Gene Expression Literature Summary

• Symbol: Snca
• Name: synuclein, alpha
• ID: MGI:1277151

37 matching records from 37 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)	1	1		1		1	2	1	3	1	2	1	1	1	1		1	1	2	1		10
In situ RNA (section)		1	1	1	1	3		1	1	2	2	2	3		1	1			2		1	8
In situ RNA (whole mount)							1
Northern blot																						2
Western blot							2	1	1	1		1						1				10
RT-PCR											1								1			4
cDNA clones																						3
RNase protection							1					1						1				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Snca  synuclein, alpha   (Synonyms: alpha-Syn, alphaSYN, alpha-synuclein)
Results	Reference
5	J:141972 Akil O, Weber CM, Park SN, Ninkina N, Buchman V, Lustig LR, Localization of synucleins in the Mammalian cochlea. J Assoc Res Otolaryngol. 2008 Dec;9(4):452-63
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5	J:159933 Cano-Jaimez M, Perez-Sanchez F, Milan M, Buendia P, Ambrosio S, Farinas I, Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein. Neurobiol Dis. 2010 Apr;38(1):92-103
2	J:348105 Chen H, Luo S, Deng X, Li S, Mao Y, Yan J, Cheng Y, Liu X, Pan J, Huang H, Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20;1870(5):167189
2	J:235155 Doucet-Beaupre H, Gilbert C, Profes MS, Chabrat A, Pacelli C, Giguere N, Rioux V, Charest J, Deng Q, Laguna A, Ericson J, Perlmann T, Ang SL, Cicchetti F, Parent M, Trudeau LE, Levesque M, Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4387-96
6	J:309996 Dumas S, Wallen-Mackenzie A, Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification. Front Cell Dev Biol. 2019;7:307
1*	J:153971 Giovannone B, Tsiaras WG, de la Monte S, Klysik J, Lautier C, Karashchuk G, Goldwurm S, Smith RJ, GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet. 2009 Dec 1;18(23):4629-39
6*	J:49927 Hong L, Ko HW, Gwag BJ, Joe E, Lee S, Kim YT, Suh YH, The cDNA cloning and ontogeny of mouse alpha-synuclein. Neuroreport. 1998 Apr 20;9(6):1239-43
13*	J:48620 Hsu LJ, Mallory M, Xia Y, Veinbergs I, Hashimoto M, Yoshimoto M, Thal LJ, Saitoh T, Masliah E, Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 1998 Jul;71(1):338-44
1*	J:122792 Jacobs FM, Smits SM, Noorlander CW, von Oerthel L, van der Linden AJ, Burbach JP, Smidt MP, Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency. Development. 2007 Jul;134(14):2673-84
1	J:295412 Kim DW, Washington PW, Wang ZQ, Lin SH, Sun C, Ismail BT, Wang H, Jiang L, Blackshaw S, The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development. Nat Commun. 2020 Aug 31;11(1):4360
1	J:311902 Komuro Y, Galas L, Morozov YM, Fahrion JK, Raoult E, Lebon A, Tilot AK, Kikuchi S, Ohno N, Vaudry D, Rakic P, Komuro H, The Role of Galanin in Cerebellar Granule Cell Migration in the Early Postnatal Mouse during Normal Development and after Injury. J Neurosci. 2021 Oct 20;41(42):8725-8741
3	J:352993 Krishnamurthy A, Lee AS, Bayin NS, Stephen DN, Nasef O, Lao Z, Joyner AL, Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival. Development. 2024 Jul 15;151(14):dev202502
1	J:228865 Law C, Schaan Profes M, Levesque M, Kaltschmidt JA, Verhage M, Kania A, Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci. 2016 Jan 13;36(2):561-76
1	J:294282 Li L, Ruan X, Wen C, Chen P, Liu W, Zhu L, Xiang P, Zhang X, Wei Q, Hou L, Yin B, Yuan J, Qiang B, Shu P, Peng X, The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Rep. 2019 Jul 16;28(3):698-711.e5
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2	J:125212 Michell AW, Tofaris GK, Gossage H, Tyers P, Spillantini MG, Barker RA, The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease. Cell Transplant. 2007;16(5):461-74
1*	J:270236 Miki Y, Tanji K, Mori F, Utsumi J, Sasaki H, Kakita A, Takahashi H, Wakabayashi K, Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. Neurosci Lett. 2018 Sep 25;684:35-41
