Gene Expression Literature Summary

• Symbol: Cldn3
• Name: claudin 3
• ID: MGI:1329044

46 matching records from 46 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E8	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	P
Immunohistochemistry (section)				1		3	1	2	5	1	6	2	7	1	6	1	5	1	3	1	5	1	16
In situ RNA (section)			1	1	1	1			1		1		5		1						1		2
In situ RNA (whole mount)	1	1	1	1	1	1			1
Western blot																	2				1		2
RT-PCR		1			1		1	1	2		1		2	1	2		2	1		1	2		10

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cldn3  claudin 3   (Synonyms: Cpetr2)
Results	Reference
1	J:139649 Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J, The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 2008 Sep;29(3):423-37
1	J:228779 Alpern D, Langer D, Ballester B, Le Gras S, Romier C, Mengus G, Davidson I, TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Elife. 2014;3:e03613
2	J:178985 Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonniere L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A, The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science. 2011 Dec 23;334(6063):1727-31
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:190582 Bondow BJ, Faber ML, Wojta KJ, Walker EM, Battle MA, E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 2012 Nov 1;371(1):1-12
5	J:253618 Bonney S, Siegenthaler JA, Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. eNeuro. 2017 May-Jun;4(3):ENEURO.0378-16.2017
1*	J:214666 Brunskill EW, Potter AS, Distasio A, Dexheimer P, Plassard A, Aronow BJ, Potter SS, A gene expression atlas of early craniofacial development. Dev Biol. 2014 Jul 15;391(2):133-46
1	J:156972 De Rosa L, Antonini D, Ferone G, Russo MT, Yu PB, Han R, Missero C, p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. J Biol Chem. 2009 Oct 30;284(44):30574-82
3	J:278241 Delile J, Rayon T, Melchionda M, Edwards A, Briscoe J, Sagner A, Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord. Development. 2019 Mar 27;146(12):dev173807
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:147670 Done SC, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, Tryggvason K, Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int. 2008 Mar;73(6):697-704
1	J:153593 Dooley J, Erickson M, Farr AG, Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium. J Immunol. 2009 Oct 15;183(8):5042-9
2	J:315134 Ezan P, Andre P, Cisternino S, Saubamea B, Boulay AC, Doutremer S, Thomas MA, Quenech'du N, Giaume C, Cohen-Salmon M, Deletion of astroglial connexins weakens the blood-brain barrier. J Cereb Blood Flow Metab. 2012 Aug;32(8):1457-67
1*	J:178498 Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfo M, De Luca P, de Carvalho DP, Ceccarelli M, De Felice M, Di Lauro R, Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011 Nov 15;359(2):163-75
5*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
5*	J:93085 Hashizume A, Ueno T, Furuse M, Tsukita S, Nakanishi Y, Hieda Y, Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland. Dev Dyn. 2004 Oct;231(2):425-31
2	J:307816 Heymans C, Delcorte O, Spourquet C, Villacorte-Tabelin M, Dupasquier S, Achouri Y, Mahibullah S, Lemoine P, Balda MS, Matter K, Pierreux CE, Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function. Sci Rep. 2021 Jul 15;11(1):14519
1	J:313345 Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H, Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. Sci Rep. 2021 Nov 4;11(1):21642
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1	J:255472 Jimenez-Caliani AJ, Pillich R, Yang W, Diaferia GR, Meda P, Crisa L, Cirulli V, alphaE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation. Cell Rep. 2017 Aug 8;20(6):1295-1306
6*	J:210984 Kumar A, Lualdi M, Loncarek J, Cho YW, Lee JE, Ge K, Kuehn MR, Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Dev Dyn. 2014 Jul;243(7):937-47
2	J:190580 Lei Z, Maeda T, Tamura A, Nakamura T, Yamazaki Y, Shiratori H, Yashiro K, Tsukita S, Hamada H, EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 2012 Nov 15;371(2):136-45
1	J:278227 Li H, Jones KL, Hooper JE, Williams T, The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution. Development. 2019 Jun 17;146(12):dev174888
5	J:290414 Li J, Gordon J, Chen ELY, Xiao S, Wu L, Zuniga-Pflucker JC, Manley NR, NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development. Development. 2020 Jun 22;147(12):dev178988
