. 2010 Aug 17;19(2):207-19
1*	J:102178 Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG, Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol. 2005 Nov;25(21):9369-82
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:83651 Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R, Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol. 2003 Jun;4(6):533-9
1	J:278909 Weng SY, Yang CY, Li CC, Sun TP, Tung SY, Yen JJ, Tsai TF, Chen CM, Chen SH, Hsiao M, Huang PH, Yang-Yen HF, Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. J Hepatol. 2011 Apr;54(4):685-94
1*	J:341382 Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y, Zhou B, Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
3*	J:260330 Yang P, Li X, Xu C, Eckert RL, Reece EA, Zielke HR, Wang F, Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. Sci Signal. 2013 Aug 27;6(290):ra74
1*	J:270211 Yang P, Xu C, Reece EA, Chen X, Zhong J, Zhan M, Stumpo DJ, Blackshear PJ, Yang P, Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. Nat Commun. 2019 Jan 17;10(1):282
1	J:228522 Yang SL, Yang M, Herrlinger S, Liang C, Lai F, Chen JF, MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Dev Biol. 2015 Dec 1;408(1):140-50
1	J:315123 Zhong J, Xu C, Gabbay-Benziv R, Lin X, Yang P, Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy. Free Radic Biol Med. 2016 Jul;96:234-44