Gene Expression Literature Summary

• Symbol: Ctbp2
• Name: C-terminal binding protein 2
• ID: MGI:1201686

61 matching records from 61 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8.5	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15.5	E16	E17	E17.5	E18	E18.5	E19	E20	E	P
Immunohistochemistry (section)				1			1	1				1	1	2	3			1		34
In situ RNA (section)	1				1	2	1		1	3	3					1			1	1
Immunohistochemistry (whole mount)																1				12
In situ RNA (whole mount)				2	3	2	1
In situ reporter (knock in)		1		1	1		1
Northern blot				1	1	1														1
Western blot					1					1										1
RT-PCR						1	1			1		1					1			2
cDNA clones			1																1	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ctbp2  C-terminal binding protein 2   (Synonyms: D7Ertd45e, Gtrgeo6, Ribeye)
Results	Reference
1	J:314588 Ahmed M, Moon R, Prajapati RS, James E, Albert Basson M, Streit A, The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration. Commun Biol. 2021 Nov 3;4(1):1260
1*	J:326355 Bademci G, Lachgar-Ruiz M, Deokar M, Zafeer MF, Abad C, Yildirim Baylan M, Ingham NJ, Chen J, Sineni CJ, Vadgama N, Karakikes I, Guo S, Duman D, Singh N, Harlalka G, Jain SP, Chioza BA, Walz K, Steel KP, Nasir J, Tekin M, Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2204084119
7	J:40477 Baker RK, Haendel MA, Swanson BJ, Shambaugh JC, Micales BK, Lyons GE, In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:278101 Brightman DS, Grant RL, Ruzycki PA, Suzuki R, Hennig AK, Chen S, MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep. 2018 Aug 9;8(1):11902
1	J:332313 Cantu-Guerra HL, Papazian MR, Gorsky AL, Alekos NS, Caccavano A, Karagulyan N, Neef J, Vicini S, Moser T, Coate TM, Cochlear hair cell innervation is dependent on a modulatory function of Semaphorin-3A. Dev Dyn. 2023 Jan;252(1):124-144
1	J:248927 Clements R, Turk R, Campbell KP, Wright KM, Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development. J Neurosci. 2017 Aug 30;37(35):8559-8574
3	J:179898 Coate TM, Raft S, Zhao X, Ryan AK, Crenshaw EB 3rd, Kelley MW, Otic Mesenchyme Cells Regulate Spiral Ganglion Axon Fasciculation through a Pou3f4/EphA4 Signaling Pathway. Neuron. 2012 Jan 12;73(1):49-63
1	J:226819 Coate TM, Spita NA, Zhang KD, Isgrig KT, Kelley MW, Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons. Elife. 2015;4
1	J:297748 Collin GB, Won J, Krebs MP, Hicks WJ, Charette JR, Naggert JK, Nishina PM, Disruption in murine Eml1 perturbs retinal lamination during early development. Sci Rep. 2020 Mar 27;10(1):5647
1	J:226226 Defourny J, Poirrier AL, Lallemend F, Mateo Sanchez S, Neef J, Vanderhaeghen P, Soriano E, Peuckert C, Kullander K, Fritzsch B, Nguyen L, Moonen G, Moser T, Malgrange B, Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells. Nat Commun. 2013;4:1438
1	J:232175 Diaz-Horta O, Abad C, Sennaroglu L, Foster J 2nd, DeSmidt A, Bademci G, Tokgoz-Yilmaz S, Duman D, Cengiz FB, Grati M, Fitoz S, Liu XZ, Farooq A, Imtiaz F, Currall BB, Morton CC, Nishita M, Minami Y, Lu Z, Walz K, Tekin M, ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5993-8
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:283627 Dunbar LA, Patni P, Aguilar C, Mburu P, Corns L, Wells HR, Delmaghani S, Parker A, Johnson S, Williams D, Esapa CT, Simon MM, Chessum L, Newton S, Dorning J, Jeyarajan P, Morse S, Lelli A, Codner GF, Peineau T, Gopal SR, Alagramam KN, Hertzano R, Dulon D, Wells S, Williams FM, Petit C, Dawson SJ, Brown SD, Marcotti W, El-Amraoui A, Bowl MR, Clarin-2 is essential for hearing by maintaining stereocilia integrity and function. EMBO Mol Med. 2019 Sep;11(9):e10288
1*	J:266522 Elsen GE, Bedogni F, Hodge RD, Bammler TK, MacDonald JW, Lindtner S, Rubenstein JLR, Hevner RF, The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571
1*	J:257927 Fairchild CL, Hino K, Han JS, Miltner AM, Peinado Allina G, Brown CE, Burns ME, La Torre A, Simo S, RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
