Gene Expression Literature Summary

• Symbol: Ep300
• Name: E1A binding protein p300
• ID: MGI:1276116

38 matching records from 38 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)							1	3	1	4	5	6	2	5		1	2	5		3	1	2	1	3	4	1	1	6
In situ RNA (section)							1	1			1			1				4				1
Immunohistochemistry (whole mount)	2	1	1	1	1	1	1	2		1	2
In situ RNA (whole mount)							1	1		1				1
Northern blot																	1											1
Western blot									1		4	2		1	1	2	1	1	1	1		1	1	1	1			4
RT-PCR	1	1	1	1	1	2				1	1	1		3		2		3		2		1		1	3	1	1	5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ep300  E1A binding protein p300   (Synonyms: KAT3B, p300)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
7*	J:153786 Bhattacherjee V, Horn KH, Singh S, Webb CL, Pisano MM, Greene RM, CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development. Int J Dev Biol. 2009;53(7):1097-104
1*	J:302571 Casingal CR, Kikkawa T, Inada H, Sasaki Y, Osumi N, Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/beta-catenin, and mTOR signaling during corticogenesis. Mol Brain. 2020 Dec 16;13(1):167
19*	J:147999 Chen G, Zhu J, Lv T, Wu G, Sun H, Huang X, Tian J, Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts. J Biomed Sci. 2009;16:24
1	J:74730 Chen Q, Ash JD, Branton P, Fromm L, Overbeek PA, Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene. 2002 Feb 7;21(7):1028-37
1	J:90298 Chen Q, Liang D, Fromm LD, Overbeek PA, Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb. J Biol Chem. 2004 Apr 23;279(17):17667-73
12	J:181099 Chen Z, Gao B, Zhou X, Expression patterns of histone acetyltransferases p300 and CBP during murine tooth development. In Vitro Cell Dev Biol Anim. 2012 Jan;48(1):61-8
8	J:331267 de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL, Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A, Vihervaara A, Puustinen MC, Miozzo F, Fergelot P, Lebigot E, Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide SD, David L, Petitjean M, Taboureau O, Rodrigues-Lima F, Passemard S, Saberan-Djoneidi D, Nguyen L, Lancaster M, Sistonen L, Mezger V, CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. Nat Commun. 2022 Nov 16;13(1):7002
1*	J:266522 Elsen GE, Bedogni F, Hodge RD, Bammler TK, MacDonald JW, Lindtner S, Rubenstein JLR, Hevner RF, The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571
12*	J:352626 Gao D, Li C, Liu SY, Xu TT, Lin XT, Tan YP, Gao FM, Yi LT, Zhang JV, Ma JY, Meng TG, Yeung WSB, Liu K, Ou XH, Su RB, Sun QY, P300 regulates histone crotonylation and preimplantation embryo development. Nat Commun. 2024 Jul 30;15(1):6418
1	J:256001 Jung EM, Moffat JJ, Liu J, Dravid SM, Gurumurthy CB, Kim WY, Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707
2	J:194035 Kan A, Tabin CJ, c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
3*	J:73196 Kim RH, Flanders KC, Birkey Reffey S, Anderson LA, Duckett CS, Perkins ND, Roberts AB, SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J Biol Chem. 2001 Dec 7;276(49):46297-304
3	J:111248 Kwok RP, Liu XT, Smith GD, Distribution of co-activators CBP and p300 during mouse oocyte and embryo development. Mol Reprod Dev. 2006 Jul;73(7):885-94
2	J:155064 Lee S, Lee B, Lee JW, Lee SK, Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron. 2009 Jun 11;62(5):641-54
4*	J:75146 Li Q, Xiao H, Isobe K, Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice. J Gerontol A Biol Sci Med Sci. 2002 Mar;57(3):B93-8
1*	J:135330 Li X, Kato Y, Tsuji Y, Tsunoda Y, The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. Cloning Stem Cells. 2008 Mar;10(1):133-42
1	J:132940 Lin W, Zhang Z, Srajer G, Chen YC, Huang M, Phan HM, Dent SY, Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. Dev Dyn. 2008 Apr;237(4):928-40
