Gene Expression Literature Summary

• Symbol: Socs3
• Name: suppressor of cytokine signaling 3
• ID: MGI:1201791

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2.5	E3	E3.5	E4	E4.5	E5.5	E6.5	E7	E7.5	E8.5	E9.5	E10.5	E11	E12.5	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	P
Immunohistochemistry (section)								1		1		2			1	1	1			1		1		1	2
In situ RNA (section)															1			1					1	1	2
In situ RNA (whole mount)																	1
Northern blot									1				1	1				1	1		1	1			2
Western blot																								1	1
RT-PCR	1	1	1	2	1	1	1				2				3	1	1	2		1	1		1	1	8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Socs3  suppressor of cytokine signaling 3   (Synonyms: CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3)
Results	Reference
2	J:326354 Allegre N, Chauveau S, Dennis C, Renaud Y, Meistermann D, Estrella LV, Pouchin P, Cohen-Tannoudji M, David L, Chazaud C, NANOG initiates epiblast fate through the coordination of pluripotency genes expression. Nat Commun. 2022 Jun 21;13(1):3550
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
1*	J:171578 Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X, Protein Phosphatase 2A Catalytic Subunit alpha (PP2Acalpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway. Am J Pathol. 2011 May;178(5):2333-43
3*	J:257927 Fairchild CL, Hino K, Han JS, Miltner AM, Peinado Allina G, Brown CE, Burns ME, La Torre A, Simo S, RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
5*	J:44165 Fu X, Kamps MP, E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
3	J:253786 Hu X, Li J, Zhang Q, Zheng L, Wang G, Zhang X, Zhang J, Gu Q, Ye Y, Guo SW, Yang X, Wang L, Phosphoinositide 3-Kinase (PI3K) Subunit p110delta Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse. Sci Rep. 2016 Jun 16;6:28201
1	J:286621 Iwagawa T, Aihara Y, Umutoni D, Baba Y, Murakami A, Miyado K, Watanabe S, Cd9 Protects Photoreceptors from Injury and Potentiates Edn2 Expression. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):7
1	J:139252 Lokmane L, Haumaitre C, Garcia-Villalba P, Anselme I, Schneider-Maunoury S, Cereghini S, Crucial role of vHNF1 in vertebrate hepatic specification. Development. 2008 Aug;135(16):2777-86
1	J:258670 Mahany EB, Han X, Borges BC, da Silveira Cruz-Machado S, Allen SJ, Garcia-Galiano D, Hoenerhoff MJ, Bellefontaine NH, Elias CF, Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733
4*	J:57476 Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN, SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell. 1999 Sep 3;98(5):617-27
9	J:119192 Ozawa Y, Nakao K, Shimazaki T, Shimmura S, Kurihara T, Ishida S, Yoshimura A, Tsubota K, Okano H, SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. Dev Biol. 2007 Mar 15;303(2):591-600
7	J:62883 Polizzotto MN, Bartlett PF, Turnley AM, Expression of 'suppressor of cytokine signalling' (SOCS) genes in the developing and adult mouse nervous system. J Comp Neurol. 2000 Jul 24;423(2):348-58
4	J:200773 San Martin S, Fitzgerald JS, Weber M, Parraga M, Saez T, Zorn TM, Markert UR, Stat3 and Socs3 expression patterns during murine placenta development. Eur J Histochem. 2013;57(2):e19
2	J:268738 Sarper SE, Kurosaka H, Inubushi T, Ono Minagi H, Kuremoto KI, Sakai T, Taniuchi I, Yamashiro T, Runx1-Stat3-Tgfb3 signaling network regulating the anterior palatal development. Sci Rep. 2018 Jul 25;8(1):11208
3*	J:152946 Sferruzzi-Perri AN, Macpherson AM, Roberts CT, Robertson SA, Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
4	J:205551 Simo S, Cooper JA, Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411
2	J:128959 Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, Dubois RN, Dey SK, Stage-specific Integration of Maternal and Embryonic Peroxisome Proliferator-activated Receptor {delta} Signaling Is Critical to Pregnancy Success. J Biol Chem. 2007 Dec 28;282(52):37770-37782
1*	J:225638 Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E, Jing Y, Farjo R, Fleury G, Barlow C, Hero AO, Swaroop A, Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Hum Mol Genet. 2004 Jul 15;13(14):1487-503