1	J:86439 Ninkina N, Papachroni K, Robertson DC, Schmidt O, Delaney L, O'Neill F, Court F, Rosenthal A, Fleetwood-Walker SM, Davies AM, Buchman VL, Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene. Mol Cell Biol. 2003 Nov;23(22):8233-45
1	J:150768 Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A, Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J, Kawano H, Kasai M, The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev Biol. 2009 Jul 15;331(2):140-51
2	J:268226 Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Pique A, Szego E, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kugler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF, Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein. Hum Mol Genet. 2019 Jan 1;28(1):31-50
1	J:171698 Pramparo T, Libiger O, Jain S, Li H, Youn YH, Hirotsune S, Schork NJ, Wynshaw-Boris A, Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects. PLoS Genet. 2011 Mar;7(3):e1001331
3	J:279439 Rahimi-Balaei M, Buchok M, Vihko P, Parkinson FE, Marzban H, Loss of prostatic acid phosphatase and alpha-synuclein cause motor circuit degeneration without altering cerebellar patterning. PLoS One. 2019;14(9):e0222234
1	J:92213 Robertson DC, Schmidt O, Ninkina N, Jones PA, Sharkey J, Buchman VL, Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. J Neurochem. 2004 Jun;89(5):1126-36
1	J:156036 Schilling K, Oberdick J, The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Cerebellum. 2009 Dec;8(4):477-89
2	J:314575 Seleem AA, Expression of alpha-synuclein during eye development of mice (Mus musculus), chick (Gallus gallus domisticus) and fish (Ctenopharyngodon idella) in a comparison study. Tissue Cell. 2015 Aug;47(4):359-65
1	J:185964 Sgado P, Ferretti E, Grbec D, Bozzi Y, Simon HH, The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons. Neural Dev. 2012;7:24
2	J:68925 Simon HH, Saueressig H, Wurst W, Goulding MD, O'Leary DD, Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J Neurosci. 2001 May 1;21(9):3126-34
1	J:88592 Smidt MP, Smits SM, Bouwmeester H, Hamers FP, van der Linden AJ, Hellemons AJ, Graw J, Burbach JP, Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development. 2004 Mar;131(5):1145-55
2	J:225806 Tang FL, Erion JR, Tian Y, Liu W, Yin DM, Ye J, Tang B, Mei L, Xiong WC, VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for alpha-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease. J Neurosci. 2015 Jul 22;35(29):10613-28
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*	J:136998 Trimarchi JM, Stadler MB, Roska B, Billings N, Sun B, Bartch B, Cepko CL, Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling. J Comp Neurol. 2007 Jun 20;502(6):1047-65
1	J:333924 Wang S, Fu Y, Miyata T, Matsumoto S, Shinoda T, Itoh K, Harada A, Hirotsune S, Jin M, Functional Cooperation of alpha-Synuclein and Tau Is Essential for Proper Corticogenesis. J Neurosci. 2022 Sep 14;42(37):7031-7046
2	J:195852 Xie Q, Yang Y, Huang J, Ninkovic J, Walcher T, Wolf L, Vitenzon A, Zheng D, Gotz M, Beebe DC, Zavadil J, Cvekl A, Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. PLoS One. 2013;8(1):e54507
1	J:295435 Yli-Karjanmaa M, Larsen KS, Fenger CD, Kristensen LK, Martin NA, Jensen PT, Breton A, Nathanson L, Nielsen PV, Lund MC, Carlsen SL, Gramsbergen JB, Finsen B, Stubbe J, Frich LH, Stolp H, Brambilla R, Anthony DC, Meyer M, Lambertsen KL, TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex. Brain Behav Immun. 2019 Nov;82:279-297
1	J:242134 Zhao Z, Cao L, Reece EA, Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4489-4494
10*	J:159509 Zhong SC, Luo X, Chen XS, Cai QY, Liu J, Chen XH, Yao ZX, Expression and subcellular location of alpha-synuclein during mouse-embryonic development. Cell Mol Neurobiol. 2010 Apr;30(3):469-82