2*	J:276652 Fang Q, Zhang Y, Da P, Shao B, Pan H, He Z, Cheng C, Li D, Guo J, Wu X, Guan M, Liao M, Zhang Y, Sha S, Zhou Z, Wang J, Wang T, Su K, Chai R, Chen F, Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Sci Rep. 2019 Mar 4;9(1):3357
1	J:333967 Filova I, Pysanenko K, Tavakoli M, Vochyanova S, Dvorakova M, Bohuslavova R, Smolik O, Fabriciova V, Hrabalova P, Benesova S, Valihrach L, Cerny J, Yamoah EN, Syka J, Fritzsch B, Pavlinkova G, ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2207433119
1	J:280869 Freeman S, Mateo Sanchez S, Pouyo R, Van Lerberghe PB, Hanon K, Thelen N, Thiry M, Morelli G, Van Hees L, Laguesse S, Chariot A, Nguyen L, Delacroix L, Malgrange B, Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. EMBO Rep. 2019 Sep;20(9):e47097
1	J:155397 Fuerst PG, Bruce F, Tian M, Wei W, Elstrott J, Feller MB, Erskine L, Singer JH, Burgess RW, DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina. Neuron. 2009 Nov 25;64(4):484-97
7*	J:58553 Furusawa T, Moribe H, Kondoh H, Higashi Y, Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. Mol Cell Biol. 1999 Dec;19(12):8581-90
1	J:330325 Garcia-Anoveros J, Clancy JC, Foo CZ, Garcia-Gomez I, Zhou Y, Homma K, Cheatham MA, Duggan A, Tbx2 is a master regulator of inner versus outer hair cell differentiation. Nature. 2022 May;605(7909):298-303
1*	J:323825 Giffen KP, Li Y, Liu H, Zhao XC, Zhang CJ, Shen RJ, Wang T, Janesick A, Chen BB, Gong SS, Kachar B, Jin ZB, He DZ, Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction. Sci Adv. 2022 Apr 8;8(14):eabk0942
3*	J:233000 Gornikiewicz B, Ronowicz A, Krzeminski M, Sachadyn P, Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential. BMC Genomics. 2016;17:231
1*	J:263979 Harley RJ, Murdy JP, Wang Z, Kelly MC, Ropp TF, Park SH, Maness PF, Manis PB, Coate TM, Neuronal cell adhesion molecule (NrCAM) is expressed by sensory cells in the cochlea and is necessary for proper cochlear innervation and sensory domain patterning during development. Dev Dyn. 2018 Mar 14;
7*	J:77905 Hildebrand JD, Soriano P, Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol. 2002 Aug;22(15):5296-307
2	J:191194 Huang LC, Barclay M, Lee K, Peter S, Housley GD, Thorne PR, Montgomery JM, Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea. Neural Dev. 2012;7:38
1*	J:299026 Kannan-Sundhari A, Abad C, Maloof ME, Ayad NG, Young JI, Liu XZ, Walz K, Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival. Front Cell Dev Biol. 2020;8:576654
3	J:306276 Karaca E, Li X, Lewicki J, Neofytou C, Guerout N, Barnabe-Heider F, Hermanson O, The corepressor CtBP2 is required for proper development of the mouse cerebral cortex. Mol Cell Neurosci. 2020 Apr;104:103481
2	J:265096 Kim YJ, Ibrahim LA, Wang SZ, Yuan W, Evgrafov OV, Knowles JA, Wang K, Tao HW, Zhang LI, EphA7 regulates spiral ganglion innervation of cochlear hair cells. Dev Neurobiol. 2016 Apr;76(4):452-69
1	J:251343 Kim YJ, Wang SZ, Tymanskyj S, Ma L, Tao HW, Zhang LI, Dcc Mediates Functional Assembly of Peripheral Auditory Circuits. Sci Rep. 2016 Apr 4;6:23799
1	J:185536 Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW, Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development. 2012 Jul;139(13):2340-50
1	J:109564 Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams PR, Chen ZF, Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening. Dev Biol. 2006 Apr 15;292(2):555-64
1	J:336865 Li S, He S, Lu Y, Jia S, Liu Z, Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development. Cell Rep. 2023 May 30;42(5):112504
2	J:285747 Liu S, Liu X, Li S, Huang X, Qian H, Jin K, Xiang M, Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):5016-5027
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
1*	J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
1	J:227951 Mendus D, Sundaresan S, Grillet N, Wangsawihardja F, Leu R, Muller U, Jones SM, Mustapha M, Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear. Eur J Neurosci. 2014 Apr;39(8):1256-67
