Gene Expression Literature Summary

• Symbol: Tnfrsf1a
• Name: tumor necrosis factor receptor superfamily, member 1a
• ID: MGI:1314884

31 matching records from 31 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E5.5	E6.5	E7.5	E8.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)		1									1		2		3		2		1		1		1	3
In situ RNA (section)			1								1				3						1			1
In situ reporter (knock in)																								1
Northern blot			1	1	1				1						1						1			1
Western blot	1																							1
RT-PCR						1	1	3	1	1		2	2	1	2	1		1		1	1		2	7
RNase protection															1		1				1	1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tnfrsf1a  tumor necrosis factor receptor superfamily, member 1a   (Synonyms: CD120a, p55, p55-R, TNF-alpha-R1, TNF-alphaR1, TNFalpha-R1, TNFAR, Tnfr1, TNF-R1, TNF-R55, TNFR60, TNF receptor alpha chain, TNF-R-I, TNFRI, TNFRp55)
Results	Reference
1	J:177769 Aebischer J, Sturny R, Andrieu D, Rieusset A, Schaller F, Geib S, Raoul C, Muscatelli F, Necdin protects embryonic motoneurons from programmed cell death. PLoS One. 2011;6(9):e23764
1*	J:76222 Alcamo E, Hacohen N, Schulte LC, Rennert PD, Hynes RO, Baltimore D, Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs. J Exp Med. 2002 Jan 21;195(2):233-44
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2*	J:53584 Doi TS, Marino MW, Takahashi T, Yoshida T, Sakakura T, Old LJ, Obata Y, Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2994-9
2*	J:96841 Gong SG, Gong TW, Shum L, Identification of markers of the midface. J Dent Res. 2005 Jan;84(1):69-72
2	J:52479 Ivnitsky I, Torchinsky A, Gorivodsky M, Zemliak I, Orenstein H, Savion S, Shepshelovich J, Carp H, Fein A, Toder V, TNF-alpha expression in embryos exposed to a teratogen. Am J Reprod Immunol. 1998 Dec;40(6):431-40
3*	J:21013 Jaskoll T, Boyer PD, Melnick M, Tumor necrosis factor-alpha and embryonic mouse lung morphogenesis. Dev Dyn. 1994 OCT;201(2):137-150
1	J:69420 Jaskoll T, Melnick M, Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999 Nov 1;256(3):252-68
2	J:84726 Joswig A, Gabriel HD, Kibschull M, Winterhager E, Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reprod Biol Endocrinol. 2003 May 26;1(1):44
3*	J:94930 Kamiya A, Gonzalez FJ, TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices. Hepatology. 2004 Sep;40(3):527-36
3	J:170178 Kobayashi K, Umezawa K, Yasui M, Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biol Reprod. 2011 Feb;84(2):248-54
7*	J:17723 Kohchi C, Noguchi K, Tanabe Y, Mizuno D, Soma G, Constitutive expression of TNF-alpha and -beta genes in mouse embryo: roles of cytokines as regulator and effector on development. Int J Biochem. 1994 Jan;26(1):111-9
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:234310 Kuo TL, Weng CC, Kuo KK, Chen CY, Wu DC, Hung WC, Cheng KH, APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice. Oncogene. 2016 Apr 28;35(17):2223-34
1	J:145398 Liu XS, Li XH, Wang Y, Shu RZ, Wang L, Lu SY, Kong H, Jin YE, Zhang LJ, Fei J, Chen SJ, Chen Z, Gu MM, Lu ZY, Wang ZG, Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood. 2007 Aug 1;110(3):870-6
1*	J:317554 Louden ED, Luzzo KM, Jimenez PT, Chi T, Chi M, Moley KH, TallyHO obese female mice experience poor reproductive outcomes and abnormal blastocyst metabolism that is reversed by metformin. Reprod Fertil Dev. 2014 Dec;27(1):31-9
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
5	J:67809 Melnick M, Chen H, Zhou Y, Jaskoll T, Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec. 2001 Mar 1;262(3):318-30
1*	J:143615 Orelio C, Haak E, Peeters M, Dzierzak E, Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo. Blood. 2008 Dec 15;112(13):4895-904
1	J:225134 Ren K, Yuan J, Yang M, Gao X, Ding X, Zhou J, Hu X, Cao J, Deng X, Xiang S, Zhang J, KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development. PLoS One. 2014;9(11):e112275
11*	J:28858 Roby KF, Laham N, Kroning H, Terranova PF, Hunt JS, Expression and localization of messenger RNA for tumor necrosis factor receptor (TNF-R) i and TNF-RII in pregnant mouse uterus and placenta. Endocrine. 1995 AUG;3(8):557-562
2*	J:60742 Rosenfeld ME, Prichard L, Shiojiri N, Fausto N, Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice. Am J Pathol. 2000 Mar;156(3):997-1007
2	J:83949 Sharov AA, Weiner L, Sharova TY, Siebenhaar F, Atoyan R, Reginato AM, McNamara CA, Funa K, Gilchrest BA, Brissette JL, Botchkarev VA, Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. EMBO J. 2003 Jun 16;22(12):2992-3003
2*	J:261957 Svandova EB, Vesela B, Lesot H, Poliard A, Matalova E, Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination. Histochem Cell Biol. 2017 Apr;147(4):497-510
1	J:258557 Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S, Wu X, Wang H, Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 2016 Jan;23(1):169-81
1	J:150308 Vondenhoff MF, Greuter M, Goverse G, Elewaut D, Dewint P, Ware CF, Hoorweg K, Kraal G, Mebius RE, LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. J Immunol. 2009 May 1;182(9):5439-45
1	J:64018 Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP, Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Dev Biol. 2000 Aug 15;224(2):152-67
1	J:261826 Wang Y, Wu B, Farrar E, Lui W, Lu P, Zhang D, Alfieri CM, Mao K, Chu M, Yang D, Xu D, Rauchman M, Taylor V, Conway SJ, Yutzey KE, Butcher JT, Zhou B, Notch-Tnf signalling is required for development and homeostasis of arterial valves. Eur Heart J. 2017 Mar 1;38(9):675-686
1*	J:341382 Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y, Zhou B, Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
1	J:81255 Yilmaz ZB, Weih DS, Sivakumar V, Weih F, RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J. 2003 Jan 2;22(1):121-30
1	J:295435 Yli-Karjanmaa M, Larsen KS, Fenger CD, Kristensen LK, Martin NA, Jensen PT, Breton A, Nathanson L, Nielsen PV, Lund MC, Carlsen SL, Gramsbergen JB, Finsen B, Stubbe J, Frich LH, Stolp H, Brambilla R, Anthony DC, Meyer M, Lambertsen KL, TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex. Brain Behav Immun. 2019 Nov;82:279-297