Symbol Name ID |
Dio3
deiodinase, iodothyronine type III MGI:1306782 |
Age | E7 | E8.5 | E9.5 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19.5 | E | P |
Immunohistochemistry (section) | 1 | 1 | 2 | 1 | 2 | |||||||||||||||||
In situ RNA (section) | 3 | 1 | 2 | 1 | 1 | 3 | ||||||||||||||||
In situ reporter (knock in) | 1 | |||||||||||||||||||||
Northern blot | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 4 | 1 | 2 | 5 | |||||||||||
RT-PCR | 2 | 2 | 2 | 2 | 1 | 2 | 3 | 6 | 1 | 2 | 6 | 1 | 1 | 6 | 1 | 2 | 16 | |||||
cDNA clones | 2 | |||||||||||||||||||||
RNase protection | 1 | 1 | ||||||||||||||||||||
Primer Extension | 1 |
Dio3 deiodinase, iodothyronine type III | |
Results | Reference |
3 | J:182286 Charalambous M, Ferron SR, da Rocha ST, Murray AJ, Rowland T, Ito M, Schuster-Gossler K, Hernandez A, Ferguson-Smith AC, Imprinted gene dosage is critical for the transition to independent life. Cell Metab. 2012 Feb 8;15(2):209-21 |
7 | J:124897 Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D, Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14466-71 |
1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
2* | J:201184 Ferrara AM, Liao XH, Gil-Ibanez P, Marcinkowski T, Bernal J, Weiss RE, Dumitrescu AM, Refetoff S, Changes in thyroid status during perinatal development of MCT8-deficient male mice. Endocrinology. 2013 Jul;154(7):2533-41 |
3 | J:227474 Fonseca TL, Fernandes GW, McAninch EA, Bocco BM, Abdalla SM, Ribeiro MO, Mohacsik P, Fekete C, Li D, Xing X, Wang T, Gereben B, Bianco AC, Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14018-23 |
3 | J:324530 Fonseca TL, Russo SC, Luongo C, Salvatore D, Bianco AC, Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. Endocrinology. 2022 May 1;163(5) |
3* | J:165681 Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME, Bianco AC, Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology. 2010 Sep;151(9):4573-82 |
1 | J:287095 Hara S, Terao M, Muramatsu A, Takada S, Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method. Sci Rep. 2019 Dec 27;9(1):20202 |
4* | J:80434 Hernandez A, Fiering S, Martinez E, Galton VA, St Germain D, The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts. Endocrinology. 2002 Nov;143(11):4483-6 |
2* | J:52027 Hernandez A, Lyon GJ, Schneider MJ, St. Germain DL, Isolation and characterization of the mouse gene for the type 3 iodothyronine deiodinase. Endocrinology. 1999 Jan;140(1):124-30 |
2 | J:303008 Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Ribeiro MO, Gereben B, Bianco AC, Werneck-de-Castro JP, Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. Thyroid. 2017 Apr;27(4):577-586 |
1* | J:127743 Kawahara M, Wu Q, Ferguson-Smith AC, Kono T, Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term. FEBS Lett. 2007 Nov 13;581(27):5178-84 |
1* | J:299191 Kitazawa M, Hayashi S, Imamura M, Takeda S, Oishi Y, Kaneko-Ishino T, Ishino F, Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes. Development. 2020 Sep 2;147(21):dev185918 |
1* | J:251670 Kumamoto S, Takahashi N, Nomura K, Fujiwara M, Kijioka M, Uno Y, Matsuda Y, Sotomaru Y, Kono T, Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice. Hum Mol Genet. 2017 Oct 01;26(19):3653-3662 |
4 | J:216177 Labialle S, Marty V, Bortolin-Cavaille ML, Hoareau-Osman M, Pradere JP, Valet P, Martin PG, Cavaille J, The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30 |
3 | J:132025 Labialle S, Yang L, Ruan X, Villemain A, Schmidt JV, Hernandez A, Wiltshire T, Cermakian N, Naumova AK, Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Hum Mol Genet. 2008 Jan 1;17(1):15-26 |
1 | J:143283 Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC, A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell. 2008 Oct;15(4):547-57 |
2* | J:91849 Lin SP, Youngson N, Takada S, Seitz H, Reik W, Paulsen M, Cavaille J, Ferguson-Smith AC, Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet. 2003 Sep;35(1):97-102 |
7 | J:218428 Martinez ME, Charalambous M, Saferali A, Fiering S, Naumova AK, St Germain D, Ferguson-Smith AC, Hernandez A, Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions. Mol Endocrinol. 2014 Nov;28(11):1875-86 |
