Gene Expression Literature Summary

• Symbol: Meg3
• Name: maternally expressed 3
• ID: MGI:1202886

62 matching records from 62 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E6	E7	E7.5	E8	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E	P
In situ RNA (section)							1					1		2		1	1	6		3	1	7		2	1	2		1	1	1			1	6
In situ RNA (whole mount)	2	2	2	1	1	3	1				1	2		2		1		2		2													1	1
In situ reporter (knock in)												1		1		1			1			1	1
Northern blot	1	1	1	1	1	1		2				1			2			2					2	1	1	1	2	1		1			3	6
RT-PCR	1	1	1	1	1	3			3		3	4	1	3		4		6		5		8		5	1	4		3	1	5	1	1	2	27
cDNA clones										1	1	1		1	1			1																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Meg3  maternally expressed 3   (Synonyms: 2900016C05Rik, 3110050O07Rik, 6330408G06Rik, D12Bwg1266e, Gtl2)
Results	Reference
2	J:316654 Alexander KA, Wang X, Shibata M, Clark AG, Garcia-Garcia MJ, TRIM28 Controls Genomic Imprinting through Distinct Mechanisms during and after Early Genome-wide Reprogramming. Cell Rep. 2015 Nov 10;13(6):1194-1205
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
2	J:182286 Charalambous M, Ferron SR, da Rocha ST, Murray AJ, Rowland T, Ito M, Schuster-Gossler K, Hernandez A, Ferguson-Smith AC, Imprinted gene dosage is critical for the transition to independent life. Cell Metab. 2012 Feb 8;15(2):209-21
1	J:246103 Chatzinikolaou G, Apostolou Z, Aid-Pavlidis T, Ioannidou A, Karakasilioti I, Papadopoulos GL, Aivaliotis M, Tsekrekou M, Strouboulis J, Kosteas T, Garinis GA, ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nat Cell Biol. 2017 May;19(5):421-432
1*	J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
11*	J:82706 Croteau S, Charron MC, Latham KE, Naumova AK, Alternative splicing and imprinting control of the Meg3/Gtl2-Dlk1 locus in mouse embryos. Mamm Genome. 2003 Apr;14(4):231-41
2	J:146771 da Rocha ST, Charalambous M, Lin SP, Gutteridge I, Ito Y, Gray D, Dean W, Ferguson-Smith AC, Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting. PLoS Genet. 2009 Feb;5(2):e1000392
5	J:122577 da Rocha ST, Tevendale M, Knowles E, Takada S, Watkins M, Ferguson-Smith AC, Restricted co-expression of Dlk1 and the reciprocally imprinted non-coding RNA, Gtl2: implications for cis-acting control. Dev Biol. 2007 Jun 15;306(2):810-23
2	J:206605 Faisal M, Kim H, Kim J, Sexual differences of imprinted genes' expression levels. Gene. 2014 Jan 1;533(1):434-8
1*	J:98707 Ferguson DA, Chiang JT, Richardson JA, Graff J, eXPRESSION: An in silico tool to predict patterns of gene expression. Gene Expr Patterns. 2005 Jun;5(5):619-28
1	J:174189 Ferron SR, Charalambous M, Radford E, McEwen K, Wildner H, Hind E, Morante-Redolat JM, Laborda J, Guillemot F, Bauer SR, Farinas I, Ferguson-Smith AC, Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature. 2011 Jul 21;475(7356):381-5
2	J:153616 Gabory A, Ripoche MA, Le Digarcher A, Watrin F, Ziyyat A, Forne T, Jammes H, Ainscough JF, Surani MA, Journot L, Dandolo L, H19 acts as a trans regulator of the imprinted gene network controlling growth in mice. Development. 2009 Oct;136(20):3413-21
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
5*	J:146496 Hagan JP, O'Neill BL, Stewart CL, Kozlov SV, Croce CM, At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1. PLoS One. 2009;4(2):e4352
14*	J:290525 Han Z, Yu C, Tian Y, Zeng T, Cui W, Mager J, Wu Q, Expression patterns of long noncoding RNAs from Dlk1-Dio3 imprinted region and the potential mechanisms of Gtl2 activation during blastocyst development. Biochem Biophys Res Commun. 2015 Jul 31;463(3):167-73
1	J:287095 Hara S, Terao M, Muramatsu A, Takada S, Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method. Sci Rep. 2019 Dec 27;9(1):20202
5*	J:192195 Himes KP, Koppes E, Chaillet JR, Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013 Jan 1;373(1):72-82
1*	J:117917 Kamei Y, Suganami T, Kohda T, Ishino F, Yasuda K, Miura S, Ezaki O, Ogawa Y, Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. FEBS Lett. 2007 Jan 9;581(1):91-6
