Gene Expression Literature Summary

• Symbol: Alx3
• Name: aristaless-like homeobox 3
• ID: MGI:1277097

45 matching records from 45 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15.5	E16.5	E18.5	E	P
In situ RNA (section)				1	4	5	1	4		1	1	4	4	2	1	1	1	4
In situ RNA (whole mount)	1	1	1	1	12	16	2	8	1	1				1			2
In situ reporter (knock in)					2	1		1		1
Northern blot						1		1		1		1	1					1
RT-PCR					1	3		5
cDNA clones						1						1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Alx3  aristaless-like homeobox 3
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
7*	J:71880 Beverdam A, Brouwer A, Reijnen M, Korving J, Meijlink F, Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development. 2001 Oct;128(20):3975-86
5*	J:71422 Beverdam A, Meijlink F, Expression patterns of group-I aristaless-related genes during craniofacial and limb development. Mech Dev. 2001 Sep;107(1-2):163-7
2	J:150764 Bildsoe H, Loebel DA, Jones VJ, Chen YT, Behringer RR, Tam PP, Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Dev Biol. 2009 Jul 15;331(2):176-88
2*	J:214666 Brunskill EW, Potter AS, Distasio A, Dexheimer P, Plassard A, Aronow BJ, Potter SS, A gene expression atlas of early craniofacial development. Dev Biol. 2014 Jul 15;391(2):133-46
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1	J:171520 Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ, Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. Genesis. 2011 Apr;49(4):307-25
1	J:229484 Conte D, Garaffo G, Lo Iacono N, Mantero S, Piccolo S, Cordenonsi M, Perez-Morga D, Orecchia V, Poli V, Merlo GR, The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand. Hum Mol Genet. 2016 Feb 15;25(4):740-54
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:319847 Dinsmore CJ, Soriano P, Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors. Elife. 2022 Jan 19;11:e75106
1	J:115876 Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, Grosschedl R, SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006 Jun 2;125(5):971-86
1	J:259576 Funato N, Kokubo H, Nakamura M, Yanagisawa H, Saga Y, Specification of jaw identity by the Hand2 transcription factor. Sci Rep. 2016 Jun 22;6:28405
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1	J:193110 Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ, Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1;374(1):185-97
2	J:327183 Gu R, Zhang S, Saha SK, Ji Y, Reynolds K, McMahon M, Sun B, Islam M, Trainor PA, Chen Y, Xu Y, Chai Y, Burkart-Waco D, Zhou CJ, Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts. Development. 2022 Jul 15;149(14):dev200533
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:202450 He F, Soriano P, A Critical Role for PDGFRalpha Signaling in Medial Nasal Process Development. PLoS Genet. 2013 Sep;9(9):e1003851
1	J:90847 Hirota J, Mombaerts P, The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8751-5
3*	J:338957 Iyyanar PPR, Qin C, Adhikari N, Liu H, Hu YC, Jiang R, Lan Y, Developmental origin of the mammalian premaxilla. Dev Biol. 2023 Jul 29;503:1-9
1	J:320497 Iyyanar PPR, Wu Z, Lan Y, Hu YC, Jiang R, Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Front Cell Dev Biol. 2022;10:777887
1	J:139700 Jeong J, Li X, McEvilly RJ, Rosenfeld MG, Lufkin T, Rubenstein JL, Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development. 2008 Sep;135(17):2905-16
1	J:128941 Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y, Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 1;312(1):435-47
1	J:214694 Kur E, Mecklenburg N, Cabrera RM, Willnow TE, Hammes A, LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15;127(Pt 10):2261-8
3	J:163651 Lakhwani S, Garcia-Sanz P, Vallejo M, Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects. Dev Biol. 2010 Aug 15;344(2):869-80
2	J:276721 Liu Z, Li C, Xu J, Lan Y, Liu H, Li X, Maire P, Wang X, Jiang R, Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development. J Dent Res. 2019 May;98(5):572-579
2*	J:78343 Loebel DA, O'Rourke MP, Steiner KA, Banyer J, Tam PP, Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002 Jul;33(3):103-13
1*	J:277316 Lukacs M, Roberts T, Chatuverdi P, Stottmann RW, Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival. Elife. 2019 Jun 24;8:e45248
3*	J:71389 Manley NR, Barrow JR, Zhang T, Capecchi MR, Hoxb2 and hoxb4 act together to specify ventral body wall formation. Dev Biol. 2001 Sep 1;237(1):130-44
2*	J:344235 Nguyen TT, Mitchell JM, Kiel MD, Kenny CP, Li H, Jones KL, Cornell RA, Williams TJ, Nichols JT, Van Otterloo E, TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway. Development. 2024 Jan 1;151(1):dev202095
1	J:263684 Nie X, Zheng J, Ricupero CL, He L, Jiao K, Mao JJ, mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018 Jul;14(7):e1007491
2	J:78407 O'Rourke MP, Soo K, Behringer RR, Hui CC, Tam PP, Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev Biol. 2002 Aug 1;248(1):143-56
5*	J:332131 Perera SN, Williams RM, Lyne R, Stubbs O, Buehler DP, Sauka-Spengler T, Noda M, Micklem G, Southard-Smith EM, Baker CVH, Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach. Glia. 2020 Dec;68(12):2550-2584
1	J:345597 Quilez S, Dumontier E, Baim C, Kam J, Cloutier JF, Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465
1	J:303230 Ray AT, Mazot P, Brewer JR, Catela C, Dinsmore CJ, Soriano P, FGF signaling regulates development by processes beyond canonical pathways. Genes Dev. 2020 Dec 1;34(23-24):1735-1752
2*	J:77801 Soo K, O'Rourke MP, Khoo PL, Steiner KA, Wong N, Behringer RR, Tam PP, Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo. Dev Biol. 2002 Jul 15;247(2):251-70
1	J:182258 Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG, Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
22*	J:48587 ten Berge D, Brouwer A, el Bahi S, Guenet JL, Robert B, Meijlink F, Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm. Dev Biol. 1998 Jul 1;199(1):11-25
1*	J:71035 ten Berge D, Brouwer A, Korving J, Reijnen MJ, van Raaij EJ, Verbeek F, Gaffield W, Meijlink F, Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development. 2001 Aug;128(15):2929-38
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:257921 Wang JS, Infante CR, Park S, Menke DB, PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets. Dev Biol. 2018 Feb 1;434(1):186-195
1	J:93910 Yamada R, Mizutani-Koseki Y, Koseki H, Takahashi N, Requirement for Mab21l2 during development of murine retina and ventral body wall. Dev Biol. 2004 Oct 15;274(2):295-307
1	J:347414 Yang J, Zhu L, Pan H, Ueharu H, Toda M, Yang Q, Hallett SA, Olson LE, Mishina Y, A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis. J Clin Invest. 2024 Mar 11;134(8)
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:183887 Zhang Y, Blackwell EL, McKnight MT, Knutsen GR, Vu WT, Ruest LB, Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2. Dev Dyn. 2012 May;241(5):924-40