2* | J:308708 Martinez ME, Hernandez A, The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain. Front Neurosci. 2021;15:703730 |
1 | J:331365 Martinez ME, Pinz I, Preda M, Norton CR, Gridley T, Hernandez A, DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities. JCI Insight. 2022 Nov 8;7(21) |
3 | J:177060 Medina MC, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, Pileggi A, Hernandez A, Edlund H, Bianco AC, The Thyroid Hormone-Inactivating Type III Deiodinase Is Expressed in Mouse and Human {beta}-Cells and Its Targeted Inactivation Impairs Insulin Secretion. Endocrinology. 2011 Oct;152(10):3717-27 |
4* | J:151815 Ng L, Hernandez A, He W, Ren T, Srinivas M, Ma M, Galton VA, St Germain DL, Forrest D, A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function. Endocrinology. 2009 Apr;150(4):1952-60 |
8 | J:159022 Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B, St Germain DL, Hernandez A, Pugh EN Jr, Forrest D, Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. J Neurosci. 2010 Mar 3;30(9):3347-57 |
2 | J:194089 Peeters RP, Hernandez A, Ng L, Ma M, Sharlin DS, Pandey M, Simonds WF, St Germain DL, Forrest D, Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor alpha1. Endocrinology. 2013 Jan;154(1):550-61 |
5 | J:282947 Poncet N, Halley PA, Lipina C, Gierlinski M, Dady A, Singer GA, Febrer M, Shi YB, Yamaguchi TP, Taylor PM, Storey KG, Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos. EMBO Rep. 2020 Jan 7;21(1):e48469 |
1* | J:266963 Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H, Takada S, A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development. Hum Mol Genet. 2018 Sep 15;27(18):3283-3292 |
1 | J:241393 Saito T, Hara S, Tamano M, Asahara H, Takada S, Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice. J Reprod Dev. 2017 Feb 16;63(1):101-109 |
1 | J:195360 Seibt J, Armant O, Le Digarcher A, Castro D, Ramesh V, Journot L, Guillemot F, Vanderhaeghen P, Bouschet T, Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon. PLoS One. 2012;7(11):e48675 |
2 | J:108133 Sekita Y, Wagatsuma H, Irie M, Kobayashi S, Kohda T, Matsuda J, Yokoyama M, Ogura A, Schuster-Gossler K, Gossler A, Ishino F, Kaneko-Ishino T, Aberrant regulation of imprinted gene expression in Gtl2lacZ mice. Cytogenet Genome Res. 2006;113(1-4):223-9 |
1* | J:208718 Selmi-Ruby S, Bouazza L, Obregon MJ, Conscience A, Flamant F, Samarut J, Borson-Chazot F, Rousset B, The targeted inactivation of TRbeta gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production. Endocrinology. 2014 Feb;155(2):635-46 |
2* | J:147577 Takahashi N, Okamoto A, Kobayashi R, Shirai M, Obata Y, Ogawa H, Sotomaru Y, Kono T, Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice. Hum Mol Genet. 2009 May 15;18(10):1879-88 |
5 | J:78148 Tsai CE, Lin SP, Ito M, Takagi N, Takada S, Ferguson-Smith AC, Genomic imprinting contributes to thyroid hormone metabolism in the mouse embryo. Curr Biol. 2002 Jul 23;12(14):1221-6 |
1* | J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6 |
1 | J:207929 Yamaguchi S, Shen L, Liu Y, Sendler D, Zhang Y, Role of Tet1 in erasure of genomic imprinting. Nature. 2013 Dec 19;504(7480):460-4 |
2* | J:161712 Zaitoun I, Downs KM, Rosa GJ, Khatib H, Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting. Epigenetics. 2010 Feb;5(2):149-58 |
1* | J:344890 Zhang L, Han Z, He H, Zhang X, Zhang M, Li B, Wu Q, Meg8-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice. Genes (Basel). 2023 Jun 14;14(6) |
2 | J:346630 Zhang X, He H, Yu H, Teng X, Wang Z, Li C, Li J, Yang H, Shen J, Wu T, Zhang F, Zhang Y, Wu Q, Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature. Commun Biol. 2024 Mar 23;7(1):363 |
3* | J:166176 Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HG, Bronson RT, Klibanski A, Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development. 2010 Aug;137(16):2643-52 |
2 | J:281273 Zhu W, Botticelli EM, Kery RE, Mao Y, Wang X, Yang A, Wang X, Zhou J, Zhang X, Soberman RJ, Klibanski A, Zhou Y, Meg3-DMR, not the Meg3 gene, regulates imprinting of the Dlk1-Dio3 locus. Dev Biol. 2019 Nov 1;455(1):10-18 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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