4	J:218430 Kamimura S, Hatanaka Y, Hirasawa R, Matsumoto K, Oikawa M, Lee J, Matoba S, Mizutani E, Ogonuki N, Inoue K, Kohda T, Ishino F, Ogura A, Establishment of paternal genomic imprinting in mouse prospermatogonia analyzed by nuclear transfer. Biol Reprod. 2014 Nov;91(5):120
1*	J:127743 Kawahara M, Wu Q, Ferguson-Smith AC, Kono T, Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term. FEBS Lett. 2007 Nov 13;581(27):5178-84
2	J:158584 Kernohan KD, Jiang Y, Tremblay DC, Bonvissuto AC, Eubanks JH, Mann MR, Berube NG, ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Dev Cell. 2010 Feb 16;18(2):191-202
3	J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
1*	J:299191 Kitazawa M, Hayashi S, Imamura M, Takeda S, Oishi Y, Kaneko-Ishino T, Ishino F, Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes. Development. 2020 Sep 2;147(21):dev185918
1	J:291101 Kota SK, Lleres D, Bouschet T, Hirasawa R, Marchand A, Begon-Pescia C, Sanli I, Arnaud P, Journot L, Girardot M, Feil R, ICR noncoding RNA expression controls imprinting and DNA replication at the Dlk1-Dio3 domain. Dev Cell. 2014 Oct 13;31(1):19-33
1*	J:251670 Kumamoto S, Takahashi N, Nomura K, Fujiwara M, Kijioka M, Uno Y, Matsuda Y, Sotomaru Y, Kono T, Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice. Hum Mol Genet. 2017 Oct 01;26(19):3653-3662
4	J:216177 Labialle S, Marty V, Bortolin-Cavaille ML, Hoareau-Osman M, Pradere JP, Valet P, Martin PG, Cavaille J, The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30
1	J:132025 Labialle S, Yang L, Ruan X, Villemain A, Schmidt JV, Hernandez A, Wiltshire T, Cermakian N, Naumova AK, Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Hum Mol Genet. 2008 Jan 1;17(1):15-26
1	J:143283 Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC, A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell. 2008 Oct;15(4):547-57
1	J:294716 Liang ZS, Cimino I, Yalcin B, Raghupathy N, Vancollie VE, Ibarra-Soria X, Firth HV, Rimmington D, Farooqi IS, Lelliott CJ, Munger SC, O'Rahilly S, Ferguson-Smith AC, Coll AP, Logan DW, Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. PLoS Genet. 2020 Sep;16(9):e1008916
1*	J:91849 Lin SP, Youngson N, Takada S, Seitz H, Reik W, Paulsen M, Cavaille J, Ferguson-Smith AC, Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet. 2003 Sep;35(1):97-102
2	J:137668 Lui JC, Finkielstain GP, Barnes KM, Baron J, An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs. Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R189-96
2	J:82790 Mager J, Montgomery ND, de Villena FP, Magnuson T, Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet. 2003 Apr;33(4):502-7
5	J:106101 Manji SS, Sorensen BS, Klockars T, Lam T, Hutchison W, Dahl HH, Molecular characterization and expression of maternally expressed gene 3 (Meg3/Gtl2) RNA in the mouse inner ear. J Neurosci Res. 2006 Feb 1;83(2):181-90
1*	J:308708 Martinez ME, Hernandez A, The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain. Front Neurosci. 2021;15:703730
4*	J:105951 McLaughlin D, Vidaki M, Renieri E, Karagogeos D, Expression pattern of the maternally imprinted gene Gtl2 in the forebrain during embryonic development and adulthood. Gene Expr Patterns. 2006 Apr;6(4):394-9
1	J:45655 Miyoshi N, Kuroiwa Y, Kohda T, Shitara H, Yonekawa H, Kawabe T, Hasegawa H, Barton SC, Surani MA, Kaneko-Ishino T, Ishino F, Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1102-7
3*	J:61969 Miyoshi N, Wagatsuma H, Wakana S, Shiroishi T, Nomura M, Aisaka K, Kohda T, Surani MA, Kaneko-Ishino T, Ishino F, Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes Cells. 2000 Mar;5(3):211-20
1	J:205506 Monnier P, Martinet C, Pontis J, Stancheva I, Ait-Si-Ali S, Dandolo L, H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20693-8
2	J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1	J:112969 Ogawa H, Wu Q, Komiyama J, Obata Y, Kono T, Disruption of parental-specific expression of imprinted genes in uniparental fetuses. FEBS Lett. 2006 Oct 2;580(22):5377-84
