Gene Expression Literature Summary

• Symbol: Mmp8
• Name: matrix metallopeptidase 8
• ID: MGI:1202395

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E8.5	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)					1		1	1
In situ RNA (section)							1					2	1		1					1
In situ RNA (whole mount)							1					1
In situ reporter (knock in)																				1
Northern blot								1							1		1	1	1	2
Western blot								1									2			1
RT-PCR	1	1	1	1	1	1	1	2	1	1	1	1	1	1	3	1	5		1	10
cDNA clones															1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mmp8  matrix metallopeptidase 8   (Synonyms: Collagenase-2)
Results	Reference
8*	J:49746 Balbin M, Fueyo A, Knauper V, Pendas AM, Lopez JM, Jimenez MG, Murphy G, Lopez-Otin C, Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus. J Biol Chem. 1998 Sep 11;273(37):23959-68
1	J:198628 Cai X, Zhang W, Hu J, Zhang L, Sultana N, Wu B, Cai W, Zhou B, Cai CL, Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug;140(15):3176-87
3	J:118359 Chen L, Nakai M, Belton RJ Jr, Nowak RA, Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development. Reproduction. 2007 Feb;133(2):405-14
1	J:338185 Cordoba-Jover B, Ribera J, Portoles I, Lecue E, Rodriguez-Vita J, Perez-Sisques L, Mannara F, Solsona-Vilarrasa E, Garcia-Ruiz C, Fernandez-Checa JC, Casals G, Rodriguez-Revenga L, Alvarez-Mora MI, Arteche-Lopez A, Diaz de Bustamante A, Calvo R, Pujol A, Azkargorta M, Elortza F, Malagelada C, Pinyol R, Huguet-Pradell J, Melgar-Lesmes P, Jimenez W, Morales-Ruiz M, Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans. Liver Int. 2023 Aug;43(8):1822-1836
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:273336 Flood HM, Bolte C, Dasgupta N, Sharma A, Zhang Y, Gandhi CR, Kalin TV, Kalinichenko VV, The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Biol Open. 2019 Feb 11;8(2):bio039800
15	J:74209 Giambernardi TA, Sakaguchi AY, Gluhak J, Pavlin D, Troyer DA, Das G, Rodeck U, Klebe RJ, Neutrophil collagenase (MMP-8) is expressed during early development in neural crest cells as well as in adult melanoma cells. Matrix Biol. 2001 Dec;20(8):577-87
1	J:167063 Gordon EJ, Rao S, Pollard JW, Nutt SL, Lang RA, Harvey NL, Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development. 2010 Nov;137(22):3899-910
4	J:94723 Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, Lopez-Otin C, Krane SM, Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17192-7
3*	J:48250 Iwama A, Zhang P, Darlington GJ, McKercher SR, Maki R, Tenen DG, Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998 Jun 15;26(12):3034-43
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:178303 Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY, ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell. 2011 Oct 18;21(4):746-57
4*	J:324243 Lei Z, Liu W, Nie Y, Yang Y, Chen G, Huang L, Wu H, Lei Y, Chen L, Hu Q, Rong H, Yu S, Song Q, Tong F, Guo J, EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice. Front Immunol. 2022;13:843378
1	J:263505 Liu G, Cooley MA, Jarnicki AG, Hsu AC, Nair PM, Haw TJ, Fricker M, Gellatly SL, Kim RY, Inman MD, Tjin G, Wark PA, Walker MM, Horvat JC, Oliver BG, Argraves WS, Knight DA, Burgess JK, Hansbro PM, Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. JCI Insight. 2016 Jun 16;1(9):e86380
1	J:182928 Nagarajan P, Chin SS, Wang D, Liu S, Sinha S, Garrett-Sinha LA, Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators. J Cell Sci. 2010 Oct 15;123(Pt 20):3566-75
1	J:105134 Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z, Hebrok M, Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes. 2005 Mar;54(3):694-701
2*	J:255349 Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P, Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142
1	J:298990 Sah RK, Ma J, Bah FB, Xing Z, Adlat S, Oo ZM, Wang Y, Bahadar N, Bohio AA, Nagi FH, Feng X, Zhang L, Zheng Y, Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223
1	J:244225 Simon-Carrasco L, Grana O, Salmon M, Jacob HKC, Gutierrez A, Jimenez G, Drosten M, Barbacid M, Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev. 2017 Jul 15;31(14):1456-1468
3	J:340401 Varadinkova S, Oralova V, Clarke M, Frampton J, Knopfova L, Lesot H, Bartos P, Matalova E, Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor. Front Cell Dev Biol. 2023;11:1168866
1	J:102932 Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N, Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15791-6
4	J:215417 Wu Z, Horgan CE, Carr O, Owens RT, Iozzo RV, Lechner BE, Biglycan and decorin differentially regulate signaling in the fetal membranes. Matrix Biol. 2014 Apr;35:266-75
1	J:307538 Yonebayashi S, Tajiri K, Hara M, Saito H, Suzuki N, Sakai S, Kimura T, Sato A, Sekimoto A, Fujita S, Okamoto R, Schwartz RJ, Yoshida T, Imanaka-Yoshida K, Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C. Front Immunol. 2021;12:620541