4	J:315705 Liu S, Aldinger KA, Cheng CV, Kiyama T, Dave M, McNamara HK, Zhao W, Stafford JM, Descostes N, Lee P, Caraffi SG, Ivanovski I, Errichiello E, Zweier C, Zuffardi O, Schneider M, Papavasiliou AS, Perry MS, Humberson J, Cho MT, Weber A, Swale A, Badea TC, Mao CA, Garavelli L, Dobyns WB, Reinberg D, NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain. Mol Cell. 2021 Nov 18;81(22):4663-4676.e8
1	J:330270 Lv W, Jiang W, Luo H, Tong Q, Niu X, Liu X, Miao Y, Wang J, Guo Y, Li J, Zhan X, Hou Y, Peng Y, Wang J, Zhao S, Xu Z, Zuo B, Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex. Nucleic Acids Res. 2022 Oct 14;50(18):10733-10755
1*	J:280803 Ma J, Zhang LQ, He ZX, He XX, Wang YJ, Jian YL, Wang X, Zhang BB, Su C, Lu J, Huang BQ, Zhang Y, Wang GY, Guo WX, Qiu DL, Mei L, Xiong WC, Zheng YW, Zhu XJ, Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin. PLoS Biol. 2019 Oct;17(10):e3000461
1*	J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
5	J:66247 Naltner A, Wert S, Whitsett JA, Yan C, Temporal/spatial expression of nuclear receptor coactivators in the mouse lung. Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1066-74
17*	J:60120 Partanen M, Motoyama J, Hui CC, Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis. Int J Dev Biol. 1999 Sep;43(6):487-94
1*	J:99573 Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY, GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005 Aug;233(4):1337-47
1	J:242229 Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H, Nuclear Shp2 directs normal embryo implantation via facilitating the ERalpha tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017 May 02;114(18):4816-4821
2*	J:227228 Shrestha A, Carraro G, El Agha E, Mukhametshina R, Chao CM, Rizvanov A, Barreto G, Bellusci S, Generation and Validation of miR-142 Knock Out Mice. PLoS One. 2015;10(9):e0136913
4	J:290284 Shrestha A, Carraro G, Nottet N, Vazquez-Armendariz AI, Herold S, Cordero J, Singh I, Wilhelm J, Barreto G, Morty R, El Agha E, Mari B, Chen C, Zhang JS, Chao CM, Bellusci S, A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development. Cell Mol Life Sci. 2019 Jul;76(14):2817-2832
1*	J:63763 Tanaka Y, Naruse I, Hongo T, Xu M, Nakahata T, Maekawa T, Ishii S, Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein. Mech Dev. 2000 Jul;95(1-2):133-45
1	J:226885 Tannour-Louet M, Han S, Louet JF, Zhang B, Romero K, Addai J, Sahin A, Cheung SW, Lamb DJ, Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action. Nat Med. 2014 Jul;20(7):715-24
1	J:103823 Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F, NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY. J Biol Chem. 2005 Nov 18;280(46):38625-30
1	J:66454 Wang Z, Rose DW, Hermanson O, Liu F, Herman T, Wu W, Szeto D, Gleiberman A, Krones A, Pratt K, Rosenfeld R, Glass CK, Rosenfeld MG, Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13549-54
9*	J:74599 Warner DR, Pisano MM, Greene RM, Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue. In Vitro Cell Dev Biol Anim. 2002 Jan;38(1):48-53
1	J:211220 Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A, Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res. 2013 Dec;41(22):10199-214
1*	J:132031 Wong RL, Wlodarczyk BJ, Min KS, Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP, Finnell RH, Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Hum Mol Genet. 2008 Feb 15;17(4):587-601
1*	J:270211 Yang P, Xu C, Reece EA, Chen X, Zhong J, Zhan M, Stumpo DJ, Blackshear PJ, Yang P, Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. Nat Commun. 2019 Jan 17;10(1):282
3*	J:122808 Yang Y, Wolf LV, Cvekl A, distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens. J Mol Biol. 2007 Jun 15;369(4):917-26
4*	J:47301 Yao TP, Oh SP, Fuchs M, Zhou ND, Ch'ng LE, Newsome D, Bronson RT , Li E , Livingston DM , Eckner R, Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell. 1998 May 1;93(3):361-72