2	J:291487 Liu D, Kousa AI, O'Neill KE, Rouse P, Popis M, Farley AM, Tomlinson SR, Ulyanchenko S, Guillemot F, Seymour PA, Jorgensen MC, Serup P, Koch U, Radtke F, Blackburn CC, Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development. Development. 2020 Jun 22;147(12):dev178582
2	J:260463 Losa M, Risolino M, Li B, Hart J, Quintana L, Grishina I, Yang H, Choi IF, Lewicki P, Khan S, Aho R, Feenstra J, Vincent CT, Brown AMC, Ferretti E, Williams T, Selleri L, Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion. Development. 2018 Mar 1;145(5):dev157628
1	J:338955 Maezawa S, Yukawa M, Hasegawa K, Sugiyama R, Iizuka M, Hu M, Sakashita A, Vidal M, Koseki H, Barski A, DeFalco T, Namekawa SH, PRC1 suppresses a female gene regulatory network to ensure testicular differentiation. Cell Death Dis. 2023 Aug 4;14(8):501
4	J:345312 Mak S, Hammes A, Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development. Int J Mol Sci. 2024 Jan 24;25(3)
1	J:302357 Masuzaki R, Ray KC, Roland J, Zent R, Lee YA, Karp SJ, Integrin beta1 Establishes Liver Microstructure and Modulates Transforming Growth Factor beta during Liver Development and Regeneration. Am J Pathol. 2021 Feb;191(2):309-319
5*	J:169091 Mineta K, Yamamoto Y, Yamazaki Y, Tanaka H, Tada Y, Saito K, Tamura A, Igarashi M, Endo T, Takeuchi K, Tsukita S, Predicted expansion of the claudin multigene family. FEBS Lett. 2011 Feb 18;585(4):606-12
1	J:177153 Mirza M, Petersen C, Nordqvist K, Sollerbrant K, Coxsackievirus and adenovirus receptor is up-regulated in migratory germ cells during passage of the blood-testis barrier. Endocrinology. 2007 Nov;148(11):5459-69
4	J:309668 Montero-Herradon S, Garcia-Ceca J, Zapata AG, Altered Maturation of Medullary TEC in EphB-Deficient Thymi Is Recovered by RANK Signaling Stimulation. Front Immunol. 2018;9:1020
8	J:293206 Munoz JJ, Tobajas E, Juara S, Montero S, Zapata AG, FoxN1 mediates thymic cortex-medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis. Histochem Cell Biol. 2019 Dec;152(6):397-413
1*	J:72106 Niimi T, Nagashima K, Ward JM, Minoo P, Zimonjic DB, Popescu NC, Kimura S, claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol Cell Biol. 2001 Nov;21(21):7380-90
3	J:279661 Nikolopoulou E, Hirst CS, Galea G, Venturini C, Moulding D, Marshall AR, Rolo A, De Castro SCP, Copp AJ, Greene NDE, Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2. Nat Commun. 2019 Jun 6;10(1):2487
4*	J:116647 Ohazama A, Sharpe PT, Expression of claudins in murine tooth development. Dev Dyn. 2007 Jan;236(1):290-4
5*	J:107229 Ohta H, Adachi H, Inaba M, Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J Vet Med Sci. 2006 Feb;68(2):149-55
4	J:180511 Patel RM, Myers LS, Kurundkar AR, Maheshwari A, Nusrat A, Lin PW, Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol. 2012 Feb;180(2):626-35
1	J:214094 Reeh KA, Cardenas KT, Bain VE, Liu Z, Laurent M, Manley NR, Richie ER, Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014 Aug;141(15):2950-8
1	J:265031 Sequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G, Watt FM, Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nat Commun. 2018 Aug 24;9(1):3437
1*	J:165127 Thompson PD, Tipney H, Brass A, Noyes H, Kemp S, Naessens J, Tassabehji M, Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis. PLoS One. 2010;5(9)
6*	J:117802 Troy TC, Li Y, O'malley L, Turksen K, The temporal and spatial expression of Claudins in epidermal development and the accelerated program of epidermal differentiation in K14-CaSR transgenic mice. Gene Expr Patterns. 2007 Feb;7(4):423-30
7	J:173368 Wang X, Ouyang H, Yamamoto Y, Kumar PA, Wei TS, Dagher R, Vincent M, Lu X, Bellizzi AM, Ho KY, Crum CP, Xian W, McKeon F, Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia. Cell. 2011 Jun 24;145(7):1023-35
8*	J:181271 Westmoreland JJ, Drosos Y, Kelly J, Ye J, Means AL, Washington MK, Sosa-Pineda B, Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
2	J:183127 Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B, Pancreas-specific deletion of prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology. 2012 Apr;142(4):999-1009.e6
1*	J:233398 Wu RC, Zeng Y, Pan IW, Wu MY, Androgen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in Spermatogenesis. Mol Endocrinol. 2015 Sep;29(9):1334-46