Gene Expression Literature Summary

• Symbol: Apaf1
• Name: apoptotic peptidase activating factor 1
• ID: MGI:1306796

25 matching records from 25 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E7	E7.5	E8.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E17	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)														1						1					1
In situ RNA (section)		1			1		1			1	1			1											1
In situ RNA (whole mount)				1		1					1			1										1
In situ reporter (knock in)						1	2				2			1
Northern blot		1	1			1		1	1					1	1	1		1	1
Western blot									1		2	1	1			1	1	1		1		1	1	2	4
RT-PCR	1			1					1		1	2						1		1	1			1	6
cDNA clones											1					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Apaf1  apoptotic peptidase activating factor 1   (Synonyms: 6230400I06Rik, Apaf1l)
Results	Reference
1	J:196570 Bae KB, Kim MO, Yu DH, Shin MJ, Kim HJ, Yuh HS, Ji YR, Kim JY, Kim JM, Hyun BH, Lee HC, Chang WK, Park SB, Kim do H, Lee HS, Choo YS, Lee S, Ryoo ZY, Overexpression of Jazf1 induces cardiac malformation through the upregulation of pro-apoptotic genes in mice. Transgenic Res. 2011 Oct;20(5):1019-31
2	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
1	J:284146 Bowen ME, McClendon J, Long HK, Sorayya A, Van Nostrand JL, Wysocka J, Attardi LD, The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes. Dev Cell. 2019 Jul 22;50(2):212-228.e6
11	J:49840 Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P, Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell. 1998 Sep 18;94(6):727-37
3*	J:89365 Cecconi F, Roth KA, Dolgov O, Munarriz E, Anokhin K, Gruss P, Salminen M, Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth. Development. 2004 May;131(9):2125-35
1	J:274697 Celaya AM, Sanchez-Perez I, Bermudez-Munoz JM, Rodriguez-de la Rosa L, Pintado-Berninches L, Perona R, Murillo-Cuesta S, Varela-Nieto I, Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Elife. 2019 Apr 2;8:e39159
1	J:144496 Chatoo W, Abdouh M, David J, Champagne MP, Ferreira J, Rodier F, Bernier G, The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci. 2009 Jan 14;29(2):529-42
7	J:244729 Chen Q, Xu J, Li L, Li H, Mao S, Zhang F, Zen K, Zhang CY, Zhang Q, MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death Dis. 2014 Mar 20;5:e1132
2	J:119657 Cheng W, Jacobs WB, Zhang JJ, Moro A, Park JH, Kushida M, Qiu W, Mills AA, Kim PC, DeltaNp63 plays an anti-apoptotic role in ventral bladder development. Development. 2006 Dec;133(23):4783-92
3	J:236189 Chinnam M, Wang X, Zhang X, Goodrich DW, Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice. Mol Cell Biol. 2016 Jun 1;36(11):1621-7
4	J:317793 De Zio D, Molinari F, Rizza S, Gatta L, Ciotti MT, Salvatore AM, Mathiassen SG, Cwetsch AW, Filomeni G, Rosano G, Ferraro E, Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015 Nov;72(21):4173-91
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*	J:227534 Gong W, Gohla RM, Bowlin KM, Koyano-Nakagawa N, Garry DJ, Shi X, Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex. J Biol Chem. 2015 Jun 12;290(24):15350-61
1*	J:268858 Ishimura A, Terashima M, Tange S, Suzuki T, Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. Cell Tissue Res. 2016 Mar;363(3):723-33
4	J:49088 Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA, Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998 Aug 7;94(3):325-37
2	J:201947 Long AB, Kaiser WJ, Mocarski ES, Caspary T, Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development. Cell Death Differ. 2013 Nov;20(11):1510-20
1*	J:182713 McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD, Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012 Mar 1;363(1):62-73
4	J:100240 Muller M, Berger J, Gersdorff N, Cecconi F, Herken R, Quondamatteo F, Localization of Apaf1 gene expression in the early development of the mouse by means of in situ reverse transcriptase-polymerase chain reaction. Dev Dyn. 2005 Sep;234(1):215-21
4	J:110339 Stoka V, Turk V, Bredesen DE, Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. FEBS Lett. 2006 Jun 26;580(15):3739-45
1	J:56519 Sun X, Meyers EN, Lewandoski M, Martin GR, Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 1999 Jul 15;13(14):1834-46
1	J:125010 Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF, BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol. 2007 Sep;27(17):6229-42
2*	J:310882 Urbanek ME, Zuo J, Genetic predisposition to tinnitus in the UK Biobank population. Sci Rep. 2021 Sep 13;11(1):18150
1*	J:170048 Vasey DB, Wolf CR, Brown K, Whitelaw CB, Spatial p21 expression profile in the mid-term mouse embryo. Transgenic Res. 2011 Feb;20(1):23-8
5	J:49841 Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, Penninger JM, Mak TW, Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell. 1998 Sep 18;94(6):739-50
2*	J:129205 Zhang J, Bahi N, Zubiaga AM, Comella JX, Llovera M, Sanchis D, Developmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissues. FEBS Lett. 2007 Dec 22;581(30):5781-6