Gene Expression Literature Summary

• Symbol: Cask
• Name: calcium/calmodulin dependent serine protein kinase
• ID: MGI:1309489

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E6.5	E9.5	E10.5	E11	E12	E12.5	E13	E13.5	E14	E14.5	E15	E16	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)							1						1			1			5
In situ RNA (section)											2					1			1
Northern blot					1	1		1		1		1							1
Western blot					1	1		1		1		1	1	1	1	1	1	2	8
RT-PCR	1	1	1	1					2	1				2			1	1	5
cDNA clones							1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cask  calcium/calmodulin dependent serine protein kinase   (Synonyms: DXPri1, DXRib1, LIN-2, mLin-2, Pals3)
Results	Reference
1	J:315767 Ahn SY, Kim Y, Kim ST, Swat W, Miner JH, Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development. J Am Soc Nephrol. 2013 Jun;24(7):1127-38
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:353360 Cesari E, Farini D, Medici V, Ehrmann I, Guerra M, Testa E, Naro C, Geloso MC, Pagliarini V, La Barbera L, D'Amelio M, Orsini T, Vecchioli SF, Tamagnone L, Fort P, Viscomi MT, Elliott DJ, Sette C, Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Nucleic Acids Res. 2024 May 8;52(8):4167-4184
1	J:172355 Chen CY, Lin CW, Chang CY, Jiang ST, Hsueh YP, Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. J Cell Biol. 2011 May 16;193(4):769-84
1	J:308882 Dennison BJC, Larson ED, Fu R, Mo J, Fantauzzo KA, Srsf3 mediates alternative RNA splicing downstream of PDGFRalpha signaling in the facial mesenchyme. Development. 2021 Jul 15;148(14):dev199448
2*	J:66992 Douglas KR, Camper SA, Partial transcriptome of the developing pituitary gland. Genomics. 2000 Dec 15;70(3):335-46
1	J:239715 Galazo MJ, Emsley JG, Macklis JD, Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016 Jul 06;91(1):90-106
1	J:181631 Gehman LT, Meera P, Stoilov P, Shiue L, O'Brien JE, Meisler MH, Ares M Jr, Otis TS, Black DL, The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev. 2012 Mar 1;26(5):445-60
2*	J:147029 Gerke P, Benzing T, Hohne M, Kispert A, Frotscher M, Walz G, Kretz O, Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol. 2006 Oct 1;498(4):466-75
1	J:153596 Giangreco A, Jensen KB, Takai Y, Miyoshi J, Watt FM, Necl2 regulates epidermal adhesion and wound repair. Development. 2009 Oct;136(20):3505-14
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3*	J:142671 Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, Cooper TA, A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20333-8
9*	J:50453 Laverty HG, Wilson JB, Murine CASK is disrupted in a sex-linked cleft palate mouse mutant. Genomics. 1998 Oct 1;53(1):29-41
1	J:207976 Li Q, Zheng S, Han A, Lin CH, Stoilov P, Fu XD, Black DL, The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
1	J:241274 Lie E, Ko JS, Choi SY, Roh JD, Cho YS, Noh R, Kim D, Li Y, Kang H, Choi TY, Nam J, Mah W, Lee D, Lee SG, Kim HM, Kim H, Choi SY, Um JW, Kang MG, Bae YC, Ko J, Kim E, SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion. Nat Commun. 2016 Aug 02;7:12328
1*	J:187357 Lin CW, Huang TN, Wang GS, Kuo TY, Yen TY, Hsueh YP, Neural activity- and development-dependent expression and distribution of CASK interacting nucleosome assembly protein in mouse brain. J Comp Neurol. 2006 Feb 1;494(4):606-19
1	J:322355 Longatti A, Ponzoni L, Moretto E, Giansante G, Lattuada N, Colombo MN, Francolini M, Sala M, Murru L, Passafaro M, Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice. Mol Neurobiol. 2021 Dec;58(12):6092-6110
3	J:164479 Lozovatsky L, Abayasekara N, Piawah S, Walther Z, CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. Mol Biol Cell. 2009 Nov;20(21):4489-99
2	J:114313 Naim E, Bernstein A, Bertram JF, Caruana G, Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. Kidney Int. 2005 Sep;68(3):955-65
1*	J:193641 Nakano Y, Jahan I, Bonde G, Sun X, Hildebrand MS, Engelhardt JF, Smith RJ, Cornell RA, Fritzsch B, Banfi B, A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
1	J:102649 Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS, Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol. 2005 Sep 26;170(7):1127-34
5*	J:193047 Revil T, Jerome-Majewska LA, During embryogenesis, esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes. Dev Dyn. 2013 Mar;242(3):281-90
2	J:119934 Schoch S, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Sudhof TC, Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J. 2006 Dec 13;25(24):5852-63
8*	J:62660 Setou M, Nakagawa T, Seog DH, Hirokawa N, Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 2000 Jun 9;288(5472):1796-802
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:94801 Wang TF, Ding CN, Wang GS, Luo SC, Lin YL, Ruan Y, Hevner R, Rubenstein JL, Hsueh YP, Identification of Tbr-1/CASK complex target genes in neurons. J Neurochem. 2004 Dec;91(6):1483-92
1	J:127941 Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda Y, Chiba T, Morone N, Yuasa S, Inokuchi K, Ohtsuka T, Macgregor GR, Tanaka K, Setou M, SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell. 2007 Sep 7;130(5):943-57