5*	J:192572 Qu C, Jiang T, Li Y, Wang X, Cao H, Xu H, Qu J, Chen JG, Gene expression and IG-DMR hypomethylation of maternally expressed gene 3 in developing corticospinal neurons. Gene Expr Patterns. 2013 Jan;13(1-2):51-6
1*	J:266963 Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H, Takada S, A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development. Hum Mol Genet. 2018 Sep 15;27(18):3283-3292
1	J:241393 Saito T, Hara S, Tamano M, Asahara H, Takada S, Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice. J Reprod Dev. 2017 Feb 16;63(1):101-109
1	J:264121 SanMiguel JM, Abramowitz LK, Bartolomei MS, Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring. Development. 2018 Mar 29;145(7):dev160622
9*	J:64037 Schmidt JV, Matteson PG, Jones BK, Guan XJ, Tilghman SM, The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev. 2000 Aug 15;14(16):1997-2002
29*	J:47969 Schuster-Gossler K, Bilinski P, Sado T, Ferguson-Smith A, Gossler A, The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA. Dev Dyn. 1998 Jun;212(2):214-28
5	J:195360 Seibt J, Armant O, Le Digarcher A, Castro D, Ramesh V, Journot L, Guillemot F, Vanderhaeghen P, Bouschet T, Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon. PLoS One. 2012;7(11):e48675
2	J:108133 Sekita Y, Wagatsuma H, Irie M, Kobayashi S, Kohda T, Matsuda J, Yokoyama M, Ogura A, Schuster-Gossler K, Gossler A, Ishino F, Kaneko-Ishino T, Aberrant regulation of imprinted gene expression in Gtl2lacZ mice. Cytogenet Genome Res. 2006;113(1-4):223-9
5	J:125994 Steshina EY, Carr MS, Glick EA, Yevtodiyenko A, Appelbe OK, Schmidt JV, Loss of imprinting at the Dlk1-Gtl2 locus caused by insertional mutagenesis in the Gtl2 5' region. BMC Genet. 2006;7:44
11	J:65111 Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, Freeman T, Johnson MH, Paulsen M, Ferguson-Smith AC, Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Curr Biol. 2000 Sep 21;10(18):1135-8
2*	J:147577 Takahashi N, Okamoto A, Kobayashi R, Shirai M, Obata Y, Ogawa H, Sotomaru Y, Kono T, Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice. Hum Mol Genet. 2009 May 15;18(10):1879-88
1	J:228807 Umansky KB, Gruenbaum-Cohen Y, Tsoory M, Feldmesser E, Goldenberg D, Brenner O, Groner Y, Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration. PLoS Genet. 2015 Aug;11(8):e1005457
1	J:324246 Van de Pette M, Dimond A, Galvao AM, Millership SJ, To W, Prodani C, McNamara G, Bruno L, Sardini A, Webster Z, McGinty J, French PMW, Uren AG, Castillo-Fernandez J, Watkinson W, Ferguson-Smith AC, Merkenschlager M, John RM, Kelsey G, Fisher AG, Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice. Nat Commun. 2022 May 5;13(1):2464
1	J:207929 Yamaguchi S, Shen L, Liu Y, Sendler D, Zhang Y, Role of Tet1 in erasure of genomic imprinting. Nature. 2013 Dec 19;504(7480):460-4
4	J:290593 Yen YP, Hsieh WF, Tsai YY, Lu YL, Liau ES, Hsu HC, Chen YC, Liu TC, Chang M, Li J, Lin SP, Hung JH, Chen JA, Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity. Elife. 2018 Oct 12;7:e38080
2*	J:161712 Zaitoun I, Downs KM, Rosa GJ, Khatib H, Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting. Epigenetics. 2010 Feb;5(2):149-58
1*	J:344890 Zhang L, Han Z, He H, Zhang X, Zhang M, Li B, Wu Q, Meg8-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice. Genes (Basel). 2023 Jun 14;14(6)
4	J:346630 Zhang X, He H, Yu H, Teng X, Wang Z, Li C, Li J, Yang H, Shen J, Wu T, Zhang F, Zhang Y, Wu Q, Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature. Commun Biol. 2024 Mar 23;7(1):363
3*	J:166176 Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HG, Bronson RT, Klibanski A, Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development. 2010 Aug;137(16):2643-52
3*	J:213692 Zhu JG, Shen YH, Liu HL, Liu M, Shen YQ, Kong XQ, Song GX, Qian LM, Long noncoding RNAs expression profile of the developing mouse heart. J Cell Biochem. 2014 May;115(5):910-8
2	J:281273 Zhu W, Botticelli EM, Kery RE, Mao Y, Wang X, Yang A, Wang X, Zhou J, Zhang X, Soberman RJ, Klibanski A, Zhou Y, Meg3-DMR, not the Meg3 gene, regulates imprinting of the Dlk1-Dio3 locus. Dev Biol. 2019 Nov 1;455(1):10-18