Gene Expression Literature Summary

• Symbol: Slc7a5
• Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
• ID: MGI:1298205

22 matching records from 22 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E4	E7	E7.5	E8.5	E9.5	E10.5	E11.5	E13.5	E14	E14.5	E15	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)									1		1	1	1			2				1		1			5
In situ RNA (section)								1	1	1	3	2	1			1					2			1	5
In situ RNA (whole mount)								1		1	1	1												1
Western blot											1	1	1				1	1	1						3
RT-PCR	1	1	1	1	1	1	1		1	1	3	3	6	2	1	3	1	1	2	1	3	2	1		11

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Slc7a5  solute carrier family 7 (cationic amino acid transporter, y+ system), member 5   (Synonyms: D0H16S474E, Gm42049, LAT1, TA1)
Results	Reference
1*	J:189202 Abe S, Namba N, Abe M, Fujiwara M, Aikawa T, Kogo M, Ozono K, Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes. Endocrinology. 2012 Aug;153(8):4049-58
1	J:307863 Aryal S, Anand D, Hernandez FG, Weatherbee BAT, Huang H, Reddy AP, Wilmarth PA, David LL, Lachke SA, MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract. Hum Genet. 2020 Feb;139(2):151-184
7*	J:167825 Braun D, Kinne A, Brauer AU, Sapin R, Klein MO, Kohrle J, Wirth EK, Schweizer U, Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells. Glia. 2011 Mar;59(3):463-71
4*	J:146910 Capelo LP, Beber EH, Fonseca TL, Gouveia CH, The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells. Thyroid. 2009 Feb;19(2):171-80
19*	J:148428 Chrostowski MK, McGonnigal BG, Stabila JP, Padbury JF, LAT-1 expression in pre- and post-implantation embryos and placenta. Placenta. 2009 Mar;30(3):270-6
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*	J:201184 Ferrara AM, Liao XH, Gil-Ibanez P, Marcinkowski T, Bernal J, Weiss RE, Dumitrescu AM, Refetoff S, Changes in thyroid status during perinatal development of MCT8-deficient male mice. Endocrinology. 2013 Jul;154(7):2533-41
1*	J:241343 Furuya S, Yoshida K, Kawakami Y, Yang JH, Sayano T, Azuma N, Tanaka H, Kuhara S, Hirabayashi Y, Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency. Funct Integr Genomics. 2008 Aug;8(3):235-49
2*	J:333714 Huynh H, Zhu S, Lee S, Bao Y, Pang J, Nguyen A, Gu Y, Chen C, Ouyang K, Evans SM, Fang X, DELE1 is protective for mitochondrial cardiomyopathy. J Mol Cell Cardiol. 2023 Feb;175:44-48
1*	J:145763 Kawakami Y, Yoshida K, Yang JH, Suzuki T, Azuma N, Sakai K, Hashikawa T, Watanabe M, Yasuda K, Kuhara S, Hirabayashi Y, Furuya S, Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model. Neurosci Res. 2009 Mar;63(3):184-93
3	J:335218 Knaus LS, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M, Schwarz LA, Gorkiewicz S, Amberg N, Pauler FM, Knittl-Frank C, Tassinari M, Maulide N, Rulicke T, Menche J, Hippenmeyer S, Novarino G, Large neutral amino acid levels tune perinatal neuronal excitability and survival. Cell. 2023 Apr 27;186(9):1950-1967.e25
2	J:306925 Menendez-Montes I, Escobar B, Gomez MJ, Albendea-Gomez T, Palacios B, Bonzon-Kulichenko E, Izquierdo-Garcia JL, Alonso AV, Ferrarini A, Jimenez-Borreguero LJ, Ruiz-Cabello J, Vazquez J, Martin-Puig S, Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice. iScience. 2021 Feb 19;24(2):102124
14	J:243986 Ohgaki R, Ohmori T, Hara S, Nakagomi S, Kanai-Azuma M, Kaneda-Nakashima K, Okuda S, Nagamori S, Kanai Y, Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc. Mol Cell Biol. 2017 Jun 01;37(11)
15	J:282947 Poncet N, Halley PA, Lipina C, Gierlinski M, Dady A, Singer GA, Febrer M, Shi YB, Yamaguchi TP, Taylor PM, Storey KG, Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos. EMBO Rep. 2020 Jan 7;21(1):e48469
1	J:331835 Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN, Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice. Biol Reprod. 2022 Jun 13;106(6):1292-1311
1*	J:208718 Selmi-Ruby S, Bouazza L, Obregon MJ, Conscience A, Flamant F, Samarut J, Borson-Chazot F, Rousset B, The targeted inactivation of TRbeta gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production. Endocrinology. 2014 Feb;155(2):635-46
5*	J:179032 Sharlin DS, Visser TJ, Forrest D, Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea. Endocrinology. 2011 Dec;152(12):5053-64
2	J:347601 Shen T, Wang S, Huang C, Zhu S, Zhu X, Li N, Wang H, Huang L, Ren M, Han Z, Ge J, Chen Z, Ouyang K, Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice. Biochem Biophys Res Commun. 2024 May 28;710:149883
2	J:238065 Tarlungeanu DC, Deliu E, Dotter CP, Kara M, Janiesch PC, Scalise M, Galluccio M, Tesulov M, Morelli E, Sonmez FM, Bilguvar K, Ohgaki R, Kanai Y, Johansen A, Esharif S, Ben-Omran T, Topcu M, Schlessinger A, Indiveri C, Duncan KE, Caglayan AO, Gunel M, Gleeson JG, Novarino G, Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder. Cell. 2016 Dec 01;167(6):1481-1494.e18
4	J:318908 Wilson RL, Troja W, Courtney J, Williams A, Jones HN, Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome. Placenta. 2022 Jan;117:131-138
3	J:151324 Wirth EK, Roth S, Blechschmidt C, Holter SM, Becker L, Racz I, Zimmer A, Klopstock T, Gailus-Durner V, Fuchs H, Wurst W, Naumann T, Brauer A, de Angelis MH, Kohrle J, Gruters A, Schweizer U, Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. J Neurosci. 2009 Jul 29;29(30):9439-49
2	J:335524 Zhu S, Nguyen A, Pang J, Zhao J, Chen Z, Liang Z, Gu Y, Huynh H, Bao Y, Lee S, Kluger Y, Ouyang K, Evans SM, Fang X, Mitochondrial Stress Induces an HRI-eIF2alpha Pathway Protective for Cardiomyopathy. Circulation. 2022 Sep 27;146(13):1028-1031