Gene Expression Literature Summary

• Symbol: Cited2
• Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
• ID: MGI:1306784

51 matching records from 51 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E5.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)													1		1								1					1	1		2
In situ RNA (section)									1	2	1		2	1	3		1	1	1	3	10		2				2				4
In situ RNA (whole mount)							1	1	1	2	3	1	2	1	2		1	1	1	1			3							1
In situ reporter (knock in)								1	3	2	2		5		2				1	1	2		2		1		1				1
Northern blot																	1		2	3	2		3	2	2		2				2
Western blot																						1				1					1
RT-PCR	1	1	1	1	1	1					2	1	1	1	2	1	2		1	2	1		1				1	1		1	4
cDNA clones								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cited2  Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2   (Synonyms: Mrg1, Msg2, p35srj)
Results	Reference
1	J:76593 Bamforth SD, Braganca J, Eloranta JJ, Murdoch JN, Marques FI, Kranc KR, Farza H, Henderson DJ, Hurst HC, Bhattacharya S, Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet. 2001 Dec;29(4):469-74
1*	J:74736 Barbera JP, Rodriguez TA, Greene ND, Weninger WJ, Simeone A, Copp AJ, Beddington RS, Dunwoodie S, Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet. 2002 Feb 1;11(3):283-93
2	J:213829 Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG, Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014;9(2):e89397
2	J:208419 Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M, Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
6*	J:153786 Bhattacherjee V, Horn KH, Singh S, Webb CL, Pisano MM, Greene RM, CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development. Int J Dev Biol. 2009;53(7):1097-104
1	J:87725 Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS, Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development. 2004 Feb;131(4):797-806
4*	J:123322 Boyle S, Shioda T, Perantoni AO, de Caestecker M, Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Dev Dyn. 2007 Aug;236(8):2321-30
2	J:150743 Buaas FW, Val P, Swain A, The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet. 2009 Aug 15;18(16):2989-3001
1	J:189064 Chassot AA, Bradford ST, Auguste A, Gregoire EP, Pailhoux E, de Rooij DG, Schedl A, Chaboissier MC, WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad. Development. 2012 Dec;139(23):4461-72
1	J:153549 Chen Y, Carlson EC, Chen ZY, Hamik A, Jain MK, Dunwoodie SL, Yang YC, Conditional deletion of Cited2 results in defective corneal epithelial morphogenesis and maintenance. Dev Biol. 2009 Oct 1;334(1):243-52
3	J:139006 Chen Y, Doughman YQ, Gu S, Jarrell A, Aota S, Cvekl A, Watanabe M, Dunwoodie SL, Johnson RS, van Heyningen V, Kleinjan DA, Beebe DC, Yang YC, Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development. 2008 Sep;135(17):2939-48
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
11*	J:46929 Dunwoodie SL, Rodriguez TA, Beddington RS, Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev. 1998 Mar;72(1-2):27-40
2	J:241101 Fame RM, Dehay C, Kennedy H, Macklis JD, Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex. Cereb Cortex. 2017 Mar 01;27(3):1817-1830
7	J:234341 Fame RM, MacDonald JL, Dunwoodie SL, Takahashi E, Macklis JD, Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity. J Neurosci. 2016 Jun 15;36(24):6403-19
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:315113 Hafner R, Bohnenpoll T, Rudat C, Schultheiss TM, Kispert A, Fgfr2 is required for the expansion of the early adrenocortical primordium. Mol Cell Endocrinol. 2015 Sep 15;413:168-77
1	J:185205 Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M, Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 2012 May;8(5):e1002728
1*	J:138815 Kawaguchi A, Ikawa T, Kasukawa T, Ueda HR, Kurimoto K, Saitou M, Matsuzaki F, Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis. Development. 2008 Sep;135(18):3113-24
1	J:240175 Kelleher AM, Peng W, Pru JK, Pru CA, DeMayo FJ, Spencer TE, Forkhead box a2 (FOXA2) is essential for uterine function and fertility. Proc Natl Acad Sci U S A. 2017 Feb 07;114(6):E1018-E1026
1*	J:320762 Kingsley PD, Greenfest-Allen E, Frame JM, Bushnell TP, Malik J, McGrath KE, Stoeckert CJ, Palis J, Ontogeny of erythroid gene expression. Blood. 2013 Feb 7;121(6):e5-e13
2	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
1	J:163651 Lakhwani S, Garcia-Sanz P, Vallejo M, Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects. Dev Biol. 2010 Aug 15;344(2):869-80