1	J:248772 Olivares AM, Han Y, Soto D, Flattery K, Marini J, Mollema N, Haider A, Escher P, DeAngelis MM, Haider NB, The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017 Sep 1;429(1):343-355
1	J:230346 Omori Y, Kitamura T, Yoshida S, Kuwahara R, Chaya T, Irie S, Furukawa T, Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Genes Cells. 2015 May;20(5):408-26
1	J:248731 Salehi P, Ge MX, Gundimeda U, Michelle Baum L, Lael Cantu H, Lavinsky J, Tao L, Myint A, Cruz C, Wang J, Nikolakopoulou AM, Abdala C, Kelley MW, Ohyama T, Coate TM, Friedman RA, Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. PLoS Genet. 2017 Oct;13(10):e1007048
1	J:311495 Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman RA, Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct;17(5):417-31
1	J:138693 Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T, Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat Neurosci. 2008 Aug;11(8):923-31
1	J:277160 Sherrill HE, Jean P, Driver EC, Sanders TR, Fitzgerald TS, Moser T, Kelley MW, Pou4f1 Defines a Subgroup of Type I Spiral Ganglion Neurons and Is Necessary for Normal Inner Hair Cell Presynaptic Ca(2+) Signaling. J Neurosci. 2019 Jul 3;39(27):5284-5298
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1	J:333986 Shrestha BR, Wu L, Goodrich LV, Runx1 controls auditory sensory neuron diversity in mice. Dev Cell. 2023 Feb 27;58(4):306-319.e5
1	J:199713 Somma G, Alger HM, McGuire RM, Kretlow JD, Ruiz FR, Yatsenko SA, Stankiewicz P, Harrison W, Funk E, Bergamaschi A, Oghalai JS, Mikos AG, Overbeek PA, Pereira FA, Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. J Assoc Res Otolaryngol. 2012 Jun;13(3):335-49
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:110332 Verger A, Quinlan KG, Crofts LA, Spano S, Corda D, Kable EP, Braet F, Crossley M, Mechanisms directing the nuclear localization of the CtBP family proteins. Mol Cell Biol. 2006 Jul;26(13):4882-94
2	J:298832 Wang H, Xiao Z, Zheng J, Wu J, Hu XL, Yang X, Shen Q, ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development. Cell Rep. 2019 May 21;27(8):2335-2353.e6
1	J:302429 Wang Z, Jung JS, Inbar TC, Rangoussis KM, Faaborg-Andersen C, Coate TM, The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development. eNeuro. 2020 Jul/Aug;7(4):ENEURO.0179-20.2020
1	J:274446 Wei W, Liu B, Jiang H, Jin K, Xiang M, Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development. Mol Neurobiol. 2019 Mar;56(3):1719-1736
5*	J:278092 Weng JS, Nakamura T, Moriizumi H, Takano H, Yao R, Takekawa M, MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing. Commun Biol. 2019;2:227
1	J:267715 Wiwatpanit T, Lorenzen SM, Cantu JA, Foo CZ, Hogan AK, Marquez F, Clancy JC, Schipma MJ, Cheatham MA, Duggan A, Garcia-Anoveros J, Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1. Nature. 2018 Nov;563(7733):691-695
1	J:278320 Wolter S, Mohrle D, Schmidt H, Pfeiffer S, Zelle D, Eckert P, Kramer M, Feil R, Pilz PKD, Knipper M, Ruttiger L, GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing. Front Neural Circuits. 2018;12:65
1	J:343328 Xie Z, Ma XH, Bai QF, Tang J, Sun JH, Jiang F, Guo W, Wang CM, Yang R, Wen YC, Wang FY, Chen YX, Zhang H, He DZ, Kelley MW, Yang S, Zhang WJ, ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
1	J:287680 Yamamoto H, Kon T, Omori Y, Furukawa T, Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development. Cell Rep. 2020 Jan 21;30(3):658-671.e5
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:207904 Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV, A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife. 2013;2:e01341
1	J:280168 Zhu C, Cheng C, Wang Y, Muhammad W, Liu S, Zhu W, Shao B, Zhang Z, Yan X, He Q, Xu Z, Yu C, Qian X, Lu L, Zhang S, Zhang Y, Xiong W, Gao X, Xu Z, Chai R, Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice. Front Mol Neurosci. 2018;11:362
1*	J:264159 Zurner M, Mittelstaedt T, tom Dieck S, Becker A, Schoch S, Analyses of the spatiotemporal expression and subcellular localization of liprin-alpha proteins. J Comp Neurol. 2011 Oct 15;519(15):3019-39