Gene Expression Literature Summary

• Symbol: Ppp2ca
• Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
• ID: MGI:1321159

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15.5	E16.5	E18	E18.5	E	P
Immunohistochemistry (section)	1										2	1			2		2
In situ RNA (section)											2
Immunohistochemistry (whole mount)	1	1	2	1												1
In situ RNA (whole mount)												1
Northern blot																	1
Western blot						2	1	2	1	1		2	1	1	1		8
RT-PCR					1	1		1			1				1		2
cDNA clones																	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ppp2ca  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform   (Synonyms: PP2A)
Results	Reference
1	J:240005 Aldiri I, Ajioka I, Xu B, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio LA, Dyer MA, Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. Development. 2015 Dec 01;142(23):4092-106
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2*	J:171578 Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X, Protein Phosphatase 2A Catalytic Subunit alpha (PP2Acalpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway. Am J Pathol. 2011 May;178(5):2333-43
6	J:60100 Gotz J, Kues W, The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies. Biol Chem. 1999 Sep;380(9):1117-20
3*	J:50519 Gotz J, Probst A, Ehler E, Hemmings B, Kues W, Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12370-5
3	J:184036 Gu P, Qi X, Zhou Y, Wang Y, Gao X, Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis. 2012 May;50(5):429-36
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3	J:294837 Huang C, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, Chen G, Yin Z, Hu Y, Loss of PP2A Disrupts the Retention of Radial Glial Progenitors in the Telencephalic Niche to Impair the Generation for Late-Born Neurons During Cortical Development. Cereb Cortex. 2020 Jun 1;30(7):4183-4196
1	J:264469 Lee JA, Wang Z, Sambo D, Bunting KD, Pallas DC, Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. J Biol Chem. 2018 Jun 22;293(25):9636-9650
5	J:320195 Liu B, Sun LH, Huang YF, Guo LJ, Luo LS, Protein phosphatase 2ACalpha gene knock-out results in cortical atrophy through activating hippo cascade in neuronal progenitor cells. Int J Biochem Cell Biol. 2018 Feb;95:53-62
2*	J:135212 Liu WB, Li Y, Zhang L, Chen HG, Sun S, Liu JP, Liu Y, Li DW, Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Mol Vis. 2008;14:762-73
1*	J:202973 Lu T, Chen R, Cox TC, Moldrich RX, Kurniawan N, Tan G, Perry JK, Ashworth A, Bartlett PF, Xu L, Zhang J, Lu B, Wu M, Shen Q, Liu Y, Richards LJ, Xiong Z, X-linked microtubule-associated protein, Mid1, regulates axon development. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19131-6
1*	J:103128 Machka C, Kersten M, Zobawa M, Harder A, Horsch M, Halder T, Lottspeich F, Hrabe de Angelis M, Beckers J, Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns. 2005 Dec;6(1):94-101
1*	J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
1	J:138002 Ortega-Gutierrez S, Leung D, Ficarro S, Peters EC, Cravatt BF, Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. PLoS One. 2008;3(7):e2486
5	J:308917 Panicker N, Coutman M, Lawlor-O'Neill C, Kahl RGS, Roselli S, Verrills NM, Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55alpha, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development. Front Cell Dev Biol. 2020;8:358
1	J:355261 Rehmani T, Dias AP, Applin BD, Salih M, Tuana BS, SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
1	J:346063 Rehmani T, Dias AP, Kamal M, Salih M, Tuana BS, Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway. Int J Mol Sci. 2024 Mar 1;25(5)
1*	J:121900 Sasaki M, Ohnishi M, Tashiro F, Niwa H, Suzuki A, Miyazaki J, Kobayashi T, Tamura S, Disruption of the mouse protein Ser/Thr phosphatase 2Cbeta gene leads to early pre-implantation lethality. Mech Dev. 2007 Jul;124(6):489-99
1	J:181834 Su YQ, Sugiura K, Sun F, Pendola JK, Cox GA, Handel MA, Schimenti JC, Eppig JJ, MARF1 regulates essential oogenic processes in mice. Science. 2012 Mar 23;335(6075):1496-9
1*	J:139034 Traweger A, Wiggin G, Taylor L, Tate SA, Metalnikov P, Pawson T, Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10402-7
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:306388 Yen YT, Chien M, Wu PY, Hung SC, PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Commun Biol. 2021 Jun 2;4(1):658
1	J:228307 Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, He L, Cang Y, Boast S, Chen YH, Thibault H, Scherrer-Crosbie M, Goff SP, Li B, Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71