2*	J:321499 Lee DR, Rhodes C, Mitra A, Zhang Y, Maric D, Dale RK, Petros TJ, Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain. Elife. 2022 Feb 17;11:e71864
1	J:132940 Lin W, Zhang Z, Srajer G, Chen YC, Huang M, Phan HM, Dent SY, Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. Dev Dyn. 2008 Apr;237(4):928-40
6*	J:168841 Lopes Floro K, Artap ST, Preis JI, Fatkin D, Chapman G, Furtado MB, Harvey RP, Hamada H, Sparrow DB, Dunwoodie SL, Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis. Hum Mol Genet. 2011 Mar 15;20(6):1097-110
4	J:290696 Lopez-Tello J, Perez-Garcia V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernandez de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN, Fetal and trophoblast PI3K p110alpha have distinct roles in regulating resource supply to the growing fetus in mice. Elife. 2019 Jun 26;8:e45282
1	J:199431 Macdonald ST, Bamforth SD, Braganca J, Chen CM, Broadbent C, Schneider JE, Schwartz RJ, Bhattacharya S, A cell-autonomous role of Cited2 in controlling myocardial and coronary vascular development. Eur Heart J. 2013 Aug;34(32):2557-2565
2	J:137951 MacDonald ST, Bamforth SD, Chen CM, Farthing CR, Franklyn A, Broadbent C, Schneider JE, Saga Y, Lewandoski M, Bhattacharya S, Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res. 2008 Aug 1;79(3):448-57
1	J:261809 Mayer C, Hafemeister C, Bandler RC, Machold R, Batista Brito R, Jaglin X, Allaway K, Butler A, Fishell G, Satija R, Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462
1	J:94514 McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN, The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan;132(1):189-201
1*	J:161209 Michell AC, Braganca J, Broadbent C, Joyce B, Franklyn A, Schneider JE, Bhattacharya S, Bamforth SD, A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2. Dev Dyn. 2010 Jul;239(7):1988-94
1*	J:198109 Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones ML, Rakic S, Molnar Z, Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59
1*	J:90276 Ota MS, Loebel DA, O'Rourke MP, Wong N, Tsoi B, Tam PP, Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells. Dev Dyn. 2004 Jun;230(2):216-28
12	J:140378 Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC, Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J. 2007 Oct 31;26(21):4445-56
1	J:178379 Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P, Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
2	J:236978 Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL, Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep;14(9):e2000197
1*	J:106710 Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C, Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
8	J:135126 Val P, Martinez-Barbera JP, Swain A, Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development. 2007 Jun;134(12):2349-58
1*	J:115291 Vigano MA, Lamartine J, Testoni B, Merico D, Alotto D, Castagnoli C, Robert A, Candi E, Melino G, Gidrol X, Mantovani R, New p63 targets in keratinocytes identified by a genome-wide approach. EMBO J. 2006 Nov 1;25(21):5105-16
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:330190 Wagner NR, Sinha A, Siththanandan V, Kowalchuk AM, MacDonald JL, Tharin S, miR-409-3p represses Cited2 to refine neocortical layer V projection neuron identity. Front Neurosci. 2022;16:931333
7*	J:97216 Weninger WJ, Floro KL, Bennett MB, Withington SL, Preis JI, Barbera JP, Mohun TJ, Dunwoodie SL, Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development. 2005 Mar;132(6):1337-48
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
7*	J:109335 Withington SL, Scott AN, Saunders DN, Lopes Floro K, Preis JI, Michalicek J, Maclean K, Sparrow DB, Barbera JP, Dunwoodie SL, Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. Dev Biol. 2006 Jun 1;294(1):67-82
7*	J:136063 Xu B, Qu X, Gu S, Doughman YQ, Watanabe M, Dunwoodie SL, Yang YC, Cited2 is required for fetal lung maturation. Dev Biol. 2008 May 1;317(1):95-105
1*	J:80801 Yahata T, Takedatsu H, Dunwoodie SL, Braganca J, Swingler T, Withington SL, Hur J, Coser KR, Isselbacher KJ, Bhattacharya S, Shioda T, Cloning of Mouse cited4, a Member of the CITED Family p300/CBP-Binding Transcriptional Coactivators: Induced Expression in Mammary Epithelial Cells. Genomics. 2002 Dec;80(6):601-13
1*	J:78364 Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YC, The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10488-93